Haematology

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Anaemia

History:

- Chest pain
- Shortness of breath
- Fatigue
- Diet – vegan?
- Drug Hx

? Source of blood loss

- PR bleed
- Haematemesis
- Menorrhagia
- Haematuria
- Epistaxis

? Red flags

- Weight loss
- Night sweats
- Fever
- FHx of cancer
- Smoking
- Alcohol intake

Examination:

- Appearance / colour
- Conjunctiva
- Weight
- Chest
- Abdomen
- PR

Differentials:

- Microcytic – IDA, thal


- Normo – blood loss, bone marrow, chronic disease
- Macro – B12, folate, alcohol, hypothyroidism

Management (dependent on the type of anaemia):

- Blood film and reticulocyte count


- Ferritin, B12, folate, transferrin sats
- Immunoglobulins, serum protein electrophoresis, serum free light chains
- Renal and liver function
- ESR and CRP
- Autoimmune screen to exclude chronic inflammation
- Coeliac screen, Urinalysis for occult blood loss
- Upper and lower GI investigation in: All men and post-menopausal women
- Targeted GI investigation in pre-menopausal women with upper GI symptoms or FH of
colorectal cancer
- Persistent IDA despite treatment – routine referral to haematology

https://www.nwlondonccg.nhs.uk/application/files/6116/0405/1009/1._Anaemia_pathway.pdf

https://www.nwlondonccg.nhs.uk/application/files/4715/9376/8471/
iron_deficiency_anaemia_v1.pdf

Abnormal bleeding / bruising history:

https://www.nwlondonccg.nhs.uk/application/files/
4116/0405/1011/20._Abnormal_bleeding_and_bruising.pdf

High platelets:

https://www.nwlondonccg.nhs.uk/application/files/3216/0405/1010/12._Thrombocytosis.pdf

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