CRC Perak Bulletin Issue 05

Issue 05 Clinical Research Centre
Perak Networks BULLETIN
Editorial Committee:
Inside this issue:
Contents
CRC HRPB Ipoh:
Dr. Philip Rajan
Dr. Lim Xin Jie
Suria Junus
Perak State Research Meeting 2022
CRC Hospital Taiping: In Focus

Prema Muninathan
Recombinant SARS-CoV-2 Fusion Protein
CRC Hospital Seri Manjung: Vaccine Booster
Chiew Shoen Chuen
Norsarlizna Mat Sari RCT of Ivermectin For Post-Exposure
Dr. Ting Siew Ying Prophylaxis For COVID-19 Infection Among
Close Contacts (I-CPEP)
Premature death due to road traffic

Advisors:

accidents
Perak State Health Director
Dr. Sirajuddin bin Hashim Research Grant

MOH Research Grant (MRG)

Hospital Raja Permaisuri Bainun, Ipoh

Director Ministry of Science,
Dr. Megat Iskandar bin Technology and Innovation
Megat Abdul Hamid

(MOSTI) Grant
Hospital Taiping Director
Other Malaysian Research
Dr. Hjh Narimah Yusof Summary Event

Grants
Hospital Seri Manjung Director of 2022
Dr. Nordin bin Nasir
CRC's Research Performance Upcoming Event
In Year 2023
e-ISSN 2682-7867 Meet The Team
© 2023 Clinical Research Centre Hospital Raja Permaisuri Bainun. All Rights Reserved Page 1
Perak State Research
24 NOVEMBER 2022
Jabatan Kesihatan
Meeting 2022
Negeri Perak
On November 24th, 2022, the Perak State Research Moving on to CRC Taiping, Dr. Cheah
Meeting was held at Jabatan Kesihatan Negeri (JKN) Wee Kooi, the Head of CRC Taiping,
Perak. Dr. Sirajuddin bin Hashim, Pengarah Kesihatan highlighted the issue of inadequate
Negeri, presided over the meeting, which was attended manpower support from the hospital
by 67 representatives from the JKN, Pejabat Kesihatan and shared the exciting news of a
Daerah (PKD), heads of services, hospitals, Klinik possible collaborative work between
Kesihatan (KK), and CRCs. During the meeting, the CRC Taiping with the Institute of Medical
chairperson congratulated all Perak health Research (IMR) and Pantai Group on an
professionals for their contributions to research in axiom genotyping project. Turning
2022. He emphasized the importance of evidence- attention to CRC Seri Manjung, the
based decision-making in health care and emphasis was on that the current
encouraged all attendees to participate in research infrastructure of CRC Seri Manjung will be
despite their hectic work schedules. substantially improved, according to Dr.
Ngah Shih Hang, the Head of CRC Seri
Subsequently, the heads of CRCs shared their Manjung. Following that, Mr. Venoo
accomplishments in 2022 and goals for 2023. Dr. Philip Kuppusamy (Associate Regional
Rajan, the Head of CRC HRPB, shared the updated Manager of Clinical Research Malaysia)
standard of practice for tracing electronic medical shared CRM Perak's accomplishments
records for research use in HRPB. In order to overcome and praised CRM Seri Manjung and CRM
workplace limitations in CRC HRPB, it was highlighted Taiping for enrolling the world's first
by Dr. Philip that there is a proposal together with CRM patients in several projects. He
in place to restore an old building for the CRM HRPB emphasized the need for GCP
team to use. In regards to future plans, he disclosed certification for physicians interested in
that there will be more collaborative research and doing industrial sponsored research.
training in partnership with Taylor's University in 2023.
After all the sharing sessions, the meeting was open to the
floor for participants to address any concerns or express
any thoughts in regards to research. Clinicians took the
opportunity to raise questions and seek clarification on
matters related to research like funding for publication
fees. In addition, clinicians also used the opportunity to
encourage others to conduct research by sharing their own
experiences with it. Furthermore, Dr S. Sivanandarajah,
Director of Hospital Slim River also grab the chance to
explore the prospects and process of establishing a CRC in
Hospital Slim River.
Page 2
IN FOCUS
I-CPEP TRIAL
Randomized, Double Blind, Placebo Controlled Clinical
Trial of Ivermectin For Post Exposure Prophylaxis For
COVID-19 Infection Among Close Contacts
Hospital
Taiping
Ivermectin is an antiparasitic drug and has been used as a treatment for

COVID-19 in a few countries. However, the I-TECH study findings do not
support the use of ivermectin for patients with COVID-19 in Malaysia. I-CPEP
was then designed to assess the efficacy of Ivermectin as post-exposure
prophylaxis in asymptomatic adults (≥18 years of age) who had close-contact
exposure to a confirmed case of COVID-19 patient.
The study was initiated by Dr. Cheah

Wee Kooi as PI and supported by 10
health clinics; 7 in Perak, 1 each in
Penang, Kedah, & Perlis. The
investigational product (IP) was
supplied by Hovid Sdn. Bhd. It was
approved by MREC on 17th November
2021.

Read More
NMRR-21-1371-60569 Page 3
Principal Investigator: Dr. Cheah Wee Kooi
The flow of study starts with

screening for eligible subjects.
Ivermectin (0.4 mg/kg/day -
maximum 24 mg) was given orally
on Day 1 and Day 3 after the
nasopharyngeal swab was
confirmed negative for Covid-19.
Follow-ups were through phone
calls until day 14. The subject
needed to be present at the health
clinic twice; at screening and on
day 8. The drug safety was
monitored through blood
parameters and adverse effects
reported by the subjects.
Total subject to be recruited is 300; 30 from each site with 15 on each arm. First
patient was randomized on 17th February 2022. However, subsequent
recruitment was hindered by changes of policy in managing close contact
although thousands were screen for eligibility. Protocol was amended twice
tailored to the situational Covid-19 management to ensure enough sample size
from each site.
In late April 2022, the government

had announced that quarantine is
no more mandatory for
asymptomatic close contact. Five
months into the study, total
recruitment was far from target.
After discussion with Hovid and
interim data analysis, the study
was terminated on 8th November
2022 due to recruitment
challenges with only 50 subjects
made it to the final list.
5 month study durations Total subject to be recruited is 300 10 health clinics
Page 4
Hospital Seri Manjung NMRR-21-1565-61053
Principal Investigator: Dr. Lee Li Yuan
RECOMBINANT SARS-COV-2 FUSION

PROTEIN VACCINE (V-01) BOOSTER
PHASE III - RCT

Hospital Seri Manjung team, led by Dr. Lee Li Yuan has
recruited a total of 114 subjects for this COVID -19
vaccine booster trial, namely: A Global, Multi-Center,
Randomized, Double-Blind, Placebo-Controlled, Phase
III Clinical Study to Evaluate the Efficacy, Safety and
Immunogenicity of Sequential Immunization of
Recombinant SARS-CoV-2 Fusion Protein Vaccine
(V-01) Against Covid-19 in Healthy Adults aged 18
years and Older after the Vaccination of 2 Doses
of Inactivated Vaccines.
Study Objective:
This study aims to evaluate the
relative efficacy of recombinant
SARS-CoV-2 fusion protein
vaccine (V-01) as a booster to
prevent symptomatic infection
and RT-PCR positive COVID-19 Vaccine (V-01) efficacy
compared with the placebo was 47.8%
control group.
Findings:
This study is conducted at multiple sites in Malaysia and Pakistan, with total recruitment
of 10 218 subjects. V-01 vaccine efficacy was 47.8% (95%CI: 22.6 to 64.7) as per the
principle of intention-to-treat. Most common adverse events include transient, mild-to
moderate injection site pain, fever, headache and fatigue. Serious adverse events are
almost equal in both V-01 vaccine and placebo groups (0.12% versus 0.16%). These
interim results are published in an international journal with Dr. Lee Li Yuan as the co-
author.
Protocol No.: TG2102V01 Page 5

IS IPOH AN
AGE-FRIENDLY CITY?
[NMRR-19-3191-51748]
Introduction: In response to the world's rapidly ageing
In Malaysia, only Ipoh
population, the World Health Organization (WHO)
and Taiping are
launched the "Age-friendly Cities" programme in 2005.
members of the WHO
According to the WHO initiative, a "age-friendly" city is one
Global Network of
Age-Friendly Cities that encourages active ageing; it maximises opportunities
and Communities for health, involvement, and security in order to improve
(GNAFCC). people's quality of life as they age.
In particular, 16.7% of Ipoh's 739,700 residents are over the

age of 60. In collaboration with JKN Perak and MBI, CRC
HRPB conducted a study in Ipoh to evaluate the baseline
characteristics of eight domains of Age-Friendly Cities,
namely housing, outdoor spaces and buildings,
transportation, job opportunities and civic participation,
social participation, respect and social inclusion,
communication and information, and community
support and health services.
Quantitative study:
The data were analyzed descriptively with frequencies and
CRC HRPB used an exploratory
percentages, while gap score analysis was performed for 32
sequential mixed-method design to
items of the 8 age-friendly domains. The gap scores were
explore older residents' perceptions
generated by comparing the importance and availability
of the importance, availability, and
scores. Of the 8 domains, housing (55.4%) and transportation
perceived gap of the features
(50.7%) reported the highest mean perceived gap scores. Out of
specified under each domain to
the 32 elements, the highest mean gap percent scores were
determine if Ipoh is an age-friendly
observed in elderly priority parking bays (83.8%), home visits by
city, and systematically integrated
healthcare professionals (78.9%), financial assistance for home
quantitative and qualitative findings.
modification and purchase (66.3%), and affordable housing
options (63.6%).
The mean percent gap scores were compared between the city center and non-city center
respondents. Significantly higher gap scores were observed among the city center respondents in
4 elements, including modified rest-rooms for people with disabilities (40.3% in the city center vs.
30.0% in non-city center); well-maintained parks and facilities (26.8% vs. 16.5%), a range of
volunteer activities (29.9% vs. 22.2%) and free access to computers and the internet (56.0% vs.
49.0%). In contrast, respondents in the non-city center reported a significantly higher mean gap
percent score in nursing homes for older people (28.3% in the non-city center vs. 16.4% in the city
center), a variety of healthcare professionals (34.7% vs. 27.2%) and the variety of cultural
celebrations (35.9% vs. 24.0%).
Clinical Research Centre, Hospital Raja Permaisuri Bainun, Ipoh Page 6

CONT.
MORE INFO AVAILABLE IN THE PUBLISHED ARTICLE:
Chang CT, Lim XJ, Supramaniam P, Chew CC, Ding LM, Rajan P. Perceived Gap of Age-
Friendliness among Community-Dwelling Older Adults: Findings from Malaysia, a Middle-
Income Country. Int J Environ Res Public Health. 2022 Jun 11;19(12):7171.
doi: 10.3390/ijerph19127171. PMID: 35742420; PMCID: PMC9223156.
alitative approach
Qu : Digital divide: Inability to learn
about information technology
“Unmet needs" are gaps between
01
due to financial constrain.
an individual's self-assessment of
long-term care needs and the “We don't know much about IT
actual resources available to (information technology) ... Of
Theme 1:
address those needs. A framework course, we can (join online classes),
Person
analysis approach guided by the 5P but not at such a high cost.” (P06)
Ecological Model of Ageing was
02
adopted. The term 5P is refer to five
distinct domains: person (micro),
process (meso), place (macro),
and policymaking (macro), and it is
based on the (prime) relationship Theme 2:
with the health environment. Process
Economic security: I
receive a small pension
each month, which is
clearly insufficient for me.
That is one of the main
03
reasons I must continue
working on it. (P05)
“We can't even use Theme 3:

the field. You can't Place
even play football
Exercise,
“They may want to be with your
sports and
creative and become grandchildren...
You can’t play.” recreation
cashless, so hopefully “They want us to
(P03) facilities;
you will comply, but you use Grab, but it's
must recognize that Affordability;
too expensive for
many people are still Accessibility
us.” (P04)
older persons.” (P03)
Note: P: Older adult, C: Caregiver, K: Key-informant Page 7

CONT. Qualitative approach
Governance: “I cannot find one

(a nursing home) that is good
enough for me to send my loved
ones to.” (K01)
Theme 4:
Policy making 04
Multidisciplinary collaboration: “A geriatrician,
for example, will serve as the coordinator, so we will
hold a multi-disciplinary team meeting” (K01)
Inclusiveness: “I'm not OKU. It's ridiculous that senior citizens are
not allowed to drive, as recently reported in the media (at the time
this study took place) ... So, you instil fear in people like us.” (P04)
05
Health promotion: "Even starting
in schools, taking enough calcium
and vitamin D would have prevented Conclusion: The findings served
the 20 to 30-year-old ladies from as a baseline input for local city
Theme 5:
osteoporosis. But, many people don't councils to make improvements
Prime
know about that.” (K01) to Ipoh city not only to meet the
benchmark of GNAFCC but also
to plan for short- and long-term
intervention in creating an age-
friendly environment. A
multifaceted approach is
recommended to specifically
address the unmet needs among
older adults in the local context.
In the global context, the
information from this study adds
Respite care: "It is not the popular respite care, like knowledge to existing aging
giving the caregivers a break. The family caregivers research that allows researchers
said they can't afford (RM) 500 a day for home to make comparisons among the
private nursing. (C1) age-friendly cities.
Note: P: Older adult, C: Caregiver, K: Key-informant Page 8

Hospital Seri Manjung
CLINICAL AND COMPUTED TOMOGRAPHICAL PATTERNS OF PULMONARY

THROMBOEMBOLIC DISEASE ASSOCIATED WITH COVID-19 INFECTION:
A TERTIARY HOSPITAL ANALYSIS
This study aims to study the

clinical characteristics, computed
This is a retrospective cohort study in
which we retrospectively review all tomographical features of
hospitalized patients with confirmed pulmonary thromboembolic
COVID-19 infection who had undergone disease associated with COVID-19
CT pulmonary angiogram (CTPA)
infection.
examinations for suspected PTE disease
between April 2021 and May 2021 in
Hospital Tengku Ampuan Rahimah.
A total of 184 COVID-19 patients who were suspected to
have PTE disease were included in this study. CTPA
examinations revealed a total of 150 patients (81.5%)
suffered from concomitant PTE disease. Among the PTE
cohort, the commonest comorbidities were diabetes COVID-19 patients suffered 81%
mellitus (n=78), hypertension (n=66) & dyslipidemia from concomitant PTE disease
(n=25). They were generally more ill than the non-PTE
cohort as they reported a significantly higher COVID-19
disease category during CTPA examination with 52% have diabetes mellitus
p=0.042.
diagnosed with
Expectedly, the length of both intensive care unit stays 44%
(median number of days 8 vs. 3; p=0.021) and hospital hypertension
stays (median number of days 14.5 vs. 12; p=0.006) were
significantly longer. Intriguingly, almost all the subjects 16% were dyslipidemia
had received either therapeutic anticoagulation or
thromboprophylactic therapy prior to CTPA
examination (n=173, 94.0%).
Overall, PTE disease remains prevalent
Besides, laboratory data analysis among COVID-19 patients despite
identified a significantly higher peak timely administration of
CRP (median 124.1 vs. 82.1; p=0.027) thromboprophylactic therapy. The
and ferritin levels (median 1469 vs. presence of hyperinflammatory
1229; p=0.024) among them. activities, unique thrombotic locations
as well as concurrent pulmonary
Evaluation of CT features showed that COVID-19
parenchyma and vasculature
pneumonia pattern (p<0.001) & pulmonary angiopathy
aberrations in our PTE cohort implicate
(p<0.001) were significantly more profound among the immunothrombosis as the principal
PTE cohort. To note, the most proximal pulmonary mechanism of this novel phenomenon.
thrombosis was located in the segmental (n=3, 2.0%) & We strongly recommend future
subsegmental pulmonary arteries (n=147, 98.0%). Also, researchers to elucidate this important
the thrombosis predominantly occurred in bilateral clinical disease among our post-COVID
lungs with multilobar involvement (n=95, 63.3%). vaccination populations.
NMRR-21-1732-61096 (IIR) Page 9

SURVIVAL ANALYSIS OF PULMONARY THROMBOEMBOLIC DISEASE ASSOCIATED WITH COVID-
19 INFECTION: A COMPARISON BETWEEN GERIATRIC AND NON-GERIATRIC POPULATIONS
Hospital Seri Manjung
This study aims to explore the survival patterns among hospitalized COVID-19 cases
complicated with pulmonary thromboembolic disease. This is a retrospective cohort
study in which we retrospectively review all hospitalized Covid-19 cases complicated
with pulmonary thromboembolic disease admitted to Hospital Tengku Ampuan
Rahimah between 1st April 2021 and 31st May 2021. Demographic, clinical &
laboratory data were retrieved, whilst CTPA images were analyzed by a senior
radiologist.
Analysis of the CT features A total of 150 patients were recruited,

demonstrated that the most comprising 45 geriatric patients and 105 non-
proximal pulmonary thrombosis geriatric patients. The prevalence rate of
specifically limited to the hypertension, diabetes mellitus and
segmental and subsegmental dyslipidaemia were higher among the geriatric
pulmonary arteries in both cohort. Interestingly, the percentage of
cohorts. The elderly suffered patients with fever and diarrhoea were
from a significantly higher in- significantly higher among the non-geriatric
hospital mortality rate and their cohort. The geriatric cohort also recorded a
cumulative probability of significantly lower absolute lymphocyte count
survival was significantly lower. at presentation and albumin level during
admission. Despite earlier presentation, the
NMRR-21-1558-59028 geriatric cohort suffered from more severe

disease.
In conclusion, typical COVID-19 symptoms may

be absent among the elderly, prompting a
lower threshold of suspicion during the COVID-
19 pandemic. Additionally, the elderly
demonstrated a higher probability of adverse
outcomes despite earlier presentation and
treatment.
Page 10
Hospital Raja Permaisuri Bainun
The impact of the COVID-19 pandemic on premature death due to

road traffic accidents in Perak State
Background of the study: The standard expected YLL measure has been
The rate of road traffic death is considerably reported as valuable analytic tool as the foundation of
high in South-East Asia with 20.7 deaths per the measurement is based on the comparison of the
100,000 people. In Malaysia, transport accident age at death and the standard life expectancy curve
has been reported as one of the five principle (Aragón, T. J., et. al, 2008, Murray CJ, et. al, 1996).
causes of death in year 2020 with 3.8% died
Furthermore, the spatial patterns of the trends and
due to road traffic accidents (DOSM, 2021).
characteristics of fatal road accidents can be
Life expectancy in Malaysia in 2021 is 75.6 visualized using Geographical Information System
years. Meaning, a newborn baby in the year (GIS). Visualization of the incidence of accidents and
2021 is expected to live until the age of 75.6 deaths on the geographical mapping layers against the
years. How many years will be lost due to road infrastructure and facilities could facilitate planning
traffic fatalities? Premature death especially and prevention strategies by the stakeholders.
due to road traffic accidents is preventable loss
The novel coronavirus (COVID-19) outbreak has been
of life (Aragón T. J., et. al, 2008, Murray C.J, et.
declared as a pandemic on March 2020. Various
al, 1996).
methods to prevent the spread of the COVID-19
Mortality indicators like incidence, prevalence, infection through stay-at-home orders, social
mortality and case fatality rate were often used distancing as well as temporary closures of
to signify the mortality due to road traffic businesses and services have been implemented. The
accidents. However, the impact of the Movement Control Order (MCO) was established in
premature death can be measured using Years the country on 18 March 2020 and was followed by
of Life Lost (YLL). the Conditional Movement Control Order (CMCO),
Recovery Movement Control Order (RMCO) and the
Objectives:
MCO by states which all ended in June 2021 through
To explore the shift in trend patterns and the implementation of the National Recovery Plan
spatial distribution of the road traffic (NRP). COVID-19 has changed the pattern of life
fatalities as an impact of the COVID-19 regardless of geographical, age-group and gender
pandemic in Perak State, Malaysia. distribution on the globe.
To determine the burden of premature death
using YLL in Perak State, Malaysia Page 11
Cont.
Overview:
Fatal road traffic accident/crash fatality cases (n=2207) were obtained from all 14 Forensic Departments
in the government hospitals in Perak. Death Registration Book, Autopsy Request Form Pol.61 (revision
4/86), and post-mortem report were reviewed for eligible cases by trained research assistants. This study
was partially sponsored by MedRSI.
Expected outcomes:
1. Trend patterns
Reference sources: Premaa Supramaniam,
Suria Junus, Lina Hashim, Chiew Shoen
Chuen, Philip Rajan Devesahayam: The
impact of the COVID-19 pandemic on
premature death due to road traffic
accidents in Perak State, Malaysia.
Unpublished manuscript: Clinical Research
Centre (CRC), Hospital Raja Permaisuri
Bainun, Ministry of Health Malaysia, 2022,
NMRR-ID22-00218-FQQ.
2. YLL estimates
3. Spatial mapping:
Reference sources: Example of mapping by PerakGIS (Village@Perak):
Current status: Study References:

1. Aragón, T. J., Lichtensztajn, D. Y., Katcher, B. S., Reiter, R., &
Analyses on the trend patterns and YLL Katz, M. H. (2008). Calculating expected years of life lost for
estimation: - Completed and manuscript assessing local ethnic disparities in causes of premature
death. BMC public health, 8(1), 1-12.
draft in progress.
2. Department of Statistics Malaysia. (2021, July 29). Press
Analyses on the spatial mapping and Release Abridged Life Tables, Malaysia, 2019-2021.
models: - Study team is collaborating with 3. Murray, C. J., Lopez, A. D., & World Health Organization. (1996).
The global burden of disease: a comprehensive assessment of
PerakGIS and analysis is in progress.
mortality and disability from diseases, injuries, and risk factors
in 1990 and projected to 2020: summary. World Health
Organization
NMRR ID-22-00218-FQQ Page 12

HOSPITAL SERI MANJUNG Attitudes and Beliefs
to Use of Medical
Cannabis among
Malaysian's Doctors
This study aims to determine the beliefs of
medical doctors towards medical cannabis
usage for the treatment of patients,
including its perceived benefits and risks,
as well as doctors’ willingness to prescribe
medical cannabis.
NMRR ID-22-02260-DHZ (IIR)
This study is conducted at multiple sites in Malaysia. All doctors including Medical
Officer, Specialist and Consultants, registered with Malaysian Medical Council are
invited to answer an online questionnaire.
Definition of Medical Cannabis
Medical cannabis or medical marijuana uses the marijuana plant or chemicals in it to

treat diseases or conditions. It's basically the same product as recreational marijuana,
but it's taken for medical purposes.
The marijuana plant contains more than 100 different chemicals called cannabinoids.
Each one has a different effect on the body. Delta-9-tetrahydrocannabinol (THC) and
cannabidiol (CBD) are the main chemicals used in medicine. THC also produces the
"high" people feel when they smoke marijuana or eat foods containing it.
Researchers are studying whether medical marijuana can help treat a number of
conditions including; Alzheimer's disease, Appetite loss, Cancer, Crohn's disease,
Diseases affecting the immune system like HIV/AIDS or Multiple Sclerosis (MS), Eating
disorders such as anorexia, Epilepsy, Glaucoma, Mental health conditions like
schizophrenia and posttraumatic stress disorder (PTSD), Multiple sclerosis, Muscle
spasms, Nausea, Pain, Seizures, Wasting syndrome (cachexia).
The greatest amount of evidence for the therapeutic effects of cannabis relates to its
ability to reduce chronic pain, nausea, and vomiting due to chemotherapy, and
spasticity (tight or stiff muscles) from Multiple Sclerosis.
© 2021 WebMD, LLC. All rights reserved.
Page 13
RESEARCH SCOPE:
RESEARCH GRANT
Budget
Planning Monitoring
1. Introduction
The Ministry of Health (MOH) Malaysia
Research Grant or MRG is a research
fund that supports health research
and development (R&D) activities
based on the priority areas (research
that will benefit the MOH-return of
investment (ROI)) set by the MOH with
the aim to improve population health
and health delivery services.
The objectives of MRG are to:

i. provide funding to generate new scientific knowledge and discoveries,
ii. to improve health delivery services, and
iii. to encourage the development of innovative technologies among the
MOH investigators.

Page 14
Cont.
2. Mode of Application
MRG applications can be submitted throughout the year
via National Medical Research Register (NMRR).
Submissions must be made together with research
registration, application to NIH Research Review Panel
(Jawatankuasa Penilaian Penyelidikan; JPP-NIH), and
Medical Research and Ethics Committee (MREC).
3. Criteria of Application
i. The Principal Investigator (PI) must be a MOH personnel;
ii.The research funding period shall not exceed three (3) years;
iii.PI is allowed to apply and submit only two (2) research submissions at a time;
iv.Investigators who are on study leave are not allowed to be PI. However, he/she can be a
Sub-Investigator;
v. PI who has changed department/affiliation/resigned/on study leave must not continue
his role as a PI. However, can still remain as a member of the research group. The PI
must notify MRG Secretariat in writing and nominate a new PI whenever such a situation
occurs. An amendment must be submitted to MREC under such circumstances (as per
post ethical approval submission).
4. MRG Review Panel

The MRG Review Panel is chaired by the Deputy Director-
General of Health (Research and Technical Support),
MOH. Research that has been evaluated by the JPP-NIH
Panel and has received MREC approval will be brought to
the MRG Review Panel for evaluation. The decision made
by the panel is final.
5. Priority in Research Evaluation

i. Research that can support and improve an existing policy, methodology, and solution model
according to the needs of the MOH; or
ii. Research covering health issues for the purpose of increasing the value of life in the country and
globally; or
iii. Research must identify and obtain the support of MOH stakeholders; or
iv. Research that has the potential to contribute to the national strategic plan.
6. Result Notification in the MRG Application

i. Approval letters will be sent to the PI and a copy of the approval letter will be forwarded to the
respective head of the department.
ii. Allocation will be disbursed to the PI through the relevant department.

Page 15
7. Responsibility of 8. Funding Scope

Principal Investigator (PI) Further details on the categories and scopes of
funding will be made available based on the current
i. PI is responsible for carrying out approved
financial circulars applicable for that particular year.
research.
*For collaborative research between MOH and non-MOH
ii. PI is required to sign the “Surat Akujanji”. organisations, funding distribution will be made available only to
iii. PI must ensure that the research is carried the MOH department.
out effectively to achieve the objectives and
milestones within the stipulated period as
In brief, the funding categories are as follows:
well as the approved allocation; i. Travel and transportation - expenses on all domestic travels
iv. PI must present the research results to the and transportations related to research;
stakeholders upon completion of the ii. Utilities - all charges related to postage (excluding parcel
post), telephone, telex, telegraph, cable, and others;
research;
iii. Rental - rental for equipment, transportation and other
v. Research progress reports must be items related to research activities;
submitted every 6 months to MRG iv. Food and beverages - expenses for purchasing food and
Secretariat, NIH no later than July 15th and beverages for research purposes;
v. Raw materials - expenses on oil and petrol for research
January 15th.
purposes;
vi. A monthly research expenditure report vi. Research supply and materials - expenses related to
must be submitted to the MRG Secretariat, research-related supplies and materials (such as reagents, kits,
NIH no later than the 15th of the following consumables, animal bedding, stationeries, and others).
vii. Minor repair and modifications - expenses for minor repair
month. and modifications of equipment, vehicles or other items
related to research activities. The cost of maintaining the
9. Amendment to Grant existing equipment during the implementation of the

research is allowed;
Allocation viii. Services - covers printing, hospitality, honorarium,
reimbursement to the research participants or subjects,
Any amendment to the allocation must be service-based input, and others; training costs related to
approved by the Deputy Director-General of research such as workshops and others should be provided
with strong justification to be supported by the JPP-NIH
Health (Research and Technical Support)
review panel and approved by the Grant Review Panel;
who is also the Chairman of the MRG Review
**Funding must not be used to pay for expenses incurred to attend
Panel. The completed form must be sent to seminars or conferences and publication fee.
the MRG Secretariat, NIH for approval.
ix. Contract Personnel - salary and allowance for short-term
personnel, which will be hired based on the research; and
10. Implementation and x. Equipment and accessories - the amount allocated for this
category should not exceed 40% of the approved total budget.
Research Conduct Should any application exceed this limit, PI must provide
strong justifications, specifications, quotations, and
All research must be carried out based on estimations for the purchase to the grant committee.
the approved methodology and allocation
**For the purchasing of any ICT software and equipment, PI is
within the stipulated time. Approved research required to seek professional advice from the ICT department at their
will be monitored by the MRG Secretariat locality prior to the JPP-NIH panel review meeting. The technical
input from the ICT Department needs to be sent together with the
based on the following aspects: application as supporting documents. Their evaluation must cover
i. Financial performance; the plan and maintenance for related software and equipment
during and after the completion of the research.
ii. Research performance; and
iii. Outcome or Output.
Page 16
11. Research Monitoring
PI is responsible for completing and submitting
the financial reports and performance of
research under his/her supervision as follows:
i. Research financial report - must be sent to
the MRG Secretariat every month no later than
the 15th of the following month;
ii. Research progress report - reports must be
submitted semi-annually (on the 15th July and
15th January of the following year);
iii. Research findings monitoring report - reports
must be submitted every fourth quarter before
15th January of the following year.
iv. End of project report - the final research
report must be submitted within three (3) months
after the completion of the research.
**PI needs to adhere to the deadline. Failure to submit

any required report by the due date will affect the
consideration for next year’s funding.
12. Extension of Research

Application for extension of research period For further questions and inquiries,
must be submitted to the MRG Secretariat, investigator may contact the MRG
NIH before the research end date through Secretariat at:
the utility of relevant forms.
Research and Grant Management Unit,
13. Termination of Grant Level 4, Block A,
National Institutes of Health,
Each PI must ensure the implementation of
No.1, Jalan Setia Murni U13/52,
the research is in accordance with the
Declaration of Helsinki, Malaysia Good Seksyen U13, Setia Alam, 40170,
Clinical Practice (GCP), Malaysian Code of Shah Alam, Selangor
Responsible for Conduct in Research Phone: +603 -3362 8888 ext
(MCRCR), and other local regulatory 8405/8316
requirements and guidelines.
Email: nihmrg@moh.gov.my
Any violation of these Find Us

codes of conduct may
lead to the termination of
the grant.

Page 17
Ministry of Science, Technology and Innovation (MOSTI) Grant
M
inistry of Science, Technology
and Innovation (MOSTI) is the
Malaysian ministry in charge of
research, telecommunication and
information technology.
MOSTI is tasked to championing scientific
discovery and transforming innovation through
efficient, ethical and professional management of
funds for Research and Development and
Commercialisation (R&D&C); increasing the
quantity and quality of human capital in Science, MOSTI Grant
technology and innovation (STI); and wider Program Inisiatif Inovasi Sosial Malaysia (MyIS Komuniti) merupakan
inisiatif dibawah Kementerian Sains, Teknologi dan Inovasi (MOSTI)
dissemination and application of technology for dan Yayasan Inovasi Malaysia (YIM) sebagai agensi pelaksana yang
the benefit of grassroots. menjurus kepada penjanaan pendapatan untuk meningkatkan
kesejahteraan masyarakat di kawasan bandar dan luar bandar.
MAKLUMAT PROGRAM
(MYIS KOMUNITI)
YIM melaksanakan inisiatif yang
OBJEKTIF
Meningkatkan kesejahteraan hidup masyarakat
selari dengan dasar Kerajaan untuk keutamaan kepada golongan B40 dan kumpulan yang
memastikan negara mempunyai modal terkesan akibat selepas pandemik COVID-19 melalui
insan yang berpengetahuan tinggi, pelaksanaan projek aplikasi teknologi tempatan yang
berkemahiran pelbagai, berdaya berinovatif yang telah dibangunkan dan sedia
kreatif dan inovatif bagi memenuhi dilaksanakan secara mampan.
keperluan negara menjelang 2050
terutama untuk mencapai Wawasan
Kemakmuran Bersama, selain
menghadapi ledakan IR 4.0.
KELAYAKAN
i) Warganegara Malaysia.
ii) Terdiri daripada Agensi Kerajaan, Badan
Berkanun, University Awam, Syarikat
Berkaitan Kerajaan (GLC), Syarikat SKOP PEMBIAYAAN
Berhad dengan Jaminan (CLG), Syarikat Pembiayaan merangkumi perkara-perkara yang berikut:
pemula perniagaan (start-up company) i) Bahan mentah dan peralatan
yang beroperasi tidak melebihi 5 tahun, ii) Dokumentasi projek (seperti rakaman video
Pertubuhan bukan kerajaan (NGO). perjalanan program, gambar beresolusi tinggi dan
iii) Hanya projek yang mempunyai aplikasi sebagainya) [Maksimum RM2,000.00]
teknologi tempatan berinovatif dan misi iii) Perbelanjaan perkhidmatan (perundingan dan
sosial yang jelas layak memohon. pengujian)
iv) Projek mesti dilaksanakan di Malaysia. iv) Kajian impak projek [Maksimum RM5,000]
Sebarang pertanyaan: PERMOHONAN

Sekretariat Inovasi Sosial Malaysia
Yayasan Inovasi Malaysia Permohon hendaklah memohon melalui laman web
L3-E-1A & L3-E-1B, Level 3, Enterprise 4
Technology Park Malaysia YIM menggunakan sistem Innomap seperti berikut:
57000 Bukit Jalil
Kuala Lumpur https://www.mysi.innomap.my
Tel: 03 – 8996 1714
Faks: 03 – 8996 1715
Emel : sekretariat.mysi@yim.my MOSTI Grant Page 18
OTHER MALAYSIAN RESEARCH GRANTS
MALAYSIA TORAY SCIENCE FOUNDATION
(MTSF): SCIENCE & TECHNOLOGY RESEARCH
GRANT
Energetic and creative researcher, Malaysian citizen
aged below 40, residing in Malaysia, engaged in a
basic fundamental scientific research field
excluding mathematics and clinical medicine at a
research facility in Malaysia, whose work has
thepotential to contribute greatly to the
advancement of science and technology.
COLLABORATIVE RESEARCH IN Contact Us:
Malaysia Toray Science Foundation
ENGINEERING, SCIENCE AND TECHNOLOGY c/o Penfabric Sdn. Berhad
(CREST) Block B, Prai Free Industrial Zone 1, 13600 Prai, Penang.
Tel: (+604) 385 4151
Scaling Solutions for the community. The innovative Fax: (+604) 385 4194
& Intelligent City Cluster’s main intent is to bridge Email : mtsf.tml.mb@mail.toray
the industry, policy makers and universities with a Website : www.mtsf.org
common interest in developing impactful and
sustainable solutions for the ecosystem through MALAYSIA DIGITAL ECONOMY
R&D and technology applications.
CORPORATION (MDEC)
Objective: To create an innovative test bed to Malaysia Digital is a national strategic initiative by
demonstrate and test the latest solutions for the Malaysian Government to encourage and
Smart Living Applications. attract companies, talents and investment while
enabling Malaysian businesses and Rakyat to play
Contact Us:
CREST (Collaborative Research in Engineering, Science & a leading part in the global digital revolution and
Technology) (950906-A) sains@usm, digital economy. To provide opportunity and
Block C, Ground Floor No 10 Persiaran Bukit Jambul, 11900 platform for digital creative content creators in
Bayan Lepas, Penang. developing and creating digital creative content.
Email: info@crest.my
Tel: +60 (0)4 652 0088 Contact Us:
Malaysia Digital Economy
Corporation (MDEC) Sdn Bhd
FRGS, TRGS AND PRGS 2360 Persiaran APEC
63000 Cyberjaya
ANNUAL GRANTS AWARDED BY THE Selangor Darul Ehsan
MALAYSIAN MINISTRY OF EDUCATION Tel: 1-800-88-8338
Email: clic@mdec.com.my
Projek Malaysia Greater Research Network System
(MyGRANTS) merupakan inisiatif BKPI dalam usaha untuk
meningkatkan kecemerlangan penyelidikan negara dengan MALAYSIAN COMMUNICATIONS AND
membangunkan dan menyediakan sebuah sistem MULTIMEDIA COMMISSION
pengurusan geran-geran penyelidikan secara dalam talian.
Penggunaan MyGRANTS telah memudahkan pengurusan The Industry Promotion and Development Grant,
dan pelaksanaan Dana Penyelidikan Kementerian Pengajian also known as the ‘MTSFB Project Grant’ was
Tinggi (DP KPT) yang lebih teratur, cekap dan berkesan. initiated by MCMC in 2012. MTSFB is entrusted by
MCMC to manage the Grant and projects
Fundamental Research Grant Scheme (FRGS), implemented by Grant recipients. The MTSFB
Prototype Development Research Grant Scheme Project Grant was conceived for the purpose of
(PRGS), Trans Disciplinary Research Grant Scheme enhancing knowledge, Research & Development
(TRGS). (R&D), and establishing competitiveness in
Contact Us: technology innovation by creating a Proof-of-
Malaysian Technical Standards
Forum Bhd (MTSFB)
Concept (PoC) project that contributes to the
(200401016865 (655368-P)) communications and multimedia industry.
Level 3A, MCMC Tower 2,
Jalan Impact, Cyber 6, Contact Us:
63000 Cyberjaya, Malaysian Technical Standards
Selangor Darul Ehsan Forum Bhd (MTSFB)
Email: admin@mtsfb.org.my Level 3A, MCMC Tower 2,
Tel: +603 8680 9950 Jalan Impact, Cyber 6,
Fax: +603 8680 9940 63000 Cyberjaya,
Selangor Darul Ehsan
Email: admin@mtsfb.org.my
Other Malaysian Research Grant Page 19 Tel: +603 8680 9950; Fax: +603 8680 9940
THE CRC's RESEARCH
PERFORMANCE
CLINICAL RESEARCH CENTRE,
HOSPITAL RAJA PERMAISURI BAINUN
Summary Report: Research Performance of CRC HRPB, Ipoh
A. Number of staff in CRC/CRM Hospital Raja Permaisuri Bainun
Staff Designation
2020
2021
2022
Medical officer (MO) 4 6 10
Pharmacist 2 2 1

Research officer (RO) 1 1 1
CRC staff
Assistant research officer 1 1 1
Allied health 1 1 -
Temporary staff (PSH)/MySTEP

5 8 5
available until Dec
CRM staff Study coordinator 6 7 7
CRC HRPB available staff

(as of 31st Dec 2022): "In this office... we do Teamwork, we do Help, we do Respect,
Head of Dept.:
Punctuality, and Laughter, We do Friendship. We do Coffee and
Dr. Philip Rajan Devesahayam
-10 Medical officers Cake. We Communicate and Listen. We do Motivation.
-1 Pharmacist We do Great Things."
-2 Research officers
-1 Associate research officer
-7 CRM study coordinators
-5 Personel MySTEP staffs CRC, HRPB Ipoh Page 20
CRC, Hospital Raja Permaisuri Bainun, Ipoh
B. Type of Research Services provided 2020 2021 2022
No. of research/Case studies/Clinical audit registered

NMRR 228 108 106
No. of research/Case studies/Clinical audit
registration 142 56 53
projects with ethical approval
Consultation No. of consultations (episodes) provided 638 342 663
No. of proposals reviewed by Hospital Research

Proposal review 106 32 75
Review Committee (HRRC)
Publication &
No. of application of publication in local/ int. journals 26 25 31
presentation
No. of application of oral/poster presentation 5 5 5
submitted to CRC
Registry No. of patient registries supported 14 14 14
Training / No. of training workshops organised 18 7 16

Conference No. of Ministry of Health staff trained 719 449 1135
C. Investigator Initiated Research (IIR) Projects and Output 2020 2021 2022
No. of research projects initiated by CRC and/ or in

IIR projects 39 38 47
collaboration with other institutions
No. of published articles in local/ int. journals 16 21 26

Publications
No. of manuscripts pending publication 9 15 7
Reports No. of research reports completed 8 17 9
No. of oral presentations 1 3 3

Presentation
No. of poster presentations 8 7 2
Awards No. of awards received 5 5 2
D. Industry Sponsored Research (ISR) 2020 2021 2022
Feasibility No. of feasibility studies conducted 59 65 114
No. of on-going clinical trials 36 35 35

Clinical trials
No. of upcoming clinical trials 8 17 7
No. Name Award/achievement details in 2022
1. Dr. Philip Rajan Devesahayam Best Editor Award of Medical Journal of Malaysia 2021/22
Best Poster Award in15th National Conference for Clinical Research (NCCR) 2022 for
2. Chang Chee Tao study title Perceived unmet needs of age-friendly environment: Qualitative exploration of
older adults' perception in a Malaysian city [NMRR-19-3191-51748]
Page 21
CRC, HRPB Ipoh
PUBLICATION
List of Publication CRC HRPB 2022
No. Publication Details
Lee FS, Sararaks S, Yau WK, Ang ZY, Jailani AS, Abd Karim Z, Naing L, Krishnan T, Chu AR, Junus S, Ahmad MS,
Sapiee N, Veloo VW, Manoharan S, A Hamid M. Fall determinants in hospitalized older patients: a nested case-
1.
control design - incidence, extrinsic and intrinsic risk in Malaysia. BMC Geriatr. 2022 Mar 3;22(1):179.
doi:10.1186/s12877-022-02846-6.
C KW Wong, Chii-Chii Chew, E-Li Leong, LH Chia, BH Lee, AP Anthonysammy, M Gobalan, KS Thong, SR Sulaiman,
2. KW Foong. The Challenges and Strategies in Managing Intensive Care Units for COVID-19 Pandemic in Malaysia.
Malaysian Journal of Medicine and Health Sciences 18(1): 331-336, Jan 2022.
IZ Mohamad, C KW Wong, Chii-Chii Chew, E-Li Leong, BH Lee, CK Moh, K Chenasammy, S CL Lim, HB Ker. The
3. landscape of antibiotic usage among COVID-19 patients in the early phase of pandemic: a Malaysian national
perspective. Journal of Pharmaceutical Policy & Practice 15, 4 (2022). https://doi.org/10.1186/s40545-022-00404-4
Ju‑Ying Ang, E‑Li Leong, HK Chan, AA Shafe, SQ Lee, P Mutiah,R VM Lim, CM Loo, R US Rajah, M M.Ahmad Shah, Z J.
4. Osman, LC Yeoh, D Krisnan, K Bhojwani. Health-Related Quality Of Life Of Malaysian Patients With Chronic Non-
Malignant Pain And Its Associated Factors: A Cross-Sectional Study. BMC Musculoskeletal Disorders (2022) 23:400.
https://doi.org/10.1186/s12891-022-05354-1
Chii-Chii Chew, Xin-Jie Lim, LL Low, KM Lau, M Kari, UK Shamsudin, Philip Rajan. The challenges in managing the
5.
growth of indigenous children in Perak State, Malaysia: A qualitative study. PLoS ONE 17(3): e0265917.
https://doi.org/10.1371/journal.pone.0265917.
Lim Xin Jie, Philip Rajan, Teh HM, Raja FB, Tan JN. Analysis of pediatric cochlear implant candidacy: Single center,
6.
retrospective observational study. Med J Malaysia. 2022 Mar; 77(2):143-149. PMID: 35338619.
Aie Yen Tan, Chee Tao Chang, Yong King Yu, Yi Xin Low, Najah Fatehah Mohd Razali, Sui Yan The, Shaun Wen Huey
7. Lee. Adverse Events Following BNT162b2 mRNA COVID-19 Vaccine Immunization among Healthcare Workers in a
Tertiary Hospital in Johor, Malaysia. Vaccines. 2022; 10(4):509. https://doi.org/10.3390/vaccines10040509.
Shea Jiun Choo, Chun Zheng Ng, Yi Jing Ong, Kamariah Shamsinar Kamarul Baharin, Chee Tao Chang. Intravenous
8. human immunoglobulin utilization patterns and cost analysis in a Malaysian tertiary referral hospital. J of Pharm
Policy and Pract 15, 31 (2022). https://doi.org/10.1186/s40545-022-00430-2.
Fun Wee Hoo, Chee Tao Chang, Mohd Haz Hairul Amran. Home parenteral nutrition during the COVID-19
9. pandemic: Experience in a tertiary referral hospital in Malaysia. Clin Nutr. 2022 Mar;41(3):630-631. doi:
10.1016/j.clnu.2022.01.013.
Chee Tao Chang, Xin Jie Lim, Premaa Supramaniam, Chii Chii Chew, Lay Ming Ding, Philip Rajan. Perceived Gap of
10. Age-Friendliness among Community-Dwelling Older Adults: Findings from Malaysia, a Middle-Income Country. Int J
Environ Res Public Health 2022; 19(12):7171. https://doi.org/10.3390/ijerph19127171.
Shea Jiun Choo, Chee Tao Chang, Balamurugan Tangiisuran, Mohd Faiz Abdul Latif, Nor Aida Sanusi, Sabariah
Noor Harun. Abstinence Rate, Adverse Events and Withdrawal Symptoms after Varenicline Use and Predicting
11.
Factors of Smoking Abstinence: A Multicentre Single-State Study in Malaysia. Int J Environ Res Public Health. 2022
Jun 24;19(13):7757. doi: 10.3390/ijerph19137757
Lim SCL, Hor CP, Tay KH, Anilawati MJ, Tan WH, Ker HB, Chow SC, Masliza Z, Cheah WK, Lim HH, Khalid KE, Cheng
JT, Mohd-Unit H,AN N, Nasruddin AZ, Low LL, Khoo SW, Loh JH, Zaidan NZ, Ab-Wahab S, Song Li Herng, Koh HM,
12. King TL, Lai NM, Chidambaram SK, M. Peariasamy K. Efficacy of Ivermectin Treatment on Disease Progression
Among Adults with Mild to Moderate COVID-19 and Comorbidities: The I-TECH Randomized Clinical Trial. JAMA
Intern Med. 2022182(4):426-435. doi:10.1001/jamainternmed.2022.0189
Chang, C.T., Ong, S.Y., Lim, X.J., Chew, L.S. and Rajan, P. Managing nirmatrelvir/ritonavir during COVID-19:
13. pharmacists’ experiences from the Perak state of Malaysia. Journal of Pharmaceutical Policy and Practice15
(1).doi:10.1186/s40545-022-00469-1.
Page 22
CRC, HRPB Ipoh
Cont. Publication
No. Publication Details
Chii‑Chii Chew, Hasni‑Adha Ibrahim, Venugopalan K. Balan, Nor‑Azizah Abd‑Aziz, Hooi‑Meng Puah And Amar‑Singh
14. HSS. Growth management and prevalence of underweight of indigenous children (Orang Asli) in Peninsular
Malaysia: a clinical audit. BMC Pediatrics (2022) 22:481. https://doi.org/10.1186/s12887-022-03532-7.
Lai, Q.X., George Visuvasam D., Loh C.L., Satday Singh A.K., Ang J.Y. Serum Concentration and Clinical Outcomes of
Weight-Based and Conventional One-Gram Loading Dose of Vancomycinin in End-Stage Kidney Disease Patients.
15.
Perak Medical Journal, 2(1), Pp. 43. Available at: https://myjms.mohe.gov.my/index.php/pmj/article/view/7096Date
accessed: 10 Oct 2022. NMRR-13-1049-17806.
Low, L.L., Tong, S.F., Ang, J.Y., Abdullah, Z., Hamid, M.A., Risman, M.S., Wong, Y.T., Jamalul-lail, N.I., Chelladorai, K.,
16. Tan, Y.P., Tay, Y.L., Nordin, A.A. and HSS, A.-S. Social responsibility perspective in public response to the COVID-19
pandemic: a grounded theory approach. BMC Public Health, 22(1). doi:10.1186/s12889-022-12819-4.
Ashamuddin N.A., Mohd Noor S., Dzulkafli A., Daywipragas S., Balakrishnan T., Osman A., Ang J.Y. HIV among Blood
17. Donors in Perak, Malaysia: A Review from 2015 to 2019. Asian Journal of Medicine and Health Sciences, 5(1), pp.13-
24. NMRR -20-1427-55339.
Chee Tao Chang, Chern Choong Thum, Xin Jie Lim, Chii Chii Chew, Philip Rajan. Monkeypox outbreak: Preventing
18. another episode of stigmatisation. Tropical Medicine & International Health, 27(9), pp.754–757.
doi:10.1111/tmi.13798.
SH Lee, ZX Yeoh, IS Sachlin, N Gazali, SA Soelar, CY Foo, LL Low, SB Syed Alwi, TM Izam Tengku K, J S, M Zaid, CY
Wong, HH Chua, S Yusuf, D Muhamad, Philip Rajan Devesahayam, HB Ker, Z Salahuddin, M Mustafa, H Sawali, HG
Lee, S Din, NA Misnan, A Mohamad, MN Ismail, C Periasamy, TS Chow,EK Krishnan, CL Leong, PF Lim, NZ Zaidan,
19.
MZ Ibrahim, SA Wahab, SS Mohd Hashim & Malaysian, COVID-19 Anosmia Research Group. Self‑reported
symptom study of COVID‑19 chemosensory dysfunction in Malaysia. Sci Rep. 2022 Feb 8;12(1):2111. doi:
10.1038/s41598-022-06029-6.
Noryantimarlina Abdullah, and Basyariatul Fathi Othman, and Kartini Ahmad, and Philip Rajan Devesahayam, and
Yazmin Ahmad Rusli, (2022) Perkembangan bahasa dan pertuturan kanak-kanak Melayu pengguna implan koklea
20.
di bawah Program Implan Koklea Kebangsaan, Kementerian Kesihatan Malaysia. Jurnal Sains Kesihatan Malaysia,
20 (1). pp. 37-50. http://dx.doi.org/10.17576/JSKM-2022-2001-04.
Yee Ho Hwee, Philip Rajan Devesahayam. Skull Base Osteomyelitis: A rare case. Perak Medical Journal, 2(1).
21.
Available at: https://myjms.mohe.gov.my/index.php/pmj/article/view/7096Date accessed: 10 June 2022.
Kugan V, Purushotman R, Philip Rajan Devesahayam. An Atypical Presentation of Nasopharyngeal Carcinoma – A

22.
Case Report. 2022 Perak State Health Department Technical Report, pg 70. MOH/P/PK 24:22 (TR). ISSN 2785-9428.
Chii‑Chii Chew, Chee‑Tao Chang, Xin‑Jie Lim, Wai‑Yin Yong, Doris George, Pathma Letchumanan, Philip Rajan, Chee
Ping Chong. The management of allergic rhinitis by pharmacists in public services: a proposed PhaRmacISt‑led
23.
Education Model (AR‑PRISE). Journal of Pharmaceutical Policy and Practice (2022) 15:80.
https://doi.org/10.1186/s40545-022-00477-1.
Chee Tao Chang, Xin-Jie Lim, Chii-Chii Chew, Philip Rajan, Huan-Keat C, Muhammad Radzi AH, Asrul Akmal S,
24. Shaun Wen Huey L. Preferences and willingness of accepting COVID-19 vaccine booster: Results from a middle-
income country. 2022 Dec 12; 40(52): 7515–7519. https://doi.org/10.1016/j.vaccine.2022.10.057.
Chang Chee Tao, Xin‑Jie Lim, Awatef Amer Nordin, Chern Choong Thum, Sondi Sararaks, Kalaiarasu Periasamy and
Philip Rajan. Health system preparedness in infectious diseases: perspective of Malaysia, a middle‑income
25.
country, in the face of monkeypox outbreaks. Tropical Medicine and Health (2022) 50:87.
https://doi.org/10.1186/s41182-022-00479-4
Arvinder Singh HS, Pei-Ling Foo, Chii-Chii Chew, Simarjeet-Singh Dhillon. Prevalence and barriers of reporting
26. needle-stick injures amongst government pharmacists working in Perak, Malaysia. Med J Malaysia Vol 77 No 6
November 2022.
Page 23
CRC HRPB families 2022
D'Boss
Dr. Josephine
Paul Durai Dr. Philip Rajan
Dr. Lim Xin Jie Dr. Devin Kumar Devesahayam
The
Dr. Sharon Linus Lojikip
Charismatic
Physician
Dr. Chow Lai
Yeng The Number
The Pillar
Maniacs
Dr. Leong E Li
Dr. Muhd Nuh
Dr. Nur Sabrina Idy Razlan THE APOTHECARIES
Abd Rahim Datin Dr. Harpreet ACE
Kaur Harbans Singh Lina Hashim
Premaa
Supramaniam
The
Ang Ju Ying Numerophile
Dr. Siti Nabilah Sis
Mohamad Zaini
Nor Aizura
l
su
Zulkifli
n
R Co
S
e I
Th
Choong Jing Wei
NoorSyamimi
Revathe Rajendran Mhd Akhir
Aisyah Ahmad
Shadzili Suria Junus
T H E S T E P - IN G 'S
Ooi Siew Har STARS
Thinessha
Wan Ainor Syahdah Muruthi
Wan Hassan
Hasni
Ruth Merry
Adha
Chin E
Swarnaletchumi i Wei Song
Billy
Kanapathy Dr.
n
Gregory Domnic Thia
Zu
Juin
Norharjiana
Surianti
Good Luck in your study
Sunilje
et
Singh
Chew Chii Chii Chang Chee Tao
Page 24
Clinical Research Centre,
Hospital Taiping
Summary Report: Research Performance of
CRC Hospital Taiping
A. Number of staff in CRC/CRM Hospital Taiping
Staff Designation
2020
2021
2022

Pharmacist 2 2 2

Research officer (RO) 1 1 1
CRC staff Assistant research officer - - -
Allied health 1 1 1
CRC Hosp. Taiping available staff
Temporary staff (PSH)/MySTEP
(as of 31st Dec 2022):
0 1 1
available until Dec Head of Dept.:
CRM staff Study coordinator 3 3 2 Dr. Cheah Wee Kooi
-2 Medical officers
"Coming together is a beginning. -2 Pharmacist
-1 Research officers
Keeping together is progress. Working -1 Allied Health
together is a success". - Henry Ford -2 CRM study coordinator

No. of research/Case studies/Clinical audit registered 16 20 17
NMRR
registration No. of research/Case studies/Clinical audit projects with ethical
16 19 17
approval
Research
No. of consultations (episodes) provided 57 57 58
consultation
Proposal No. of proposals reviewed by the Hospital Research Review

17 9 26
review Committee (HRRC)
Publication & No. of application of publication in local/international journals 9 6 4

presentation
submitted to
CRC Taiping No. of application of oral/poster presentation 3 3 16
Training / No. of training workshops organised 11 3 11

C. Industry Sponsored Research (ISR) 2020 2021 2022
Clinical No. of on-going clinical trials 10 14 11

trials No. of upcoming clinical trials 1 1 2
~The expert in everything was one a beginner~
CRC, Hospital Taiping Page 25

CRC, Hospital Taiping
D. Investigator Initiated Research (IIR) Projects and Output 2020 2021 2022
No. of research projects initiated by CRC and/or in

IIR projects 4 2 5
No. of published articles in local/international journals 9 6 7

Publications

Presentation
List of Publication January – December 2022
No. Article details
Ng, L.Y.; Chin, C.J.; Danial, M.; Albart, S.A.; Suppiah, P.D.; Ganasegeran, K.; Tan, W.T.; Hoo, H.E.; Teh, E.E.;
1. Karupiah, G.; et al. Validation of the Visual Cognitive Assessment Test (VCAT) for the Early Diagnosis of
Cognitive Impairment in Multilingual Population in Malaysia.Psych2022,4, 38–48.
Lim SCL, Hor CP, Tay KH, et al. Efficacy of Ivermectin Treatment on Disease Progression Among Adults
2. With Mild to Moderate COVID-19 and Comorbidities: The I-TECH Randomized Clinical Trial. JAMA Intern
Med.
Tay CL, Ng WL, Beh HC, Lim WC, Hussin N. Screening and management of osteoporosis: a survey of
3. knowledge, attitude, and practice among primary care physicians in Malaysia. Arch Osteoporos. 2022
Apr 26;17(1):72. doi:10.1007/s11657-022-01111-y.
Wang XY, Mahmood SF, Jin F, Cheah WK, Ahmad M, Sohail MA, Ahmad W, Suppan VK, Sayeed MA,
Luxmi S, Teo AH, Lee LY, Qi YY, Pei RJ, Deng W, Xu ZH, Yang JM, Zhang Y, Guan WX, Yu X. Efficacy of
4. heterologous boosting against SARS-CoV-2 using a recombinant interferon-armed fusion protein
vaccine (V-01): a randomized, double-blind and placebo-controlled phase III trial. Emerg Microbes
Infect. 2022 Jun 10:1-44.
Tan MP, Leong CL, Pang YK, Razali RM, Ismail AI, Sam I-C, Abdul Rani R, Chong J, Mohd Zim MA, Musa
AN, Leong JH, Idris S, Khor J, Cheong A, El Guerche-Séblain C, Hasmukharay K, Arumugam M, Khalid KE,
5.
Ismail I and Cheah WK. (2022). Dearth of influenza among older adults admitted with respiratory
symptoms in Malaysia during the coronavirus disease 2019 pandemic in 2021.Front. Med. 9:977614.
Narwani H, Sreevali M, Chan W.S., Nurul N.J. Diabetic Control among Type 2 Diabetes Mellitus (T2DM)
6. Patients before and after the Implementation of Movement Control Order (MCO) due to COVID-19
Pandemic. Asian Journal of Medicine and Health Sciences Vol 5 Issue 2 November 2022.
Mohammad M.A.A., Narwani H., Chng X. Y., Osman A. Timeliness of Interhospital Patient Transfer (IHT)
7. within Hospital Kluster Perak Utara, Malaysia. Asian Journal of Medicine and Health Sciences Vol 5
Issue 2 November 2022.
It is always the simple that produces the marvelous by Amelia Barr

Page 26
CRC, Hospital Taiping
No. Name Award/achievement details in 2022

3rd place CRC oral presentation in Perak Research Conference 2022 for study title
1. Chua Kin Wei Evaluation of the Tolerability and Effectiveness of Tenecteplase in Patients with ST-Segment
Elevation Myocardial Infarction in A Secondary Hospital in Malaysia: A Retrospective Case Series
MEET THE CREW:

C CRC HOSPITAL TAIPING
r
l Directo
CR
Hospita
Dr Nar
imah B
t Yusof
i,
Wee Koo
Dr Cheah acist
Head of
C R C Pharm
eon g
Wai S
Chan
Dr Narwani Hussin, o er
p h
Christ
Deputy Head
Rani,
than, bdul
Chu Munina silaw
a t i i A
a Ki Prema r fficer
Pha nW h Off e
ic Dr Ro cal O
rma ei, Researc M e d i
cist
an ah,
in Raih
Nur Fat
CRM S C RM SC
Sree raya, C
v
ali M Siti Su
Reg uthu
iste v
red adivelu
Nur ,
se
Page 27
C L I N I C AL RE SEA R C H CE N T RE
Hospital
Seri
Manjung
CRC Hospital Seri SU M M A R Y R E P O R T: R E S E A R C H P E R F O RM ANC E

Manjung available staff OF C R C H O S P I TA L S E R I M A N J U N G
(as of 31st Dec 2022):
Head of Dept.: A. Number of staff in CRC/CRM Hospital Seri Manjung
Dr. Nga Shih Hang Staff Designation
2020
2021
2022
-1 Medical officers
-1 Pharmacist Pharmacist 1 1 1
-1 Allied Health Research officer (RO) - - -
-2 CRM study coordinator
CRC staff Assistant research officer - - -

Allied health 1 1 1
"It always seems Temporary staff (PSH)/
MySTEP available until 1 1 0
impossible until it's Dec
done" - Nelson Mandela CRM staff Study coordinator 2 2 2

No. of research/Case studies/Clinical audit registered 10 18 27
NMRR
registration No. of research/Case studies/Clinical audit projects with ethical
11 11 11
approval
Research
No. of consultations (episodes) provided 432 499 489
consultation
Proposal No. of proposals reviewed by the Hospital Research Review

6 16 18
review Committee (HRRC)
Publication & No. of application of publication in local/international journals 8 8 7

presentation
submitted to
CRC Taiping No. of application of oral/poster presentation 0 2 10
No. of training workshops organised 2 4 9

Training /
Page 28
CRC Hospital
Seri Manjung
C. Investigator Initiated Research (IIR) Projects and Output 2020 2021 2022
No. of research projects initiated by CRC and/or in

IIR projects 19 21 23
No. of published articles in local/international journals 3 4 1

Publications

Presentation
D. Industry Sponsored Research (ISR) 2020 2021 2022
No. of on-going clinical trials 9 11 12

Clinical trials
No. of upcoming clinical trials 2 2 9
No. Publication details
Idris, I., Mafauzy, M.M., Baharuddin, K.A., Alwi, F., Mohamad, W.S., 2022. Localized tetanus
1. mimics acute perforated viscus: A diagnostic challenge and review of case reports. Turk J
Emerg Med, 22(4), pp. 226-229.
ward
A Ms. Chiew Shoen Chuen
2 has won the Best
2
Presentation Award
20
(among the CRC's Oral

presentation) in the
Perak Annual Medical
Research Conference
2022, for the study title
of Are Malaysian
Children Aware of Their
Rights?
Page 29
Clinical Research Centre,
Hospital Seri Manjung Squad
Dr Nordin b. Nasir
Hospital Director
Azirah Osman, Dr Zarina Fu
SC CRM ad
Deputy Dire
ctor
ih Hang
"Success is best Sh
when it's shared" a
(H
g
Dr N
OD
Dr Farah Alwi
Deputy CRC Publication
)
Consultation
Research Training
CRC H. Seri Manjung

Ying rsarlizn
a
g Siew er) Sn. No
Dr Tin O f f ic S ar i
al Mat
(Medic anager
)
(CRC M
M ovinrgd
forwa er
togeth Chiew Shoen Chuen
(Pharmacist)
Lailye Zuraida Abu

Bakar, SC CRM
The strength of the team is

each individual member.
The strength of each member is
the team.~ Phil Jackson
Page 30
A L L C R C ' S
FUTURE PLAN
SUMMARY OF ISSUES AND FUTURE PLANS FOR CRC HRPB
Future Plans Issues Updates [Year 2022]
Hospital Director agreed to let CRC HRPB to Meeting with Hospital director, CRM and
take over the old nursing college administrative CRC on the application for funds from CRM
block. for refurbish works.
We had put up application for RMK, Request for renovation of old nursing
unfortunately till today we have not received college to set up ISR facilities for
any feedback. allocation from CRM.
Research
Infrastructure
and Space Early of 2021, CRC HRPB also submitted to Unit
Pembangunan to apply for Pembangunan
No further updates.
warrant to renovate the building but we have
not received any update from them.
Total allocation RM324,740.00 applied through

Need to perform budgeting estimation due
Pemohonan Peruntukan BP06000 (naiktaraf,
increase of cost.
ubahsuai dan pembaikan)
Investigator Initiated Research (IIR):
i. Ageing Friendly City Project (within Perak State):
Presentation to stakeholders:
• The Mayor, Ipoh City Council (April 2022 &
September 2022)
• The Perak State Health Director (April
2022)
Ipoh has been successfully registered as a
member the WHO’s Global Network for Age-
Publication:
friendly Cities and Communities in Dec 2019.
Published 1 article in International Journal
A mixed method study exploring the view of
of Environmental Research and Public
elderly and their caregivers was initiated in Feb
Health
2020. Quantitative baseline survey started in
DOI: 10.3390/ijerph19127171.
Health clinics in Kinta District, social events in
Ipoh since Feb 2020. Awarded with NIH grant.
Presentation:
1.Oral:
2020: Data collection expected to resume after
• Bengkel Pembangunan Keupayaan ke
hiring temporary staffs (Pekerja Sambilan
Arah
Harian - PSH).
Bandar dan Komuniti Mesra Usia di
2021: Quantitative baseline survey: Manuscript
Malaysia
writing & Qualitative telephone interviews were
(April 2022)
conducted
• The National Conference on Ageing 2022
(October 2022)
Large-scale
2.Poster:
Nationwide
Best poster Award – 15th NCCR (National
Research
Conference for Clinical Research 2022)
Projects
ii. Pneumococcal surveillance study:
A collaborative study was initiated between CRC

HRPB and Paediatrics Department of HRPB to
study on the Invasive Pneumococcal Vaccine
Program among children 5 years old and below
admitted into Malaysian Public Hospitals. Current status:
Still on-going. Monitoring Phase.
Commenced in Dec 2020, thus the multi-sites
surveillance study was carried out. Expected
year of completion is 2026. The study received
funding from GSK.
iii. Clinical audit on Malnourished Orang Asli Children:
Presentation to stakeholders:
Currently, the intervention is in progress to
• Nutrition Department, Ministry of Health
identify the root-causes via qualitative Focus
Malaysia (Bahagian Pemakanan, Jabatan
Group Discussion (FGD) and in-Depth interview
Kesihatan Awam) September 2022
(IDI) among healthcare providers of Mobile
Team Orang Asli Services.
Publication:
1 article published in PLoS One
2020 & 2021: Qualitative FGD and IDI
DOI: 10.1371/journal.pone.0265917
CRC HRPB, Ipoh Page 31

F U T U R E P L A N C O N T .
Investigator Initiated Trial (IIT):
Randomized Control Trial - VICSEL (Vitamin C):
Collaboration between CRC HRPB, Medical

and Anaesthesiology & Intensive Care
Department of HRPB involving multicentre
in Peninsular Malaysia. Current status:
Pending MREC approval
2020: Protocol development
2021: MREC approval, CTX and Grant
application in progress
Registry:
Drowning registry:
On-going registry for the paediatric

Current status:
population (<18 years). There is a plan to
• The inclusion of adult population into the
include adult population in the registry.
registry did not materialise because there is
a lack of funding for dedicated system and
2021:
human resource from VIP Unit, MOH.
• Suspended plan to include adult
• Still on-going. Data collection and analysis
population in the registry
to produce report by early next year 2023.
• Plan to collate 2 years for report
Large-scale
Investigator Sponsored Research (ISR) - Hybrid / Collaboration:
Nationwide
Research
Projects i. Randomized, Double -Blinded, Placebo
Controlled Phase III Clinical Trial for the
Evaluation of Efficacy and Safety of SARS-
CoV-2 Vaccine, Inactivated (Vero Cell) in
Healthy Population Aged 18 Years and
Above in Malaysia
Current status:
Extended: Study document sent for archive.
A Multi-centre, Randomized, Double-blind,
Placebo-controlled Phase III Clinical Trial
to Evaluate the Efficacy, Immunogenicity
and Safety of COVID-19 Vaccine (Vero Cell),
Inactivated Booster Dose in Adults Aged 18
Years and above
ii. Ivermectin Treatment Efficacy in Covid-

19 High Risk Patients (I-TECH Study): A 1 article published in JAMA Internal Medicine
Multicentre Open-label Randomized DOI: 10.1001/jamainternmed.2022.0189
Controlled Clinical Trial
Covid-19 related studies by CRC staffs:
A total of 21 Covid-19 related studies were

conducted:
Published 16 Covid-19 related articles in • Published – 3
year 2020-2021 • Data analysis – 6
• Data collection – 10
• NMRR registration - 2
i. CRC bulletin:
CRC bulletin was published electronically to

publicize the past, present and future
Dissemination of Current status:
research activities and updates in Perak by
Research • Plan to produce annual bulletins starting
CRC HRPB, CRC Taiping and CRC Seri
Findings and 2022.
Manjung.
Translation into • Current issue in progress with added
Practice features:
Bulletin was produced quarterly since 2019.
1) To promote Perak Annual Medical Research
Plan to produce biannual bulletins starting
Centre Conference.
2020.
2) To promote article submission to ePMJ.
2021: Published Issue 04

ii. Electronic Perak Medical Journal (e-PMJ):
Published the first issue of full articles

Volume 2, Issue 1 (14 articles), August 2022:
One conference proceeding was published:

Electronic Perak Medical Journal (e-PMJ)
• 12th Annual Malaysian Rehabilitation
was an initiative to capture studies
Medicine Conference, July 2022; Volume 2,
conducted by Perak state researchers and
Supplement 1 Conference Proceedings of 24
to increase the visibility of researches
abstracts
conducted in the region
Two conference proceedings will be published:
Two conference proceedings were
• 12th ASEAN & 9th Perak Health Congress on
published:
Primary Health Care, August 2022; Volume 2,
Dissemination of • 11th ASEAN & 8th Perak Health Congress
Supplement 2 Conference Proceedings of 28
Research on Primary Health Care, June 2019; Volume
abstracts
Findings and 1, Special Issue 1 (20 abstracts)
• Perak Research Conference, October 2022;
Translation into • Perak Research Conference, August 2019;
Volume 2, Supplement 3 Conference
Practice Volume 1, Special Issue 2 (53 abstracts)
Proceedings of 19 abstracts
On-going acceptance and peer-review of new

articles submitted to ePMJ.
iii. Request from Dewan Bahasa & Pustaka (DBP):
Use of infographic from research output

for the publication of the revised Primary
School Standard Curriculum (KSSR)
textbook, revision 2017 for use starting in Not related
2022.
[Study: Is Our Child Safe on the Escalator?
NMRR-16-2191-33056]
Current in-house human capacity:
• Completed PHD – 1
• Pursuing PHD – 2
• Completed Master – 2 staffs
• Completed Masters – 3
• Pursuing Master – 3 staffs
• Pursuing Masters – 3
• Completed Degree – 1
• CRM – 6 staffs
• CRM staffs – 7 staffs
Training & workshop:

Staff
Development and • Successfully conducted thematic analysis,
Training • Successfully conducted virtual trainings pharmacoeconomics, NMRR, research and
using Google Classroom & Zoom platform in statistics trainings / workshops.
year 2021. • Invited Prof. Dr. Adi Negara for
• External trainer for research Questionnaire Validation & Sample Size
brainstorming for Institut Latihan Calculation Workshops.
Kementerian Kesihatan Malaysia (ILKKM) • Co-organiser for Clinical Audit workshop
Sultan Azlan Shah for undergraduates. series with Paediatric Dental.
• More workshops with external experts to • External trainer for proposal writing
be conducted on health economics, workshop – Hospital Slim River and Hospital
advanced statistical analyses, EQ5D, Teluk Intan.
questionnaire validation, outcome • External reviewer for the Dental Health
translation & qualitative thematic analysis. Systems Research Review Meeting.
• Conducted a series of 15 in-house CREs.
• Request for additional hospital posts as

listed below:
i. Pembantu Tadbir (N19) to assist in CRC
daily administrative activities.
No further updates. Currently hiring contract
ii. Contract Research Officer posts.
staff (MySTEP) to facilitate CRC HRPB
administrative tasks.
• Due to insecurity of PSH and MySTEP
positions and turnover of CRC HRPB well-
Staff trained staffs left the organization to
Requisition obtain secure post.
To accelerate the application and approval

for MySTEP staffs due to the need to
conduct research projects.
No further updates.
Identify an in-charge person in JKN Perak
to work with CRC Hospital pertaining
MySTEP hiring process.

i. Research focus & consultation:
CRC HRPB is emphasizing in the transition

in a new direction to achieve the units’
mission and vision. Below are the
strategies:
• Involvement in collaborative research

Initiation of research projects through
projects with clinicians especially with
collaboration:
Public Health and/or Dental (Research
Camps).
• Research collaboration with departments in
• Consultative services limited to segmental
Hospital.
consultation and committed involvement
through collaborative studies with
• Research collaboration between CRCs in
clinicians.
Perak State.
• Focus more on the translational studies so
that research findings can be translated
Initiation of Health System Research projects
into the services.
at Perak State level.
• Involved in Covid-19 studies (public
health).
• Invited as facilitators for Bengkel
pembentangan Kertas Kerja Health System
Research, Perak State Oral Health Division,
2021.
ii. Clinical audit:
Clinical audit is not under CRC HRPB.

Clarified with HRPB QA unit, that Clinical
Audit should be handled by the Hospital Co-organised Clinical Audit 3-series workshop
Quality Unit. with Perak State Paediatric Dental
CRC HRPB committed to assist as Department.
Issues trainer/facilitators for clinical audit
workshops and trainings.
iii. Calibration and maintenance of ISR related equipment:
Discussed the calibration matters with

CCRN ICR.
Feedback from KSU: all equipment under
CRC Hospital should be maintained and
No further update.
calibrated using the organisation
operational budget.
KSU agreed to provide more allocation for
calibration if necessary.
iv. Research census in Perak:
• To identify the mechanism to capture

research conducted in Perak:
i. To capture research conducted in Perak

via NMRR
ii. Feedback from District & Health Clinics
The upgraded version 2 of the NMRR system,
iii. ISR through CRM
disabled the generation of census reports
iv. Others
through the system. Thus, research report
was generated using conventional data
• The research activities to be captured for
collection via departments, internal records
the following:
and KPI reporting.
i. New research
ii. On-going research
iii. Completed research
iv. Dissemination of research findings
through publication & presentation
"Planning Is Bringing The Future Into The Present So That You Can Do Something About It Now"
~ Alan Lakein

A L L C R C ' S
FUTURE PLAN
SUMMARY OF ISSUES AND FUTURE PLANS FOR
CRC HOSPITAL TAIPING AND SERI MANJUNG
Future Plans CRC Hospital Taiping CRC Hospital Seri Manjung
To apply for budget for purchasing of the following:

i. ECG Machine, Model CR150 Brand: Welch Allyn
ii. Mindray Beneheart D3 With Pacer Defibrillator
Machine with Emergency Trolley
iii. Centrifuge (Refrigerated), Brand: Eppendorf
Research
Purchasing of -80 Degree iv. Mini Centrifuge (Non-Refrigerated), Brand:
Infrastructure
Celsius freezer Hettich
and Space
v. -40 PHCbi Biomedical Plasma Freezer
vi. Spot Vital Sign (NIBP) Mediana
vii. Heartsine Samaritan Defibrillator AED
viii. 2 laptops
ix. 2 laser printers
To publish the following research projects in journal:

i. Clinical and Computed Tomographical Patterns of
Pulmonary Thromboembolic Disease associated with
COVID-19 Infection: A Tertiary Hospital Analysis.
ii. Survival Analysis of Pulmonary Thromboembolic
Disease associated with Covid-19 Infection: A
Comparison between Geriatric and Non-geriatric
Populations.
Large-scale • Collaboration with Public iii. Are Malaysian children aware of their rights?
Nationwide Health in environmental health iv. Moral Distress among Healthcare Professionals in
Research • Collaboration with ILKKM on Malaysia during the COVID-19 Pandemic.
Projects research projects
To involve in the following nationwide research:
i. Knowledge, Attitude and Practice Regarding
Clinical Research Among Researchers from
Government Hospitals and Institute for Clinical
Research, Malaysia.
ii. The rate of blood culture contamination and
common organisms isolated in Malaysian Public
Hospitals.
Dissemination • ICPEP - pending sponsor

of Research approval
To sponsor publication of good quality research
Findings and • Burnout among nurses -
papers in journal for CRC staffs.
Translation pending publication
into Practice • 10 on 10 - pending publication
TGP Training - 1
Application for Masters - 2
Application for PhD - 2
Training on audit MSQH/ ISO - 1 To sponsor and facilitate research-related training
Staff
Training for Clinical Trial for CRC and hospital staffs (virtual and physical).
Development
Management - 1
and Training
Training for Qualitative To conduct the routine workshops as planned in 2023.
Research - 1
Attending research related
training as needed.
Staff 2 Medical Officer

NIL
Requisition 1 MyStep Personnel
"The future Does Not Get Better By Hope, It Gets Better By Plan. And To Plan
For The Future We Need Goals" ~ Jim Rohn
CRC Hospital Taiping CRC Hospital Seri Manjung Page 35

CRC, HOSPITAL SERI MANJUNG 2022 EVENT
2022 SUMMARY OF EVENT

CLINICAL RESEARCH CENTRE, HOSPITAL SERI MANJUNG
A) PROPOSAL WRITING WORKSHOP B) BASIC BIO-STATISTICS WORKSHOP
Date: 21st February 2022 Date: 7th – 8th March 2022

Time: 2.00 pm - 5.00 pm Time: 8.00 am - 5.00 pm
Place/Platform: Zoom Meeting Place/Platform: Zoom Meeting
Speaker: Speaker:
Dr. Ting Siew Ying & Dr. Ting Siew Ying,
Ms. Chiew Shoen Chuen Ms. Chiew Shoen Chuen,
Total Participants: 33 Dr. Leong E Li (CRC HRPB),
Ms. Premaa Supramaniam (CRC HRPB),
Ms. Suria Junus (CRC HRPB).
Total Participants: 21
C) INTRODUCTION TO CLINICAL
RESEARCH WORKSHOP E) GOOD CLINICAL PRACTICE
WORKSHOP - HYBRID
Date: 28th – 29th March 2022
Time: 2.00 pm - 5.00 pm
Date: 23rd – 25th May 2022
Place/Platform: Zoom Meeting
Time:
Speaker:
8.00 am - 5.00 pm (Day 1 & 2) - Lecture
Dr. Nga Shih Hang (CRC HSM),
8.00 am - 10.30 am (Day 3) - Lecture
Dr. Chang Meng Lee (Medical Dept. HSM),
2.00 pm - 3.00 pm (Day 3) - Exam
Dr. Ting Siew Ying (CRC HSM),
Place/Platform:
Ms. Chiew Shoen Chuen (CRC HSM),
Zoom Meeting (Lecture)
Mr. Gobi Hariyanayagam Gunasekaran
Open University Malaysia (OUM) Manjung
(Pharmacy Dept. HSM),
Learning Centre (Exam)
Ms. Lailye Zuraida Bte Abu Bakar (CRM, HSM).
Speaker:
Dr. Nga Shih Hang (CRC HSM)
Dr. Chang Meng Lee (Medical department, HSM)
D) NMRR REGISTRATION WORKSHOP Ms. Aarti Devi Ram Dev (Clinical Management, PPD Malaysia)
Dr. Cheah Wee Kooi (CRC Hospital Taiping)
Date: 25th April 2022
Dr. V Paranthaman a/l P. Vengadasalam (PKD Kinta)
Time: 2.15 pm - 4.30 pm
Ms. Safiya Mohd Razif (NPRA)
Mr. Ahmad Izwan Abdul Rani (NPRA)
Speaker:
Dr. Ting Siew Ying,
Ms. Chiew Shoen Chuen
PAGE 36
CRC, HOSPITAL SERI MANJUNG 2022 EVENT
F) PUBMED SEARCH & REFERENCING

WORKSHOP H) SAMPLE SIZE CALCULATION FOR
Date: 4th July 2022 RESEARCH WORKSHOP
Time: 9.00 am - 4.00 pm
Date: 16th –17th August 2022
Time: 8.00 am - 5.00 pm
Speaker:
Dr. Narwani Hussin
Speaker:
(CRC Hospital Taiping)
Professor Dr. Adinegara Bin Lutfi Abas
(Manipal University College, Malaysia)
G) SCIENTIFIC WRITING WORKSHOP I) PERAK ANNUAL MEDICAL RESEARCH

Date: 25th – 26th July 2022
CONFERENCE
Time: 1.50 pm - 5.00 pm
Date: 6th September 2022
Time: 8.00 am - 5.00 pm
Speaker:
Place/Platform: Auditorium, Hospital
Dr. Cheah Wee Kooi (CRC Hospital Taiping)
Raja Permaisuri Bainun, Ipoh
Mr. Chan Huan Keat (CRC Hospital Sultanah
Detail:
Bahiyah, Alor Star)
Jointly organized with CRC HRPB, CRC
Hospital Taiping, JKN Perak and
Sponsored by PGMES
UPCOMING EVENT
CLINICAL RESEARCH CENTRE, HOSPITAL SERI MANJUNG
YEAR 2023
FEB MAR APR MAY JUN JUL AUG OCT
1 4 5
6 - 8 JUN
1/20 ice
hop l Pract
23
7 8 mar 9 9 may 11 JUL 12 23 - 25

Basic Bio- NMRR Scientific oCT
Registration
2/20 ice
statistics Writing
Wo linica
Workshop Workshop Workshop

hop l Pract
23
rks
dC
13 9 mar 11 12 apr 12 JUL 16 AUG

Goo
Wo linica
Basic Bio- apr Perak Annual

Clinical Research
Scientific
Introduction to
statistics Writing Medical

Workshop
rks
Research
dC
Workshop Workshop
Conference
Goo
23 feb 24 12 25 26 JUN 27 28
apr Pubmed
Proposal
Writing Search and
Workshop Referencing
29 30 31
To be announced
Sample Size Calculation
for Research
*Note: This is a tentative events. Any update or changes will be announced by the organizer.
PAGE 37
Clinical Research Centre, Hospital Taiping
2022,
CRC Taiping
Events Summary
Protocol Intermediate Good Clinical Taiping

Writing SPSS Practice Research Day,
Workshop, Workshop, Workshop, 29 September 2022
22-24 March 14-15 June 21-23 June 2022
2022 2022
Roadshow to Nearest
MOH Facilities
Roadshow to
PKD Kerian,
2 June 2022
Roadshow to
PKD LMS,
7 June 2022
UPCOMING EVENT 2023
PAGE 38
Clinical Research Centre, Hospital Taiping
TENTATIVE EVENT
FOR THE YEAR
2023
18 Jan
1 Pubmed Short Training
20 - 21 Feb
2 Introduction to Clinical
Research
To be announced
3 Proposal Writing Workshop
15 - 17 May
4 Good Clinical Practice
Workshop
Event on
13 - 15 Jun
2023 5 Basic SPSS Workshop
22 Jun
6 Google e-form short
Training
12 - 13 Jul
7 Manuscript Writing
Workshop
22 - 23 Aug
8 Qualitative Research
Workshop
20 - 21 Sep
9 Intermediate SPSS
Workshop
PAGE 39
Clinical Research Centre, Hospital Raja Permaisuri Bainun
Summary List of CRC HRPB Key Activities in 2022
Training Offered Number of Jointly
No Date Outcomes
& Content Participants Organised
Virtual and Hands-on Training – This course

demonstrates the main functions of ATLAS.ti
for understanding qualitative data through

Qualitative Data integration and reporting, practice on how to

11 – 12 Jan University
1. Analysis With 29 analyse different data formats (textual,
2022 Utara Malaysia
ATLAS.ti 9 images, audio, video, maps) using thematic
coding and learn how to write the findings
based on the visual, textual & numerical
reports of ATLAS.ti.
CME Paediatric Virtual - Sharing knowledge on how to do a Paediatric

2. 27 Jan 2022 25
department critical appraisal of the published article Department
Virtual and Hands-on Training –Introduction

to basic statistical methods and data analysis,
7 – 8 Feb Basic Bio-
Data entry, Data transformation, Descriptive CRC Seri
3. 2022 statistics 22
statistics, Inferential statistics, Strategy in Manjung
Workshop
choosing appropriate statistical test and test
of comparisons.
Virtual – Introduction to clinical research,

Overview of research process, Formulating a
research question, Objective & hypothesis,
CME Hospital
Literature review, Ethical issues & IRB, study
4. 18 Feb 2022 Bahagia Ulu 30 HBUK
designs, Data collection – tool & data
Kinta
management, basic Statistical analysis –
descriptive & inferential, Measure of effect,
Proposal writing & NIH guidelines.
CME Kolej Sains

15 Mar 2022 Virtual – NMRR Registration with post-basic
5. Kesihatan 65 KSKB Ulu Kinta
student batch 2022
Bersekutu
Virtual and Hands-on Training -Introduction

to health research, Identification and
prioritization of research problems/areas,
Formulation of objectives, research questions
Basic Research & hypotheses, Planning the measurements,
11 – 12 Apr
6. Methodology 50 Study design options in medical and health CRC HRPB
2022
Workshop research, Variables, Determination of sample
size, Sampling methods, Data collection
methods and techniques, Ethical issues in
health research and Writing a research
proposal and research registration
Virtual and Hands-on Training – Introduction

and principles of pharmacoeconomics,
National
costings and evaluation, measuring outcome,
27 – 28 Apr Pharmacoecono Pharmaceutical
7. 47 type of outcome validity and realibility of EQ-
2022 mics workshop Regulatory
5D, HUI3, SF-36, Analysis CEA and CUA,
Agency
decision tree modelling, markov modelling,
evaluation reporting
Virtual – Introduction to NMRR website.

Update on the new version of NMRR V2.0.
CME Hospital Sharing on the guideline research
8. 29 Apr 2022 Raja Permaisuri 360 registration and ethical submission in NMRR ICT HRPB
Bainun website. Document required for the
submission and lastly the timeline for
approval.
Virtual – Introduction to NMRR registration.

NMRR hands-on Update on the new version of NMRR V2.0.
9. 19 May 2022 57 CRC HRPB
online course Hands-on training for register NMRR account
and research registration.
PAGE 40
Clinical Research Centre, Hospital Raja Permaisuri Bainun
Cont. Summary List of CRC HRPB Key Activities in 2022

Training Offered & Number of
No Date Outcomes Jointly Organised
Content Participants
Virtual – Introduction to Clinical Audit,

How to Perform Clinical Audit: 5 stages
approach – Stage 1: Plan for the audit,
Stage 2: Select standard and criteria,
Clinical Audit Paediatric Dental &
10. 1 Jun 2022 26 Stage 3: Measuring performance, Stage
Workshop State Dental
4: Making improvements and Stage 5:
Sustain improvements. Do’s and don’ts
in Clinical Audit, NMRR Registration,
Proposal presentation by Groups
Virtual – Introduction to questionnaire

validation. To learn and acquire basic
Questionnaire skills in designing questionnaires. To
29 – 30 Jun Manipal University
11. Validation For 36 understand the principles & apply
2022 College Malaysia
Research appropriate tools in dealing with validity
and reliability. Hands on training in
questionnaire’s design and validation.
Introduction to research, Identification

and prioritization of research
Proposal Writing
12. 20 Jul 2022 26 problems/areas, Formulation of Hospital Slim River
Workshop
objectives, Hands-on protocol
development and group presentation.
Hands-on Training on Introduction to

basic statistical methods and data
analysis, Data entry, Data
Basic Biostatistics
13. 27 Jul 2022 33 transformation, Descriptive statistics, CRC HRPB
Workshop
Inferential statistics, Strategy in
choosing appropriate statistical test and
test of comparisons.
Hands-on Training on basic skills of the

utilization and application of sample size
calculation in research and manuscript
Sample Size
16 – 17 Aug writing. The workshop also covers basic CRC Hospital Seri
14. Calculation for 30
2022 knowledge of types of research Manjung
Research
methodology and statistical tools to
assist in determining the appropriate
sample size calculation technique.
Virtual – Introduction to health system

research by CRC HRPB and reviews of 8
Dental Health
new dental health research proposal for Dental Health
15. 23 Aug 2022 Systems Research 36
year 2022. The update of 13 on-going State Department,
Review
dental health research study by the
participants.
CRC HRPB, JKN

Perak, HRPB Ipoh,
Perak Annual Virtual conference - 20 research projects
PGMES Ipoh, CRC
16. 6 Sep 2022 Medical Research 263 conducted in Perak were presented
Hospital Taiping,
Conference orally
CRC Hospital Seri
Manjung
Perak State Update on CRC / research activities and

Research procedures, discussion on the future
17. 24 Nov 2022 67 JKN Perak
Committee plans and needs for research and CRC
Meeting development in Perak State
PAGE 41
CLINICAL RESEARCH CENTRE, HOSPITAL RAJA PERMAISURI BAINUN
2023 Upcoming Events
FEB MAR MAY JUN
28 FEB - 1 MAR 14 - 16 MAR 8 MAY 8 - 9 JUN

Basic Introduction to NMRR Introduction
Research R, Systematic Registration to
Methodology Review and Workshop Epidemiology
Meta-analysis
JUN JUL AUG 04
15 JUN 10 - 11 JUL 16 AUG 26 OCT

Manuscript Basic Perak Annual Perak
Writing Bio-statistics Medical Research
Workshop Research State Meeting
Conference
PAGE 42
ELECTRONIC-
PERAK MEDICAL
JOURNAL
ePMJ
About the e-PMJ

The e-PMJ is a joint effort between the Postgraduate In 1997, the journal was first indexed with the
Medical Education Society (PGMES) of Hospital Raja National Library of Malaysia. In 2019, the
Permaisuri Bainun (HRPB) and Clinical Research electronic version was published as e-PMJ. All
Centre (CRC) HRPB. The PGMES was first started in articles published, including editorial and
1991 and officially registered in 1993. letters, represent the views of the authors and
not necessarily those of the Editorial Board or
In 1992, in support of promoting educational activity
the Ministry of Health.
in HRPB (formerly known as Hospital Ipoh), the first
edition of Medical Practice Hospital Ipoh was
Acknowledgement
published, which was a compilation of full text
research articles from HRPB. In 2007, Medical We are grateful to the Director-General,
Practice Ipoh was renamed as Perak Medical Journal, Ministry of Health Malaysia for permission to
reflecting a wider scope of the journal coverage. publish the articles in the e-PMJ.
Milestones For readers:

Conference Proceedings of 11th ASEAN &
8th Perak Health Congress on Primary Health Care We encourage readers to sign up for the
publishing notification service for this journal.
Volume 1 (Supp 01) 2019 Use the Register link at the top of the home
page for the journal. This registration will result
Conference Proceedings of Perak Research in the reader receiving the Table of Contents
Conference 2019 by email for each new issue of the journal. This
Volume 1 (Supp 02) (2019) list also allows the journal to claim a certain
level of support or readership. See the
e-PMJ Articles journal's Privacy Statement, which assures
readers that their name and email address will
Volume 2 (Issue 01) (2022) not be used for other purposes.
Conference Proceedings of 12th Annual Malaysian
Rehabilitation Medicine Conference For authors:
Volume 2 (Supp 01) (2022)
Interested in submitting to this journal? We
12th ASEAN & 9th Perak Health Congress on recommend that you review the About the
Primary Health Care Journal page for the journal's section policies,
Volume 2 (Supp 02) (2022) as well as the Instructions for Authors (May
2022). Authors need to register with the
Perak Annual Medical Research Conference 2022 journal prior to submitting or, if already
registered, can simply log in and begin the
Volume 2 (Supp 03) (2022) five-step process.
For more info, visit us at:

https://myjms.mohe.gov.my/index.php/pmj
Disclaimer: Acknowledgement:
The materials and information on Special thanks to Prema Muninathan,
this bulletin have been prepared or Dr. Ting Siew Ying, Chiew Shoen Chuen,
assembled by the organisation and Norsarlizna Mat Sari, Dr. Lim Xin Jie, Dr.
are intended for informational
Leong E Li, Ang Ju Ying, Premaa
purposes only. The pictures showed
Supramaniam, Thinessha Muruthi for
are for general information and not
the support and contribution in
meant to be invasive.
preparing this bulletin.
VISIT US:
THE HOSPITAL CRC NETWORK NEAREST TO YOU.
Ipoh Taiping
Clinical Research Centre, Clinical Research Centre
Level 4, Ambulatory Care Centre (ACC), Hospital Taiping
Hospital Raja Permaisuri Bainun, Jalan Taming Sari
Jalan Raja Ashman Shah, 34000 Taiping, Perak
30450 Ipoh, Tel. No.: 05-820 4000
Perak Darul Ridzuan. ext.:8400
T: 05-208 5146
Seri Manjung
Clinical Research Centre (Pusat
Penyelidikan Klinikal)
Hospital Seri Manjung,
32040 Seri Manjung Perak.
Tel: 05 - 689 6639 / 05- 688 2245
Fax: 05 - 688 4013 / 05 - 688 2245
Bulletin
© 2023 Clinical Research Centre Hospital Raja Permaisuri Bainun. All Rights Reserved

CRC Perak Bulletin Issue 05

Uploaded by

Document Information

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

CRC Perak Bulletin Issue 05

Uploaded by

Copyright:

Available Formats

Issue 05 Clinical Research Centre

Perak Networks BULLETIN

Inside this issue:

CRC Hospital Taiping: In Focus

Premature death due to road traffic

MOH Research Grant (MRG)

Hospital Raja Permaisuri Bainun, Ipoh

Ivermectin is an antiparasitic drug and has been used as a treatment for

The study was initiated by Dr. Cheah

The flow of study starts with

In late April 2022, the government

5 month study durations Total subject to be recruited is 300 10 health clinics

RECOMBINANT SARS-COV-2 FUSION

PHASE III - RCT

Protocol No.: TG2102V01 Page 5

In particular, 16.7% of Ipoh's 739,700 residents are over the

Clinical Research Centre, Hospital Raja Permaisuri Bainun, Ipoh Page 6

with the health environment. Process

“We can't even use Theme 3:

Note: P: Older adult, C: Caregiver, K: Key-informant Page 7

Governance: “I cannot find one

Note: P: Older adult, C: Caregiver, K: Key-informant Page 8

CLINICAL AND COMPUTED TOMOGRAPHICAL PATTERNS OF PULMONARY

This study aims to study the

NMRR-21-1732-61096 (IIR) Page 9

Hospital Seri Manjung

Analysis of the CT features A total of 150 patients were recruited,

NMRR-21-1558-59028 geriatric cohort suffered from more severe

In conclusion, typical COVID-19 symptoms may

The impact of the COVID-19 pandemic on premature death due to

Reference sources: Example of mapping by PerakGIS (Village@Perak):

Current status: Study References:

NMRR ID-22-00218-FQQ Page 12

Definition of Medical Cannabis

Medical cannabis or medical marijuana uses the marijuana plant or chemicals in it to

© 2021 WebMD, LLC. All rights reserved.

MOH Research Grant (MRG)

The objectives of MRG are to:

MOH Research Grant (MRG)

4. MRG Review Panel

5. Priority in Research Evaluation

6. Result Notification in the MRG Application

MOH Research Grant (MRG)

7. Responsibility of 8. Funding Scope

9. Amendment to Grant existing equipment during the implementation of the

**PI needs to adhere to the deadline. Failure to submit

12. Extension of Research

Any violation of these Find Us

MOH Research Grant (MRG)

Sebarang pertanyaan: PERMOHONAN

A. Number of staff in CRC/CRM Hospital Raja Permaisuri Bainun

Medical officer (MO) 4 6 10

Temporary staff (PSH)/MySTEP

CRM staff Study coordinator 6 7 7

CRC HRPB available staff

B. Type of Research Services provided 2020 2021 2022

No. of research/Case studies/Clinical audit registered

Consultation No. of consultations (episodes) provided 638 342 663

No. of proposals reviewed by Hospital Research

Registry No. of patient registries supported 14 14 14

Training / No. of training workshops organised 18 7 16

No. of research projects initiated by CRC and/ or in

No. of published articles in local/ int. journals 16 21 26

Reports No. of research reports completed 8 17 9