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  • Isogeometric Solvers For Cardiac Reaction-Diffusion Equations Coupled With Induced Pluripotent Stem Cell Ionic Models

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    SOFIA BOTTI
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    The document discusses using isogeometric solvers to couple cardiac reaction-diffusion equations with induced pluripotent stem cell ionic models to simulate action potential propagation in engineered ventricles. Specifically, it uses a multiphysics approach to couple a cardiac Monodomain reaction diffusion model with stem cell ionic models. The coupled model is then discretized using Isogeometric Analysis in space and finite differences in time to virtually represent a ventricle composed of derived cardiomyocytes.

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    The document discusses using isogeometric solvers to couple cardiac reaction-diffusion equations with induced pluripotent stem cell ionic models to simulate action potential propagation in engineered ventricles. Specifically, it uses a multiphysics approach to couple a cardiac Monodomain reaction diffusion model with stem cell ionic models. The coupled model is then discretized using Isogeometric Analysis in space and finite differences in time to virtually represent a ventricle composed of derived cardiomyocytes.

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    13 views1 page

    Isogeometric Solvers For Cardiac Reaction-Diffusion Equations Coupled With Induced Pluripotent Stem Cell Ionic Models

    Uploaded by

    SOFIA BOTTI
    The document discusses using isogeometric solvers to couple cardiac reaction-diffusion equations with induced pluripotent stem cell ionic models to simulate action potential propagation in engineered ventricles. Specifically, it uses a multiphysics approach to couple a cardiac Monodomain reaction diffusion model with stem cell ionic models. The coupled model is then discretized using Isogeometric Analysis in space and finite differences in time to virtually represent a ventricle composed of derived cardiomyocytes.

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    © All Rights Reserved
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    ICIAM 2023, August 4 – 8, Tokyo, Japan

    Isogeometric solvers for cardiac reaction-diffusion equations


    coupled with Induced Pluripotent Stem Cell ionic models

    immediate

    Abstract
    Regenerative cardiology is recently employing human induced pluripotent stem cells derived cardiomy-
    ocytes to advance in patient-specific medicine. A multiphysics approach to the problem allows to couple
    the cardiac Monodomain reaction diffusion model with stem cell ionic models to simulate the action
    potential propagation in the engineered ventricle. The coupled model is then discretized using Isoge-
    ometric Analysis in space and finite differences in time to obtain a virtual representation of a derived
    cardiomyocytes ventricle.

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