Republic of the Philippines

UNIVERSITY OF EASTERN PHILIPPINES

University Town, Northern Samar

COLLEGE of NURSING and ALLIED HEALTH SCIENCES

DRUG ANALYSIS
 SPECIFIC CONTRAINDIC DRUG ADVERSE SPECIFIC NURSING
NAME OF DRUG INDICATION
ACTION ATION INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic Name: Cause potent and To induce or Contraindicated in Carboprost MATERNAL Use cautiously during first All patients receiving
Oxytocin selective stimulation stimulate labor patients tromethamine: May and second stages of labor oxytocin I.V. must be under
of uterine and hypersensitive to enhance adverse/toxic CNS: Subarachnoid because uterine continuous observation by
Brand Name: mammary gland To reduce drug. effect of Oxytocin. hemorrhage, seizures, hypertonicity, titanic trained personnel who have
postpartum Avoid combination
Pitocin smooth muscles. coma contraction, cervical a thorough knowledge of
bleeding after
Contraindicated Cyclopropane laceration, uterine rupture, the drug and are qualified
expulsion of
Dosage: when vaginal anesthetics: May cause CV: Arrhythmias, and maternal and fetal death to identify complications.
placenta
delivery isn’t less pronounced HTN, PVCs have been reported.
To Induce or stimulate Incomplete, advised when bradycardia and Discontinue oxytocin
labor: inevitable, or cephalopelvic hypotension. Use GI: Nausea, Vomiting Drug wouldn’t be expected infusion immediately if
Adult: Initially, 0.5 to 1 elective abortion disproportion is together cautiously. to cause fetal abnormalities uterine hyperactivity or
milliunit/minute I.V. present or when GU: Abruptio placenta, when used as indicated. Use fetal distress occurs.
Dinoprostone: May
infusion. Increase rate by delivery requires titanic uterine cautiously in pregnant or Administer oxygen to the
enhance oxytocic effects
1 to 2 milliunits/minute conversion, as in of Oxytocin. contractions, breastfeeding women mother. Mother and fetus
at 30 to 60 minute transverse lie Concomitant use isn’t postpartum hemorrhage, must be evaluated by
intervals until normal recommended. If used uterine rupture, responsible physician.
contraction is established Contraindicated in sequentially, monitor impaired uterine blood
fetal distress when uterine activity closely. flow, pelvic hematoma, Drug is used to induce or
To reduce postpartum delivery isn’t Administer oxytocin 30 increased uterine reinforce labor only when
minutes after removing
bleeding after expulsion imminent, in motility. pelvis is known to be
dinoprostone vaginal
of placenta: prematurity, in insert and 6 to 12 hours adequate, when vaginal
Adult: 10 to 40 units in other obstetric after application of Hematologic: delivery is indicated, when
1000 mL of D5W emergencies, and dinoprostone gel. Afibronogenemia, fetal position is favorable.
injection, lactated ringer in patients with possible related to Use drug only in hospital
solution, or NSS I.V. severe toxemia or Drugs that prolong QT postpartum bleeding where critical care facilities
infused at rate needed to hypertonic uterine interval: May increase and prescriber are
sustain uterine patterns risk of life-threatening Other: Anaphylaxis, immediately available
cardiac arrhythmias,
contraction and control death from oxytocin
including torsades de
uterine atony. Use cautiously, if pointes. Use together induced water Monitor fluid intake and
at all, in patients cautiously. intoxication, output. Antidiuretic effect
Incomplete, inevitable, with invasive hypersensitivity may lead to fluid overload,
or elective abortion: cervical cancer and Misoprostol: May reaction. seizures, and coma from
Adult: 10 units I.V. in those with increase oxytocin water intoxication
infusion at 10 to 20 previous cervical adverse effects. Do not FETAL
milliunits (20 to 40 or uterine surgery, use together
Monitor and record uterine
drops/minute) grand multiparity, CNS: Infant brain contractions, HR, BP,
Vasoconstrictors: May
uterine sepsis, cause severe HTN if damage, seizures. intrauterine pressure, fetal
Route: traumatic delivery, oxytocin is given within HR and character of blood
I.V and I. M or over distended 3 to 4 hours of CV: Bradycardia, loss at least every 15
uterus vasoconstrictor in patient arrhythmias, PVCs. minutes.
Therapeutic class: receiving caudal block
Oxytocics anesthetic. Avoid using EENT: Neonatal retinal
together.
hemorrhage.
Pharmacologic Class:
Exogenous Hormones Hepatic: Neonatal
 Republic of the Philippines
UNIVERSITY OF EASTERN PHILIPPINES
University Town, Northern Samar

COLLEGE of NURSING and ALLIED HEALTH SCIENCES

DRUG ANALYSIS
 SPECIFIC CONTRAINDIC DRUG ADVERSE SPECIFIC NURSING
NAME OF DRUG INDICATION
ACTION ATION INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic name: Provide the Prevent If a newborn or No significant Vitamin K Accurate dosing: Vitamin K Obtain a complete medical
Vitamin K necessary cofactor hemorrhagic their family has a interactions are known administration to should be administered at history and check for any
for the production of disease of newborn history of other than antagonist of newborns is generally the recommended dose, as contraindications or
Brand name: coagulation factors anaphylaxis or coumarin anticoagulants considered safe, with determined by the infant's allergies to Vitamin K or its
components. Prepare the
k-100, Mephynton, in the liver, which other allergic few adverse reactions weight and age. Overdosing
injection and ensure that it
Phytonadione are essential for reaction to Vitamin reported or underdosing can increase is at the correct dose and
normal blood K or its the risk of adverse that it has not expired.
Dosage: clotting. components, However, some adverse reactions.
0.1 ml administration may reactions that have been Explain the purpose,
be contraindicated reported include: Proper administration benefits, and potential risks
Route: technique: The injection of Vitamin K
administration to the
Intramuscular Allergic reactions: In should be given slowly and
parents or guardians of the
rare cases, an infant deeply into the mid-vastus infant. Obtain their
Pharmacologic class: may experience an lateralis muscle, to informed consent before
Anticoagulant allergic reaction to the minimize the risk of local administering the injection.
Vitamin K injection, reactions, hitting of sciatic
Therapeutic class: including symptoms nerves, and bleeding. Administer the injection
Coagulation Modifier such as rash, itching, slowly and deeply into the
swelling, or difficulty muscle, following proper
Consideration of medical
infection control procedures
Reference: breathing. history: The decision to to minimize the risk of
Nursing 2021 Drug administer Vitamin K to a infection.
Handbook Local reactions: The newborn should take into
injection site may account the infant's medical Observe the infant for any
MedlinePlus become red, swollen, or history, including any adverse reactions, such as
tender after family history of allergic allergic reactions, local
administration. These reactions or medical reactions, jaundice, or
reactions are usually blood clots, for at least 15
conditions that may affect
minutes after
mild and resolve on Vitamin K metabolism. administration. Document
their own. any adverse reactions and
report them to the
Jaundice: In some healthcare provider
cases, administration of immediately.
Vitamin K to newborns
has been associated Accurately document the
with an increased risk date, time, dose, and route
of Vitamin K
of jaundice, a condition
administration in the
characterized by infant's medical record.
yellowing of the skin
and eyes.
 Republic of the Philippines
UNIVERSITY OF EASTERN PHILIPPINES
University Town, Northern Samar

COLLEGE of NURSING and ALLIED HEALTH SCIENCES

DRUG ANALYSIS
 SPECIFIC CONTRAINDIC DRUG ADVERSE SPECIFIC NURSING
NAME OF DRUG INDICATION
ACTION ATION INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic name: The specific drug Hepatitis B If a newborn or There are no known Most side effects are Before administering the Assess the newborn for any
Hepatitis B Vaccine action of the prophylaxis their family has a interactions with other mild and go away on vaccine, review the contraindications or
Hepatitis B vaccine history of vaccines or drugs their own within a few newborn's medical history allergies to any of the
Brand name: is to stimulate the anaphylaxis or days. to ensure that there are no vaccine components and
Recombivax HB Dialysis immune system to other allergic  Pain or redness contraindications or review the medical history
Formulation produce an antibody reaction to yeast or in injection site allergies to any of the to ensure that the vaccine is
response against the other components  Mild fever vaccine components. appropriate.
Dosage: HBV, providing of the vaccine,
0.5 ml protection against administration may In some rare cases , Explain the purpose and Explain the purpose and
infection and be contraindicated serious side effects can benefits of the Hepatitis B benefits of the Hepatitis B
Route: reducing the risk of occur vaccine to the parents or vaccine to the parents or
.Intramuscular chronic liver  Anaphylaxis guardians of the newborn guardians of the newborn
disease, liver cancer,  GBS and obtain their informed and provide them with
Pharmacologic class: and death  Stevens- consent before information about any
Vaccines Johnson administering the vaccine. potential risks or side
Syndrome effects. Obtain informed
Therapeutic class: Store the vaccine according consent before
Preventive Vaccine to the manufacturer's administering the vaccine.
instructions to ensure that it
Reference: remains at the correct Prepare the vaccine by
Nursing 2021 Drug temperature and has not checking the expiration
Handbook expired. date, ensuring that it has
been stored at the correct
Medscape.com temperature, and verifying
that the vaccine is not
MedlinePlus discolored or otherwise
visually altered.

Administer the vaccine

using the appropriate
injection technique, such as
intramuscular injection, and
observe the newborn for
any adverse reactions, such
as allergic reactions, local
reactions, or fever.

Accurately document the

date, time, dose, and route
of the Hepatitis B vaccine
administration in the
newborn's medical record
and report any adverse
reactions to the healthcare
 Republic of the Philippines
UNIVERSITY OF EASTERN PHILIPPINES
University Town, Northern Samar

COLLEGE of NURSING and ALLIED HEALTH SCIENCES

DRUG ANALYSIS
 SPECIFIC CONTRAINDIC DRUG ADVERSE SPECIFIC NURSING
NAME OF DRUG INDICATION
ACTION ATION INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Crede’s Prophylaxis Inhibits protein To prevent If a newborn or There are no known Most side effects are Ensure that the correct Assess the newborn for any
synthesis; usually ophthalmia their family has a interactions with other mild and go away on technique is used to contraindications or
Generic name: bacteriostatic, but neonatorum caused history of vaccines or drugs their own within a few administer the eye drops, allergies to the eye drops
Erythromycin may be bactericidal by Neisseria anaphylaxis or days such as applying gentle and review the medical
gonorrhoeae or
in high other allergic  Minor ocular pressure to the tear duct history to ensure that the
Chlamydiaa
Brand name: concentrations or trachomatis in reaction to drug or irritations and after instillation to prevent prophylaxis is appropriate.
Erygel against highly newborn its components, redness the solution from flowing
susceptible administration may out of the eye. Explain the purpose and
Dosage: organism. be contraindicated benefits of Crede's
Ribbon of ointment Wash your hands prophylaxis to the parents
about 1cm long in lower thoroughly before or guardians of the newborn
conjunctival sac of each administering the eye drops and provide them with
eye shortly after birth to prevent the introduction information about any
of bacteria or other potential risks or side
Route: pathogens into the eye. effects. Obtain informed
Ophthalmic Ointment consent before
Store the eye drops administering the eye
Pharmacologic class: according to the drops.
Macrolides manufacturer's instructions
to ensure that they remain Prepare the eye drops by
Therapeutic class: sterile and effective. checking the expiration
Antibiotic date, ensuring that they
Observe the newborn for have been stored at the
Reference: any adverse reactions, such correct temperature, and
Nursing 2021 Drug as redness, itching, or verifying that the solution is
Handbook discharge from the eye, and not discolored or otherwise
report them to the visually altered.
Medscape.com healthcare provider
immediately. Administer the eye drops
MedlinePlus using the appropriate
technique, such as applying
gentle pressure to the tear
duct after instillation, and
observe the newborn for
any adverse reactions, such
as redness, itching, or
discharge from the eye.

Accurately document the

date, time, and dose of the
Crede's prophylaxis
administration in the
newborn's medical record
and report any adverse
 Republic of the Philippines
UNIVERSITY OF EASTERN PHILIPPINES
University Town, Northern Samar

COLLEGE of NURSING and ALLIED HEALTH SCIENCES

DRUG ANALYSIS
 SPECIFIC CONTRAINDIC DRUG ADVERSE SPECIFIC NURSING
NAME OF DRUG INDICATION
ACTION ATION INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic name: Temporarily Local anesthetic Patients with a CNS depressants: Allergic reactions: Patients with a history of The nurse should assess the
Lidocaine inhibiting the for pudendal history of Medications that cause Lidocaine can cause an allergic reactions to local patient's medical history,
sodium channels in blocks during labor hypersensitivity or drowsiness, such as allergic reaction in anesthetics should inform including allergies, cardiac
Brand name: the nerve fibers, to provide pain allergic reactions sedatives or some patients, resulting their healthcare provider disease, liver disease,
relief during tranquilizers, can
Lidocaine, Lidoderm which helps to to lidocaine or any in symptoms such as before receiving a pudendal respiratory disease, and any
vaginal delivery increase the sedative
prevent the of its components effects of lidocaine and itching, hives, shortness block with lidocaine. other relevant conditions
Dosage: transmission of pain Also given near the should not receive increase the risk of of breath, or before administering a
Usual dose of lidocaine signals. The end of birth for an a pudendal block respiratory depression. anaphylaxis. Patients with cardiac pudendal block with
for a pudendal block numbness caused by episiotomy with lidocaine disease or heart conditions lidocaine.
during labor is 20-30 mg the pudendal block Monoamine oxidase Nerve damage: In some should inform their
per injection, up to a typically lasts for Patients with a inhibitors (MAOIs): cases, lidocaine can healthcare provider before The nurse should assist in
MAOIs, which are a
maximum of 120 mg. several hours, history of seizure cause nerve damage, receiving a pudendal block calculating the correct
type of antidepressant
providing pain relief disorders or who resulting in symptoms with lidocaine. dosage of lidocaine based
medication, can interact
Route: during the labor and are taking with lidocaine and such as numbness, on the patient's individual
ID, IM, in perineal delivery process. medications that increase the risk of tingling, or weakness in Patients with liver disease circumstances, including
region increase the risk of serious adverse the affected area. or liver dysfunction should age, weight, and medical
seizures should not reactions, such as high inform their healthcare history.
Pharmacologic class: receive a pudendal blood pressure and Cardiac adverse provider before receiving a
Local Anesthetics block with seizures. reactions: Lidocaine can pudendal block with The nurse should closely
lidocaine. cause adverse reactions lidocaine. monitor the patient for
Antiarrhythmics: Certain
Therapeutic class:\ medications used to treat related to the heart, adverse reactions, including
Analgesics Patients with liver heart arrhythmias, such such as bradycardia, Patients with respiratory changes in heart rate, blood
or kidney problems as quinidine or heart block, or cardiac disease or respiratory pressure, and respiratory
Reference: may have an procainamide, can arrest. dysfunction should inform rate.
Nursing 2021 Drug increased risk of interact with lidocaine their healthcare provider
Handbook adverse reactions and increase the risk of Respiratory depression: before receiving a pudendal The nurse should accurately
to lidocaine, and cardiac adverse Lidocaine can cause
reactions, such as heart block with lidocaine. document the
Medscape.com the use of a respiratory depression, administration of the
block or cardiac arrest.
pudendal block which is a reduction in The dosage of lidocaine pudendal block with
MedlinePlus with lidocaine Phenytoin: Phenytoin, the patient's ability to used for a pudendal block lidocaine, including the
should be carefully which is a medication breathe normally. during labor should be dose, route, and any
considered in these used to treat seizures, Seizures: In rare cases, carefully calculated based adverse reactions that
cases. can interact with lidocaine can cause occur.
on the patient's individual
lidocaine and increase seizures.
the risk of adverse circumstances, including
reactions, such as the patient's age, weight,
seizures or nerve and medical history.
damage.

Beta-blockers: Beta-
blockers, which are
Monitoring: Patients
medications used to treat
high blood pressure or receiving a pudendal block
heart problems, can with lidocaine should be
interact with lidocaine closely monitored for
and increase the risk of adverse reactions and any
 Republic of the Philippines
UNIVERSITY OF EASTERN PHILIPPINES
University Town, Northern Samar

COLLEGE of NURSING and ALLIED HEALTH SCIENCES

DRUG ANALYSIS
 SPECIFIC CONTRAINDIC DRUG ADVERSE SPECIFIC NURSING
NAME OF DRUG INDICATION
ACTION ATION INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic name: Stimulate uterine To prevent and Hypertension: Selective serotonin Nausea: Methergine can The patient's medical The nurse should monitor
Methylergonovine contractions, which treat postpartum Patients with reuptake inhibitors cause nausea, which can history should be carefully the patient's vital signs,
maleate helps to prevent hemorrhage caused uncontrolled (SSRIs): Taking SSRIs, be accompanied by assessed before including blood pressure,
postpartum bleeding by uterine atony or hypertension or such as fluoxetine or vomiting. administering methergine, heart rate, and respiratory
subinvolution sertraline, while
Brand name: and promote the preeclampsia particularly if they have a rate, to ensure that the
receiving methergine can
Methergine return of the uterus should not receive increase the risk of Headache: Methergine history of heart disease, patient is tolerating the
to its pre-pregnancy methergine during serotonin syndrome, can cause headache, hypertension, or other medication.
Dosage: size. This helps to labor, as it can which is a potentially which can be severe and cardiovascular conditions.
0.2 mg after delivery of prevent excessive cause a significant life-threatening persistent. The nurse should ensure
the anterior shoulder, bleeding and to increase in blood condition. The dosage of methergine that the correct dose of
after delivery of reduce the risk of pressure. Dizziness: Methergine should be carefully methergine is administered
Antihypertensive
placenta, or during the blood clots. can cause dizziness, controlled to minimize the at the appropriate time.
medications: Taking
puerperium Cardiac disease: which can increase the risk of adverse reactions.
antihypertensive
Patients with heart medications, such as risk of falls and other The nurse should observe
Route: disease or cardiac beta blockers or calcium injuries. Vital signs, including blood the patient for signs of
I.M. or I.V arrhythmias should channel blockers, while pressure, heart rate, and adverse reactions, including
not receive receiving methergine can Chest pain: Methergine respiratory rate, should be severe headache, dizziness,
Pharmacologic class: methergine, as it increase the risk of can cause chest pain, monitored regularly during or changes in heart rate, and
Ergot Alkaloids can cause hypotension, or low which can be methergine administration. report any concerning
blood pressure.
significant changes accompanied by symptoms to the physician.
Therapeutic class:\ in heart rate and Migraine medications: tightness or pressure in The patient's current
Oxytocics rhythm. Taking migraine the chest. medications should be The nurse should maintain
medications, such as carefully evaluated for accurate records of the
Reference: Hemorrhage: triptans, while receiving Hypertension: potential drug interactions patient's vital signs,
Nursing 2021 Drug Patients who are methergine can increase Methergine can cause with methergine medication administration,
Handbook experiencing heavy the risk of adverse hypertension, or high and any adverse reactions.
vaginal bleeding or effects, such as nausea, blood pressure, which
dizziness, and headache. Methergine should not be
Medscape.com who have a history can increase the risk of used to induce labor in The nurse should educate
of significant Ergot alkaloids: Taking heart disease and other women who are not in the patient and their family
MedlinePlus postpartum other ergot alkaloids, cardiovascular active labor.. about the use of methergine
bleeding should such as conditions. during labor, including the
not receive dihydroergotamine or potential benefits and risks.
methergine, as it ergotamine, while Tachycardia:
can worsen the receiving methergine can Methergine can cause
bleeding. increase the risk of ergot tachycardia, or rapid
toxicity, which can cause
heartbeat, which can
significant adverse
Allergic reactions: effects. increase the risk of
Patients who have heart attack and other
a known allergy to cardiac events.
ergot alkaloids or
any component of Tremors: Methergine
the medication can cause tremors,
should not receive which can affect the
methergine. patient's ability to
perform fine motor