MUSNI, THEO ROI NCM116A | MEDWARD

BSN 3B2 JULY 28, 2022

DRUG STUDY

DRUG NAME INDICATION, MECHANISM OF SIDE CONTRAINDICATIO NURSING

DOSAGES, ACTION EFFECTS/ADVERSE NS RESPONSIBILITIES
FREQUENCY, REACTION
ROUTE

Adjust-a-dose (for -Inhibits cell-wall CV: thrombophlebitis. • Contraindicated in • Dosage is expressed

GENERIC NAME: all indications): synthesis during patients hypersensitive as total drug. Each 1.5-g
- ampicillin If CrCl in adults is 15 bacterial GI: diarrhea. to drug or other vial contains 1 g
sodium–sulbac to 29 mL/minute/1.73 multiplication. Hematologic: penicillins, in those ampicillin sodium and
tam sodium m2, give 1.5 to 3 g agranulocytosis, with sensitivity to 0.5 g sulbactam sodium.
every 12 hours; if CrCl leukopenia, multiple allergens, and
BRAND NAME: is 5 to 14 thrombocytopenia, in those with • In patients with
mL/minute/1.73 m2, thrombocytopenic mononucleosis because impaired renal
- Unasyn give 1.5 to 3 g every 24 purpura. of high risk of function, decrease
hours. Give dose after maculopapular rash. frequency of
hemodialysis. Skin: pain at injection administration.
site, thrombophlebitis, • Contraindicated in
Intra-abdominal, rash, urticaria. patients with a history • Monitor LFT results
gynecologic, and of cholestatic jaundice during therapy,
skin-structure Other: or hepatic dysfunction especially in patients
infections caused by hypersensitivity associated with with impaired liver
susceptible strains reactions. ampicillin–sulbactam function.
injection.
Adults: • If large doses are
1.5 to 3 g IM or IV • Use cautiously in given or if therapy is
every 6 hours. Don't patients with other prolonged, bacterial or
exceed 4 g/day of drug allergies fungal superinfection
sulbactam. (especially to may occur, especially in
cephalosporins) elderly, debilitated, or
Children age 1 or because of possible immunosuppressed
older weighing 40 kg cross-sensitivity and patients.
or more (skin and in those with renal
skin-structure impairment. • Watch for signs and
infections only): symptoms of
1.5 to 3 g IV or IM
every 6 hours for no Dialyzable drug: Yes. hypersensitivity, such
longer than 14 days. as erythematous
Don't exceed 4 g/day Overdose S&S: maculopapular rash,
sulbactam. Neuromuscular urticaria, and
hyperexcitability, anaphylaxis.
Children age 1 or seizures.
older weighing less • Monitor for CDAD,
than 40 kg (skin and which can be fatal.
skin-structure Antibiotic may need to
infections only): be stopped and other
300 mg/kg/day IV in treatment begun.
divided doses every 6
hours for no longer than • Tell patient to report
14 days. all adverse reactions,
Continue therapy with including rash, fever, or
an appropriate oral chills. A rash is the
antiinfective agent if most common allergic
necessary. reaction.

• Warn patient that IM

injection may cause
pain at injection site.