Worksheet-7

BIOLOGY Practice Book

Worksheet-7 Q.8 A hemophiliac may:

A) Suffer from immune deficiency
(Variation and Genetic/ inheritance)
B) Suffer from respiratory infection
Q.1 Diagrams showing the order and
C) Bleed to death
distance between genes; constructed
D) Suffer from hypertension
using crossover information is called:
Q.9 Hemophilia is of:
A) Recombination C) Segregation
A) Two types C) Four types
B) Genetic maps D) Phenotype
B) Three types D) One types
Q.2 Trait which can only in human male:
Q.10 The percentage of Hemophiliac patients
A) Color blindness
suffering from type – C is:
B) Haemophilia
A) Negligible C) 20%
C) Hypophosphatemic rickets
B) 80% D) 30%
D) Tfm
Q.11 Pick up the one that affects more men as
Q.3 A type of genetic analysis in which a
compared to women:
trait is traced through several
A) Hemophilia – A
generations of a family to determine
B) Both Hemophilia A and B
how the trait is inherited is called:
C) Hemophilia – B
A) Pedigree analysis C) Gene linkage
D) Hemophilia – C
B) Genetic maps D) Crossing over
Q.12 Type of Hemophilia which affects the
Q.4 Humans have X – linked recessive traits
both men and women equally is:
like:
A) Hemophilia – A
A) Hemophilia
B) Both Hemophilia – A and
B) Vitamin D – resistant rickets
Hemophilia – B
C) Hypophosphatemic rickets
C) Hemophilia – B
D) SRY gene
D) Hemophilia – C
Q.5 Humans have:
Q.13 Chances for a man to be affected by
A) 46 chromosomes
Hemophilia – A and B are:
B) 46 pairs of chromosomes
A) Greater than a woman
C) 23 chromosomes
B) Equal to a woman
D) 22pairs of chromosomes
C) Less than a woman
Q.6 Hemophiliac’s blood fails to clot
D) Variable as compared to woman
properly after an injury, because of the
Q.14 Pick up the disorder that occurs by one
following reasons, EXCEPT:
recessive allele in man but by two
A) A reduction of blood clotting factors
recessive alleles in woman:
B) A malfunction of blood clotting factors
A) Hemophilia – A
C) A complete absence of blood clotting
B) Hemophilia – C
factors
C) Hemophilia – B
D) A reduction in hemopoitic stem cells
D) Hemophilia – A and B
Q.7 Hemophilia is a serious:
Q.15 It zigzags from maternal grandfather
A) Hereditary disease
through a carrier daughter to a
B) Cardiovascular disease
grandson:
C) Physiological disease
A) Hemophilia – A
D) Immunodeficiency
B) Hemophilia – C
C) Hemophilia – B
D) Hemophilia – A and B

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Q.16 A hemophiliac man receive ‘Xh’ Q.22 Following are the symptoms of
indirectly from his: testicular feminization syndrome,
A) Father’s father EXCEPT:
B) Mother’s father A) Female genitalia
C) Grandfather’s father B) No breast
D) Grandmother’s father C) Blind vagina
Q.17 The single recessive allele for hemophilia D) Degenerated testes
is expressed successfully in the: Q.23 All daughters of an affected father, but
A) Hemizygous daughter none of his sons are affected in case of:
B) Homozygous son A) X – linked dominant traits
C) Hemizygous son B) Y – linked dominant traits
D) Heterozygous son C) X – linked recessive traits
Q.18 A son of a carrier daughter will be D) Y – linked recessive traits
affected by hemophilia if he inherits X Q.24 Gene linkage means:
chromosome of: A) Linkage of a gene with male
A) Maternal grandmother or paternal B) Linkage of a gene with female
grandmother C) Linkage of a gene with particular
B) Maternal grandfather or maternal gender
grandmother D) Linkage of a gene with a particular
C) Paternal grandmother or paternal gene
grandfather Q.25 The term “linkage” was coined by:
D) Paternal grandfather, maternal A) G. Mendel C) T.H. Morgen
grandfather B) W. Sutton D) T. Boveri
Q.19 The pedigree of Queen Victoria’s family Q.26 A male human is heterozygous for
shows hemophilic sons in generation autosomal genes A and B and is also
no.: hemizygous for haemophilic gene h.
A) II C) IV what proportion of his spers will be
B) III D) II, III and IV all abh?
Q.20 Pick up the sign denoting carrier A) 1/8 C) 1/16
daughter: B) 1/32 D) 1/4
Q.27 A diseased man marries a normal
A) C) woman. They get three daughters and
five sons. All the daughters were
diseased and sons were normal. The
B) D) gene of this disease is:
A) Sex linked dominant
Q.21 The cause of testicular feminization B) Sex linked recessive
syndrome is: C) Sex limited character
A) A recessive gene on X – chromosome D) Autosomal doiminant
B) A recessive gene on Y – chromosome Q.28 Haemophilic man marries a normal
C) A dominant gene on X – chromosome woman. Their offsprings will be:
D) A dominant gene on Y – chromosome A) All haemophilic
B) All boys haemophilic
C) All girls haemophilic
D) All normal

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Q.29 A woman with two genes for
haemophilia and one gene for colour
blindness on one of the ‘X’
chromosomes marries normal man.
How will the progeny be?
A) 50% haemophilic colour blind sons
and 50% normal sons
B) 50% haemophilic daughters (carrier)
and 50% colour blind daughters (carrier)
C) All sons and daughters haemphilic and
colour-blind
D) Haemphilic and colour blind daughters
Q.30 Haemophilia is more common in males
because it is a:
A) Recessive character carried by Y-
chromosome
B) Dominant character carried by Y-
chromosome
C) Dominant trait carried by X-
chromosome
D) Recessive trait carried by X-
chromosome
Q.31 Humans X – linked dominant trait is:
A) Hemophilia
B) Color blindness
C) Hypophosphatemia
D) Pattern baldness
Q.32 Which one of the following traits, does
not exhibit sex linkage?
A) Protonopia
B) Tritanopia
C) Deuteranopia
D) Hemophilia A
Q.33 Such traits whose genes are located on
both x and y chromosomes are called:
A) X and Y linked traits
B) Pseudoautosomal traits
C) Mixed traits
D) Pseudoautosomal and X and Y linked
traits
Q.34 Which type of haemophilia is an
autosomal recessive trait?
A) A
B) C
C) B
D) Both B and C
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Q.35 A carrier woman will have a
hemophiliac son when married to a:
A) Normal man
B) Affected man
C) Either normal or hemophiliac man
D) Carrier man
Q.36 Which of the following is X-linked
recessive trait in humans?
A) Hypophosphatemic ricket
B) Haemophilia
C) Maleness
D) Testicular feminization syndrome
Q.37 Hemophilia affects males more than
females because of:
A) Dominant autosome
B) X-linked dominant inheritance
C) X-linked recessive inheritance
D) Y-linked inheritance
Q.38 Chances for a man to be affected by
Hemophilia – A and B are:
A) Greater than a woman
B) Less than a woman
C) Equal to a woman
D) Always variable
Q.39 Genes for color blindness, hemophilia
and gout form a linkage group on:
A) Sex chromosome
B) Autosome
C) X – chromosome
D) Y – chromosome
Q.40 Which one of the traits zigzags from
maternal grand father through a carrier
daughter to a grandson?
A) Autosomal traits
B) Y-linked traits
C) X-linked recessives traits
D) X & Y-linked dominants traits
Q.41 It is not practically possible in humans:
A) Experimental mating
B) Determining the pattern of inheritance
C) Pedigree analysis
D) Mating
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Q.42 X – linked dominant traits are common Q.50 ________ provided experimental
in: evidence in support of chromosomal
A) Males theory of inheritance:
B) Females A) Calvin bridges C) T. H. Morgan
C) Insects B) W.S. Sutton D) Carl Correns
D) Males and females Q.51 _______ traits inherit as zigzag from
Q.43 Number of pairs of autosomes in maternal grandfather through a carrier
humans is: daughter to a grandson:
A) 23 A) X-linked
B) 24 B) Y-linked
C) 21 C) Autosomal
D) 22 D) Sex influenced
Q.44 Gene linkage means: Q.52 Which one of the following minimized
A) Linkage of a gene with male the chances of variation?
B) Linkage of a gene with female A) Crossing over
C) Linkage of a gene with particular B) Recombination
gender C) Meiosis
D) Linkage of a gene with a particular D) Gene linkage
gene Q.53 A female can be hemophiliac, if her
Q.45 The total number of linkage groups in parents have following genotype:
human being is: A) XHXH x XhY
A) Two B) XHXh x XHY
B) Twenty-Three C) XHXH x XHY
C) Forty six D) XHXh x XhY
D) Not fixed Q.54 XO condition in drosophila produces:
Q.46 Genes showing linkage are always A) Sertile female
located on: B) Sertile male
A) Same chromosome of different C) Fertile male
genomes D) Fertile female
B) Different chromosomes of same Q.55 Hemophilic man marries a normal
genome woman, their offsprings will be:
C) Same chromosome of same genome A) All hemophilic
D) Different chromosomes of different B) All boys hemophilic
genomes C) All daughters hemophilic
Q.47 What are the number of linkage groups D) All normal
in Drosophila? Q.56 Which one of the following will be
A) 4 C) 16 hemophilic?
B) 8 D) 32 A) XHYh
Q.48 Linked genes can be separated by: B) XHYH
A) Crossing over C) Mitosis C) XhY
B) Mitosis D) Apoptosis D) XHY
Q.49 Sex chromosomes in human male are:
A) Analogous and heteromorphic
B) Homologous and heteromorphic
C) Non-homologous and heteromorphic
D) Homologous homomorphic

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ANSWER KEY (Worksheet-7) Q.3 Answer is “Pedigree analysis”

Explanation: A type of genetic analysis
1 B 22 B 43 D
in which a trait is traced through several
2 D 23 A 44 D
generations of a family to determine how
3 A 24 D 45 B the trait is inherited. The information is
4 A 25 C 46 C displayed in a pedigree chart using
5 A 26 A 47 A standard symbols.
6 D 27 A 48 A Q.4 Answer is “Hemophilia”
7 A 28 D 49 B Explanation: The gene for hemophilia is
8 C 29 B 50 C located on X-chromosome and it is a
9 B 30 D 51 A recessive trait. However, vitamin D
10 A 31 C 52 D resistant rickets also called as
hypophophatemic rickets is controlled by
11 B 32 B 53 D
a dominant allele located on X –
12 D 33 D 54 B chromosome. SRY gene is located on short
13 A 34 B 55 D arm of Y – chromosome
14 D 35 B 56 C Q.5 Answer is “46 chromosomes”
15 D 36 B Explanation: 44 autosomes and 2 sex
16 B 37 C chromosomes.
17 C 38 A Q.6 Answer is “A reduction in hemopoitic
18 B 39 C stem cells”
19 D 40 C Explanation: Hemopoisis is associated
with formation of new blood cells. It is not
20 D 41 A
associated with blood clotting. However
21 A 42 B deficiency of blood clotting factors,
EXPLANATION malfunction of blood clotting factors and a
Q.1 Answer is “Genetic maps” complete absence of blood clotting factors
Explanation: Diagrams showing the may cause hemophilia of different types.
order of and distance between genes; Q.7 Answer is “Hereditary disease”
constructed using crossover information is Explanation: Hemophilia A, B and C are
called genetic maps. exclusively inherited and most prevalent
Q.2 Answer is “Tfm” types of hemophilia, however, hemophilia
Explanation: Testicular feminization A and B are sex-linked recessive traits,
syndrome is a rare X – linked recessive whereas hemophilia C is autosomal.
trait. Although the persons affected by this Parahemophilia is a type of
trait have a male set of XY chromosome, hemophilia which may be inherited or
yet tfm gene on their X chromosome acquired. Acquired hemophilia (caused by
develops them physically into females. autoantibodies against factor VIII) is non-
They have breast, female genitalia, a blind inherited. So majority of the types of
vagina but no uterus. Degenerated testis hemophilia are inherited
are also present in abdomen. Such Q.8 Answer is “Bleed to death”
individuals are happily married as females Explanation: As there is some deficiency
but are sterile. It is an androgen or complete absence of clotting factors, in
insensitivity syndrome. Male sex hormone case of an injury bleeding will not stop.
testosterone has no effect on them. Q.9 Answer is “Three types”
Explanation: There are three major
inherited types of hemophilia i.e. A, B and
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BIOLOGY
C which have been mentioned in textbook
of Biology. However there are two other
types of hemophilia as well i.e.
parahemophilia and acquired
hemophilia. But according to textbook
three is correct answer.
Q.10 Answer is “Negligible”
Explanation: The frequency of
Hemophilia-C in human population is less
than 1 percent.
Q.11 Answer is “Hemophilia A and B”
Explanation: Hemophilia A and B being
sex linked (X-linked) recessive traits
occurs 17% more in men as compared to
women.
Q.12 Answer is “Hemophilia - C”
Explanation: As it is autosomal.
Q.13 Answer is “Greater than a woman”
Explanation: The gene of sex linked (X-
linked) traits is located on X-chromosome.
In such traits female (having homologous
pair of X-chromosome) is diallelic and can
have three types of genotypes i.e. XHXH or
XHXh or XhXh. Out of these three types of
genotypes only XhXh will cause
hemophilia i.e. 1/3 or 33%.
On the other hand male having
single X chromosome is monoallelic and
as a result only two types of genotypes are
possible XHY or XhY : XhY will be
hemophilic which represents ½ or 50%
subtracting 33 from 50 we get 17. Thus
sex-linked (X-linked) recessive traits
appear 17% more in male as compared to
female.
Q.14 Answer is “Hemophilia A and B”
Explanation: All X-linked traits including
Hemophilia A and B are monoallelic in
male (XhY) because their genes are located
on X chromosome and male have single X-
chromosome however female will be
diallelic (having two X chromosomes).
Q.15 Answer is “Hemophilia A and B”
Explanation: All X-linked recessive traits
exhibit zigzag inheritance. An affected
male will transfer his single X
chromosome (Xh) to his daughter and
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other X chromosome will be contributed
by mother (XH). Thus daughter will be
carrier (XHXh). Now she will produce two
types of gametes i.e. 50% XH and 50% Xh.
Her son getting Xh from mother will be
hemophiliac. Thus the gene of disorder of
maternal grandfather after passing through
female gender in next generation appears
again in male gender in third generation.
Q.16 Answer is “Mother’s father”
Explanation: Xh is inherited by a male
directly from his affected or carrier
mother. However, the mother have
inherited it from her father or mother. Thus
the male will inherit it indirectly from
mother’s father or mother’s mother.
Q.17 Answer is “Hemizygous son”
Explanation: In sex linked (X-linked) traits
male cannot be homozygous because the
genes for such traits are located on X-
chromosomes and male have single X-
chromosome. Thus male will be
hemizygous dominant XH (Normal) or
hemizygous recessive Xh (hemophiliac).
Q.18 Answer is “Maternal grandfather or
maternal grandmother”
Explanation: Xh is inherited by a male
directly from his affected or carrier
mother. However, the mother have
inherited it from her father or mother. Thus
the male will inherit it indirectly from
mother’s father or mother’s mother.
Q.19 Answer is “II, III and IV all”
Explanation: Except generation-I, all the
rest of the generations shown in figure
22.28 of Textbook of biology have
hemophiliac sons.
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Q.20 Answer is “D”
Explanation: A circle with dot in centre
indicates carrier daughter.
Q.21 Answer is “A recessive gene on X-
chromosome”
Explanation: tfm gene located on X-
chromosome controls it.
Q.22 Answer is “No breasts”
Explanation: A person suffering from
testicular feminization syndrome have
breasts like a female.
Q.23 Answer is “X-linked dominant trait”
Explanation: As sons receive Y-
chromosome from father and X-
chromosome from mother. Whereas
daughters receive X chromosome from
both parents
Q.24 Answer is “Linkage of a gene with a
particular gene”
Explanation: All genes located on the
same chromosomes are linked to each
other. This phenomenon of staying
together is called linkage. Gene linkage is
a physical relationship between genes.
Q.25 Answer is “T.H Morgan”
Explanation: Linkage is the phenomenon
of certain genes staying together during
inheritance through generations without
any change or separation due to their being
present on the same chromosome. Linkage
was first suggested by Sutton and Voveri
(1902-1903) when they propounded the
famous “chromosomal theory
inheritance.” Bateson and Punnett (1906)
while working on sweet pea found that the
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factors for certain characters do not show
independent assortment. However, it was
Morgan (1910) who clearly proved and
defined linkage on the basis of his
breeeding experiments in fruit fly
(Drosophila melanogaster).
Q.26 Answer is “1/8”
Explanation: The male humanis
heterozygous for autosomal gene A and B
and also hemizygous for haemophilic gene
h, then his genotype will be AaBbXhY
because haempphilia is a sex linked trait
that is present on X-chromosome. So, the
total number of gametes will be abXh, abY,
ABXh, ABY, AbXh, AbY, aBXh, aBY. So
the proportion of abXh sperm will be 1/8.
Q.27 Answer is “Sex linked dominant”
Explanation: In the inheritance pattern of
sex chromosomes X-chromosome of
father always passes to daughter and X-
chromosome of mother passes to son. As
the father is diseased and allthe girls
inherit it, it is obvious the disease is sex-
linked. The mother is not a carrier (as
evident form the fact that no son is
diseased). Thus, the gene is dominat and
expresses even in heterozygous condition.
Q.28 Answer is “All normal”
Explanation: Haemophilia is caused by
recessive gene located in the X-
chromosome. When a haemophilic man
(XhY) marries a normal women (XX),
produces carrier girls (XXh) and normal
boys (XY), i.e. all their offsprings will be
normal.
of
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Q.31 Answer is “Hypophosphatemia”

Explanation:
Disorders Nature
Hemophilia A & B are X linked
recessive traits, whereas,
C is autosomal recessive
trait
Color blindness Protanopia and
deuteranopia are X
linked recessive traits
whereas, tritanopia is
autosomal recessive trait.
Q.29 Answer is “50% haemphilic daughters Hypophosphatemia X linked dominant trait
(carrier) and 50% colour blind Pattern baldness Sex influenced trait.
daughters (carrier)”
Explanation: Both diseases are produced
by a recessive gene which lies on the X-
chromosomes. A woman having both gene
for haemophilia on one X-chromosome
and gene for colour blindness on another
X-chromosome will have genotype XhXc.

Thus, progeny includes 50% haemphilic

daughters (carrier) and 50% colour blind Q.32 Answer is “Tritanopia”
daughters (carrier). Explanation:

Q.33 Answer is “Pseudoautosomal and X and

Q.30 Answer is “Recessive trait carried by X-
chromosome”
Explanation: Haemophilia is more
common in males because it is a recessive
trait carried by X-chromosome.
Haemphilia A is the most common X-
linked genetic disease that prevents normal
blood clotting when blood vessels are
ruptured.
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Y linked traits”
Explanation: Such traits whose genes are
located on both x and y chromosomes are
called Pseudoautosomal and X and Y
linked traits.
Q.34 Answer is “C”
Explanation:
A Haemophilia A and B are non -
B allelic recessive sex – linked trait
C Autosomal recessive trait
Q.35 Answer is “Affected man”
Explanation: It is a serious hereditary
disease because a haemophiliac may bleed
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to death even from minor cuts.
Haemophilia is of three types: A, B and C.
Haemophilia A and B are non - allelic
recessive sex - linked, but haemophilia C
is an autosomal recessive trait. 80%
haemophiliacs, suffer from haemophilia A
due to abnormality of factor VIII, about
20% suffer from haemophilia B due to
disturbance in factor IX, but less than 1%
suffer from haemophilia C due to
reduction in factor XI. Being X - linked
recessives, haemophilia A and B affect
men more than women, but haemophilia C
affects both the sexes equally because it is
autosomal. Chances for a man to be
affected by haemophilia A and B are
greater than a woman. A woman can suffer
from haemophilia A or B only when she is
homozygous for the recessive allele, but a
man with just one recessive allele will
display the trait. Haemophilia A and B
zigzag from maternal grandfather through
a carrier daughter to a grandson. It never
passes direct from father to son. Gene for
normal is H. Gene for haemophilia A is h.
In generation I of this pedigree (Fig. 22.27)
a man (I - 2) suffering from haemophilia A
marries a normal woman (I - 1). He passes
haemophilia gene to his daughter (II - 2)
through his X chromosome. He cannot
pass this gene to his son (II - 3) because the
son receives only Y chromosome from
him. His daughter (II - 2) also receives
another X but with normal dominant allele
from her mother (I - 1).
Q.36 Answer is “Haemophilia”
Explanation: Haemophilia is a rare X-
linked recessive trait.
Q.37 Answer is “X-linked recessive
inheritance”
Explanation: Being X - linked recessives,
haemophilia A and B affect men more than
women, but haemophilia C affects both the
sexes equally because it is autosomal.
Chances for a man to be affected by
haemophilia A and B are greater than a
woman.
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Q.38 Answer is “Greater than a woman”
Explanation:
Q.39 Answer is “X-chromosome”
Explanation:
Q.40 Answer is “X-linked recessives traits”
Explanation: It is a common hereditary
disease. Like any sex - linked recessive
trait, it also zigzags from maternal
grandfather through a carrier daughter to a
grandson. It never passes direct from
father to son. This type of colour blindness
is more common in men than women,
because chances for a male to be affected
by it are much more than a female.
Q.41 Answer is “Experimental matings”
Explanation: Experimental matings are
not practically possible in humans. Mode
of inheritance of human traits can be traced
through pedigrees.
Q.42 Answer is “Females”
Explanation: Pattern of X - linked
dominant inheritance is different from X -
linked recessive. It is more common in
females than males.
Q.43 Answer is “22”
Explanation: Humans have 46
chromosomes in the form of 23 pairs. 22
pairs are of autosomes and one pair is of
sex-chromosomes.
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Q.44 Answer is “Linkage of a gene with a
particular gene”
Explanation: Gene linkage is a physical
relationship between genes. A chromosomal theory of inheritance.
chromosome carries its linked genes en
bloc in the form of a linkage group.
Q.45 Answer is “Twenty-three”
Explanation: The number of linkage
groups corresponds to the number of
homologous pairs of chromosomes. Man
has 23 linkage groups. Genes for colour
blindness, haemophilia, gout etc. form one
linkage group on human X - chromosome.
Q.46 Answer is “Same chromosome of same
genome”
Explanation: All the genes located on the
same chromosome are linked to each
other. This phenomenon of staying
together of all the genes of a chromosome.
Q.47 Answer is “4”
Explanation: The number of linkage
groups in Drosophila are 4.
Q.48 Answer is “Crossing over”
Explanation: Linked genes can be
separated by crossing over. Closer the two
gene loci, more strongly are their genes
linked. The farther apart two genes lie,
greater are chances of their separation
through crossing over.
Q.49 Answer is “Homologous and
heteromorphic”
Explanation: Sex chromosomes in human
male are homologous and heteromorphic.
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Q.50 Answer is “T. H. Morgan”
Explanation: T. H. Morgan provided
experimental evidence in support of
Q.51 Answer is “X-linked”
Inheritance of Sex-Linked Traits
Sex-linked inheritance follows a very specific
pattern.
•A son inherits his X chromosome only
from his mother.
• A daughter gets as X chromosome
from each parent.
• An X-linked trait passes in a crisscross
fashion from maternal grandfather
(P1) though his daughter (F1) to the
grandson (F2). It never passes direct
from father to son because a son
inherits only Y chromosome from
father.
Q.52 Answer is “Gene linkage”
Inheritance of Linked Gene
As it is mentioned earlier, that linked genes
tend to be inherited together (en bloc
inheritance) in theoffspring, so usually they
do not show recombination and do not assort
independently in the offspring so the idea
Mendelianratio of independent assortment is
deviated.
Q.53 Answer is “XHXh x XhY”
Genetics of haemophiliac:
• Because the hemophilia allele is
recessive and carried on the X
chromosome, hemophilia is
predominantly a male disorder.
• In fact, hemophilia is extremely rare
infemales because there are so few
hemophiliac males that survive to
marry and reproduce.
• Largely the phenotypically normal
female carrier maintains the faulty
allele in human population.
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Q.54 Answer is “Sertile male”

Q.55 Answer is “All normal”

Hemophilic man marries a normal woman,
their offsprings will be all normal.
Q.56 Answer is “XhY”
Genetics
• Because the hemophilia allele is
recessive and carried on the X
chromosome, hemophilia is
predominantly a male disorder.
• In fact, hemophilia is extremely rare
infemales because there are so few
hemophiliac males that survive to
marry and reproduce.
Largely the phenotypically normal female
carrier maintains the faulty allele in
human population.

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