SP23: PPRAD 1793 Clinical Pharmacokinetics Equation Sheet

𝐶𝑜𝑛𝑐𝑒𝑛𝑡𝑟𝑎𝑡𝑖𝑜𝑛 𝑅𝑖𝑠𝑒 = 𝐷𝑜𝑠𝑒/𝑉𝑑 𝑘𝑒 = 𝐶𝑙⁄ 𝑡1/2 = 0.693⁄𝑘

𝑉𝑑 𝑒

𝐶𝑜𝑛𝑐𝑒𝑛𝑡𝑟𝑎𝑡𝑖𝑜𝑛1
𝑙𝑛 ( ⁄𝐶𝑜𝑛𝑐𝑒𝑛𝑡𝑟𝑎𝑡𝑖𝑜𝑛 )
2
𝑘𝑒 =
𝑇𝑖𝑚𝑒 𝑏𝑒𝑡𝑤𝑒𝑒𝑛 𝑡𝑤𝑜 𝑝𝑜𝑖𝑛𝑡𝑠

𝐶𝑃𝑐𝑎𝑙𝑐𝑢𝑙𝑎𝑡𝑒𝑑 = 𝐶𝑃𝑘𝑛𝑜𝑤𝑛(𝑒−𝑘𝑒(𝑡)) OR 𝐶𝑃𝑐𝑎𝑙𝑐𝑢𝑙𝑎𝑡𝑒𝑑 = 𝐶𝑃𝑘𝑛𝑜𝑤𝑛⁄ −𝑘𝑒(𝑡)

𝑒

(𝐷𝑜𝑠𝑒⁄𝑡𝑖𝑚𝑒 𝑖𝑛𝑓𝑢𝑠𝑒𝑑)
𝐶𝑃𝑠𝑠 = 𝐶𝑃⁄ 𝐶𝑃𝑠𝑠(𝑓𝑜𝑟 𝑐𝑜𝑛𝑡𝑖𝑛𝑢𝑜𝑢𝑠 𝑖𝑛𝑓𝑢𝑠𝑖𝑜𝑛) =
(1 − 𝑒 −𝑘𝑒(𝑡𝑎𝑢)) 𝐶𝑙

𝑃𝑒𝑟𝑐𝑒𝑛𝑡 𝑟𝑒𝑚𝑎𝑖𝑛𝑖𝑛𝑔 = (𝑒−𝑘𝑒(𝑡)) 𝑃𝑒𝑟𝑐𝑒𝑛𝑡 𝑜𝑓 𝑆𝑡𝑒𝑎𝑑𝑦 𝑆𝑡𝑎𝑡𝑒 𝐴𝑐ℎ𝑖𝑒𝑣𝑒𝑑 = (1 − 𝑒−𝑘𝑒(𝑡))

𝐴𝑐𝑐𝑢𝑚𝑢𝑙𝑎𝑡𝑖𝑜𝑛 𝑓𝑎𝑐𝑡𝑜𝑟: 1⁄(1 − 𝑒−𝑘𝑒 (𝑡𝑎𝑢))

𝑉𝑚𝑥𝐶
𝐷𝑜𝑠𝑒 × 𝑆 = 𝐷𝑜𝑠𝑒 =
𝑉𝑑𝑥𝐶𝑑𝑒𝑠𝑖𝑟𝑒𝑑
𝐾𝑚+𝐶 𝑆

𝑆𝑢𝑝𝑝𝑙𝑒𝑚𝑒𝑛𝑡𝑎𝑙 𝑏𝑜𝑙𝑢𝑠 (𝑚𝑔) = (𝐷𝑒𝑠𝑖𝑟𝑒𝑑 𝑙𝑒𝑣𝑒𝑙 − 𝑂𝑏𝑠𝑒𝑟𝑣𝑒𝑑 𝑙𝑒𝑣𝑒𝑙) × 𝑉𝑑

𝐾𝑚𝑥𝑉𝑑
𝑡 = × [(2.3 × 𝑉 ) − (0.9 × 𝑋 )] 𝐴𝑈𝐶 = 𝐷𝑜𝑠𝑒⁄
90% (𝑉𝑚𝑎𝑥−𝑋𝑑)2 𝑚𝑎𝑥 𝑑 𝐶𝑙
𝐶(𝑜𝑏𝑠𝑒𝑟𝑣𝑒𝑑)
𝐻𝑦𝑝𝑜𝑎𝑙𝑏𝑢𝑚𝑖𝑛𝑒𝑚𝑖𝑎(𝑛𝑜 𝑟𝑒𝑛𝑎𝑙 𝑓𝑎𝑖𝑙𝑢𝑟𝑒) − 𝐶(𝑛𝑜𝑟𝑚𝑎𝑙) = [( )( ) ]
⁄ 0.29 𝑎𝑙𝑏𝑢𝑚𝑖𝑛 + 0.1
𝐶(𝑜𝑏𝑠𝑒𝑟𝑣𝑒𝑑)
𝐻𝑦𝑝𝑜𝑎𝑙𝑏𝑢𝑚𝑖𝑛𝑒𝑚𝑖𝑎(𝑟𝑒𝑛𝑎𝑙 𝑓𝑎𝑖𝑙𝑢𝑟𝑒) − 𝐶(𝑛𝑜𝑟𝑚𝑎𝑙) = )( ) ]
⁄[(0.1
𝑎𝑙𝑏𝑢𝑚𝑖𝑛 + 0.1

DIGOXIN CALCULATIONS & REPORTED VALUES

Bioavailability of tablets = 0.7 𝐶𝑠𝑠 × 𝑉𝑑
𝐿𝐷 =
𝐹
Bioavailability of elixir = 0.8 𝐶 𝑠𝑠 × 𝐶𝑙 × 𝑡𝑎𝑢
𝑀𝐷 =
𝐹
Bioavailability of IV = 1.0 𝑉 = [(3.8 𝐿 ⁄𝑘𝑔) (𝑊𝑡)] + [(3.1)(𝐶𝑟𝐶𝑙)]
Clinically hypothyroid factor = 0.7
Clinically hyperthyroid factor = 1.3

𝑇𝑜𝑡𝑎𝑙 𝐶𝑙(𝑤𝑖𝑡ℎ𝑜𝑢𝑡 𝐶𝐻𝐹) = [(0.8 𝑚𝐿⁄𝑘𝑔⁄𝑚𝑖𝑛)(𝑊𝑡)] + 𝐶𝑟𝐶𝑙

𝑇𝑜𝑡𝑎𝑙 𝐶𝑙(𝑤𝑖𝑡ℎ 𝐶𝐻𝐹) = [(0.33 𝑚𝐿⁄𝑘𝑔⁄𝑚𝑖𝑛)(𝑊𝑡)] + (0.9)𝐶𝑟𝐶𝑙