Republic of the Philippines

UNIVERSITY OF EASTERN PHILIPPINES

University Town, Northern Samar

COLLEGE of NURSING and ALLIED HEALTH SCIENCES

DRUG ANALYSIS
 SPECIFIC CONTRAINDIC DRUG ADVERSE SPECIFIC NURSING
NAME OF DRUG INDICATION
ACTION ATION INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic Name: Cefuroxime is a Perioperative Contraindicated Drug-Drug: CV: Phlebitis, Obtain specimen for Monitor patient for signs
Cefuroxime type of Prophylaxis in patients thrombophlebitis culture and sensitivity and symptoms of
cephalosporin hypersensitive to Aminoglygosides: test before giving first superinfection and
Brand Name: antibiotic that is drug or other May cause synergistic GI: Diarrhea, dose diarrhea and treat
Zinacef commonly used in cephalosporins activity against some pseudomembranous appropriately
perioperative organism; may colitis, nausea, Before giving drug,
(before and after Use cautiously in increase anorexia, vomiting. ensure paitent isn’t Drug may increase INR
Dosage: patients and risk of bleeding.
surgery) settings nephrotoxicity. allergic to penicillins pr
750-mg, 1.5-g vials, Hematologic:
to prevent and hypersensitive to cephalosporins Monitor patient
infusion packs
treat bacterial penicillin Live-virus vaccines: Hemolytic anemia,
infections. It because of May decrease thrombocytopenia, Other specific Don’t confuse drug with
Route:
works by possibility of effectiveness of live- transient neutropenia, precautions involves other cephalosporins that
Intravenous (IV)
inhibiting bacterial cross sensitivity virus vaccines. eosinophilia pregnancy, lactation, and sound alike
Frequency: cell wall synthesis, with other beta- Concurrent use isn’t reproduction which does
For perioperative causing the lactam antibiotics recommended. Other: Anaphalaxis, not concern the client Patient Teaching:
prophylaxis. 750 mg to bacteria to die. In Hypersensitivity Instruct the patient to
1.5 grams every 8 hours perioperative . Loop diuretics: may reaction, serum notify prescriber about
settings, increase risk of sickness rash, loose stool,
Therapeutic Class: cefuroxime is adverse renal diarrhea, or evidnce of
Second-generation typically reactions. Monitor superinfection
cephalosporines administered renal function
intravenously to
help prevent Probenecid: May
Reference:
surgical site inhibit excretion and
Nursing 2021 Drug
Handbook infections, increase cefuroxime
pneumonia, and level.
urinary tract
infections. It can Warfarin: may
also be used to increase
treat bacterial anticoagulation
infections that effects. Monitor
occur during or patient’s PT and INR
after surgery. closely.
 Republic of the Philippines
UNIVERSITY OF EASTERN PHILIPPINES
University Town, Northern Samar

COLLEGE of NURSING and ALLIED HEALTH SCIENCES

DRUG ANALYSIS

SPECIFIC CONTRAINDIC DRUG ADVERSE SPECIFIC NURSING

NAME OF DRUG INDICATION
ACTION ATION INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic Name: Direct-acting To prevent Contraindicated Drug-Drug: CNS: Headache, Don’t give by IV push. Tell patient to avoid
Metronidazole trichomonocide postoperative in patients seizures, fever, Infuse over 30-60 alcohol and alcohol
and amebicide that infection in hypersensitive to Busulfan: may vertigo, ataxia, minutes containing drugs during
Brand Name: works inside and contaminated or drug and other increase busulfan dizziness, depression, and for atleast 3 days
Flagyl, Flagyl ER, and potentially
outside the nitroimidazole toxicity weakness Other specific after treatment course
Flagyl IV RTU. contaminated
intestines. It’s surgery derivatives. precautions involves
thought to enter (Appendectomy) Cimitidine: may CV: edema, flushing, pregnancy, lactation, and Tell patient to report all
the cells of Use cautiously in increase risk of thrombophlebitisafter reproduction which does adverse reactions to
Dosage:
microorganism patients with metronidazole toxicity IV infusion. not concern the client prescribers immediately,
500 milligrams (mg)
that contain history of blood especially neurologic
Route: nitroreductase, dyscasia or CNS Disulfiram: May cause GI: nausea, symptoms.
Intravenous (IV) forming ustable disorder and in acute psychosis and abdominal pain or
compounds that those with retinal confusion cramping, stomatitis,
Frequency: binds to DNA and or visual epigastric distress,
500 milligrams (mg) inhibit synthesis, changes. Lithium: may increase vomiting, anorexia
every 8 hours causing cell death lithium levels, which
Use cautiously in may cause toxicity GU: vaginitis,
patient with darkened urine,
Therapeutic Class: hepatic disease. Mebendazole: May polyuria, dysuria,
Antiprotozoals increase risk of cystitis, UTI
stevens-johnson
syndrome or toxic Respiratory: URI
Reference: epidermal necrolysis
Nursing 2021 Drug Skin: Rash, genital
Handbook pruritus

Other: Decreased
libido, overgrowth of
non susceptible
organisms
 Republic of the Philippines
UNIVERSITY OF EASTERN PHILIPPINES
University Town, Northern Samar

COLLEGE of NURSING and ALLIED HEALTH SCIENCES

DRUG ANALYSIS

SPECIFIC CONTRAINDICA DRUG ADVERSE SPECIFIC NURSING

NAME OF DRUG INDICATION
ACTION TION INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic Name: Competitively Perioperative Contraindicated to Drug-drug: CNS: Headache, Assess patient for High dose or prolonged I.V.
Ranitidine inhibits action of setting. patients malaise, vertigo abdominal pain, note therapy may increase ALT
histamine at H2 Ranitidine is hypersensitive to Atazanavir: May presence of blood in levels. Monitor ALT levels
receptor sites or administered drug and in those impair atazanavir EENT: blurred vision emesis, stool, or gastric daily
Brand Name: intravenously to
parietal cells, with acute absorption aspirate.
Zantac prevent Don’t confuse ranitidine
decreasing acid porphyria Hepatic: Jaundice
gastroesophagea with rimatidine.
secretion. l reflux and Delavirdine: may Other specific
peptic ulcer Prolonged impair delavirdine Others: anaphalaxis, precautions involves
Dosage: Patient Teaching:
disease, which treatment may absorption burning, itching pregnancy, lactation, and
50mg
can occur during lead to vitamine sensation reproduction which does Urge patient to avoid
or after surgery b12 malabsorption Glipizie: may increase not concern the client cigarette smoking because
Route: and deficiency. hypoglycemia effect this may increase gastric
Intravenous (IV) The Magnitude of acid secresion and worsen
deficiency is dose Iron salts: may reduce disease
related and absorption of iron
Frequency: association is salts Advice patient to report all
50mg every 8 hours. stronger to those adverse reactions,
younger than age Ketoconazole: may especially abdominal pain,
30. decrease ketoconazole blood in stool or emesis.
Classification:
concentration
Therapeutic Class:
Antiulcer drugs
Midazolam: may
prolong sedation
Reference:
Nursing 2021 Drug Warfarin: may
Handbook interfere with warfarin
clearance.
 Republic of the Philippines
UNIVERSITY OF EASTERN PHILIPPINES
University Town, Northern Samar

COLLEGE of NURSING and ALLIED HEALTH SCIENCES

DRUG ANALYSIS
 SPECIFIC CONTRAINDICA DRUG ADVERSE SPECIFIC NURSING
NAME OF DRUG INDICATION
ACTION TION INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic Name: Unknown. Tramadol is Contraindicated in Drug-drug: CNS: dizziness, Caution patient or Reassess patient’s level of
Tramadol Throught to bind indicated for: patients headache, caregiver of patient pain at least 30 minutes
to opiod hypersensitive to Benzodiazipines: may somnolence, vertigo, taking an opiod with a after minutes after
receptors and Pain drug or opioids. cause slow or difficult seizures, anxiety, benzodiazepine, CNS administration
Brand Name: inhibit reuptake management: breathing, sedation, asthenia, CNS depressant or alcohol tp
ConZip, Durela, Tramadol is Monitor CV and respiration
of norepinephrine Contraindicated in and death. stimulation seek immediate medical
Ralivia, Tridural used to manage status, especially within the
and serotonin patients with GI attention for dizziness,
moderate to first 24 hours to 72 hours of
severe pain, obstruction, Carbamazipine: May CV: Vasodilation, light-headedness, therapy initiation and after
Route: including paralytic increase tramadol HNT, Peripheral extreme sleepiness,
including pain dosage increases
Intravenous (IV) ileus metabolism edema
related to slowed or difficult
surgery or breathing. Monitor bladder and bowel
Dose: injury. Contraindicated in Opioids: may cause EENT: visual function
100mg initially then 50mg
patients with addictive effects disturbances, Other specific
Analgesia: significant nasopharengitis, precautions involves For better analgesic effects,
Tramadol is respiratory Cyclobenzaprine, rhinitis, sinusitis pregnancy, lactation, and give drug before onset of
Frequency: used to provide
100mg initially then 50mg depression or SSNRIs, SSRIs: may reproduction which does intense pain.
pain relief
every 8 hours during and after acute or severe increase risk of GI: Constipation, not concern the client
bronchial asthma seizures nausea, vomiting, In case of overdose,
surgery, helping
to improve or hypercapnia. abdominal pain, naloxone may also increase
Therapeutic Class: patient comfort anorexia, diarrhea, risk of seizures
Analgesics and reduce the dry mouth
need for other Monitor patient’s drug
pain dependence
GU: Urine retention,
Reference: medications. pelvic pain, UTI
Nursing 2021 Drug Withdrawal syndrome may
Handbook occur if drug is stopped
Metabolic: Weight
abruptly, reduce dosage
Loss gradually.

Respiratory,
Bronchitis,
respiratory depression

Skin: Diaphoresis,
Pruritus, Rash

Others: Chills,
withdrawal
syndrome, accidental
injury
 Republic of the Philippines
UNIVERSITY OF EASTERN PHILIPPINES
University Town, Northern Samar

COLLEGE of NURSING and ALLIED HEALTH SCIENCES

DRUG ANALYSIS
 SPECIFIC CONTRAINDICA DRUG ADVERSE SPECIFIC NURSING
NAME OF DRUG INDICATION
ACTION TION INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic Name: May inhibit Ketoralac is Allergy: Drug-drug: CNS: dizziness, Correct hypovolemia Watch for and immediately
Ketoralac prostaglandine indicated for: Individuals who headache, before giving the drug evaluate signs and
synthesis to have a known ACE inhibitors: may drowsiness, sedation symptoms of heart attack
produce anti- Acute pain allergy to cause renal Contraindicated for
Brand Name: inflammatory, management: ketorolac or other impairment CV: Arrythmias, epidural or intrathecal Carefully observe patients
Toradol Ketorolac is with coagulopathies and
analgesic, and NSAIDs should edema, HTN, administration due to its
used to manage those taking anticoagulants
antipyretic effects not use this Anticoagulas: May palpitations alcohol content
acute pain,
Route: medication. increase anticoagulant
including pain Drug inhibit platelet
Intravenous (IV) levels in blood EENT: increase NSAIDs may increase
related to aggregation and can
surgery or Peptic ulcer lacrimation, nasal risk of serious
Dose: prolong bleeding time
injury. disease or Antihypertensives: discomfort, rhinitis thrombotic events, MI,
30mg
bleeding may decrease stroke, which can be fatal Patient Teaching:
Analgesia: disorders: effectiveness GI: dyspepsia, GI
Ketorolac is Individuals with a pain, nausea, Other specific
Frequency: Advise patient to maintain
used to provide constipation
30mg every 6 hours history of peptic Disulfiram: May cause precautions involves adequate fluid intake
pain relief
during and after ulcer disease or severe alcohol pregnancy, lactation, and
bleeding intolerance because GU: Renal failure reproduction which does Advise patient to be alert
surgery, helping
Therapeutic Class: to improve disorders, such as injection form not concern the client for signs and symptoms of
NSAIDS patient comfort hemophilia, contains alcohol Hematologic: CV events
and reduce the should not use decrease platelet
need for other ketorolac due to Lithium: may increase adhesion Tell patient to promptly
Reference: pain report edema and weight
an increased risk lithium levels
Nursing 2021 Drug medications.. Skin: Diaphoresis, gain
of gastrointestinal
Handbook pruritus, rash
bleeding. Methotrexate: may
Teach patient the warning
decrease methotrexate signs and symptoms of
Active bleeding: clearance and increase hepatoxicity and GI
Individuals with toxicity bleeding and to notify
active bleeding, prescribers immediately if
such as those with Drug-herb such as any of these occurs.
a recent history of horse chestnut, red
a stroke or a clover: may cuase
history of gastric bleeding
or intestinal
bleeding, should White willow: may
not use ketorolac. contain similar
components to
Severe liver or ketoralac
kidney disease:
Individuals with Drug lifestyle:
severe liver or alcohol: may increase
kidney disease risk of GI bleeding