4/14/23, 10:45 PM Varicella Zoster (Chickenpox) - StatPearls - NCBI Bookshelf

Varicella Zoster (Chickenpox)

Ayoade F, Kumar S.

Continuing Education Activity

Chickenpox or varicella is a contagious disease caused by the varicella-zoster virus (VZV). The virus is responsible for chickenpox (usually primary
infection in non-immune hosts) and herpes zoster or shingles (following reactivation of latent infection). Chickenpox results in a skin rash that forms
small itchy blisters which scab over. This activity describes the cause, presentation, and pathophysiology of chickenpox and highlights the role of the
interprofessional team in the treatment and prevention of this infection.

Objectives:

Identify the etiology of chickenpox.

Review the presentation of chickenpox.
Outline the treatment and management options available for chickenpox.
Explain interprofessional team strategies for improving care coordination and outcomes in patients with chickenpox.

Access free multiple choice questions on this topic.

Introduction
Chickenpox or varicella is a contagious disease caused by the varicella-zoster virus (VZV). The virus is responsible for chickenpox (usually primary
infection in non-immune hosts) and herpes zoster or shingles (following reactivation of latent infection). Chickenpox results in a skin rash that forms
small, itchy blisters, which scabs over. It typically starts on the chest, back, and face then spreads. It is accompanied by fever, fatigue, pharyngitis, and
headaches which usually last five to seven days. Complications include pneumonia, brain inflammation, and bacterial skin infections. The disease is
more severe in adults than in children. Symptoms begin ten to 21 days after exposure, but the average incubation period is about two weeks.

Chickenpox is a worldwide, airborne disease that is spread by coughing and sneezing, and also by contact with skin lesions. It may start to spread one
to two days before the rash appears until all lesions are crusted over. Patients with shingles may spread chickenpox to those who are not immune
through blister contact. The disease is diagnosed based on the presenting symptoms and confirmed by polymerase chain reaction (PCR) testing of the
blister fluid or scabs. Tests for antibodies may be performed to determine if immunity is present. Although reinfections by varicella may occur, these
reinfections are usually asymptomatic and much milder than the primary infection.

The varicella vaccine was introduced in 1995 and has resulted in a significant decrease in the number of cases and complications. It prevents about
70% to 90% of infections and 95% of severe disease. Routine immunization of children is recommended. Immunization within three days of exposure
may still improve outcomes in children. [1][2][3]

Etiology
Chickenpox or varicella is caused by the varicella-zoster virus (VZV), a herpesvirus with worldwide distribution. It establishes latency after primary
infection, a feature unique to most herpes viruses. [4]

It is acquired by inhalation of infected aerosolized droplets. This virus is highly contagious and can spread rapidly. The initial infection is in the
mucosa of the upper airways. After 2-6 days, the virus enters the circulation and another bout of viremia occurs in 10-12 days. At this time the
characteristic vesicle appears. IgA, IgM, and IgG antibodies are produced but it is the IgG antibodies that confer life long immunity. After the primary
infection, varicella localized to sensory nerves and may reactivate later to produce shingles.

Epidemiology
Varicella occurs in all countries and is responsible annually for about 7000 deaths. In temperate countries, it is a common disease of children, with
most cases occurring during the winter and spring. In the United States, it accounts for more than 9000 hospitalizations annually. Its highest
prevalence is in the 4 to 10-year-old age group. Varicella has an infection rate of 90%. Secondary cases in household contacts tend to have more severe
disease than primary cases. In the tropics, varicella tends to occur in older people and may cause more serious disease. Adults will get deep pock
marks and more prominent scars.[5][6][7]

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Pathophysiology
Exposure causes the production of host immunoglobulin G, M, and A. IgG antibodies persist for life and confer immunity. Cell-mediated immune
responses are important in limiting the duration of primary varicella infection. After primary infection, it is theorized varicella spreads to mucosal and
epidermal lesions to local sensory nerves. It then remains latent in the dorsal ganglion cells of the sensory nerves. The immune system keeps the virus
in check but reactivation can still occur later in life and results in the clinically distinct syndrome of herpes zoster (shingles), postherpetic neuralgia,
and sometimes Ramsay Hunt syndrome type II. Varicella zoster can harm the arteries in the neck and head, resulting in a stroke.

The United States Advisory Committee on Immunization Practices (ACIP) suggests that all adult older than the age of 60 years old get vaccinated to
avoid herpes zoster. One in five adults who had chickenpox as children, especially those who are immune-suppressed,  get singles. Shingles are most
commonly found in adults older than the age of 60 who were diagnosed with chickenpox before the age of 1.[8][9]

History and Physical

The prodromal symptoms in adolescents and adults are aching muscles, nausea, decreased appetite, and headache followed by a rash, oral sores,
malaise, and a low-grade fever. Oral manifestations may precede the skin rash. In children, the illness may not be preceded by prodromal symptoms,
and the initial sign could be a rash or oral cavity lesions. The rash begins as small red dots on the face, scalp, torso, upper arms and legs. Over the next
ten to 12 hours it progresses to small bumps, blisters, and pustules; and eventually umbilication and scabs formation. Of note, the rash of chickenpox
occur in crops and are typically at different stages of evolution.

At the blister stage, intense pruritus is present. Blisters may occur on the palms, soles, and genital area. Commonly, visible evidence develops in the
oral cavity and tonsil areas in the form of small ulcers which can be painful and itchy; this enanthem may precede the external exanthem by one to
three days. These symptoms appear ten to 21 days after exposure. Adults may have a more widespread rash and longer fever, and they are more likely
to develop pneumonia, the most important complication in adults.

Because watery nasal discharge containing live virus precedes exanthems by one to two days, the infected person is contagious one to two days before
recognition of the disease. In the majority of cases, the infection resolves itself within two to four weeks.

A common complication is a secondary bacterial infection that can present as cellulitis, impetigo or erysipelas.

Disseminated primary varicella is usually seen in immunocompromised individuals and carries a very high mortality. CNS complications are rare but
may present as Guillain barre syndrome or encephalitis.

Primary varicella infection during pregnancy can also affect the fetus, who may present later with chickenpox. In addition, the virus also has the
potential to cause the varicella congenital syndrome.

Evaluation
The diagnosis of varicella infection is primarily based on the signs and symptoms. Confirmation is by examination of the fluid within the vesicles,
scraping of lesions that have not crusted or by blood for evidence of an acute immunologic response. Polymerase chain reaction (PCR) has the highest
yield and can be utilized for non-skin samples such as bronchoalveolar lavage sample and cerebrospinal fluid. Direct fluorescent antibody testing has
largely replaced the Tzanck test. The vesicular fluid can also be cultured, but the yield is low compared to PCR.  Blood tests are used to identify a
response to acute infection (IgM), previous infection, and subsequent immunity (IgG). Prenatal diagnosis of fetal varicella can be performed using
ultrasound, though a delay of 5 weeks following primary maternal infection is advised. A PCR (DNA) test of the amniotic fluid can be performed,
though the risk of spontaneous abortion due to amniocentesis is higher than the risk of the baby developing fetal varicella. [10][11]

Treatment / Management
Treatment is symptomatic relief of symptoms. As a protective measure, those infected are usually required to stay at home while they are infectious.
Keeping nails short and wearing gloves may prevent scratching and reduce the risk of secondary infections. [12][13][1]

Topical calamine lotion may relieve pruritus. Daily cleansing with warm water will help avoid secondary bacterial infection. Acetaminophen may be
used to reduce fever. Avoid aspirin as it may cause Reye syndrome. People at risk of developing complications and who have had significant exposure
may be given intramuscular varicella-zoster immune globulin, a preparation containing high titers of antibodies to varicella-zoster virus, to help
prevent the disease.[14]

In children, acyclovir decreases symptoms by one day if taken within 24 hours of the start of the rash, but it has no effect on complication
rates, and it is not recommended for individuals with normal immune function.

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In adults, infection tends to be more severe, and treatment with antiviral drugs (acyclovir or valacyclovir) is advised if they can be started
within 24 to 48 hours of rash onset. Supportive care such as increasing water intake and the use of antipyretics and antihistamines are an
important part of the management. Antivirals are typically indicated in adults, including pregnant women because this group is more prone to
complications. The preferred treatment is usually oral therapy, but for immunocompromised patients, intravenous antivirals are indicated.

The varicella-zoster immunoglobulin is used to manage patients who are immunocompromised. In addition, a live attenuated vaccine has been
available since 1995. There is high seroconversion following the vaccine which is long lasting. Adverse effects of the vaccine are rare.

Differential Diagnosis
Insect bites
Impetigo
Small pox
Drug eruptions
Dermatitis herpetiformis

Prognosis
In healthy children, the prognosis is excellent. However, in immunocompromised individuals, the infection has high morbidity.

Consultations
Pediatrician
Infectious disease consultant

Pearls and Other Issues

Chickenpox is rarely fatal. Non-immune pregnant women and those immunocompromised are at highest risk. Arterial ischemic stroke associated with
childhood chickenpox is a significant risk. Varicella pneumonia is the most common cause of fatality in adults (10% to 30%), and in those requiring
mechanical ventilation, this may reach 50%.

In pregnant women, antibodies produced as a result of immunization or previous infection are transferred via the placenta to the fetus. Varicella
infection in pregnant women could spread via the placenta and infect the fetus. If infection occurs during the first 28 weeks of pregnancy,
congenital varicella syndrome may develop. Effects on the fetus can include underdeveloped toes and fingers, structural eye damage, neurological
disorder, and anal and bladder malformation.

If maternal infection occurs seven days before delivery and up to eight days following birth, the baby may develop neonatal varicella with
presentation ranging from mild rash to disseminated infection. Newborns who develop symptoms are at a high risk of pneumonia and other serious
complications.

Maternal herpes zoster, on the other hand, constitutes little risk of neonatal complications or congenital varicella syndrome probably because of
established circulating maternal antibodies.

Enhancing Healthcare Team Outcomes

Chickenpox is usually acquired after inhalation of aerosolized droplets from an infected individual. The majority of cases occurring in children less
than 10. The key to lowering the morbidity of chickenpox is via education. Besides the primary caregiver, the nurse practitioner and pharmacist play a
vital role in patient education. The parents of infected children should be told to trim the child's fingernails to avoid or minimize skin damage and the
associated bacterial infections. Further, parents should be told not to give aspirin to young children to control fever, because of the risk of developing
Reye syndrome. Finally, the parents should be told to apply cold compresses and keep the skin moisturized to prevent the itching and dryness.[15][16]
[17] All clinicians should urge parents to get their children vaccinated because this can prevent the morbidity associated with the infection. The
vaccine is safe and very effective. Children who are immunocompromised should be referred to an infectious disease specialist for further
management. (Level V) Clinicians should also educate pregnant women who are seronegative for chickenpox to avoid contacts with patients with an
active infection. All pregnant women who develop chickenpox must be managed by a team of specialists who can make a decision regarding
treatment.

Outcomes

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For most children who develop chickenpox, the outcome is excellent. However, in immunocompromised individuals, there is increased morbidity and
mortality. [18][19][20](Level V)

Review Questions
Access free multiple choice questions on this topic.
Comment on this article.

Figure
Chickenpox (Varicella). Contributed by the Center for Disease Control and Prevention (CDC)

References
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Publication Details

Author Information and Affiliations

Authors

Folusakin Ayoade1; Sandeep Kumar2.

Affiliations
1
University of Miami
2
VA Medical Center

Publication History

Last Update: October 15, 2022.

Copyright
Copyright © 2023, StatPearls Publishing LLC.

This book is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) (
http://creativecommons.org/licenses/by-nc-nd/4.0/ ), which permits others to distribute the work, provided that the article is not altered or used commercially. You are not
required to obtain permission to distribute this article, provided that you credit the author and journal.

Publisher

StatPearls Publishing, Treasure Island (FL)

NLM Citation

Ayoade F, Kumar S. Varicella Zoster (Chickenpox) [Updated 2022 Oct 15]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-.

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