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Productlnformation
Sodiumthiocyanate

ProductNumberS 7757
Storeat RoomTemperature

Replacement
for ProductNumber207993

ProductDescription PreparationInstructions
Molecular
Formula:NaSCN Thisproductis solublein water(133mg/ml),yieldinga
Molecular
Weight 81.07 clear,colorless
solution.lt is alsosolublein alcohol
CASNumber:540-72-7 andacetone.'
Synonyms: sodiumsulfocyanate,
sodiumrhodanide,
thiocyanate
sodium' Storage/Stability
Aqueoussolutionsof NaSCNare neutral.The
Sodiumthiocyanate is a chaotropicagentthatis aqueous"dissolution
of NaSCNis an endothermic
utilizedin suchlargescaleapplications as a spinning process.'
solventfor polyacrylonitrileproduction,a hardenin$
accelerator for cementand concretemixes.and in the References
o usedas 1. TheMercklndex,12thed.,Ent4ff9463.
a photographic stabilizer,
a corrosioninhibitor,a 2. Menez,R.,andDucruix, A.,A toxinthat
polymerstabilizer, andan intermediate in the recognizes muscarinic acetylcholine receptors.
production of herbicidesandinsecticides. NaSCN Preparation and characterization of crystals
mayalsobe utilizedin the production of other suitablefor structuralanalysis.J. Mol.Biol.,
thiocyanates.' 232(3),997-998(1993).
3. Park,S. Y., et al.,Crystallization
andpreliminary
NaSCNlowersthe meltingtemperature of proteins X-raydiffractionanalysisof a cytochromeP450
andenhances theirsolubility,
andhasbeenusedin (CYP119)from Su/folobussolfatartcus.Acta
boththe_cryslallization
and purification
of Crystallogr.D Biol.Crystallogr.,56(Pt9), 1173-
proteins.2'3i'5'u
NaSCNhasalsobeenutilizedin the 1175(2000).
preparation
of novelaggntsfor the synthesisof 4. Laggerbauer, B.,et al.,ThehumanU5-200kD
peptidylthiohydantoins.'
A studyof the effectsof DEXH-boxproteinunwindsU4IUORNAduplices
thiocyanate
on chymotrypsinogen secondarystructure in vitro.Proc.Natl.Acad.Sci.USA,95(8),4188-
andaggregation duringfreezing,drying,and 41e2(1ee8).
rehydration
hasbeenreported.o purification
5. Shukla,A. A., et al., Preparative of a
recombinant proteinby hydrophobic interaction
Precautionsand Disclaimer chromatography: modulationof selectivity
by the
ForLaboratory
UseOnly. Notfor drug,household
or useof chaotropic additives.Biotechnol. Prog.,
otheruses. 18(3),556-564(2002).
6. Fuchs,H.,et al.,Determination of optimalnon-
denaturing elutionconditionsfromaffinitycolumns
by a solid-phase screen.Biotechniques, 31(3),
584,586,588-90,passim(2001).