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編號 353 國立成功大學一 00 學年度碩士班招生考試試題

象所組別:藥理學研究所
考試科目:生理學 考試 日期; 0220 . 節 次 ;3

※考生請注意 : 本試題口可由相關計算機

1. 甘1e following questions are about cardiovascular functlons. (20%)

A. Ape 悶。 n with a heart rate of 40 has no P waves but normal QRS' complexes
on the ECG. Why?
B. The following experìmental data are obtalned for an anlmal before and after
administration of a drug. Before: Heart rate 80 beats/mln , and stroke volume
80 ml/bea t. After: Heart rate 100 beats/min , and stroke volume 64 m l/bea t. If
total peripheral resist ance remains unchanged , what 15 the effect ofthe drug
on mean arterlal pressure?
ιWhen all of the arterlal baroreceptors are denervated In an 似perlmental
anlmal, what happens to Its mean arterlal pr揖sure?
D. What happens to the hematocrlt wlthln several hours after a hemorrhage?

2. Answer the following question about a typlcal neuron. (20%)

A. What are the condltlon5 that glve rlse to the restlng membrane potentlal?
Explaln. What are the roles of membrane perm 閉 blllty and Na , K-ATPase on
the membrane potentlal? Are they dlrect or Indlrect?
B. What Is the lonlc basls of an actlon potentlal? Ex plaln In terms of the role of
voltag e-gated channels and the posltlve-feedback cycle.
C. What are threshold and the relatlve and absolute refracto吋 pe吋 ods?
Explaln In terms of the lonlc basls of the actlon potentlal.

3. A full-term newborn baby is abnormally small . What 15 the probable cause? Is It

due to deficlency In growth hormone, thyrold hormones, or In utero nutrition?
(10%)

4. De5cribe the mechanlsms and chemlcal messengers involved 閃閃 urltlon. What

are the effect5 of prostaglandlns on the female reproductlve system? (10%)

5. Patients with severe uncontrolled diabetes mellitus produce large amount of

organic acids. What 15 the ventllation pattern In th 自e patients and do their
arterlal POz and PC02 Increa5e or decrease? (10%)

6. How does a drug that Inhlblt5 the renal tubular secretlon of H+ fons, affect the
body's balance of sodlum , water, and H+ lon? (10%)

(背面仍有題目，請繼續作答)
編號: 353 眉立成功大學 -00 學年度碩士班招生考試試題 共〉頁﹒第 2賈

系所組別;藥理學研究所
考試科曰:生理學 考試曰翩 。 220 . 動次 :3

的生請注意:本組口可歌可棚計算機

7. The following experiments were performed on a single-unit smooth muscle in the

gastrointestinal tract. a. Stimulating the parasympathetic nerves to the muscle
produced a contraction. b. Applying sodium channel blocker led to a failure to
contract upon stimulating the parasympathetic nerves. c. Applying an
anticholinergic drug , dld not prevent the muscle from contracting when the
parasympathetic nerve was stimulated. From these observations, what mlght
one conclude about the mechanism by whlch parasympathetic nerve
stlmulatlon produces a contraction of the smooth musclei' (10%)

8‘ The peripheral chemoreceptors are denervated in an experimental anlma l, and

the animal then breathes a gas mixture containing 10 % oxygen. What changes
occur In the animal's ventilatlon? What changes occur when this denervated
anlmalls glven a mlxture of alr contalnlng 21 % 02 and 5 % C02 to breathe?
(10%)