Current Medical Diagnosis &Treatment 2023 >Schizophrenia Spectrum Disorders

Maxine A. Papadakis, Stephen J. McPhee, Michael W. Rabow, Kenneth R. McQuaid+

Table 25–5.Adverse factors associated with atypical antipsychotic medications (listed in alphabetical order).

Medication Weight Gain Hyperlipidemia New-Onset Diabetes Mellitus QTc Prolongation1

Aripiprazole +/– – – ++

Asenapine +/– +/– +/– +++

Clozapine +++ +++ +++ +/–

Lurasidone – – – –

Olanzapine +++ +++ +++ +/–

Paliperidone + +/– +/– +++

Quetiapine ++ ++ ++ +++

Risperidone ++ ++ ++ +

Ziprasidone +/– – – +++

1QTc prolongation is a side effect of many medications and suggests a possible risk for arrhythmia. Prescriber’s Letter 2011;18(12):271207.

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