Lhasa Carcinogenicity Database Report

Report Date Software Version Database Version

24 January 2023 07:06:06 2.0.2 2021.1

Trichloroacetic acid
Summary

Species Lhasa TD50 Gold TD50 Result Sex Tumour Sites

(mg/kg/day) (mg/kg/day)

Positive Female Liver

Mouse 386 584 Positive Male Liver

No Data Unspecified -

No Data Female -

Rat - - Negative Male -

No Data Unspecified -

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Chemical Structure
Chemical Name Trichloroacetic acid

Synonym(s) Trichloromethanecarboxylic acid;

Trichloroethanoic acid

CAS Registry Number® 76-03-9

Chemistry Unique Identifier 76-03-9

Molecular Weight 163.39

Molecular Formula C2HCl3O2

SMILES OC(C(Cl)(Cl)Cl)=O

InChI InChI=1/C2HCl3O2/c3-
2(4,5)1(6)7/h(H,6,7)/f/h6H

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Study Details and Citations
Study 1 of 4
Species Sex Strain Route Exposure Time Experiment Time Result Vehicle Frequency Reliability
Mouse Female B6C3F1 Drinking water 51 week(s) 51 week(s) Positive Not specified Not specified 4- Not assignable

Observations

Lhasa TD50 Lhasa 99% Lhasa 99% Gold TD50 Gold 99% Gold 99%
Tumour Site : Tumour Types Author Call p Value
(mg/kg/day) Lower CI Upper CI (mg/kg/day) Lower CI Upper CI
Liver : Adenoma- hepatocellular Not specified <=0.233 378 182.969 2063.146 891 212 -

Dose (mg/kg/day) 0 65.4 218 654 - - - - - - - - -

Incidence 1/40 3/40 3/19 2/19 - - - - - - - - -

Lhasa TD50 Notes: Lhasa TD50s were calculated using the summary method. CPDB calculated the TD50 value using the summary method.

Lhasa TD50 Lhasa 99% Lhasa 99% Gold TD50 Gold 99% Gold 99%
Tumour Site : Tumour Types Author Call p Value
(mg/kg/day) Lower CI Upper CI (mg/kg/day) Lower CI Upper CI
Liver : Carcinoma- hepatocellular Positive <=0.0005 397 211.108 2988.981 576 218 2400

Dose (mg/kg/day) 0 65.4 218 654 - - - - - - - - -

Incidence 0/40 0/40 0/19 5/19 - - - - - - - - -

Lhasa TD50 Notes: Lhasa TD50s were calculated using the summary method. CPDB calculated the TD50 value using the summary method.

Literature Reference(s)

Author Article Title Journal Year of Publication Volume Page(s) Reference Type
Pereira MA Carcinogenic activity of Fundamental and Applied Toxicology 1996 31 192-199 Primary reference
dichloroacetic acid and
trichloroacetic acid in the liver
of female B6C3F1 mice

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 Notes
Results notes

Results for only a small number of tissues were reported

Study 2 of 4
Species Sex Strain Route Exposure Time Experiment Time Result Vehicle Frequency Reliability
Mouse Female B6C3F1 Drinking water 82 week(s) 82 week(s) Positive Not specified Not specified 4- Not assignable

Observations

Lhasa TD50 Lhasa 99% Lhasa 99% Gold TD50 Gold 99% Gold 99%
Tumour Site : Tumour Types Author Call p Value
(mg/kg/day) Lower CI Upper CI (mg/kg/day) Lower CI Upper CI
Liver : Adenoma- hepatocellular Positive <=0.0005 395 288.7 1917.952 688 334 2310

Dose (mg/kg/day) 0 65.4 218 654 - - - - - - - - -

Incidence 2/90 4/53 3/27 7/19 - - - - - - - - -

Lhasa TD50 Notes: Lhasa TD50s were calculated using the summary method. CPDB calculated the TD50 value using the summary method.

Lhasa TD50 Lhasa 99% Lhasa 99% Gold TD50 Gold 99% Gold 99%
Tumour Site : Tumour Types Author Call p Value
(mg/kg/day) Lower CI Upper CI (mg/kg/day) Lower CI Upper CI
Liver : Carcinoma- hepatocellular Positive <=0.0005 533 371.713 3340.156 916 421 3250

Dose (mg/kg/day) 0 65.4 218 654 - - - - - - - - -

Incidence 2/90 0/53 5/27 5/19 - - - - - - - - -

Lhasa TD50 Notes: Lhasa TD50s were calculated using the summary method. CPDB calculated the TD50 value using the summary method.

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 Literature Reference(s)

Author Article Title Journal Year of Publication Volume Page(s) Reference Type
Pereira MA Carcinogenic activity of Fundamental and Applied Toxicology 1996 31 192-199 Primary reference
dichloroacetic acid and
trichloroacetic acid in the liver
of female B6C3F1 mice

Notes
Results notes

Results for only a small number of tissues were reported

Study 3 of 4
Species Sex Strain Route Exposure Time Experiment Time Result Vehicle Frequency Reliability
Mouse Male B6C3F1 Drinking water 61 week(s) 61 week(s) Positive Not specified Not specified 4- Not assignable

Observations

Lhasa TD50 Lhasa 99% Lhasa 99% Gold TD50 Gold 99% Gold 99%
Tumour Site : Tumour Types Author Call p Value
(mg/kg/day) Lower CI Upper CI (mg/kg/day) Lower CI Upper CI
Liver : Adenoma- hepatocellular Not specified <=0.027 - - - 551 211 -

Dose (mg/kg/day) 0 833 - - - - - - - - - - -

Incidence 2/22 8/22 - - - - - - - - - - -

Lhasa TD50 Notes: Tumour incidence was only recorded for a single concentration. Therefore Lhasa TD50 values were not calculated. CPDB calculated the TD50 value using the summary method.

Lhasa TD50 Lhasa 99% Lhasa 99% Gold TD50 Gold 99% Gold 99%
Tumour Site : Tumour Types Author Call p Value
(mg/kg/day) Lower CI Upper CI (mg/kg/day) Lower CI Upper CI
Liver : Carcinoma- hepatocellular Positive <=0.001 - - - 513 220 1970

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 Dose (mg/kg/day) 0 833 - - - - - - - - - - -
Incidence 0/22 7/22 - - - - - - - - - - -

Lhasa TD50 Notes: Tumour incidence was only recorded for a single concentration. Therefore Lhasa TD50 values were not calculated. CPDB calculated the TD50 value using the summary method.

Literature Reference(s)

Author Article Title Journal Year of Publication Volume Page(s) Reference Type
Herren-Freund SL, Pereira MA, The carcinogenicity of Toxicology and Applied Pharmacology 1987 90 183-189 Primary reference
Khoury MD, Olson G trichloroethylene and its
metabolites, trichloroacetic acid
and dichloroacetic acid, in
mouse liver

Notes
Results notes

Results for only a small number of tissues were reported

Study 4 of 4
Species Sex Strain Route Exposure Time Experiment Time Result Vehicle Frequency Reliability
Rat Male Fischer 344 Drinking water 104 week(s) 104 week(s) Negative Not specified Not specified 4- Not assignable

Observations

Lhasa TD50 Lhasa 99% Lhasa 99% Gold TD50 Gold 99% Gold 99%
Tumour Site : Tumour Types Author Call p Value
(mg/kg/day) Lower CI Upper CI (mg/kg/day) Lower CI Upper CI
Liver : Adenoma- hepatocellular Negative <=0.667 - - - 6720 623 -

Dose (mg/kg/day) 0 2.5 25 250 - - - - - - - - -

Incidence 1/29 1/32 3/32 2/29 - - - - - - - - -

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 Lhasa TD50 Notes: The original study authors considered this negative. Therefore no Lhasa TD50 value was calculated. CPDB calculated the TD50 value using the summary method.

Lhasa TD50 Lhasa 99% Lhasa 99% Gold TD50 Gold 99% Gold 99%
Tumour Site : Tumour Types Author Call p Value
(mg/kg/day) Lower CI Upper CI (mg/kg/day) Lower CI Upper CI
Liver : Carcinoma- hepatocellular Negative <=0.102 - - - 5480 893 -

Dose (mg/kg/day) 0 2.5 25 250 - - - - - - - - -

Incidence 0/29 0/32 0/32 1/29 - - - - - - - - -

Lhasa TD50 Notes: The original study authors considered this negative. Therefore no Lhasa TD50 value was calculated. CPDB calculated the TD50 value using the summary method.

Lhasa TD50 Lhasa 99% Lhasa 99% Gold TD50 Gold 99% Gold 99%
Tumour Site : Tumour Types Author Call p Value
(mg/kg/day) Lower CI Upper CI (mg/kg/day) Lower CI Upper CI
Liver : Multiple tumour types Negative <=0.667 - - - 6720 623 -

Dose (mg/kg/day) 0 2.5 25 250 - - - - - - - - -

Incidence 1/29 1/32 3/32 2/29 - - - - - - - - -

Lhasa TD50 Notes: The original study authors considered this negative. Therefore no Lhasa TD50 value was calculated. CPDB calculated the TD50 value using the summary method.

Literature Reference(s)

Author Article Title Journal Year of Publication Volume Page(s) Reference Type
DeAngelo AB, Daniel FB, Most BM, Failure of monochloroacetic Journal of Toxicology and 1997 52 425-445 Primary reference
Olson GR acid and trichloroacetic acid Environmental Health
administered in the drinking
water to produce liver cancer in
male F344/N rats

No Notes

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