Gram (+) Gram (-)

Staph
Staph Strep. Strep. E.faecalis, Pseud. Mouth
epi/ PEK HNPEK CAPES B.frag atyp other info or bacteria
aureus Pneum Viridans E.faecium aerug anaer.
MRSA
PCN +/- BL +R + + N men + GPC +/- BL Treponema pallidum, Actinomyces, GPR, S. pyogenes Rheum fever proph.
Penicillins

+PE BL + BL Not
Ampicillin, Amoxicillin +/- BL + + + + +/- BL Listeria, Shigella, Salmonella, GBS
Not K K
Ampicillin-Sulbactam, Augmentin + + + + + + + +
Oxacillin, Nafcillin, Dicloxcillin + + + MSSA (DOC)
Piperacillin-tazobactam + + + + + + CPES + + +
Cefazolin, Cephalexin 1st + +R + + PEK +
Cefuroxime 2nd + + + + + +
Cefoxitin or Cefotetan 2nd + + + + + + +
Cephalosporins

Cefotaxime, Ceftriaxone 3rd + + + + + + +

Ceftazidime, Aztreonam 3rd + + + + Aztreonam: IgE-mediated hypersens. to PCN, Ceph, or Carba
Cefepime 4th + + + + + + + +
+/-
Ceftaroline 5th + MR + + + +/- faecalis + + + the only B-lactam that has activity against MRSA and MRSE (Staph epi)
CPES
Ceftazidime-avibactam (Avycaz) + + + CRE + + + Has activity against kpc-Gm (-)
Ceftolozane-tazobactam (Zerbaxa) + + + + + + MDR + + no actiivty against kpc-
Carbapenems

Imipenem, Meropenem, Doripenem + + + + faecalis + + + + + + BacterioSTATIC against E. faecalis

Mero-vaborbactam, Imi-relebactam + + + + faecalis + CRE + + + + + similar spec as mero, but has activity against kpc producing Enterobacteriacae

Ertapenem + + + + + CPES + +
Vancomycin + MR + + + + Meningitis (IT), C dif (PO), SSTI/Bacteremia/Pneum/Menin/Osteomy (IV)
Linezolid, Tedizol + MR + + + + VRE
+ VRE
Synercid (Dalfopristin-Quinupristin) + MR + + +
faecium
Dapto + MR + + + + VRE
+ (higher
Telavancin, Orita, Dalba + MR + + + MIC for VR
strains)
Most potent vs Pseudomonas in HAI pneumonia, Mycoplasma, Legionella >
Ciprofloxacin +/- R +/- R + (poor) + +U + + + + +
Chlamydia
Excellent in Mycoplasma, Legionella > Chlamydia (good in community-aquired
Levofloxacin +/- R +/- R + Resp + +U + + + + + +
pneumonia)
FQs

Excellent in Mycoplasma, Legionella > Chlamydia (good in community-aquired

Moxifloxacin +/- R +/- R + Resp + +U + + + + +/- R +
pneumonia)
Excellent in Mycoplasma, Legionella > Chlamydia (good in community-aquired
Delafloxacin + MR + + + + + + + + + + +
pneumonia)
Gent/Tobra synergy w B-lactam or vanco + + + +
plazomicin synergy w B-lactam or vanco + CRE + + + lower peak needed with UTIs bc AMG [ ] so well in bladder/urine/kidneys
AMG

Mycobacteria (Streptomycin (IM) also covers mycobacteria). Amikacin higher

Amikacin synergy w B-lactam or vanco + + + +
suscep rates than gent/tobra
H-both Mycobacterium avium complex (MAC), H. pylori, Azithromycin is PREFERRED for
Clari/Azith +/- R +/- R +R + +
N-azith txt for N. gonn
Doxy + MR + MR +R + + +/- R HN + +
Tigecycline + MR + MR + + + VRE + + +/- + + +
Clinda + Dtest +/- + + + +
Flagyl + +
TMP/SMX + MR + +/- R + + + +
nitrofurant +U +U +U EK/U +/- U
Polymixin B, Colistin (Poly E) EK H EK CA E + Salmonella, Shigella, [NOT anaerobes or Gm (-) cocci]