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Bacteria (Micropara)
Bacteria (Micropara)
LIFE CYCLE
SECTION: CON-1C
C. diphtheriae causes the disease diphtheria which
primarily affects the upper respiratory tract. The
Family Corynebacteriaceae: Corynebacterium bacteria can invade any of the mucous membranes
(diphtheria) and have a 2–5-day incubation period. Different
sites of infection cause different clinical forms of
diphtheria with varying severity. The most
I. DESCRPTION commons site of infection is the pharynx and
tonsils, but the bacteria can also invade the nasal
Corynebacterium diphtheriae is a gram-positive, tissues, larynx, and skin. Anterior nasal diphtheria is
rod-shaped bacterium that is classified in the usually quite like the common cold in symptoms
phylum Actinobacteria and the family and severity because the location of the infection
Corynebacteriaceae. It is a pathogen, meaning that does not allow for large-scale systemic absorption
it can cause disease in humans and animals. of the diphtheria toxin.
Corynebacterium diphtheriae is the pathogenic
bacterium that causes diphtheria. It is also known as The ultimate outcome of the disease depends on
the Klebs–Löffler bacillus, because it was how much toxin is absorbed into the bloodstream.
discovered in 1884 by German bacteriologists The toxin has degenerative effects on the heart,
Edwin Klebs (1834–1912) and Friedrich nerves, spleen, muscles, liver, and kidneys. In the
Löffler (1852–1915). Corynebacterium diphtheriae most severe cases, an infected person will develop
is further classified into different biotypes based on myocarditis or neuritis, which leads to heart failure
its ability to produce certain toxins and enzymes. and local paralysis most commonly of the soft
The most common biotypes of C. diphtheriae are palate, respectively. The fatality rate is
gravis, intermedius, and mitis. approximately 5-10% of cases, but is higher for
young children or the very old.
II. PATHOGENIC