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  • 5 - Ecologia de Fiebre Hemorragica Boliviana

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    Sergio Luis Fernandez Salinas
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    This document summarizes research on the systematics of Calomys, a genus of rodents that serve as reservoirs for Machupo virus, which causes Bolivian hemorrhagic fever. The researchers sequenced mitochondrial DNA from over 60 Calomys specimens across several species to clarify their relationships. They found multiple species were previously lumped together as C. callosus. Accurately defining Calomys species is important for understanding the ecology and epidemiology of Machupo virus. The research highlights how systematics research can aid public health efforts like vector control and predictive disease modeling.

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    5_Ecologia de fiebre hemorragica boliviana

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    This document summarizes research on the systematics of Calomys, a genus of rodents that serve as reservoirs for Machupo virus, which causes Bolivian hemorrhagic fever. The researchers sequenced mitochondrial DNA from over 60 Calomys specimens across several species to clarify their relationships. They found multiple species were previously lumped together as C. callosus. Accurately defining Calomys species is important for understanding the ecology and epidemiology of Machupo virus. The research highlights how systematics research can aid public health efforts like vector control and predictive disease modeling.

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    12 views10 pages

    5 - Ecologia de Fiebre Hemorragica Boliviana

    Uploaded by

    Sergio Luis Fernandez Salinas
    This document summarizes research on the systematics of Calomys, a genus of rodents that serve as reservoirs for Machupo virus, which causes Bolivian hemorrhagic fever. The researchers sequenced mitochondrial DNA from over 60 Calomys specimens across several species to clarify their relationships. They found multiple species were previously lumped together as C. callosus. Accurately defining Calomys species is important for understanding the ecology and epidemiology of Machupo virus. The research highlights how systematics research can aid public health efforts like vector control and predictive disease modeling.

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    of 10

    15/08/2014

    Systematics of Calomys
    Epidemiology of Bolivian Hemorraghic
    Fever
    Jorge Salazar Bravo, Jerry W. Dragoo, Terry L.
    Yates
    Univ. of New Mexico, Albuquerque, NM 87131

    • 1959
    “Black Typhus”
    San Joaquin

    1
    15/08/2014

    Symptoms 1

    Karl Johnson

    2
    15/08/2014

    Machupo Virus

    Calomys callosus (Rengguer 1830)

    3
    15/08/2014

    Calomys callosus for Hershkovitz, 1962

    C. bolivae
    C. fecundus
    C. muriculus
    C. venustus
    C. callidus
    C. callosus
    C. expulsus

    Late 80s & Early 1990: Olds & Vitullo et al.

    • Olds: Calomys callosus  Calomys venustus


    based on morphology

    • Vitullo et al. : Calomys callidus  Calomys venustus


    based on chromosomal information
    C. callidus 2n=48; C. venustus 2n=56

    4
    15/08/2014

    Margin ZP ant. M1
    Parapt. fossae enlarged

    Mesoflex
    Mesopt Fos > tooth from M3 Not reduced

    However...
    • Dots: records of “C. callosus”
    to 1998

    • Endemic area of BHF Latino virus


    and Machupo Virus
    • Lack of agreement in the
    areas of distribution
    WHY??

    5
    15/08/2014

    Methods:

    • Sequenced complete cyt-b in 62 specimens of


    Calomys (several species), using Smith and
    Patton 1993, and our primers (981 & 480) to obtain
    1143 bp)

    • Sequenced complete control region in 31 animals


    assigned to Calomys callosus or Calomys venustus
    from Argentina, Bolivia, and Paraguay (1009 bp)

    Control Region

    6
    15/08/2014

    Methodology

    • Maximum Likelihood, Maximum Parsimony,


    Neighbor Joining in PAUP*.

    • All substitution, unordered -- info is on third base position

    • Bootstrap values and majority rule consensus values

    C. sorellus
    C. cal - Beni
    C. cal - foothills
    C. cal - Chaco
    C. venustus

    7
    15/08/2014

     The Importance of Systematics to Public Health


    •Ecological work
    •Epidemiology
    •Vector Control
     The importance of Systematics to Multidi-
    sciplinary Research
    • Combination of efforts and resources
     Coevolutionary studies of host/parasite evol.
    • Predictive models    Monitoring/Control

    Acknowledgements:

    Funding Agencies: (NSF, CDC-Atlanta, HIS,


    UNM, LAI-UNM)

    Lab/Museum work: David Tinnin, Bill Gannon


    Mariel Campbel, Jon Dunnum.

    Life in General: Jackie (wife), Fernando & Sofia

    8
    15/08/2014

    Savanah
    Yungas Forest

    Chaco

    9
    15/08/2014

    10

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