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NAME: Delos Reyes, Aerica L. III.

LIFE CYCLE
SECTION: CON-1C
C. diphtheriae causes the disease diphtheria which
primarily affects the upper respiratory tract. The
Family Corynebacteriaceae: Corynebacterium bacteria can invade any of the mucous membranes
(diphtheria) and have a 2–5-day incubation period. Different
sites of infection cause different clinical forms of
diphtheria with varying severity. The most
I. DESCRPTION commons site of infection is the pharynx and
tonsils, but the bacteria can also invade the nasal
Corynebacterium diphtheriae is a gram-positive, tissues, larynx, and skin. Anterior nasal diphtheria is
rod-shaped bacterium that is classified in the usually quite like the common cold in symptoms
phylum Actinobacteria and the family and severity because the location of the infection
Corynebacteriaceae. It is a pathogen, meaning that does not allow for large-scale systemic absorption
it can cause disease in humans and animals. of the diphtheria toxin.
Corynebacterium diphtheriae is the pathogenic
bacterium that causes diphtheria. It is also known as The ultimate outcome of the disease depends on
the Klebs–Löffler bacillus, because it was how much toxin is absorbed into the bloodstream.
discovered in 1884 by German bacteriologists The toxin has degenerative effects on the heart,
Edwin Klebs (1834–1912) and Friedrich nerves, spleen, muscles, liver, and kidneys. In the
Löffler (1852–1915). Corynebacterium diphtheriae most severe cases, an infected person will develop
is further classified into different biotypes based on myocarditis or neuritis, which leads to heart failure
its ability to produce certain toxins and enzymes. and local paralysis most commonly of the soft
The most common biotypes of C. diphtheriae are palate, respectively. The fatality rate is
gravis, intermedius, and mitis. approximately 5-10% of cases, but is higher for
young children or the very old.

II. PATHOGENIC

Corynebacterium diphtheriae is the bacterium that REFERENCES:


causes the disease called diphtheria.
Bacteriophages introduce a gene into the bacterial https://www.bing.com/ck/a?!&&p=e2ad85f7b0b
cells that makes a strain toxigenic. The strains that 60a11JmltdHM9MTY3NjQxOTIwMCZpZ3VpZ
are not infected with these viruses are harmless. C. D0wOTA4NDAwZi1iN2I1LTZiMzEtMmMxMy
diphtheriae is a rod-shaped, Gram-positive, 01MjY3YjY4NTZhNjUmaW5zaWQ9NTMwMQ
nonspore-forming, and nonmotile bacterium. &ptn=3&hsh=3&fclid=0908400f-b7b5-6b31-
C. diphtheriae has shown to exclusively infect 2c13-
humans. It is believed that humans may be the 5267b6856a65&psq=corynebacterium+diphtheri
reservoir for this pathogen. However, there has been ae+&u=a1aHR0cHM6Ly93d3cubmNiaS5ubG0u
extremely rare cases in which C. diphtheriae bmloLmdvdi9ib29rcy9OQks1NTkwMTUv&ntb
has been found in animals. These infections were =1
only toxigenic in two dogs and two horses.
https://www.bing.com/ck/a?!&&p=e55abc907bd
The most common routes of entry for C. 3bbf7JmltdHM9MTY3NjQxOTIwMCZpZ3VpZ
diphtheriae are the nose, tonsils, and throat. D0wOTA4NDAwZi1iN2I1LTZiMzEtMmMxMy
Individuals suffering from the disease may 01MjY3YjY4NTZhNjUmaW5zaWQ9NTM4Mg
experience sore throat, weakness, fever, and &ptn=3&hsh=3&fclid=0908400f-b7b5-6b31-
swollen glands. This could cause even more 2c13-
dangerous symptoms such as shortness of breath. 5267b6856a65&psq=corynebacterium+diphtheri
If left untreated, diphtheria toxin may enter the ae+&u=a1aHR0cHM6Ly9taWNyb2Jlbm90ZXM
bloodstream, causing damage to the kidneys, uY29tL2NvcnluZWJhY3Rlcml1bS1kaXBodGhl
nerves, and heart. Extremely rare complications cmlhZS8&ntb=1
include suffocation and partial paralysis.

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