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  • DDX - by Location

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    Osama
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    This document provides information on the differential diagnosis of bone lesions based on their location. For kids, epiphyseal lesions are often chondroblastoma or infection, while diaphyseal lesions could be osteoid osteoma or Ewing's sarcoma. In adults, giant cell tumor is common in the epiphysis, while malignant fibrous histiocytoma, osteosarcoma or chondrosarcoma often occur in the metaphysis. Ewing's sarcoma, lymphoma or adamantinoma frequently present in the diaphysis. Certain lesions have predilections for specific locations like the epiphysis, metaphysis or diaphysis. Location provides clues to likely diagnoses.

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    DDx - by location

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    This document provides information on the differential diagnosis of bone lesions based on their location. For kids, epiphyseal lesions are often chondroblastoma or infection, while diaphyseal lesions could be osteoid osteoma or Ewing's sarcoma. In adults, giant cell tumor is common in the epiphysis, while malignant fibrous histiocytoma, osteosarcoma or chondrosarcoma often occur in the metaphysis. Ewing's sarcoma, lymphoma or adamantinoma frequently present in the diaphysis. Certain lesions have predilections for specific locations like the epiphysis, metaphysis or diaphysis. Location provides clues to likely diagnoses.

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    6 views3 pages

    DDX - by Location

    Uploaded by

    Osama
    This document provides information on the differential diagnosis of bone lesions based on their location. For kids, epiphyseal lesions are often chondroblastoma or infection, while diaphyseal lesions could be osteoid osteoma or Ewing's sarcoma. In adults, giant cell tumor is common in the epiphysis, while malignant fibrous histiocytoma, osteosarcoma or chondrosarcoma often occur in the metaphysis. Ewing's sarcoma, lymphoma or adamantinoma frequently present in the diaphysis. Certain lesions have predilections for specific locations like the epiphysis, metaphysis or diaphysis. Location provides clues to likely diagnoses.

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    of 3

    Oncology

    Differential Diagnosis – Location


    Kids:
    Epiphyseal - Chondroblastoma (<20 yrs) Diaphyseal - Osteoid osteoma / OBlast
    - EG - INFECTION - EG
    - Ewing’s, lymphoma
    Metaphyseal - ABC / UBC / GCT - Adamantinoma / OFD
    - NOF/fibrous dysplasia
    - EG
    - Enchondroma
    - Osteosarcoma

    Adults:
    Ephiphyseal - GCT
    - EG
    - Chondrosarcoma (Clear Cell)

    Metaphyseal - MFH
    - Osteosarcoma
    - Chondrosarcoma
    - Chondormyxoid Fibroma

    Diaphyseal - Ewing’s
    - Lymphoma
    - Adamantinoma
    - Chondrosarcoma
    Epiphyseal lesions:
    Chondroblastoma (Ch) and giant cell tumor (GCT) are almost
    invariably centered in the epiphysis. Chondroblastoma is a
    rare tumor seen in children & adolescents with open growth
    plates. GCT is the most common tumor of epiphyses in
    skeletally mature individuals with closed growth plates. GCT
    often shows metaphyseal extension. Typically eccentrically
    located
    Metaphyseal intramedullary lesions:
    Osteosarcoma is usually centered in the metaphysis.
    Chondrosarcoma and fibrosarcoma often present as
    metaphyseal lesions. Osteoblastoma, enchondroma, fibrous
    dysplasia, UBC, & ABC are common in this location.
    Metaphyseal lesions centered in the cortex:
    Classic location for a non-ossifying fibroma (NOF). Also, a
    common site for osteoid osteoma.
    Metaphyseal exostosis:
    Osteochondroma. (cortical and medullary contact)
    Diaphyseal intramedullary lesions:
    Favored location for Ewing's sarcoma, lymphoma, (small
    round blue cells) myeloma. Common for fibrous dysplasia
    and enchondroma.
    Diaphyseal lesions centered in the cortex:
    Adamantinoma, osteoid osteoma.

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