Author Year Species strain Age

Ahmet et al., 2006 Rats SD 8 weeks

Leandra et al., 2008 Rats Wistar 30 days
Yusuf et al., 2009 Rats Wistar 5-6 weeks
Azu et al., 2010 Rats SD Unspecified
Ahmed et al., 2011 Rats Unspecified Unspecified
Emad et al., 2012 Rats Wistar Unspecified
Narayana et al., 2013 Rats SD 13-25 weeks
Iman et al., 2014 Rats SD 2 months
Adejuwon et al., 2015 Rats Wistar Unspecified
Kiran et al., 2015 Rats SD 9-10 weeks
 Body
Duration Frequency Route Vehicle Dosage
weight
210-250 g 5 & 50 days Single dose (D1) i.p. Saline 7 mg/kg b.w.
Unspecified 12 hr max. N/A i.p. Saline 5 mg/kg
340-350 g 40 days 5 consecutive doses i.p. Saline 7 mg/kg b.w./day
200 g 4 weeks Single dose (D1) i.p. Saline 10 mg/kg b.w.
120-150 g 4 weeks Once a week i.p. Saline 2 mg/kg b.w.
220 g 15 days Single dose (D1) i.p. Saline 10 mg/kg b.w.
Unspecified 63 days 5 doses per 21 day cycle i.p. Saline 1.5 mg/kg b.w.
200 g 10 days Single dose (D1) i.p. Saline 7 mg/kg b.w.
200 g 5 days Single dose (D21) i.p. Saline 10 mg/kg b.w.
250-300 g 28 days Single dose (D1) i.p. Saline 10 mg/kg b.w.
 Author Year Species strain Age

Swathy et
2006 Rats SD Unspecified
al.,
Maneesh et
2007 Rats Wistar 10-12 weeks
al.,
120-180
Begg et al., 2008 Rats SD
days
Martinez et
2009 Rodent C. callosus 3 months
al.,

Talebi et al., 2010 Rats Wistar 10 week

Nabil eid et
2011 Rats Wistar Unspecified
al.,
Dosumu et
2012 Rats SD Unspecified
al.,

Uygur et al., 2013 Rats Wistar 3 months

Olutope et
2014 Rats Unspecified Unspecified
al.,

Siervo et al., 2015 Rats Wistar 90 days

 Body
Duration Route Vehicle Dosage
weight
Drinking
90-110 g 60 days p.o. 4 g/kg b.w.
water
Distilled 1.6 g/kg
100-120 g 28 days p.o.
water b.w.
>10 g/kg
367-582 g 5 weeks p.o. Water
b.w./pair

47 g 120 days p.o. Water 20% v/v

5% v/v of
200-225 g 50 days p.o. Water
99% ethanol

300 g 12 weeks p.o. Water 36% v/v

150-170 g 4 weeks p.o. Water 30% v/v

40% v/v at
275-325 g 8 weeks p.o.* Water
3g/kg b.w.
25% v/v at
130 – 340 g 10 weeks p.o. Water
5g/kg
25% v/v at 2
320 g 63 days p.o. Water
g/kg