Pathogenic

Mycobacteria
 Mycobacteria
Aerobic Rod

Acid-Fast Bacillus

Lipid

Gram Positive /
Gram Negative
Ziehl-Neelsen

Carbolfuchsin Heat Acid-Alcohol Methylene Blue

 Mycobacteria
Mycobacterium Mycobacterium
tuberculosis leprae

Tuberculosis
Atypical Leprosy
Mycobacterium
Mycobacteria chelonae

Mycobacterium Avium- Mycobacterium

intracellulare Complex kansassi M. tuberculosis

MAIC

Tuberculosis
M. leprae
Like Disease
Disease

Tuberculosis
 Pathogenesis Mycobacterium
tuberculosis
Endotoxins Exotoxins

Macrophage
Exudative Granulomatous
Lesion Lesions

Inflammatory
Response

Lungs Lungs Blood Steam

Important Properties Obligate Aerobe

Upper lobe of Kidney

Lung

18 Hours
Negative
Result

6-8 Weeks Lowenstein-

Jensen Medium
 Aerosol
Acid Alkalis Dehydration

INH
MDR Strains
Multiple Antibiotics

Chromosomal
Mycolic Acid Gene Catalase Peroxidase
Mutation

Mutation
Component Structure Function

Mycolic Acid
Acid-Fast
(C78-C90)

Cord Factor
Virulence
(Trehalose Dimycolate)

Delayed
Proteins
Hypersensitivity

Lipid
(Phthicerol Dimycocerosate) Pathogenesis
 Transmission

Healthy Diseased Reservoir

M. bovis

Smear-Positive Smear-Negative

Unpasteurized
Milk
 Resistance

+
CD4 T-Cell Macrophage Antibodies

Tuberculin Skin Test / Mantoux Test

0.1 mL of 5
tuberculin Thickening /
units Redding ≥ 15 mm No Known Risk

PPD 48-72
Dermis Hours ≥ 10 mm High Risk

Deficient Cell-
Subcutaneous ≥ 5 mm Mediated Immunity
 Clinical Features

Meningitis
Destructive
Arthritis

Pulmonary

Kidney
Abdominal
 Diagnosis Positive Negative

Detection Amplification
Blood Sample

MDRTB
MGIT
NAATs Extraction
IGRA

TB Antigen

INF-Alpha
Lysis Purification
Treatment

Standard Regimen MDRTB Previous Incomplete Treatment

Aminoglycosides MDR Patient
6 Months RMP / INH
Fluoroquinolones
Residence
2 Months EMB / PZA Ethionamide / Cycloserine
Failure to Regimen

Latent / Asymptomatic
XDR Non-Compliance
Infections

INH DOT
6-9 Months INH (Daily Observe Therapy)
RMP
3 Months 3HP Fluoroquinolones
Preventions
Prophylaxis

M. bovis
BCG Pasteurized
INH RMP
Milk

BCG Vaccine

Blood Sample

QFT
$

PPD Skin Test

INF-Gamma
PPD
Watch Anytime, Anywhere!
Stream videos on your device, cast to your TV, or listen in the background.
Download our Android / iOS App & Start Learning Today!