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Bio2 11 - 12 Q3 0102 PF FD
Bio2 11 - 12 Q3 0102 PF FD
General Biology 2
1/2
Science, Technology, Engineering, and Mathematics
Have you tried playing
Snakes and Ladders
with your friends or
siblings? What
determines your
chances of winning?
2
When playing Snakes and
Ladders, your probability
of winning depends on
the outcomes of
throwing dice and the
random chances of
encountering snakes and
ladders.
3
Likewise,
biological
inheritance also
relies on certain
chances of
transmitting genes
from parents to
their offspring.
4
If you are given a plant with a
dominant trait, how would you
know if it is homozygous or
heterozygous?
5
Learning Competency
At the end of the lesson, you should be able to do the following:
6
Learning Objectives
At the end of the lesson, you should be able to do the following:
7
Dominance in Garden Peas
TESTCROSS
9
Use of Testcross
CASE 1 CASE 2
F1
10
Use of Testcross
CASE 1 CASE 2
F1
11
Use of Testcross
CASE 1 CASE 2
F1
12
Use of Testcross
CASE 1 CASE 2
13
Use of Testcross
CASE 1 CASE 2
14
Use of Testcross
CASE 1 CASE 2
15
Use of Testcross
CASE 1 CASE 2
F1 All with round seeds (Aa) Some with round seeds (Aa),
some with wrinkled seeds (aa)
16
Is the cross between a tall pea
and a dwarf pea an example of a
testcross? Why?
17
Problem Solving Techniques
Punnett Square
APPLICATIONS
OF
INHERITANCE
LAWS
Forked-Line Probability
Method Methods
18
Punnett Square
19
Sample Punnett Square
5. Distribute alleles.
6. Combine alleles.
7. Determine phenotypes.
8. Determine ratios. 20
Sample Punnett Square
5. Distribute alleles.
6. Combine alleles.
7. Determine phenotypes.
8. Determine ratios. 21
Sample Punnett Square
5. Distribute alleles.
6. Combine alleles.
7. Determine phenotypes.
8. Determine ratios. 22
Sample Punnett Square
5. Distribute alleles.
6. Combine alleles.
7. Determine phenotypes.
8. Determine ratios. 23
Sample Punnett Square
5. Distribute alleles.
6. Combine alleles.
7. Determine phenotypes.
8. Determine ratios. 24
Sample Punnett Square
5. Distribute alleles. AB Ab aB ab
6. Combine alleles.
ab
7. Determine phenotypes.
8. Determine ratios. 25
Sample Punnett Square
5. Distribute alleles. AB Ab aB ab
6. Combine alleles.
AaBb Aabb aaBb aabb
ab
7. Determine phenotypes.
8. Determine ratios. 26
Sample Punnett Square
5. Distribute alleles. AB Ab aB ab
6. Combine alleles.
AaBb Aabb aaBb aabb
ab round, round, wrinkled, wrinkled,
7. Determine phenotypes.
yellow green yellow green
8. Determine ratios. 27
Sample Punnett Square
6. Combine alleles.
GR: 1/4 AaBb: 1/4 Aabb: 1/4 aaBb: 1/4 aabb
7. Determine phenotypes.
PR: 1/4 round, yellow: 1/4 round, green: 1/4
wrinkled, yellow: 1/4 wrinkled, green
8. Determine ratios. 28
Six Possible Monohybrid Crosses
CASE 1 AA × AA
A A
A cross
between A AA AA
two
homozygous A AA AA
dominant
parents. GR: 100% or all AA
PR: 100% or all dominant
29
Six Possible Monohybrid Crosses
CASE 2 AA × Aa
A A
A cross
between
A AA AA
homozygous
dominant and a Aa Aa
heterozygous
parents. GR: 1/2 AA: 1/2 Aa
PR: 100% or all dominant
30
Six Possible Monohybrid Crosses
CASE 3 Aa × Aa
A a
A cross
between
A AA Aa
heterozygous
individuals or a Aa aa
hybrids.
GR: 1/4 AA: 2/4 Aa: 1/4 aa
PR: 3/4 dominant : 1/4 recessive
31
Six Possible Monohybrid Crosses
CASE 4 Aa × aa
A A
A cross
between two
a Aa Aa
true-breeding
individuals a Aa Aa
with different
traits GR: 100% or all Aa
PR: 100% or all dominant
32
Six Possible Monohybrid Crosses
CASE 5 Aa × aa
A a
A cross
between a a Aa aa
hybrid and a
recessive
a Aa aa
individual.
GR: 1/2 Aa: 1/2 aa
PR: 1/2 dominant : 1/2 recessive
33
Six Possible Monohybrid Crosses
CASE 6 aa × aa
a a
A cross
between a aa aa
two
recessive
a aa aa
individuals.
GR: 100% or all aa
PR: 100% or all recessive
34
Forked-Line Method
Requires analysis of each
monohybrid cross
FORKED-LINE
METHOD
Can determine
No need to identify
offspring ratios
the alleles directly
35
Forked-Line Method
5. Make branches.
6. Combine genotypes.
7. Multiply probabilities.
8. Determine ratios. 36
Forked-Line Method
5. Make branches.
6. Combine genotypes.
7. Multiply probabilities.
8. Determine ratios. 37
Forked-Line Method
6. Combine genotypes.
7. Multiply probabilities.
8. Determine ratios. 38
Forked-Line Method
6. Combine genotypes.
7. Multiply probabilities.
8. Determine ratios. 39
Forked-Line Method
5. Make branches.
6. Combine genotypes.
6. Multiply probabilities.
7.
7. Determine ratios.
8. 40
Forked-Line Method
5. Make branches.
6. Combine genotypes.
6. Multiply probabilities.
7.
7. Determine ratios.
8. 41
Forked-Line Method
5. Make branches.
6. Combine genotypes.
6. Multiply probabilities.
7.
7. Determine ratios.
8. 42
Forked-Line Method
5. Make branches.
6. Combine genotypes.
6. Multiply probabilities.
7.
7. Determine ratios.
8. 43
Forked-Line Method
5. Make branches.
6. Combine genotypes.
6. Multiply probabilities.
7.
7. Determine ratios.
8. 44
Forked-Line Method
5. Make branches.
6. Combine genotypes.
6. Multiply probabilities.
7.
7. Determine ratios.
8. 45
Forked-Line Method
5. Make branches.
6. Combine genotypes.
6. Multiply probabilities.
7.
7. Determine ratios.
8. 46
Forked-Line Method
3. Analyze
Create first
eachcolumn.
cross.
4. Create
Createsecond
first column.
column.
5. Create
Make branches.
second column.
6. Make
Combine
branches.
genotypes.
6. Combine
7. Multiply probabilities.
phenotypes.
7. Determine ratios.
8. 47
Forked-Line Method
3. Analyze
Create first
eachcolumn.
cross.
4. Create
Createsecond
first column.
column.
5. Create
Make branches.
second column.
6. Make
Combine
branches.
genotypes.
6. Combine
7. Multiply probabilities.
phenotypes.
7. Determine ratios.
8. 48
Forked-Line Method
5. Create
Make branches.
second column.
6. Make
Combine
branches.
genotypes.
6. Combine
7. Multiply probabilities.
phenotypes.
7. Determine ratios.
8. 49
Forked-Line Method
5. Create
Make branches.
second column.
Mm × Mm
6. Make
Combine
branches.
genotypes.
6. Combine
7. Multiply probabilities.
phenotypes. Nn × Nn
7. Determine ratios.
8. 50
Forked-Line Method
3. Analyze
Create first
eachcolumn.
cross.
4. Create
Createsecond
first column.
column.
5. Create
Make branches.
second column.
6. Make
Combine
branches.
genotypes.
6. Combine
7. Multiply probabilities.
phenotypes.
7. Determine ratios.
8. 52
Forked-Line Method
3. Analyze
Create first
eachcolumn.
cross.
4. Create
Createsecond
first column.
column.
5. Create
Make branches.
second column.
6. Make
Combine
branches.
genotypes.
6. Combine
7. Multiply probabilities.
phenotypes.
7. Determine ratios.
8. 53
Forked-Line Method
3. Analyze
Create first
eachcolumn.
cross.
4. Create
Createsecond
first column.
column.
5. Create
Make branches.
second column.
6. Make
Combine
branches.
genotypes.
6. Combine
7. Multiply probabilities.
phenotypes.
7. Determine ratios.
8. 54
Forked-Line Method
3. Analyze
Create first
eachcolumn.
cross.
4. Create
Createsecond
first column.
column.
5. Create
Make branches.
second column.
6. Make
Combine
branches.
genotypes.
6. Combine
7. Multiply probabilities.
phenotypes.
7. Determine ratios.
8. 55
Forked-Line Method
3. Analyze
Create first
eachcolumn.
cross.
4. Create
Createsecond
first column.
column.
5. Create
Make branches.
second column.
6. Make
Combine
branches.
genotypes.
6. Combine
7. Multiply probabilities.
phenotypes.
7. Determine ratios.
8. 56
Forked-Line Method
3. Analyze
Create first
eachcolumn.
cross.
4. Create
Createsecond
first column.
column.
5. Create
Make branches.
second column.
6. Make
Combine
branches.
genotypes.
6. Combine
7. Multiply probabilities.
phenotypes.
7. Determine ratios.
8. 57
Probability Methods
58
Probability Methods
PROBABILITY
METHODS
59
How do the sum and product
rules of probability apply to the
laws of inheritance?
60
Probability Methods
AA 1 or 100% 0
Aa 1/2 or 50% 1/2 or 50%
aa 0 1 or 100%
61
Probability Methods
Product
Rule
62
Probability Methods
Product
Rule
The chance of
two or more
independent
events to occur
together is
equal to the
product of their
individual
probabilities.
63
Probability Methods
The chance of
two or more
independent
events to occur
together is
equal to the
product of their
individual
probabilities.
64
Probability Methods
The chance of
two or more
independent
events to occur
together is
equal to the
product of their
individual
probabilities.
68
Probability Methods
Sum
Rule
74
Probability Methods
Sum
Rule
The probability
of either of two
mutually
exclusive events
occurring is
equal to the sum
of their
individual
probabilities.
75
Probability Methods
Example 1: You are given one turn or attempt to roll a
Sum die, and you want to determine the chance of landing
Rule with two or four.
The probability
of either of two
mutually
exclusive events
occurring is
equal to the sum
of their
individual
probabilities.
76
Probability Methods
Example 1: You are given one turn or attempt to roll a
Sum die, and you want to determine the chance of landing
Rule with two or four.
Given: One attempt to roll a die.
The probability
of either of two
mutually
exclusive events
occurring is
equal to the sum
of their
individual
probabilities.
77
Probability Methods
Example 1: You are given one turn or attempt to roll a
Sum die, and you want to determine the chance of landing
Rule with two or four.
Given: One attempt to roll a die.
The probability
Asked: Chance of either 2 or 4.
of either of two
mutually
exclusive events
occurring is
equal to the sum
of their
individual
probabilities.
78
Probability Methods
Example 1: You are given one turn or attempt to roll a
Sum die, and you want to determine the chance of landing
Rule with two or four.
Given: One attempt to roll a die.
The probability
Asked: Chance of either 2 or 4.
of either of two
mutually Theory: With only an attempt, one
exclusive events cannot get both; we can only land a
occurring is 2 or a 4.
equal to the sum
of their
individual
probabilities.
79
Probability Methods
Example 1: You are given one turn or attempt to roll a
Sum die, and you want to determine the chance of landing
Rule with two or four.
Given: One attempt to roll a die.
The probability
Asked: Chance of either 2 or 4.
of either of two
mutually Theory: With only an attempt, one
exclusive events cannot get both; we can only land a
occurring is 2 or a 4.
equal to the sum
of their Conclusion: These events are
individual mutually exclusive.
probabilities.
80
Probability Methods
Example 1: You are given one turn or attempt to roll a
Sum die, and you want to determine the chance of landing
Rule with two or four.
The probability
of either of two
mutually
exclusive events
occurring is
equal to the sum
of their
individual
probabilities.
83
Probability Methods
The probability
of either of two
mutually
exclusive events
occurring is
equal to the sum
of their
individual
probabilities.
84
Probability Methods
90
Let’s Practice!
In humans, the deposition of melanin in the skin, eyes, and hair is
under the control of a gene that is inherited through complete
dominance. The recessive mutant allele is characterized by the
impaired pigmentation, which results in the condition called
albinism. If a normally pigmented couple, each of whom has an
albino parent, had children, what is the expected genotypic and
phenotypic ratios of their children with respect to the trait? Use a
Punnett square to justify your answer.
91
Let’s Practice!
In humans, the deposition of melanin in the skin, eyes, and hair is
under the control of a gene that is inherited through complete
dominance. The recessive mutant allele is characterized by the
impaired pigmentation, which results in the condition called
albinism. If a normally pigmented couple, each of whom has an
albino parent, had children, what is the expected genotypic and
phenotypic ratios of their children with respect to the trait? Use a
Punnett square to justify your answer.
The genotypic ratio of the cross is 1/4 AA: 2/4 Aa: 1/4 aa.
The phenotypic ratio is 3/4 pigmented and 1/4 albino.
92
Try It!
93
Let’s Practice!
In humans, the presence of dimples are controlled by dominant
alleles while the presence of a hitchhiker’s thumb is recessive. The
absence of dimples and the presence of a hitchhiker’s thumb in an
individual requires two copies of the recessive alleles. By using the
forked-line method, determine the genotypic and phenotypic ratios
of the children of a couple, wherein the male is heterozygous for
both traits, while the female is heterozygous for hitchhiker’s
thumb, but has no dimples.
94
Let’s Practice!
In humans, the presence of dimples are controlled by dominant
alleles while the presence of a hitchhiker’s thumb is recessive. The
absence of dimples and the presence of a hitchhiker’s thumb in an
individual requires two copies of the recessive alleles. By using the
forked-line method, determine the genotypic and phenotypic ratios
of the children of a couple, wherein the male is heterozygous for
both traits, while the female is heterozygous for hitchhiker’s
thumb, but has no dimples.
The genotypic ratio is 1/8 GGHh: 1/8 GGhh: 2/8 (or 1/4)
GgHh: 2/8 (or 1/4) Gghh: 1/8 ggHh: 1/8 gghh.
95
Let’s Practice!
In humans, the presence of dimples are controlled by dominant
alleles while the presence of a hitchhiker’s thumb is recessive. The
absence of dimples and the presence of a hitchhiker’s thumb in an
individual requires two copies of the recessive alleles. By using the
forked-line method, determine the genotypic and phenotypic ratios
of the children of a couple, wherein the male is heterozygous for
both traits, while the female is heterozygous for hitchhiker’s
thumb, but has no dimples.
97
Let’s Practice!
Two separate crosses were performed in peas. The first cross
involved seed shape and seed color. The second cross involves
height, inflorescence, and flower colors. The phenotypes of the
parents and offspring are given below. Give the complete
genotypes of both parents and offspring for both crosses. Use A for
seed shape, B for seed color, C for height, D for inflorescence, and E
for flower color.
Cross 1 Cross 2
round, yellow × wrinkled, green tall, terminal, white × dwarf, axial, violet
1/4 round, yellow 1/4 tall, axial, violet
1/4 round, green 1/4 dwarf, axial, violet
1/4 wrinkled, yellow 1/4 tall, terminal, violet
1/4 wrinkled, green 1/4 dwarf, terminal, violet 98
Let’s Practice!
Two separate crosses were performed in peas. The first cross
involved seed shape and seed color. The second cross involves
height, inflorescence, and flower colors. The phenotypes of the
parents and offspring are given below. Give the complete
genotypes of both parents and offspring for both crosses. Use A for
seed shape, B for seed color, C for height, D for inflorescence, and E
for flower color.
103
Let’s Sum It Up!
104
Let’s Sum It Up!
105
Let’s Sum It Up!
106
Let’s Sum It Up!
107
Let’s Sum It Up!
109
Challenge Yourself
● Slide 2: Snake and Ladders by Gaurav Dhwaj Khadka is licensed under CC BY-SA 4.0 via Wikimedia
Commons.
111
Bibliography
Brooker, J. Concepts of Genetics (1st ed.). New York, USA: McGraw-Hill Companies Inc., 2012.
Klug, W.S, and Cummings, M.R. Concepts of genetics (6th ed). Upper Saddle River, N.J: Prentice-Hall.
2003.
Pierce, B. Genetics: a conceptual approach (8th ed). New York: W.H. Freeman. 2012.
Reece J., Taylor M., Simon E., and Dickey J. Campbell Biology: Concepts and Connections (7th ed.). Boston:
Benjamin Cummings/Pearson. 2011.
Snustad, D.P., and Simmons, M.J. Principles of Genetics (6th ed.). Hoboken, NJ: Wiley. 2012.
112