PMID- 30580081

OWN - NLM
STAT- MEDLINE
DCOM- 20200330
LR - 20200330
IS - 1879-1379 (Electronic)
IS - 0022-3956 (Linking)
VI - 110
DP - 2019 Mar
TI - L-theanine in the adjunctive treatment of generalized anxiety disorder: A
double-blind, randomised, placebo-controlled trial.
PG - 31-37
LID - S0022-3956(18)30991-9 [pii]
LID - 10.1016/j.jpsychires.2018.12.014 [doi]
AB - Partial or non-response to antidepressants in Generalized Anxiety Disorder
(GAD)
is common in clinical settings, and adjunctive biological interventions may
be
required. Adjunctive herbal and nutraceutical treatments are a novel and
promising treatment option. L-theanine is a non-protein amino acid derived
most-commonly from tea (Camellia sinensis) leaves, which may be beneficial in
the
treatment of anxiety and sleep disturbance as suggested by preliminary
evidence.
We conducted a 10-week study (consisting of an 8-week double-blind
placebo-controlled period, and 1-week pre-study and 2-week post-study
single-blinded observational periods) involving 46 participants with a DSM-5
diagnosis of GAD. Participants received adjunctive L-theanine (450-900 mg) or
matching placebo with their current stable antidepressant treatment, and were
assessed on anxiety, sleep quality, and cognition outcomes. Results revealed
that
adjunctive L-theanine did not outperform placebo for anxiety reduction on the
HAMA (p = 0.73) nor insomnia severity on the Insomnia Severity Index (ISI;
p = 0.35). However, LT treated participants reported greater self-reported
sleep
satisfaction than placebo (ISI item 4; p = 0.015). Further, a separation in
favour of L-theanine was noted on the ISI in those with non-clinical levels
of
insomnia symptoms (ISI ≤ 14; p = 0.007). No significant cognitive effects
(trail
making time and the modified emotional Stroop) were revealed. While this
preliminary study did not support the efficacy of L-theanine in the treatment
of
anxiety symptoms in GAD, further studies to explore the application of L-
theanine
in sleep disturbance are warranted.
CI - Copyright © 2018 Elsevier Ltd. All rights reserved.
FAU - Sarris, Jerome
AU - Sarris J
AD - NICM Health Research Institute, Western Sydney University, Westmead, NSW,
Australia; The Professorial Unit, The Melbourne Clinic, Department of
Psychiatry,
The University of Melbourne, Richmond, VIC, Australia. Electronic address:
j.sarris@westernsydney.edu.au.
FAU - Byrne, Gerard J
AU - Byrne GJ
AD - The University of Queensland, Faculty of Medicine, Discipline of Psychiatry,
Herston, QLD, Australia.
FAU - Cribb, Lachlan
AU - Cribb L
AD - The Professorial Unit, The Melbourne Clinic, Department of Psychiatry, The
University of Melbourne, Richmond, VIC, Australia.
FAU - Oliver, Georgina
AU - Oliver G
AD - The Professorial Unit, The Melbourne Clinic, Department of Psychiatry, The
University of Melbourne, Richmond, VIC, Australia.
FAU - Murphy, Jenifer
AU - Murphy J
AD - The Professorial Unit, The Melbourne Clinic, Department of Psychiatry, The
University of Melbourne, Richmond, VIC, Australia.
FAU - Macdonald, Patricia
AU - Macdonald P
AD - The University of Queensland, Faculty of Medicine, Discipline of Psychiatry,
Herston, QLD, Australia.
FAU - Nazareth, Sonia
AU - Nazareth S
AD - The University of Queensland, Faculty of Medicine, Discipline of Psychiatry,
Herston, QLD, Australia.
FAU - Karamacoska, Diana
AU - Karamacoska D
AD - NICM Health Research Institute, Western Sydney University, Westmead, NSW,
Australia.
FAU - Galea, Samantha
AU - Galea S
AD - The Professorial Unit, The Melbourne Clinic, Department of Psychiatry, The
University of Melbourne, Richmond, VIC, Australia.
FAU - Short, Anika
AU - Short A
AD - The University of Queensland, Faculty of Medicine, Discipline of Psychiatry,
Herston, QLD, Australia.
FAU - Ee, Carolyn
AU - Ee C
AD - NICM Health Research Institute, Western Sydney University, Westmead, NSW,
Australia.
FAU - Birling, Yoann
AU - Birling Y
AD - NICM Health Research Institute, Western Sydney University, Westmead, NSW,
Australia.
FAU - Menon, Ranjit
AU - Menon R
AD - The Professorial Unit, The Melbourne Clinic, Department of Psychiatry, The
University of Melbourne, Richmond, VIC, Australia.
FAU - Ng, Chee H
AU - Ng CH
AD - The Professorial Unit, The Melbourne Clinic, Department of Psychiatry, The
University of Melbourne, Richmond, VIC, Australia.
LA - eng
PT - Clinical Trial, Phase II
PT - Journal Article
PT - Randomized Controlled Trial
PT - Research Support, Non-U.S. Gov't
DEP - 20181208
PL - England
TA - J Psychiatr Res
JT - Journal of psychiatric research
JID - 0376331
RN - 0 (Antidepressive Agents)
RN - 0 (Glutamates)
RN - 0 (Plant Preparations)
RN - 8021PR16QO (theanine)
SB - IM
MH - Adult
MH - Antidepressive Agents/*pharmacology
MH - Anxiety Disorders/complications/*drug therapy
MH - Cognitive Dysfunction/*drug therapy/etiology
MH - Double-Blind Method
MH - Drug Therapy, Combination
MH - Female
MH - Glutamates/administration & dosage/*pharmacology
MH - Humans
MH - Male
MH - Middle Aged
MH - *Outcome Assessment, Health Care
MH - Plant Preparations/administration & dosage/*pharmacology
MH - Sleep Initiation and Maintenance Disorders/*drug therapy/etiology
OTO - NOTNLM
OT - Anxiety
OT - GAD
OT - L-theanine
OT - Randomised controlled trial
OT - Sleep
EDAT- 2018/12/24 06:00
MHDA- 2020/03/31 06:00
CRDT- 2018/12/24 06:00
PHST- 2018/08/26 00:00 [received]
PHST- 2018/12/06 00:00 [revised]
PHST- 2018/12/07 00:00 [accepted]
PHST- 2018/12/24 06:00 [pubmed]
PHST- 2020/03/31 06:00 [medline]
PHST- 2018/12/24 06:00 [entrez]
AID - S0022-3956(18)30991-9 [pii]
AID - 10.1016/j.jpsychires.2018.12.014 [doi]
PST - ppublish
SO - J Psychiatr Res. 2019 Mar;110:31-37. doi: 10.1016/j.jpsychires.2018.12.014.
Epub
2018 Dec 8.