Beleza Nanovetores

NANO
NAILS
BODY CARE
Actives: Essential Oils of
Lemongrass, Melaleuca
and Clove

Characteristics

Aspect: Creamy to
yellow milky liquid;
Usage concentration:
1.0 to 25%;
Stability pH: 4.0 to 8.0.
26.08.2020 - Rev.: 03

Benefits
• Antifungal action
• Antimicrobial
• Antiseptic
• Repairing
• Strengthening

Application
Cream gel and liquid base.
Nano Nails is a blend of active ingredients encapsula-
ted in lipid particles with an average particle diameter
greater than 200 nm. The blend encapsulation through
the technology developed by Nanovetores allows the
stabilization of sensitive and complex components to
be formulated in their free form. The active ingredient
acts in the fight against leukonychia, as well as in the
repair and strengthening of nails in general. Due to its
natural characteristics and non-existent chemical
aggression, Nano Nails can be used daily providing, in
continuous applications, the repair of damaged,
opaque, and brittle nails.

Description
Nano Nails is a natural cosmetic ingredient consisting
of a blend of lemongrass, melaluca and clove essen-
tial oils encapsulated in high permeation nanoparticles
with proven clinical effectiveness in repairing damaged
nails, with opaque, whitish and brittle appearance,
normally diagnosed as leukonychia.
Safety
The effectiveness of products for nails’ application is
compromised by the complexity of the nail structure
that makes it difficult for the actives to permeate. The
technology developed and patented by Nanovetores,
present in Nano Nails, favors the increased permea-
tion of the nanoencapsulated actives until the deeper
layers of the nail plate, where the active will have an
effective, safe and fast action.

61%
of the volunteers who participated in the efficacy
study showed an effective improvement in the
treatment of leukonychia after 4 days of product application.

*REPORT: ALL-E-ES-16267-01-11-10.
Lemongrass Essential Oil

The lemongrass is a plant originally from Asia, mainly

from India. From it is extracted an essential oil whose
main component is Citral (Geraniol), which is most
responsible for the antifungal, antimicrobial, anti-
inflammatory and analgesic properties of this oil (1,2).

Clove Essential Oil

The clove is a dry flower bud from a tree native to the
Moluccas Islands in Indonesia. The properties of its
essential oil are attributed to its main constituent,
eugenol, which has an important antibacterial and
antifungal effect.

Melaleuca Essential Oil

The main component of Melaleuca Essential Oil is
terpen-4-ol, which according to studies is responsi-
ble for the antiseptic and antimicrobial actions that
occur through a leukocyte activation mechanism. Its
antimicrobial action includes fungi, yeasts, gram
negative bacteria and the herpes simplex virus.
According to Hammer (3), Melaleuca essential oil can
cause allergic reactions in pre-disposed individuals.
These reactions are caused not by the oil itself, but
by products of the oxidation reaction that occurs by
exposing the oil's components to light and oxygen.
The encapsulation of the active promotes controlled
release and protects it from interaction with the
other components of the formula and with the envi-
ronment, preventing oxidation and avoiding poten-
tial skin irritation.
The encapsulation also promotes the occlusion of
the characteristic odor of Melaleuca Essential Oil,
ensuring an improvement in the sensory of the final
product.
Efficacy Test
Test 1: Product Effectiveness against Leukonychia.
Evaluated Product: Nano Nails 25% in cream base.

BEFORE AFTER

Conclusion: The product showed proven efficacy in the treatment of Leukonychia in 61% of the cases evaluated,
with effective improvement after 4 days of product application.

Test 2: Reduction of Nail Streaks

Evaluated Product: Nano Nails 25% on nanostructured liquid base.

BEFORE AFTER

Conclusion: It was observed that, after 7 days of using the study sample, there was a significant reduction in
flaking and whitish appearance of the skin in the nail folds 1, reduction in roughness 2 and waviness 3 of the nail
plate, the latter, given by the reduction of the depth of the longitudinal streaks. The simulated 3D image was
obtained by the projection of the roughness calculated in a rectangular area of the nail plate 2. The undulation
was obtained through the profilometry curve obtained across the nail plate 3.
Formula Suggestion

Nano Nails 25% in Cream Base

PHASE I % PHASE II % PHASE III %

EDTA.............................0,05
Glycerin........................3,00
Water qsp..........................100,00
Technique: Heat to 75 - 80°C
Hydroxyethyl.................0,55
Technique: Reserve
Olivax...................................1,00
Olivem 1000...........................2,50
MEG...............................5,50
Cetostearyl alcohol 30/70......2,30
BHT.......................................0,05
Dimeticone..........................1,00
Mineral oil...............................3,75
TCM.......................................3,75
Technique: Heat to 75 - 80°C

FASE IV %
Nano Nails...........................25,00
Preservative.............................qs

Technique: Reserve

1. Disperse phase II in I so as not to form lumps;

2. Add phase III on I + II at 80°C under stirring;
3. Adjust pH to 5.5 to 6.0;
4. Add phase IV below 40°C.

NOTE: It is recommended to use a concentration of 25% in creams or in the nanostructured liquid base (Nanovetores) for
the proposed treatment and repair. For products whose proposal is maintenance and beautification, it can be used in a
concentration of 1 to 5%.
The application to hydrate and repair the cuticles should be in a concentration of 1 to 5%.
* As it contains natural actives, the product may undergo changes in color and odor.

Mode of Use
1. For the proposed treatment and repair, apply on the nails (without polish) 2 times a day.
2. To hydrate the cuticles, apply once a day (with or without polish).
Regulatory Information

INCI Name CAS Number

AQUA 7732-18-5

OLEIC ACID 122-80-1

STEARIC ACID 57-11-4

POTASSIUM CETYL PHOSPHATE 84861-79-0

CYMBOPOGON FLEXUOSUS OIL 91844-92-7

MELALEUCA ALTERNIFOLIA LEAF OIL 68647-73-4

PHENOXYETHANOL 112-99-6

CAPRYLYL GLYCOL 1117-86-8

EUGENIA CARYOPHYLLUS LEAF OIL 8015-97-2

BHT 128-37-0

Physical - Chemical
Information

Aspect Milky and Viscous

Liquid
Color Cream to Yellow

Odor Characteristic

pH 5,0 a 7,0

Dispersion of encapsu-
Dispersibility
lated actives in water

Relative Density 0,9 to 1,1 g/mL Marketing Appeals

Characterization Blend
• Strengthens nails;
Emulsions O / W and W / O up to
Compatibility 25%. In nail polishes up to 5% • Moisturizes nails and cuticles;
• Repairs white spots (leukonychia);
• Contains natural actives.
Storage
Keep at a temperature
between 20 ° C - 25 ° C.

Incompatibility
Ethanol and other organic solvents.
 Bibliographic References

1. TASKINEN, J.; MATHELA, D.K.; MATHELA, C.S. Compo-

Our production process is based
on Green Chemistry, being wa-
ter-based and free of organic sol-
vents, totally sustainable. We do not
generate waste that could be harm-
ful to users or the environment
sition of the essential oil of Cymbopogon flexuosus. Jour-
nal of Chroma-tography A, v. 262, p. 364-366, 1983.
2. CHANDRASHEKAR, K.S.; PRASANNA, K.S. Analgesic
and Anti-inflammatory Activities of the Essential oil from
Cymbopogon flexuosus. Pharmacognosy Journal, v. 2, n.
14, p. 23-25, 2010. BUDHIRAJA, S.S.; et al. Biological Acti-
vity of Melaleuca alternifolia (TeaTree) Oil
3. HAMMER, K.A.; et al. A review of the toxicity of Melaleu-
ca alternifolia (tea tree) oil. Food and Chemical Toxicolo-
gy, v. 44, p. 616-625, 2006. GÜLÇIN, I.; et al. Antioxidant
activity of clove oil - A powerful antioxidant source.

We do not test on animals. All

tests are conducted in trust-
worthy laboratories with human
volunteers.

Essential oils, Vitamins, Acids

and Natural Extracts are highly
oxidative substances that de-
grade quickly and react con-
stantly with the medium and
other cosmetic compounds
(light, oxygen, packaging, pre-
servatives, fragrances, surfac-
tants, etc.). By encapsulating
it, we guarantee the stability
of the active ingredients and
protect them from potential re-
actions with the formulation or
the environment.
Nanovetores Encapsulation
Technology

Active Ingredient Protection against Greater Permeation on the contact sur-

- face due to the small size of the capsule.
nal environment and other components of the
cosmetic formulation.

Monodispersity, that ensures control of the Surface Charge Control of the par-
particle size, providing adequate permeation to
its proposed action. contact surface.

Secure particles larger than 200nm, bio- Water Base. Active ingredients are man-
compatible and biodegradable.
ensuring safety for users and the environment.

Use Encapsulated Active Ingredients

and Ensure:
• Stability Improvement •
• Increased compability in the formulation refrigeration)
• • Increased Solubility
• Increased skin permeation • Prolonged release
• Reduced dose • Increased effectiveness
 Nanovetores Tecnologia S.A.

Tel.: +55 (48) 3205-6262 | Cel.: +55 (48) 9664-0099

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