NAME OF DRUG MECHANISM INDICATION/ ADVERSE EFFECT/ SIDE EFFECT DRUG NURSING RESPONSIBILITIES

OF ACTION CONTRAINDICATION INTERACTION

GENERIC: Amikacin Interferes with NDICATIONs: CNS: Confusion, depression, Before:
proteinsynthesis Severe systemic infections of numbness, trem-
BRAND: Amikin in bacterial cell CNS, respiratory, GI, urinary Dx:
bybinding to tract, bone, skin, soft tis- CNS: Confusion, depression,numbness, trem-ors, a. Assess patient for
CLASS ribosomal sues caused by seizures, muscle twitching,neurotoxicity, previous sensitivity
:THERAPEUTIC: subunit,which Staphylococcus aureus dizziness,vertigo, tinnitus,neuromuscularblockade Reaction
Antibiotic causes (MSSA), Pseudomonas with respiratoryparalysis
misreading aeruginosa, Escherichia coli, b. Assess patient for
PHARMACOLOGIC: CV: Hypotension orhypertension signs and symptoms
ofgenetic code; Enterobacter,
Aminoglycosid of infection,
inaccuratepeptide Acinetobacter, Providencia,
EENT: Ototoxicity, deafness including
ROUTE:IM or IV sequence forms Citrobacter, Serratia,
inprotein chain, Proteus, Klebsiella characteristics of
GI: Nausea, vomiting,anorexia, bilirubin wounds, putum,
causingbacterial pneumoniae
death CONTRAINDICATION: urine, stool, WBC
GU: Oliguria, hematuria, renaldamage,azotemia, renal
Pregnancy D, mild to .10,000/mm3
failure,nephrotoxicity
moderate infections, earache, temp;
hypersensitivity to HEMA: Eosinophilia, anemia obtain baseline
aminoglycosides, sulfites information before
DRUG TO DRUG INTEG: Rash, burning, urticaria,dermatitis, alopecia and during
INTERACTION: Treatment
Increased: masking
c. Assess for allergic
Acyclovir, amphotericin B,
reactions: rash,
cidofovir, cycloSPO-
urticaria,
RINE, vancomycin:
Pruritus
nephrotoxicity
DimenhyDRINATE, Tx:
ethacrynic acid: a. Obtain weight
increasedmasking of ototoxicity before treatment;
effects with amikaci
calculation of
dosage is usually
based on ideal body
weight but may be calculated on
actual body weight

EDx:
a. Teach patient to
report sore throat,
bruising, bleeding,
joint pain; may
indicate blood
dyscrasias (rare)

During:
Dx:
a. Monitor VS during
infusion, watch for
hypotension,

change in pulse
b. Assess IV site for
thrombophlebitis including
pain, redness, swelling
q30min;

c. Assess bowel pattern

daily; if severe diarrhea
occurs, product should be
Discontinued

Tx:
a. change site if
needed; apply
warm compresses to
discontinued
Site

Tx:
a. Provide comfort
measures to help the
patient tolerate drug
effects.
EDx:
a. Advise patient to
contact prescriber if
vaginal itching,
loose foul-smelling
stools, furry tongue
occur; may indicate
Superinfection

b. Pregnancy/breastfe
eding: tell prescriber
if pregnancy is
planned or
suspected or if
breastfeeding; do
not use in
pregnancy,
breastfeeding