First let's proceed to diarrhea.

So it says here in the slide that cordia africana leaves and root bark can be
used as a treatment for diarrhea and this particular claim is backed up by two studies. one is from Ferede
and associates. In their study, the researchers show alient findings that the 80% methanolic extract has
antidiarrheal capacity, with the antisecretory and antimotility properties as possible mechanisms that
render this pharmacological effect. A similar study by Arsie et al. (2016) also claimed that “the root bark
extract of C. africana was found to be effective in preventing castor oil-induced diarrhea and intestinal
motility in a dose-dependent manner. Therefore, both studies are a welcoming development since
diarrhea remains one of the top 10 causes of death in African countries. Also, this study implied that the
use of Cordia africana leaf as an antidiarrheal agent in Ethiopian folklore medicine is true.

In addition, Codia africana stem bark has been clinically seen to be a potential treatment for jaundice
and liver disorders. So jaundice is actually a condition wherein the skin or the eyes become yellow, which
is an indication of poor liver functioning, just as the one seen here on the slide. This was backed up
Geresu et al. who revealed in their study that C. afircana stem bark extract and solvent fractions were
able to increase the ALT, AST and triglycerides of the test animals relative to the baseline data. This then
indicates high levels of hepatoprotective properties. So what does this imply? This implies that the plant
material is a good agent for the treatment of liver diseases as it is claimed in traditional medical practice.

Third, Cordia africana leaves can be used as treatment for malaria. Wondafrash et al. (2019) sought to
assess the antimalarial activity of C. africana , as traditionally believed by people From this, findings
reveal that the 80% methanol leaf extract of the plant species has a significant antimalarial activity in a
dose-dependent manner compared to the positive control in all the three evaluated animal models. This
indicates that the methanolic extract of C. africana can be used as a potential treatment for malaria,
which has been a major cause of morbidity and mortality among children and pregnant women in many
parts of Africa. Again, this study is consistent with the plant’s ethnomedicinal use.