B.Sc.(Engg.

) 3rd Year 1st Semester Final Examination-2021

Department of Biomedical Engineering
Course Title: Biomedical Instrumentation and Diagnostics
Course Code: BME-3101
Time: 4 Hours Full Marks: 70

[N.B. The figures in the margin indicate full marks. Answer any five of the following questions]

1. a) Define Biomedical instrumentation. Why it is needed? 3

b) Describe the generalized medical instrumentation system with a proper diagram. 4
c) What are the problems encountered in measuring a living system. 3
d) Compare spectrophotometer and electrophoresis. 2
e) How pH meter used for pCO2 measurement. 2

2. a) State and explain Beer-Lambert Law. 3

b) Describe the Construction of a spectrophotometer. 4
c) What is a Colorimeter? Explain the basic components of a single beam filter photometer. 4
d) Define an isosbestic point with examples. 3

3. a) Distinguish between electron microscope and fluorescence microscope. 4

b) Define cell staining. What purposes stain the cell? 3
c) Narrate the principle of ELISA. 3
d) Explain the hearing mechanism of a human ear. 4

4. a) Define a blood gas analyzer. Classify the principles of blood gas analyzer. 3
b) Show the complete block diagram of a blood gas analyzer. 3
c) Describe the principle of Coulter blood cell counter. 4
d) Explain curve method for the calibration of an instrument. 4

5. a) What is an analytical instrument? Mention the elements of an analytical instrument. 3

b) Narrate the basic building blocks of an analytical instrument. 4
c) Define a chromatography. And classify it. 3
d) Explain the block diagram of a gas chromatography. 4

6. a) Mention the role of FACS in disease diagnosis. 4

b) Describe the principle operation of LASER Doppler blood flow meter. 4
c) Write down the principle operation of ELISA. 4
d) Distinguish between FACS and PCR. 2

7. a) Define anesthesia machine? Why it is used? 3

b) Write the principle of electromagnetic blood flow meter. 4
c) Draw the block diagram of square wave blood flow meter. 3
d) Explain the construction of a basic water sealed spirometer. 4

8. a) What is diagnosis? Briefly explain the basic components of a medical diagnostic system. 4
b) Describe the construction of ECG machine with a suitable block diagram. 4
c) Write the comparison among the X-ray, MRI and CT-Scan techniques. 3
d) Explain the interaction of radiation with matter. 3