- Hello, all participant of the International Society of Hypertension Annual Meeting two

thousand twenty two,

- I am Mulia Pradnyaandara from Udayana University, Bali, Indonesia
- Here, I would like to present A Systematic Review And Meta-analysis entitled:
- “Impact of SARS-CoV-2 Infection to Risk and Severity of Hypertension in Pregnamncy
and Its Outcome to The New Born”
-
- ladies and gentlemen, COVID-19 is still global health issue, which that existence persists
until this day
- Various comorbidities have been known to be a predisposing factor for SARS-CoV-2
infection with the proportion of hypertension as the most dominant comorbidity.
- COVID-19 is also known to have a poor outcome on pregnant women and their
newborns
- In this population, physiological changes during pregnancy involving the
cardiorespiratory and immune systems, cause changes in response to SARS-CoV-2
infection.
- Some studies also show the possibility of the fetus can be infected with COVID-19 during
the period of fetal development.
- However, that results are still debatable, because larger data from wide study are
needed to validate these findings
- Therefore, we conducted a systematic review and meta-analysis to determine the
relationship between COVID-19 in pregnancy and the risk and severity of hypertension
in pregnancy, in term of preeclampsia and its outcome in newborns.

- For Methods, We performed a systematic search in databases for studies examining

impact of SARS-CoV-2 infection on pregnancy.
- Included studies were evaluated for risk of bias based on the Newcastle Ottawa Score. A
meta-analysis was conducted using the data extracted from each study.
- Review Manager five point four was utilized to compute the summary of outcomes.
- Our outcomes of interest are preeclampsia, preeclampsia with severe features,
eclampsia, fetal distress and still birth.
- the other outcomes are preterm birth under thirty seven week, instrumental labor,
sectio caesaria and birth defect.

- And here is the results of our study.

- The final result of the search, we identified twenty two observational studies involving
one million twenty five hundred fourty eight pregnancy patients that meet our inclusion
and exclusion criteria.
- Based on the analysis, SARS-CoV-2 infection in pregnancy significantly increased the risk
of preeclampsia with Odd ratio two point zero one, and the severity based on the high
prevalence of preeclampsia with severe features with Odd ratio three point zero four.
- For the poor newborns outcomes, in terms of incidence of preterm birth, fetal distress
and still birth were also significantly associated with SARS-CoV-2 infection with odd ratio
one point sixty five, nineteen pont eighteen, two point twelve, respectively.
- So, for the conclusion :
- First, COVID-19 in pregnancy increases the risk of preeclampsia as well as the severity of
preeclampsia.
- Second, Preeclampsia together with COVID-19 has the potential to contribute to poor
newborn outcomes,
- And Finally, Prevention and immediate treatment have the potential to provide a better
outcome for both mother and baby.

- Its all about my presentation, thankyou for the attentions.