School of Medical And Allied Sciences

Course Code : MPHT1002 Course Name: Drug delivery system

Module 5
Lecture 3
Peptide & protein drug delivery systems

Name of the Faculty: Prof. P.K Sharma Program Name: M.Pharm

 Disclaimer

• All the content material provided here is only for

teaching purpose.
 Objective

To understand the concept of parental and non-parental

route of proteins and peptide delivery system?
 Hydrogel based drug delivery system

Hydrogels are three dimensional networks of

hydrophilic polymers that are insoluble-

➢Hydro gels are polymers which have the ability to

swell in water .
➢Biodegradable hydro gels are used, due to its
biocompatibility .
Examples: Hydroxymethylacrylate, used to minimize
mechanical irritation to surrounding tissue
 Hydrogel based drug delivery system

EMULSION BASED DELIVERY

➢Emulsions can be used for parenteral drug delivery of
proteins and peptides used to prolong the release of drug.
➢e.g. subcutaneous administration of muramyl dipeptide
in a w/o emulsion. It is used to potentiate immune system.

CELLULAR CARRIERS
➢Protein and peptides can be incorporated in
erythrocytes to achieve the prolong release or targeting.
➢Resealed erythrocytes as delivery system for c-reactive
protein, and mainly used to target liver and spleen.
 PUMPS

Types of pumps:
1. IMPLANTABLE PUMPS
➢ Drug is implanted subcutaneously, and delivered by I.V
infusion.
➢ Pumps are filled with drug through a septum with a
needle.
➢ Pumps deliver drugs to central vein for 7-14 days a
constant rate.
 PUMPS

2. MECHANICAL PUMPS
➢ Easily manipulated to deliver protein and
peptide drugs.
Example: insulin has been successfully
delivered by portable syringe.
 NON PARENTERAL ROUTES OF ADMINISTRATION

Parenteral route is not properly achievable, hence other

routes are preferred.
➢Oral route.
➢Rectal route.
➢Nasal route.
➢Pulmonary route.
➢Buccal route.
➢Transdermal route.
➢Ocular route
 ORAL ROUTE

ORAL ROUTE

❖Encapsulated peptides or proteins in amino acids with

microsphere of approximately 10 micron in diameter , used
for oral delivery.
Example: Insulin and heparin.
❖Orally administered insulin produces hypoglycemic effect

DISADVANTAGES:
Acid catalyzed degradation in stomach.
❖Proteolysis in GIT.
 Transdermal route of administration

Transdermal route of administration

➢This is topical medication.
➢Drug is absorbed through the skin.
EX: Insulin, vasopressin
ADVANTAGES:
➢Controlled administration of drug is possible.
➢Improved patient compliance.
➢ Drugs with short half lives can be administered.
DISADVANTAGES:
➢High intra and inter patient variability.
➢Low permeation because of high molecular weight.
➢Hydrophilicity and lipophilicity of stratum corneum.
 Approaches for protein and peptide drug delivery

Number of approaches are available for effective

protein and peptide drug delivery.
➢They are
▪IONTOPHORESIS
▪PHONOPHORESIS
▪PENETRATION ENHANCERS
▪PRODRUG
 Approaches for protein and peptide drug delivery

➢Iontophoresis: Used for local and systemic

delivery of proteins and peptides. In this an electric
current is used to drive the molecules across the
skin surface.
Example: Transport of insulin using iontophoresis.

➢Phonophoresis: The absorption is enhanced by

thermal effect of ultrasonic waves and subsequent
alteration of physical structure of skin surface.
Pulmonary route of administration
 Pulmonary route of administration

ADVANTAGES:
➢Decrease in dose requirement.
➢Fast absorption
➢Increased patient compliance

DISADVANTAGES:
➢Inflammation may be observed in lungs.
➢Degree of bioavailability was less due to hydrolytic
enzymes present in lungs
 Rectal route of administration

Rectal route of administration

➢Rectum is highly vascularised body cavity.
➢Rectal mucosa is devoid of villi.
➢Drugs are in form of suppositories, gel, dry
powders.
EX: Insulin, calcitonin
ADVANTAGES:
➢Reduced proteolytic degradation.
➢Improved systemic bioavailability with co-
administration of absorption enhancers.
EX: surfactants Large dose can be administered.
 Conclusion

Students studied concept of parental and non-parental

route of proteins and peptide delivery system.
 References

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