MEHANISM OF INDICATION/ SIDE EFFECTS AND NURSING

ACTION CONTRAINDICATION ADVERSE EFFECTS CONSIDERARTIONS

Generic name: Amikacin is most Indications: Kidney damage and hearing Always wash hands
Amikacin often used for Suspected or proven late-onset loss are the most important thoroughly and disinfect
treating severe, neonatal sepsis. effects. to help prevent the
Brand name: Amicin hospital-acquired Treatment of serious infections due spread of infection. Use
infections with to susceptible strains of Gram Numbness, skin tingling, universal precautions or
Classification: multidrug-resistant negative bacilli resistant to other muscle twitching, or seizures. isolation procedures as
Aminoglycosides Gram-negative aminoglycosides. indicated for specific
bacteria. Treatment of serious gram-negative patients.
Dosage: Inhibits protein bacillary infections and infections
15mg/kg/day synthesis in bacteria caused by staphylococci when
at level of 30S penicillins or other less toxic drugs  Assess patient
Frequency: QD q8- ribosome. are contraindicated. for signs and
12hr symptoms of
Therapeutic Effects: Contraindications: Hypersensitivity infection prior to
Route: IV/IM Bactericidal action. to amikacin/other aminoglycosides. and throughout
therapy.
Spectrum: Most 1. Extreme caution in neonates with  Instruct patient
aminoglycosides renal dysfunction. to continue
notable for activity taking
against P. 1. Most parenteral products medication
aeruginosa, contains bisulfides and around the clock
Klebsiella should be avoided in until finished
pneumoniae, E. patients with known completely, even
coli, Proteus, tolerance. Products if feeling better.
Serratia, containing benzyl alcohol  Keep patient
Acinetobacter, should be avoided in hydrated during
Staphylococcus neonates. therapy.
aureus. In treatment  Instruct patient
2. Use cautiously in: Renal
of enterococcal to report signs of
impairment (dose
infections, synergy
adjustments necessary;
with a penicillin is hypersensitivity.
required. blood level monitoring
useful in preventing
ototoxicity and
nephrotoxicity); Hearing
impairment; Pedi: Neonates
have increased risk of
neuromuscular blockade;
cautious use due to difficulty
in assessing auditory and
vestibular function and
immature renal function.