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Role of Intrastromal
Injections in Fungal Keratitis

This page was enrolled in the International Ophthalmologists

contest.

Original article Gunjan Saluja, MD

contributed by:

All contributors: Colleen Halfpenny, M.D., Gunjan

Saluja, MD and Vatinee Bunya, MD

Assigned editor: Colleen Halfpenny, M.D.

Review: Assigned status Up to Date

by Colleen Halfpenny, M.D. on September 27, 2020.

Introduction

Antifungal Drugs

Commonly used
Intrastromal Antifungal
Drugs

Preparation of
intrastromal drug
concentration

Voriconazole vial 

Intrastromal dose of Amphotericin B is 5-10ug/0.1 ml.

Preparation of intrastromal Amphotericin B is done by

reconstituting 50mg powder of Amphotericin B in 10ml
dextrose 5% to give concentration of 5mg/ml and 500
ug/0.1ml. Further this concentration is diluted with 9.9 ml
dextrose 5% in a tuberculin syringe to give concentration of
500ug/10 ml and 50ug/ml and 5 ug/0.1 ml.

The dose of Intrastromal Voriconazole is 50 ug/ 0.1 ml and is

prepared by adding 19 ml distilled water in 200 mg powder
of voriconzole to get 20 ml drug (10mg in 1 ml). 1 ml of drug
is taken and 9 ml distilled water is added to get 10 mg in 10
ml . .05 ml of this solution contains 50 ug or 0.1 ml of this
solution contains 100 ug.

Technique of giving
intrastromal injections

References
Categories: Articles Cornea/External Disease

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This page was last modified on September 27, 2020, at 03:49.

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