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Writing Informative Abstracts for Journal Articles

A
BSTRACTS SERVE 3 IMPORTANT PURPOSES: “Three general pediatric practices in Kansas City, Mo,
(1) they may persuade someone to read from January 1990 to December 2001.”
the article, (2) they allow busy readers to 4. Participants. Who was studied, and how many
learn the main results without reading the were studied? Describe important eligibility criteria.
entire article,1 and (3) they make it easy The most useful count of subjects may not be obvious.
to capture the main results in computerized databases, Refusal to participate, dropouts, and missing informa-
such as MEDLINE, which make the results available tion are potential sources of bias. We encourage authors
worldwide. Given these purposes, it is worth writing an to be forthright; give the count for the target population
informative abstract. and the count of the participants in the data actually
We suggest a structured abstract format with 8 sec- analyzed.
tions: Examples: “All 11041 children in the eighth grade;
1. Objective(s). State an objective, not necessarily a hy- adequate information was available for 9411 children
pothesis. Hypothesis testing does not fit the design of many (85%), who formed the analytic sample.” “A random
studies and sometimes leads to simplistic thumbs-up or sample of children admitted to the intensive care unit for
thumbs-down conclusions.2-4 One sentence is usually suf- bronchiolitis (N=201).” “Asthma patients 4 to 15 years
ficient. We are convinced that the best articles focus on of age were randomly assigned to the intervention (n=67)
1 objective; if you have more than 2, reconsider.5 or placebo (n=63) groups. Follow-up data on the out-
Examples: “To estimate the association between di- come were available for 55 intervention and 60 control
etary intake of kumquats and school performance.” “To patients.”
estimate the prevalence of asthma among school chil- If you did not collect the data, state the data source
dren in Iowa.” “To determine whether drug A, a new an- in this section; for example, “a survey done by the Na-
tiviral agent, reduced morbidity related to the common tional Center for Health Statistics.”
cold.” 5. Intervention(s) or Main exposure(s). This section may
2. Design. A few words can usually do the job. include interventions that were controlled by the inves-
Examples: “Case-control study.” “Randomized con- tigators or exposures that the investigators measured but
trolled trial.” “Prospective cohort study.” did not manipulate, such as smoking, use of a bicycle hel-
Not every study can be neatly summarized by a widely met, or residence in a state with a seat belt law. Skip this
understood label; a brief description of what you did may section if there was no intervention or exposure.
be necessary. Examples: “Oral acyclovir, 15 mg/kg 5 times per day
3. Setting. This is about place and time; where and when for 5 days.” “Drinking alcohol at least weekly.” “Two hours
the study participants were selected. Try to be specific of school instruction regarding seat belt use.”
without being wordy. 6. Main outcome measure(s). There is room for choice
Examples: “The Children’s Medical Center of the in this section. Imagine your objective was “To estimate
Bosporus, a referral hospital, Istanbul, Turkey, from Sep- the association of new treatment X with death among in-
tember 1, 2001, to July 31, 2002.” “All public schools in fants with sepsis.” Given this objective, the main out-
Milwaukee, Wis, during the 2001-2002 school year.” come was death prior to hospital discharge. Suppose the

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Table. Hypothetical Outcomes of 6 Randomized Trials of Drug X Compared With Placebo to Prevent Wound Infection
After a Ferret Bite: Risk Ratios for Infection in the Drug X Group Compared With the Placebo Group

Drug X Placebo
Risk Ratio
Trial Total, No. Infected, No. (%) Total, No. Infected, No. (%) (95% Confidence Interval) P Value
A 40 2 (5.0) 40 4 (10.0) 0.50 (0.10-2.58) .40
B 200 10 (5.0) 200 19 (9.5) 0.52 (0.25-1.10) .08
C 240 11 (4.6) 240 23 (9.6) 0.48 (0.24-0.96) .03
D 2000 100 (5.0) 2000 199 (10.0) 0.50 (0.40-0.63) ⬍.001
E 100 000 9500 (9.5) 100 000 10 000 (10.0) 0.95 (0.92-0.98) ⬍.001
F 2000 190 (9.5) 2000 200 (10.0) 0.95 (0.79-1.15) .60

main analysis estimated the adjusted risk ratio for death association estimated in our study is causal, some drown-
of those who received the new treatment compared with ings can be prevented if children wear life vests. How-
children who received standard treatment. It would make ever, our risk ratio estimate may be biased by confound-
the results section clearer and shorter if the main out- ing due to a lack of information about swimming ability.”
comes section said, “The main outcome was death in the But the conclusion should not say, “Laws should re-
hospital; adjusted risk ratio for death compared chil- quire parents to put their children in life vests.” If the
dren receiving the new treatment with those given stan- study did not examine the effect of a law on either life
dard treatment.” vest use or drowning rates, laws should not be men-
Suppose the objective was “To estimate the associa- tioned. Don’t use the conclusion section as a soapbox for
tion between kumquat consumption and school perfor- views that go beyond what you studied.
mance,” and there were 5 outcome measures, including Avoid clichés such as “more research is needed.” More
grade point average, scores on standardized state tests, research is always needed, especially if it funds your next
and days absent from school. It would save space to say study. Another platitude is, “This study has important
in the outcome section, “Five measures of school per- implications for pediatricians.” If there are implica-
formance; estimates of mean difference in each out- tions, state them.
come per each additional 4-oz serving of kumquats,” and Don’t make judgments based solely on a P value; con-
report the mean differences for each outcome measure sider the estimated associations and confidence inter-
in the results. vals.6-9 Imagine that you conducted a randomized con-
7. Results. The most common problem that we see in trolled trial of drug X to prevent wound infection after a
abstracts is a failure to give the main quantitative re- ferret bite. You estimated the risk ratio for infection among
sults. Give the main numerical results with estimates of bite victims given drug X compared with those given pla-
precision, such as confidence intervals.4 cebo. The Table shows hypothetical results from 6 trials
Examples: Instead of “Asthma was highly prevalent,” of drug X. As an exercise, we ask you to stop reading here
give the proportion of children who had asthma with a and write a 1- or 2-sentence summary conclusion for each
confidence interval. Rather than “The intervention arm of the 6 trial results (pretend each is the first trial of drug
had better outcomes; P⬍.01 for all comparisons,” show X). Then read our suggestions.
the proportions in each arm with each outcome and the Based on the P values, you might write, “Drug X was not
ratios or differences in these proportions with confi- associated with a statistically significant change in the risk
dence intervals. of infection” for studies A, B, and F. For studies C, D, and
Give the results that are thought to be most free of bias; E, you could write, “The risk of infection was reduced by
if there was confounding in the study, give the adjusted drug X.” These summaries would be technically correct, but
estimates of association, not the crude estimates. If some they ignore the size and precision of the risk ratios.
outcomes were considered most important prior to the Assuming that each trial was the only available evi-
analysis, just report those. Avoid reporting just those out- dence, a concluding sentence might say:
comes that were statistically significant. Only report re- Study A: “Our results were compatible with a wide
sults that pertain to the study objective. range of effects, including substantial decreases or in-
8. Conclusion(s). Conclusions should be related to the creases in the risk of infection. The clinical utility of drug
results given in the abstract. Suppose a case-control study X remains uncertain.”
of life vests and drowning reported in the results, “The Study B: “Our results were compatible with a benefi-
risk of drowning was less among children wearing life cial effect of drug X on the risk of infection, although the
vests, compared with those without vests (adjusted risk size of the benefit remains uncertain; a harmful effect
ratio, 0.5; 95% confidence interval, 0.3-0.6).” The con- seems unlikely.”
clusion might say, “If the association estimated in our Study C: Same as for study B. Studies B and C had simi-
study is causal, our results provide evidence that about lar results; the fact that B had an upper confidence in-
half of child drownings can be prevented if children wear terval slightly greater than 1 and C had an upper confi-
life vests.” If the study could not adjust for potentially dence interval slightly less than 1 does not affect our
important confounders, the conclusion might say, “If the interpretation.

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Study D: “Drug X reduced the risk of infection by about proach, most of the abstract can be cut and pasted from
half.” the manuscript, nothing will appear in the abstract that
Study E: “Although drug X reduced the risk of infec- is not in the text, and the numerical information in the
tion, the observed risk reduction was only 5%, and the abstract will agree with that in the article. Don’t worry if
true effect is not likely to be much greater than this.” the abstract sounds repetitious to your ear; it’s sup-
Study F: “We found little evidence that drug X influ- posed to repeat what the article says.
ences the risk of infection. A risk reduction of 25% or
more is doubtful given our data.” KEEP IT SHORT AND CLEAR
To make decisions about the clinical use of drug X,
one would want to consider not only the size of any effect Limit the abstract to 250 words. The goal is to have some-
of X on infection risk but also the consequences of in- thing so short that everyone will read it. If you use fewer
fected ferret bites, how easy it is to treat infected bites, than 250 words, no one will object.
the costs of prophylactic treatment and treatment after Aim for clarity above all else; if you must choose
infection occurs, and treatment side effects. A clinical trial between our advice and something that would make
of drug X cannot cover all of these issues, and therefore your abstract clearer, choose clarity and defend your
the conclusion should not provide advice based on in- choice.
complete information. Few studies by themselves yield
sufficiently broad and deep evidence to justify sweeping Peter Cummings, MD, MPH
clinical or policy recommendations.10-12 Frederick P. Rivara, MD, MPH
Thomas D. Koepsell, MD, MPH
WHAT TO LEAVE OUT Correspondence: Dr Cummings, 250 Grandview Dr,
Bishop, CA 93514 (peterc@u.washington.edu).
The statistical methods can usually be omitted from the
abstract. If you present hazard ratios, rate ratios, or mean REFERENCES
differences, it is not necessary to say in the abstract that
you used proportional hazards models, Poisson regres- 1. Saint S, Christakis DA, Saha S, et al. Journal reading habits of internists. J Gen
sion, or linear regression. Make the study design and out- Intern Med. 2000;15:881-884.
2. Gardner MJ, Altman DG. Confidence intervals rather than P values: estimation
come measures clear in the abstract, and describe the sta- rather than hypothesis testing. BMJ. 1986;292:746-750.
tistical tools in the article. For most purposes, confidence 3. Rothman KJ. Significance questing. Ann Intern Med. 1986;105:445-447.
intervals are more useful than P values.4 4. Cummings P, Rivara FP. Reporting statistical information in medical journal articles
Arch Pediatr Adolesc Med [editorial]. 2003;157:321-324.
5. Rivara FP, Cummings P. Writing for publication in Archives of Pediatrics and Ado-
SYSTEMATIC REVIEWS AND META-ANALYSES lescent Medicine Arch Pediatr Adolesc Med [editorial]. 2001;155:1090-1092.
6. Altman DG, Bland MJ. Absence of evidence is not evidence of absence. BMJ.
The abstract for a review should follow principles similar 1995;311:485.
to those previously outlined, but use 7 section headings: 7. Poole C. Low P-values or narrow confidence intervals: which are more durable?
Epidemiology. 2001;12:291-294.
Objective(s), Data sources, Study selection, Interven-
8. Alderson P. Absence of evidence is not evidence of absence. BMJ. 2004;328:476-
tion(s) or Main exposure(s), Main outcome measure(s), 477.
Results, and Conclusion(s). 9. Altman D, Bland JM. Confidence intervals illuminate absence of evidence. BMJ
[letter]. 2004;328:1016-1017.
WRITE THE ABSTRACT LAST 10. Rothman KJ, Poole C. Science and policy making. Am J Public Health [editorial].
1985;75:340-341.
11. Weiss NS. Policy emanating from epidemiologic data: what is the proper forum?
Write early drafts of the article without an abstract. Write Epidemiology. 2001;12:373-374.
the abstract only when near the final draft. With this ap- 12. Our policy on policy. Epidemiology. 2001;12:371-372.

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