Seat No.: _____ Enrolment No.

_____________

GUJARAT TECHNOLOGICAL UNIVERSITY

B.PHARM - SEMESTER– 4 EXAMINATION – WINTER -2019

Subject Code: BP402TP Date: 17-12-2019

Subject Name: Medicinal Chemistry I
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Discuss the role of hydrogen bonding and solubility in drug’s biological action 06
(b) Write a brief note on Bioisosterism 05
(c) Enumerate factors affecting drug metabolism. Explain stereo-chemical aspects 05
Q.2 (a) Outline the biosynthesis of catecholamines. Give synthesis of salbutamol 06
(b) Give a brief account on α-adrenergic blockers 05
(c) Give structure and use of (i) Clonidine (ii) Labetalol 05
Q.3 (a) Explain (i) Metabolism of paracetamol (ii) Glucuronide conjugation 06
(b) Write in brief about synthetic cholinergic blockers 05
(c) Give synthesis (i) Neostigmine (ii) Dicyclomine 05
Q.4 (a) Write SAR of β-blockers. Give synthesis of Propranolol 06
(b) Write a short note on cholinesterase inhibitors 05
(c) Give SAR of Benzodiazepines 05
Q.5 (a) Describe SAR of parasympathomimetic agents 06
(b) Give structure and use of (i) Alprazolam (ii) Valproic acid (iii) Clonazepam 05
(iv) Pentazocine (v) Diclofenac
(c) Classify general anesthetic agents 05
Q. 6 (a) Classify sedative and hypnotics 06
(b) Give SAR of Morphine analogues 05
(c) Explain with example (i) Dissociative anesthetic (ii) Cholinesterase reactivators 05
Q.7 (a) Give synthesis (i) Phenytoin (ii) Carbamazepine 06
(b) (i) Explain with example- Narcotic antagonists (ii) Give synthesis of Tolazoline 05
(c) Give synthesis of (i) Halothane (ii) Ibuprofen 05

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Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY

B.Ph. - SEMESTER–IV • EXAMINATION – WINTER-2020

Subject Code:BP402TP Date: 10/02/2021

Subject Name: Medicinal Chemistry I
Time: 02:30PM TO 04:30PM Total Marks: 54
Instructions:
1. Attempt any THREE questions from Q-1 to Q-6.
2. Q.7 is compulsory to attempt.
3. Make suitable assumptions wherever necessary.
4. Figures to the right indicate full marks.
Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY

B.Ph. - SEMESTER–IV • EXAMINATION – SUMMER -2020

Subject Code: BP402TP Date: 27-10-2020

Subject Name: Medicinal Chemistry I
Time: 10:30 AM TO 1:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Write all possible routes for the metabolism of norepinephrine. 06
(b) Write the biosynthesis of norepinephrine with chemical reactions. 05
(c) Discuss the types of cholinergic receptors with their distribution. 05
Q.2 (a) Describe the SAR of adrenergic agonists. 06
(b) Write a note on indirectly acting sympathomimetics. 05
(c) Write the synthesis of salbutamol and propranolol. 05
Q.3 (a) Discuss in brief the development of medicinal chemistry. 06
(b) Make an introductory note on phase I and phase II metabolism. 05
(c) Discuss the importance of protein binding and hydrogen bonding in producing 05
drug’s biological action.
Q.4 (a) Classify the antiepileptics with one drug’s structure from each class. 06
(b) Discuss the structural modifications of 5-phenyl-1,4-benzodiazepin-2-one. 05
(c) Write the synthesis of any two anticonvulsant drugs. 05
Q.5 (a) Define the word ‘opioids’. Write the name and structures of narcotic 06
antagonists.
(b) Write the mechanism of action of NSAIDs. Write the synthesis of any one 05
NSAID from aryl propionic acid class.
(c) Classify the NSAIDs with one drug’s structure from each class. 05
Q. 6 (a) Define neuroleptics. Write the mechanism of action and possible side effects of 06
them.
(b) Describe the structural modification of side chain of phenothiazines. 05
(c) Classify the general anaesthetics with two drugs’ structures from each class. 05
Q.7 (a) Classify the parasympathomimetics with two drugs’ structures from each class. 06
(b) Write a note on cholinesterase reactivators. 05
(c) Write the chemical class, synthesis and use of dicyclomine hydrochloride. 05

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Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY

B.PHARM - SEMESTER– 4 EXAMINATION – SUMMER -2019

Subject Code: BP402TP Date: 09-05-2019

Subject Name: Medicinal Chemistry I
Time: 10:30 AM TO 01:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Define: Chelation, Bioisosterism, Partition coefficient, Ionization, Optical 06

isomerism, Hydrogen bonding
(b) Define Xenobiotics. Give importance of CYP-450 in drug metabolism. 05
(c) What are Sympathomimetics agents? Classify them with examples. 05
Q.2 (a) Enlist different pathways of drug metabolism. Describe any two conjugation 06
reaction in drug metabolism giving specific examples.
(b) Explain: Biosynthesis and catabolism of catecholamine. 05
(c) Give the synthesis and uses of following drugs: 05
1) Carbamazepine
2) Dicyclomine HCl
Q.3 (a) Write a note on parasympatholytic agents. 06
(b) Give SAR of Benzodiazepines. 05
(c) What are antipsychotics drugs? Write SAR of phenothiazines. 05
Q.4 (a) What are NSAIDs? Classify them with two examples of each class. Write 06
synthesis of one NSAID having one chiral center.
(b) Classify General anesthetics and give synthesis of Halothane. 05
(c) Give the structures of following drugs: 05
1) Scopolamine Hydrobromide 4) Oxazepam
2) Paraldehyde 5) Secobarbital
3) Pentazocine
Q.5 (a) Write a note on Narcotic antagonists with its mechanism. 06
(b) Explain in details: Factor affecting drug metabolism including stereo 05
chemical aspects.
(c) Give the synthesis and uses of following drugs: 05
1) Methohexital sodium
2) Methadone HCl
Q.6 (a) Define Insomnia. Explain mechanism and SAR of Barbiturates. 06
(b) Explain stages of anesthesia with classification of Inhalation anesthetics. 05
(c) Write a note on Fluro buterophenones with its mechanism. 05
Q.7 (a) Classify anticonvulsants with its mechanism and SAR. 06
(b) Give SAR of Morphine analogues. 05
(c) Give the structures of following drugs: 05
1) Chlorprothixene 4) Glutethmide
2) Clonazepam 5) Carvedilol
3) Valproic acid

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 Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY

B.Pharm –SEMESTER – IV EXAMINATION – WINTER -2021

Subject Code:BP402TP Date: 21/02/2022

Subject Name: Medicinal Chemistry I
Time: 02:30PM to 05:30PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Classify adrenergic drugs with examples according the receptors they affect. 06
(b) Explain the structure activity relationship among phenylethanolamine type of 05
adrenergicagonists
(c) Explain biosynthesis of nor-adrenaline and role of MAO & COMT in its 05
metabolism
Q.2 (a) Explain structure activity relationship of beta blockers and give synthesis of 06
propranalol.
(b) Write synthesis for Phenylephrine and Salbutamol 05
(c) Mention the uses for following drugs- 05
i) Clonidine ii) Terbutaline iii) Naphazoline iv) Pseudoephedrine v)
Oxymetazoline

Q.3 (a) Give structure of a typical cholinergic agonist. Explain the effect of 06
modification at acyloxy group and quaternary ammonium group on the activity
of cholinergic agonists.
(b) Classify synthetic cholinergic blocking agents with examples and uses. Write 05
synthesis of Dicyclomine HCl.
(c) Explain mechanism of action and uses of following drugs- 05
i) Homatropine HBr. ii) Pyridostigmine iii) Pralidoxime chloride
iv) Pilocarpine v) Atropine sulphate

Q.4 (a) Answer the following in short (1.5 marks each) 06

i) What are sedatives & hypnotics?
ii) Give chemical classification of sedatives & hypnotics.
iii) What are different types of Barbiturates?
iv) Write synthesis of Diazepam.

(b) Explain the Structure Activity Relationship in Barbiturates OR 05

Benzodiazepines.
(c) Classify Anti-psychotic Drugs. Explain the structure activity relationship at 05
Alkyl side chain and basic amino group of phenothiazines.
Q.5 (a) Answer the following (2 marks each) 06
i) Give chemical classification of anticonvulsants.
ii) Explain mechanism of action of anticonvulsants.
iii) Write synthesis of Ethosuximide.

(b) Explain common structural features of anti-convulsant drugs. Write synthesis 05

of Phenytoin and Carbamazepine.
(c) Explain the mechanism of action for Narcotic and Non-Narcotic analgesics. 05
Write structures of Morphine, Methadone HCl and Ibuprofen.
Q. 6 (a) Explain various Phase-I reactions involved drug metabolism with suitable 06
examples.
(b) Describe Partition Coefficient & Optical isomerism and explain how they 05
contribute to biological action of a drug.
(c) Enlist factors affecting drug metabolism and explain any two of them. 05
Q.7 (a) Answer the following (2 marks each) 06
i) Describe the terms ‘General Anesthetics’ and ‘Dissociative Anesthetics’.
ii) Write structures of Halothane and Methohexital sodium
iii) Define Narcotic Analgesics. What is the source of Morphine?

(b) Give chemical classification of non-steroidal anti-inflammatory agents with 05

examples.
(c) Write mechanism of action and synthesis of Fentanyl citrate and Mefenamic 05
acid.
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 GUJARAT TECHNOLOGICAL UNIVERSITY
B.Pharm - SEMESTER–IV • EXAMINATION – SUMMER - 2021

Subject Code: BP402TP Date: 04/08/2021

Subject Name: Medicinal Chemistry I
Time: 10:30AM to 01:30PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.