HPC SKU Guidance: Health and Life Sciences

Extract greater value from large, increasingly complex datasets faster with
3rd Gen Intel® Xeon® Scalable processors.

Workload characterization
Cryo-Electron Microscopy Computational Quantum
Discipline Genomics Molecular Dynamics
(Cryo-EM) Mechanical Modeling
Improve understanding of individuals’ Determine molecular structures for Describe the interaction between atoms, Simulate and analyze the movement of
What It Is
genetics for better health outcomes biological studies and drug development molecules, and macromolecules atoms and molecules
• Compute intensive
• GATK: Datasets require small footprint • Compute intensive • Compute intensive
Typical • Compute intensive
• Burrows-Wheeler Aligner (BWA): BWA: • Datasets require at least 256GB RAM • Increased memory and storage for
Workload • Highly scalable codes
Memory bandwidth intensive; scales • Highly scalable codes batch size management
well up to ~40 cores
• GROMACS
• BWA • Vienna Ab initio Simulation Package
Example • Regularized Likelihood Optimization • Nanoscale Molecular Dynamics (NAMD)
• BWA mem1.0/2/0, mini-map (VASP)
Applications (RELION 3.X) • Large-scale Atomic/Molecular
• Genome Analysis Toolkit (GATK) 4.X • NWChem
Massively Parallel Simulator (LAMMPS)
Recommended Intel Xeon Gold 6326 CPU Intel Xeon Gold 6326 CPU Intel Xeon Gold 6348 CPU Intel Xeon Platinum 8362
SKU by • Intel® Select Solutions • Intel Select Solutions • High frequency • High core count
Discipline • High memory • High frequency
Intel Xeon Gold 6342 CPU Intel Xeon Gold 6336Y CPU
• Bisection bandwidth interconnects
• High core count • Intel Speed Select Technology Intel Xeon Platinum 8362 CPU
• High TDP
• High frequency
Intel Xeon Gold 6348 CPU Intel Xeon Gold 6342 CPU
• High memory
• High core count • High core count
• Intel Select Solutions
Intel Xeon Gold 6348 CPU
• High core count
• Intel Select Solutions

SKU guidance
Top Performance High per-Core Performance Scalable Performance Value
Intel Xeon Platinum 8362 CPU Intel Xeon Gold 6348 CPU Intel Xeon Gold 6338 CPU Intel Xeon Gold 6326 CPU
Cores 32 28 32 16
Frequency Base/Max (GHz) 2.8/3.6 2.6/3.5 2.0/3.2 2.9/3.5
TDP (W) 265 235 205 185
Max System Memory 6TB 6TB 6TB 6TB
Max Memory Channels 8 8 8 8
Intel® AVX-512, Intel® oneAPI Math Intel AVX-512, Intel oneAPI oneMKL, Intel MPI Library, Fortran compiler, Intel AVX-512, Intel MPI Library,
Other Intel Value Adds
Kernel Library (oneMKL), GKL Intel® MPI Library Intel oneAPI oneMKL Intel® C++ Compiler
 Breakthrough performance The Intel advantage
Industry Standard Artificial Intelligence
Comprehensive Portfolio
HPL MobileNet-v1 End-to-end capabilities to address
Up to Up to broad range of customer needs

28% higher performance

vs. prior gen¹ 66% higher AI Inference performance
with Intel® DL Boost vs. prior gen⁴
Built-in Acceleration
Intel® Advanced Vector Extensions 512
HPCG BERT-Large SQuAD
(Intel® AVX-512), Intel® Deep Learning
Up to Up to Boost (Intel® DL Boost)

41% higher performance

vs. prior gen² 74% higher AI Inference performance
with Intel DL Boost vs. prior gen⁵
Enhanced Capabilities
Memory bandwidth, 6TB total system
STREAM Triad memory (DRAM + Intel® Optane™ PMem),
Up to Life Sciences cores and frequencies

47% higher performance

vs. prior gen3 NAMD
Up to Software Ecosystem

57% higher performance Optimized community, ISV & open-

vs. prior gen⁷ source codes, plus leading tools for
HLS development and optimization

Geomean RELION
Up to Up to

1.60x higher performance

vs. prior gen⁶ 61% higher performance
vs. prior gen⁸
Get fast and cost-effective time-to-market.

Run more iterations on complex and

higher-res models to get fast results.

Run diverse workloads on the same cluster,

Consider Intel® Speed Select Technology reducing cost and time on system.
Custom-tune cores and frequencies to improve your CPU performance.

Performance Results:
1 See [108] at intel.com/3gen-xeon-config. Results may vary.
2 See [108] at intel.com/3gen-xeon-config. Results may vary.
3 See [108] at intel.com/3gen-xeon-config. Results may vary.
4 See [122] at intel.com/3gen-xeon-config. Results may vary.
5 See [128] at intel.com/3gen-xeon-config. Results may vary. Performance varies by use, configuration and other factors. Learn more at www.Intel.com/PerformanceIndex. Performance results are based on testing as of dates shown in configurations and may not reflect all publicly
6 See [108] at intel.com/3gen-xeon-config. Results may vary. available updates. No product or component can be absolutely secure. Your costs and results may vary. For more info, visit Legal Notices and Disclaimers. Intel technologies may require enabled hardware, software or service
7 See [108] at intel.com/3gen-xeon-config. Results may vary. activation. Intel does not control or audit third-party data. You should consult other sources to evaluate accuracy.
8 See [108] at intel.com/3gen-xeon-config. Results may vary. © Intel Corporation. Intel, the Intel logo, and other Intel marks are trademarks of Intel Corporation or its subsidiaries. Other names and brands may be claimed as the property of others.
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