Time-of-flight Mass Spectrometry (TOF-MS)

 
 

Increase your mass precision and time to measurements

Acqiris has experience with a large range of TOF-MS technology such as LC, GC, ICP,
SIMS, MALDI-TOF and SLIM-TOF, both in the research/quantization and in the
clinical/quantification market.

Many decision factors need to be considered when selecting the appropriate signal
acquisition card for a TOF-MS project. Decision criteria embodies technological,
financial and risks management.

Two key TOF-MS characteristics are the accuracy of the mass measurement or charge-
to-mass ratio (m/z) and the data throughput or time to measurement. Acqiris acquisition
cards technology strongly contributes in mass/intensity accuracy, mass resolution and
mass sensitivity performance. More than a signal acquisition card, Acqiris aims at
improving the signal performances of your complete TOF-MS system.

Acqiris Time-of-Flight Mass

Spectrometry (TOF-MS)
Solutions
 
 
 

 
Acqiris has experience and systems deployed in the field  with a large range of TOF-MS
technology such as LC, GC, ICP, SIMS, MALDI-TOF and SLIM-TOF, both in the
research/quantization and in the clinical/quantification market.

Many decision factors need to be considered when selecting the appropriate signal
acquisition card for a TOF-MS project. Decision criteria embodies technological,
financial and risks management.

Acqiris has two products targeted to your TOF-MS application:

SA1 product line: Entry-level 8-bit 500 MS/s – 2 GS/s signal acquisition solutions
SA2 product line: Our New Medium to High-End range signal acquisition solutions
1. Achieve accuracy and throughput in mass measurement
Two key TOF-MS characteristics are the accuracy of the mass measurement or charge-
to-mass ratio (m/z) and the data throughput or time to measurement.

 The accuracy of a mass measurement depends on many functions of the mass

spectrometer. Acqiris strongly contributes in mass/intensity accuracy, mass resolution
and mass sensitivity performance.
 The high data throughput can be achieved with acquisition modes such Acqiris
combined acquisition/readout mode and raw streaming capability above 6 GB/s
sustained.
More than a signal acquisition card, Acqiris aims at improving the signal performances
of your complete TOF-MS system.

Mass accuracy: The sampling rate (SR) is a fundamental feature. Acqiris offers a

range of products with SR from 500 MS/s and up to 10 GS/s. The customers can
always find the appropriate Acqiris solution that will precisely measure the pulse
amplitude as a function of the system and detector pulse width.

Mass Resolution: This very much depends on the bandwidth (BW), the sampling rate
(SR) and the flight time. High Mass Resolution implies that the signal acquisition card
shall not contribute to enlarge the detector pulse width FWHM (Full Width at Half
Maximum).

Mass Sensitivity: The Signal-to-Noise Ratio (SNR) limits the lowest concentration of a
substance where the signal can be distinguished from system noise. Averaging multiple
acquisitions can be used to improve the SNR but not it is not always possible, and it
lengthens the time to measurement. With proprietary analog design and specific TOF-
MS on-board processing, Acqiris provides solutions with the lowest possible SNR.

2. Reduce the total financial cost through your full project lifecycle
With a full range of products in various domains , and a large flexibility due to its
modular architecture, Acqiris offers solutions adapted to the customer innovation plans
at predictable cost. Acqiris assists from the earliest stages of system development until
the end of your product obsolescence in order for the customer to have a full control of
its budget throughout the full project’s life cycle.

3. Limit the risks with your new product introduction

Acqiris provides unique services to easier evaluation and integration into your
instrument including easy to use dedicated evaluation tools and intuitive API
(Application Programming Interface), dedicated IO sequencing, high quality/reliability,
long term support and full visibility about our product life cycle.

With one slot short PCIe signal acquisition card, and versatile electronic interfaces to
reduce your system electronic, Acqiris also contributes to help you reduce the size and
the power consumption of your system.
4. Select the signal acquisition form-factor needed in your design
Acqiris gives flexibility when designing your TOF-MS systems by providing two different
form factors: PCIe card or serial-link enclosure. You select the version that either
provides fewer constraints on your external processors, or that ensures easy design
upgrades by “leveraging” a large part of your existing systems.