Compendia Status Statement

SelenoExcell® High Selenium Yeast

Our raw material—SelenoExcell® High Selenium Yeast 1200—meets USDA microbial standards for
human food products and complies with the monograph from the United States Pharmacopeia (USP)
Food Chemical Codex (FCC) for dried yeast (First Supplement, FCC6). Additionally, SelenoExcell® High
Selenium Yeast 1200 has GRAS status under a Letter of No Objection from FDA (GRN 000260).
Furthermore, SelenoExcell® High Selenium Yeast 1200 complies with the European Union Parliament and
Council’s Directive Related to Food Supplements definition established in Commission Regulation (EC)
No 1170/2009 last amended (EU) 2017/1203 on July 5, 2017.

• Produced by culture in the presence of sodium selenite as selenium source.

• Does not contain more than 2.5 mg selenium/g in the dried form and inorganic selenium does
not exceed 1%.
• The predominant organic selenium compound present in the yeast is selenomethionine (SeMet),
which constitutes between 60 and 85% of the total selenium in the product.
• The content of other organic selenium compounds including selenocysteine does not exceed
10%.

Cypress worked with the National Cancer Institute to establish ingredient standardization for
SelenoExcell®, in which the key elements were: achievement of 100% organically bound selenium,
reduction of batch to batch variation, and selenium fingerprint. The following table identifies the selenium
forms and amounts that were consistently found in the studies of Dr. Peter Uden and colleagues:
Selenium form Percentage
Selenomethionine (SeMet) 84
Selenite 0.1
γ-Glutamyl-Se-methyl-Se-Cysteine 0.5
Se-adenosyl-Se-homocysteine 0.5
Sum of Detected Forms* 85.1

From Uden, et al., 2004 & Rayman, 2004

*Selenium speciation of SelenoExcell® demonstrated a complex of 21 selenium peaks. The selenium

forms listed above represent those forms (85.1%) in which known standards exist.

Mark E. Whitacre, Ph.D.

Chief Science Officer
June 8, 2021