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Journal of the American Nutrition Association ∠

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Research Article

Chronic Consumption of Moringa Leaf Powder (Moringa oleifera)

Concentration-Dependent Effects in a Drosophila melanogaster Type 2
Diabetes Model
Norma A. Lopez-Rodriguez, Laura K. Sanchez-Ortiz, Rosalía Reynoso-Camacho, Juan R. Riesgo-Escovar " & Guadalupe Loarca-Piña "
Received 03 Nov 2021, Accepted 21 Jan 2022, Published online: 01 Mar 2022

# Download citation $ https://doi.org/10.1080/07315724.2022.2034068

, Full Article - Figures & data . References # Citations | Metrics 0 Reprints & Permissions Get access
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Abstract

Objective

The metabolic effects of chronic consumption of food laced with different doses of moringa leaf powder (MLP) were
assessed using a heteroallelic mutant of the sole insulin receptor gene of Drosophila melanogaster (InR), and the
yellow,white (y,w) control stock.

Methods
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The MLP composition was partially determined. Both strains were raised in a standard diet (SD) or in a SD
supplemented with different MLP doses (0.5, 1.5, 2.5, 4.0, and 5.5%) until 4–5 days of emergence. Afterward, the total
carbohydrate, lipid, glucose, and triacylglyceride levels were measured in the flies. Additionally, survival and weight
changes were reported. For metabolic tests, female and male virgin flies were evaluated separately.

Results

Low MLP supplementation improved carbohydrate and glucose levels in the y,w strain. Additionally, the InR-mutant
strain reported lower lipid content when subjected to the same regimes. Survival improved in both strains with low
MLP doses, while chronic consumption of high MLP doses resulted in triacylglycerides increase, weight gain, and
survival reduction.

Conclusion

Low doses of MLP supplementation improves some metabolic parameters that affect flies’ survival, especially in the
y,w strain. Furthermore, the same low doses of MLP treatments also resulted in metabolic improvements in the InR-
mutant flies; however, MLP consumption levels should be carefully assessed.

Supplemental data for this article is available online at

% Keywords: Type 2 diabetes Moringa oleifera Drosophila melanogaster; supplementation

Acknowledgments

This study was supported by the Consejo Nacional de Ciencia y Tecnología (CONACyT)-Mexico, scholarship #711773; by
the “Fondo Química Somos Todos, 2019” funding, School of chemistry, Universidad Autónoma de Querétaro; by
PAPIIT-UNAM (Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica, Universidad Nacional
Autónoma de México) to J. R. R-E., #IN207719, and laboratory funds to J. R. R-E. We would like to acknowledge the
technical support of Dr. Juan Manuel Murillo-Maldonado.

Disclosure statement

No potential conflict of interest was reported by the authors.

Data availability statement

Data are available from the corresponding author upon reasonable request.

Additional information

Funding

Consejo Nacional de Ciencia y Tecnología (CONACyT)-Mexico #711773; Fondo Química Somos Todos, 2019, UAQ-Mexico; PAPIIT-
UNAM Mexico #IN207719.

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