Clinical chemistry

The second lab

Title of the lecture : Creatinine test

Lecturer :Yasmine Salam Hassan

 A creatinine test is a measure of how well your kidneys are performing
their job of filtering waste from your blood.

 Creatinine is a chemical compound left over from energy-producing

processes in your muscles. Healthy kidneys filter creatinine out of the
blood. Creatinine exits your body as a waste product in urine.

 A measurement of creatinine in your blood or urine provides clues to help

your doctor determine how well the kidneys are working.
 For a serum creatinine test, a member of your health care team takes
a blood sample by inserting a needle into a vein in your arm.
 For a urine test, you’ll need to provide a single sample in the clinic
or collect samples at home over 24 hours and return them to the
clinic.
 Serum creatinine is reported as milligrams of creatinine to a
deciliter of blood (mg/dL) or micromoles of creatinine to a liter of
blood (micromoles/L). The typical range for serum creatinine is:
 For adult men, 0.74 to 1.35 mg/dL (65.4 to 119.3 micromoles/L)
 For adult women, 0.59 to 1.04 mg/dL (52.2 to 91.9 micromoles/L)
Creatinine in urine
 Aminotransferases
 Aminotransferases or transaminases are a group of enzymes that
catalyze the interconversion of ammo acids and ketoacids
(oxoacids) by transfer of amino group
 The two aminotransferases of greatest clinical significance are:
 Aspartate aminotransferase (AST), formerly termed glutamate
oxaloacetate transaminase (GOT).
 Alanine aminotransferase (ALT), formerly termed glutamate
pyruvate transaminase (GPT).
QUIZ
 WHAT IS UREMIA???