Name: Melo L.

Medecielo

Nonaqueous Titrimetry (NAT)

1. What is Nonaqueous titrimetry?

Nonaqueous titrimetry is a titration of a weakly acidic or basic substance that is

carried out using nonaqueous solvents.

2. What are the advantages of nonaqueous titrimetry?

● Elimination of poor solubility of substances.

● Enhancement of weak reactivity of substances.
● Selective titration by using suitable solvent.

3. What precautions to be observed with nonaqueous titration?

● Moisture content in the system should be kept to a minimum level (less than
0.05)
● Temperature should be controlled.

4. Why moisture should be avoided in nonaqueous titration?

Moisture should be avoided in nonaqueous titration as it may cause an

interference which will greatly affect the end point. It is also stated that water may act as
a strong base on a weak basic drug.

5. In table form, compare the following: Bronsted-Lowry concept & Arrhenius concept

Bronsted-Lowry Concept Arrhenius Concept

According to the Bronsted-Lowry theory, The amphoteric property of water is

an acid is a Bronsted-Lowry acid if it has crucial, according to the Arrhenius
the ability to give a proton to another concept, since the majority of acid-base
atom. A base is deemed a chemical reactions occur in the presence
Bronsted-Lowry base if it has the ability to of water. Water is a crucial amphoteric
accept a proton from another source. substance that may function as an
From here, it can be deduced that the Arrhenius acid or base.
proton is transferred from one chemical
species to another during an acid-base
reaction.
6. Define the following: Aprotic, Protophilic, Protogenic, & Amphiprotic

● Aprotic Solvent: Most important solvent in this type of titration and are chemically
inert and they work as a catalyst.
● Protogenic Solvent: Are acidic in nature and can donate the proton and they
enhance the strength of weak bases.
● Protophilic Solvent: Are basic in nature and possess a high affinity for protons.
● Amphiprotic Solvent: Solvents which can act as both protogenic and protophilic
which means they can be acidic or basic in nature and accept and donate
protons.

Acidimetry in NAT

1. What is the most widely used titrant in NAT acidimetry?

Perchloric Acid

2. What indicators are used in titration of (1) weak bases & (2) strong bases?

● Crystal Violet for weak bases

● Methyl Red and Thymol Blue for strong bases

3. What is an exothermic reaction?

Exothermic reactions are chemical reactions that produce heat.

Alkalimetry in NAT

1. What titrants are used in NAT alkalimetry?

● Sodium methoxide solution

● Lithium methoxide solution
● Sodium aminomethoxide
● Triphenylmethane

2. What are the factors to be considered in choosing basic solvent?

● Solubility of the substance

● Strength of the basic solvent
● Sharpness of endpoints
● Non-reactivity of solvents
3. How can we determine the end point in NAT alkalimetry?

To determine the end point in NAT alkalimetry is using the potentiometer to

determine the end point.