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Uses: Saline laxative may be used to treat occasional constipation but it should not be used regularly for
this purpose.

Take this medicine by mouth. Follow the directions on the package or prescription label. Use a specially
marked spoon or container to measure each dose. Ask your pharmacist if you do not have one.
Household spoons are not accurate. Drink a full glass of fluid with each dose of this medicine. This
medicine may taste better if it is chilled before you drink it. Do not take your medicine more often than
directed.

This product is used to clean stool from the intestines before surgery or certain bowel procedures
usually with other products. It may also be used for relief of constipation. However, milder products
(e.g., stool softeners, bulk-forming laxatives) should be used whenever possible for constipation.
Magnesium citrate is a saline laxative that is thought to work by increasing fluid in the small intestine.
It usually results in a bowel movement within 30 minutes to 3 hours.

Side effects

Side effects that you should report to your doctor or health care professional as soon as
possible:

allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue breathing problems

chest pain fast, irregular heartbeat muscle weakness nausea or vomiting.

Formulation:

Magnesium Citrate Oral Solution is a sterilized or pasteurized solution containing, in each 100mL, not
less than 7.59g of anhydrous citric acid (C 6H8O7) and an amount of magnesium citrate equivalent to not
less than 1.55g and not more than 1.9g of magnesium oxide (MgO).

Magnesium Carbonate- Magnesium carbonate is a magnesium salt with formula (MgCO3). Its hydrated
forms, and tetrahydrates occur as minerals. It has a role as an antacid and a fertilizer.

Anhydrous Citric Acid- Anhydrous Citric Acid (C6H8O7) is a tricarboxylic acid found in citrus fruits.
Citric acid is used as an excipient in pharmaceutical preparations due to its antioxidant properties. It
maintains stability of active ingredients and is used as a preservative.
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Potassium Bicarbonate- (KHCO3) It is used in medicine as an antacid. Potassium bicarbonate is a

white, crystalline, slightly alkaline and salty substance. It is produced by the passage of carbon dioxide
through an aqueous potassium carbonate solution.

The KHCO3 may be replaced by 2.1 g of NAHCO3 preferably in tablet form and may further carbonated
by the use of CO2, under pressure. Stability is improved by adjusting the quantity of MgCO 3 for each
250 mL of solution so that it corresponds to 6 g of MgO and by sterilizing the solution after it has been
bottled. Proper amount of citric acid is used to allow for an excess after the neutralization of MgCO 3.
An excess is necessary to react with the HCO 3 added to form CO2 which gives flavor and therapeutic
effectiveness through formation of alkali citrates. Precipitation on standing is increased by the presence
of sucrose and CO2 and decreased by sterilization of the finished product. If sterilizers of the finished
product are not available, stopper may be sterilized by boiling with water for 20-30 minutes.

The chemical reaction involved in the preparation may be represented by the following equations:

5C3H4(OH)(COOH)3 + (MgCO3)4.Mg(OH)2 + 5H2O → 4CO2 + 11H2O + 5C3H4(OH)(COOH)(COO)2Mg

Materials: bottle, beaker, pipette or syrup dropper, graduated cylinders, funnel.

Warnings:

Do not use laxative products for longer than 1 week unless directed by a doctor. Ask a doctor before use
if you have kidney disease, sodium restricted diet, a magnesium restricted diet stomach pain, nausea or
vomiting.

Dosage is based on your medical condition, age, and response to treatment. Drink a full glass of water (8
ounces or 240 milliliters) after taking this product unless otherwise directed by your doctor. Doing so will
help prevent serious side effects (e.g., a loss of too much body water-dehydration).

If this product is used too frequently, it may cause loss of normal bowel function and an inability to
have a bowel movement without using the product (laxative dependence). If you notice symptoms of
overuse, such as diarrhea, abdominal pain, decreased weight, or weakness, contact your doctor
promptly.

Avoid taking tetracycline/quinolone antibiotics (e.g., doxycycline, tetracycline, ciprofloxacin) within 2

hours before or after this product. Doing so may decrease the effect of the antibiotic.
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References:

http://www.newdruginfo.com/pharmacopeia/usp28/v28230/usp28nf23s0_m46740.htm

https://my.clevelandclinic.org/health/drugs/20745-magnesium-citrate-oral-solution

https://www.webmd.com/drugs/2/drug-522-2202/magnesium-citrate-oral/magnesium-citrate-oral/details

https://www.nationwidechildrens.org/family-resources-education/family-resources-library/
dextromethorphan-oral-solution-and-syrup

https://my.clevelandclinic.org/health/drugs/19291-brompheniramine-oral-suspension

https://www.nationwidechildrens.org/family-resources-education/family-resources-library/
erythromycin-tablets-or-capsules-delayed-release

https://www.webmd.com/drugs/2/drug-8621-2109/bisacodyl-rectal/bisacodyl-enema-rectal/details

https://www.webmd.com/drugs/2/drug-56008/citroma-oral/details
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https://www.mvorganizing.org/how-long-do-effects-of-magnesium-citrate-last/

https://healthy.kaiserpermanente.org/health-wellness/drug-encyclopedia/drug.citrate-of-magnesia-
oral.263751

https://medlineplus.gov/druginfo/meds/a620016.html

https://www.webmd.com/drugs/2/drug-522-2202/magnesium-citrate-oral/magnesium-citrate-oral/
details?fbclid=IwAR1GCkH-IvZTl8QSrZ6PZhFodcwhVIuqpvvfJR2jlaqykJf0XOU4FmY9eFs

https://en.wikipedia.org/wiki/Magnesium_citrate

https://medlineplus.gov/druginfo/meds/a619019.html?
fbclid=IwAR2PptPSj4dsplUbFitYB0F43oGwwegD8-XgIrDgWJUB9rEQUcTo5Ty-ZYA

https://www.medicalnewstoday.com/articles/322588?
fbclid=IwAR0f18Jnr8NCbGwR8FVJUTc4ShfwAaZQbF8wKcbzouC5jSJWb8A4QOq2wB0#_noHeade
rPrefixedContent

https://www.healthline.com/health/essential-oils-for-constipation#lemon-oil

https://rxistsource.blogspot.com/2014/12/preparation-of-solutions-part-ii.html