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Post Menstrual Bleeding
Post Menstrual Bleeding
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Uterine Bleeding in the Postmenopausal Period
• Pregnancies and periods before menopause metrium cells in a PAP smear is abnormal and
(regular cycles?). needs endometrial tissue sampling (see below).
• Duration and frequency of bleeding. • Ultrasound: you can detect thickened endo-
• Symptoms of atrophy (dryness of the vagina, metrium (polyps, hyperplasia, endometrial can-
dyspareunia, dysuria) or prolapse present? cer), fibroids and ovarian masses. A useful cut-off
• Vaginal discharge. point for thickened endometrium is around
• Abdominal swelling or pain. 3–4 mm in postmenopausal women.
• Sexual history: sexually transmitted infections • Biopsy for histology if suspicion of cervical or
(STIs)? endometrial carcinoma. A cervical biopsy can be
• Contraception before menopause (IUD)? obtained using a special cervical biopsy forceps
and can detect cervical cancer in almost 100%
and genital schistosomiasis in about 50%. For
EXAMINATION endometrial sampling (do this in postmeno-
pausal women with thickened endometrium
• Obesity: women with morbid obesity [body
>3–4 mm on ultrasound) you could use the
mass index (BMI) >30; see Chapter 8 on how to
smallest cannula of a manual vacuum aspiration
calculate BMI] have a high level of estrogen.
(MVA) set (see Chapter 6) or perform a dilata-
• Speculum examination:
tion and curettage (D&C). The big advantage of
N Signs of atrophy: pale, dry vagina sometimes
a MVA is that you can perform this without
with petechia (small red spots caused by sub-
anesthesia in most women. The advantage of
mucosal bleeding).
D&C is that if postmenopausal blood loss is
N Prolapse with pressure sores?
caused by endometrium polyps the D&C can be
N Cervical carcinoma?
therapeutic. Make sure you can send the sample
N Vaginal discharge? Cervicitis?
to a place where histology can be done within a
N Endometrial polyp visible in vagina?
reasonable time.
N If possible perform a test for pre-stadia of
• Hysteroscopy is an advanced diagnostic test:
cervical cancer like a human papillomavirus
with a scope you can inspect the inside of the
(HPV) test or a VIA; see Chapter 26.
uterus. In many low-resource settings this is not
N Presence of grainy sandy patches – alterations
available yet (see Chapter 1).
are considered to be characteristic of schisto-
somiasis in the cervix.
N IUD thread.
• PVE: fibroids or pelvic masses? If you suspect TREATMENT
advanced cervical carcinoma do a rectal exami-
Endometrial malignancies need a hysterectomy
nation as described in Chapter 1.
with removal of ovaries (see Chapter 26 and Chap-
If you cannot find a plausible benign cause of post- ter 19 for TAH; Chapter 20 explains how to do a
menopausal blood loss the woman should undergo vaginal hysterectomy).
two tests: first an ultrasound to measure the thick- Hyperplasia with atypia needs a hysterectomy
ness of the endometrium and to look for pelvic while hyperplasia without atypia can best be treated
masses and secondly a test to exclude a premalig- with a levonorgestrel (LNG)-IUD (Mirena®).
nancy of the cervix (HPV or VIA). Second-best therapy is oral progestogens like
medroxyprogesterone acetate (10 mg/day for 3
months). In both cases repeat the sampling of the
ADDITIONAL TESTS
endometrium after 3 months. When performing an
• HPV or VIA tests to screen for pre-stadia of cer- MVA after 3 months you can leave the IUD in situ!
vical cancer (see Chapter 26). If you work in a Polyps protruding through the cervix can be
facility in which a PAP smear can be made this grasped with a sponge-holding forceps and you can
is a useful test in postmenopausal bleeding: you twist them off.
can detect pre-stadia of cervical cancer as well as Atrophy of the vagina can be treated with topi-
the presence of (abnormal) endometrium cells. cal estrogen cream, for example estriol cream 2–3
In postmenopausal women presence of endo- times a week.
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Postmenopausal
Bleeding: do speculum,
vaginal examination and
screen for cervical cancer
Abnormal cervix:
No abnormalities
Atrophy of vagina Prolapse Endometrial polyp possible cervical
seen
cancer or schistosomiasis
(see
(see Chapter 23)
chapter 25) possible histology
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US: endometrium US: endometrium
< 4 mm: review ш 4 mm: do endometrial
after 2 months tissue sampling
Figure 1 Flowchart for management of postmenopausal bleeding. PAP, cytological smear for detection of pre-stadia of cervix cancer; HPV, human papilloma virus test;
US, ultrasound; VIA, visual inspection of cervix with acetic acid
Uterine Bleeding in the Postmenopausal Period
For granulosa cell cancer, please see Chapter 28 World Health Organization. Report of an informal working
and for prolapse Chapter 23. group on urogenital schistosomiasis and HIV transmission.
WHO/HTM/NTD/PCT/2010.5. Geneva: WHO, 2009
FLOWCHART: POSTMENOPAUSAL Kaur J, Dey P, Saha SC, et al. Cervical cytology in patients
BLEEDING with postmenopausal bleeding. Diagn Cytopathol 2009;
38:496–8
All women with postmenopausal bleeding should Timmermans A, Opmeer BC, Khan KS, et al. Endometrial
have detailed history taking and full gynecological thickness measurement for detecting endometrial cancer in
examination (as in Chapter 1): do speculum, vagi- women with postmenopausal bleeding: a systematic review
nal examination and screen for pre-stadia of cervi- and meta-analysis. Obstet Gynecol 2010;116:160–7
cal cancer (Figure 1). Gallos ID, Shehmar M, Thangaratinam S, et al. Oral pro-
gestogens vs levonorgestrel-releasing intrauterine system
FURTHER READING for endometrial hyperplasia: a systematic review and meta-
analysis. Am J Obstet Gynecol 2010;203:547e1–10
Marret H, Fauconnier A, Chabbert-Buffet N, et al. Clinical
practice guidelines on menorrhagia: management of abnor-
mal uterine bleeding before menopause. Eur J Obstet Gyne-
col Reprod Biol 2010;152:133–7
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