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Name: Mary Vhenn C.

Samonte Subject: General Biology


Gr & Sec: 11 – STEM Date: 08 – 23 – 22

Cell - the smallest unit that


can live on its own and that
makes up all living organisms
and the tissues of the body. A
cell has three main parts: the cell
membrane, the nucleus, and the
cytoplasm.

Cell Nucleus - The nucleus is


one of the most obvious parts
of the cell when you look at a
picture of the cell. It's in the
middle of the cell, and the
nucleus contains all of the
cell's chromosomes, which
encode the genetic material.
So this is really an important
part of the cell to protect.

Study: Morphological Granulometric Features of Nucleus in Automatic Bone


Marrow White Blood Cell Classification.

The proportion of counts of different types of white blood cells in the bone
marrow, called differential counts, provides invaluable information to doctors for
diagnosis. Due to the tedious nature of the differential white blood cell counting process,
an automatic system is preferable. In this paper, we investigate whether information
about the nucleus alone is adequate to classify white blood cells.
This is important because segmentation of nucleus is much easier than the
segmentation of the entire cell, especially in the bone marrow where the white blood cell
density is very high. In the experiments, a set of manually segmented images of the
nucleus are used to decouple segmentation errors. We analyze a set of white-blood-
cell-nucleus-based features using mathematical morphology. Fivefold cross validation is
used in the experiments in which Bayes' classifiers and artificial neural networks are
applied as classifiers. The classification performances are evaluated by two evaluation
measures: traditional and classwise classification rates.

Furthermore, we compare our results with other classifiers and previously


proposed nucleus-based features. The results show that the features using nucleus
alone can be utilized to achieve a classification rate of 77% on the test sets. Moreover,
the classification performance is better in the classwise sense when the a priori
information is suppressed in both the classifiers

References:

 C. H. Dunphy, "Applications of flow cytometry and immunohistochemistry to diagnostic

hematopathology", Arch. Pathol. Lab. Med., vol. 128, no. 9, pp. 1004-1022, Sep. 2004.

 L. W. Diggs, D. Sturm and A. Bell, The Morphology of Human Blood Cells, IL, Abbott

Park:Abbott Lab., 1985.

 V. Minnich, Immature Cells in the Granulocytic Monocytic and Lymphocytic Series, IL,

Chicago:Amer. Soc. Clinical Pathologists Press, 1982.

 S. Sanei and T. K. M. Lee, "Cell recognition based on PCA and Bayesian

classification", Proc. 4th Int. Symp. Ind. Compon. Anal. Blind Signal Separation, pp.

239-243, 2003.

 M. Beksac, M. S. Beksac, V. B. Tipi, H. A. Duru, M. U. Karakas and A. N. Cakar, "An

artificial intelligent diagnostic system on differential recognition of hematopoietic cells

from microscopic images", Cytometry, vol. 30, pp. 145-150, 1997.`

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