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California Department of Public Health Occupational Health Branch California Safe Cosmetics Program July 2019 Reportable Ingredients List
California Department of Public Health Occupational Health Branch California Safe Cosmetics Program July 2019 Reportable Ingredients List
California Department of Public Health Occupational Health Branch California Safe Cosmetics Program July 2019 Reportable Ingredients List
The California Safe Cosmetics Act of 2005 requires cosmetic manufacturers to disclose to the California Department of Public Health (CDPH) all
products containing ingredients known or suspected to cause cancer, birth defects, or other reproductive toxicity as determined by the authoritative
scientific bodies cited in California Health and Safety Code Section 111791.5. These bodies are 1) the California Office of Environmental Health
Hazard Assessment (Proposition 65 List of Chemicals Known to Cause Cancer or Reproductive Toxicity); 2) U.S. Environmental Protection
Agency (U.S. EPA); 3) National Toxicology Program (NTP) Office of Health Assessment and Translation (OHAT) (formerly Center for the
Evaluation of Risks to Human Reproduction (CERHR)); 4) NTP’s Report on Carcinogens (RoC); and 5) the International Agency for Research on
Cancer (IARC).
To assist companies with reporting, CDPH has compiled this list of reportable ingredients based on lists and reports available from these
organizations. Please note that the authoritative bodies are continually updating published information. For the most up-to-date guidance on
reportable chemicals, please refer directly to the lists and reports available from these organizations.
Chemical Abstract Service (CAS) Registry Numbers and synonyms are provided for some of the listed chemicals. However, this guidance
document is not all-inclusive. Manufacturers may still be required to report a chemical to CDPH even if a specific synonym or CAS number for an
ingredient is not listed here.
Note to consumers: Not all of these chemicals are found in cosmetic products. Also, note that the likelihood of a cosmetic product leading to
cancer or reproductive harm depends on many factors, including but not limited to the amount and type of exposure to chemicals in the product.
The chemicals are listed here because of findings from research on the chemicals and not on cosmetic products.
For more information on the California Safe Cosmetics Program, please visit our webpage at: www.cdph.ca.gov/Cosmetics or call us at (877) 325-
3223.
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Chemical Synonyms CAS No.
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-
1 Semustine 13909-09-6 x x
nitrosourea (Methyl-CCNU)
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
2 13010-47-4 x x x
(CCNU) (Lomustine)
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
13010-47-4 x x
(CCNU) (Lomustine)
3 1,1,1,2-Tetrachloroethane 630-20-6 x x x x
4 1,1,2,2-Tetrachloroethane 79-34-5 x x x x
6 1,1-Dichloroethane 75-34-3 x x x
7 1,1-Dimethylhydrazine (UDMH) 57-14-7 x x x x
8 1,2,3-Trichloropropane 96-18-4 x x x x
9 1,2-Dibromo-3-chloropropane (DBCP) 96-12-8 x x x
1,2-Dibromo-3-chloropropane (DBCP) 96-12-8 x x
10 1,2-Dichloropropane 78-87-5 x x x
11 1,2-Diethylhydrazine 1615-80-1 x x x
12 1,2-Dimethylhydrazine 540-73-8 x x x
13 1,2-Epoxybutane 106-88-7 x x
14 1,3-Butadiene 106-99-0 x x x
1,3-Butadiene 106-99-0 x x x x x x
15 1,3-Dichloro-2-propanol (1,3-DCP) 96-23-1 x x x
16 1,3-Dichloropropene 542-75-6 x x x
17 1,3-Dinitropyrene 75321-20-9 x x x
18 1,3-Propane sultone 1120-71-4 x x x
19 1,4-Butanediol dimethanesulfonate Busulfan 55-98-1 x x x x
20 1,4-Dichloro-2-butene 764-41-0 x x
21 1,4-Dichloro-2-nitrobenzene 89-61-2 x x
22 1,4-Dioxane 123-91-1 x x x x
23 1,6-Dinitropyrene 42397-64-8 x x x
24 1,8-Dinitropyrene 42397-65-9 x x x
25 1-[(5-Nitrofurfurylidene)-amino]-2-imidazolidinone 555-84-0 x x x
26 1-Amino-2,4-dibromoanthraquinone 81-49-2 x x x x
27 1-Amino-2-methylanthraquinone 82-28-0 x x
28 1-Bromopropane 1-BP 106-94-5 x x x x
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Chemical Synonyms CAS No.
58 2-Aminoanthraquinone 117-79-3 x x
59 2-Aminofluorene 153-78-6 x x
60 2-Bromopropane (2-BP) 75-26-3 x x x
61 2-Chloronitrobenzene 88-73-3 x x
62 2-Chloropropionic acid 598-78-7 x x
63 2-Ethylhexyl acrylate 103-11-7 x x
64 2-Mercaptobenzothiazole 149-30-4 x x x
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Chemical Synonyms CAS No.
90 3-Nitrobenzanthrone 17117-34-9 x x
91 4-(N-Nitrosomethylamino)-1-(3-pyridyl)1-butanone 64091-91-4 x x
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Chemical Synonyms CAS No.
12510-42-8
407 Erionite x x x
66733-21-9
408 Estradiol 17B 50-28-2 x x
409 Estragole 140-67-0 x x
410 Estrogen therapy, postmenopausal --- x x
Estrogen-progestogen (combined) used as
411 --- x x x x
menopausal therapy
412 Estrogens, nonsteroidal, e.g. diethylstilbestrol --- x x x
413 Estrogens, steroidal --- x x
414 Estrone 53-16-7 x x
415 Estropipate 7280-37-7 x x x
416 Ethanol in alcoholic beverages 64-17-5 x x x
417 Ethinylestradiol 57-63-6 x x
418 Ethionamide 536-33-4 x x
419 Ethoprop 13194-48-4 x x
420 Ethyl acrylate 140-88-5 x x x
421 Ethyl alcohol in alcoholic beverages --- x x
422 Ethyl dipropylthiocarbamate 759-94-4 x x x
423 Ethyl methanesulfonate 62-50-0 x x x
424 Ethyl-4,4'-dichlorobenzilate 510-15-6 x x
425 Ethylbenzene 100-41-4 x x x
426 Ethylene dibromide 1,2-Dibromoethane 106-93-4 x x x x x
Ethylene dibromide 1,2-Dibromoethane 106-93-4 x x x x
427 Ethylene dichloride (1,2-Dichloroethane) 107-06-2 x x x x
428 Ethylene glycol (ingested) 107-21-1 x x
429 Ethylene glycol monoethyl ether 110-80-5 x x x
430 Ethylene glycol monoethyl ether acetate 111-15-9 x x x
431 Ethylene glycol monomethyl ether 109-86-4 x x x
432 Ethylene glycol monomethyl ether acetate 110-49-6 x x x
433 Ethylene oxide 75-21-8 x x x x x
Ethylene oxide 75-21-8 x x x x
434 Ethylene thiourea 96-45-7 x x x
Ethylene thiourea 96-45-7 x x
435 Ethyleneimine 151-56-4 x x
436 Etodolac 41340-25-4 x x x
437 Etoposide 33419-42-0 x x x
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Chemical Synonyms CAS No.
Etoposide 33419-42-0 x x
Etoposide in combination with cisplatin and
438 33419-42-0 x x x
bleomycin
Etoposide in combination with cisplatin and
15663-27-1
bleomycin
Etoposide in combination with cisplatin and
11056-06-7
bleomycin
439 Etretinate 54350-48-0 x x
440 Fenoxaprop ethyl 66441-23-4 x x x
441 Fenoxycarb 72490-01-8 x x x
442 Filgrastim 121181-53-1 x x
443 Fluazifop butyl 69806-50-4 x x x
444 Flunisolide 3385-03-3 x x x
445 Fluoro-edenite fibrous amphibole --- x x
446 Fluorouracil 51-21-8 x x
447 Fluoxetine 54910-89-3 x x x x
448 Fluoxetine hydrochloride (Prozac) 59333-67-4 x x x x
Fluoxetine hydrochloride (Prozac) 56296-78-7 x x x x
449 Fluoxymesterone 76-43-7 x x
450 Flurazepam hydrochloride 1172-18-5 x x
451 Flurbiprofen 5104-49-4 x x x
452 Flutamide 13311-84-7 x x
453 Fluticasone propionate 80474-14-2 x x
454 Fluvalinate 69409-94-5 x x x
455 Folpet 133-07-3 x x x
456 Formaldehyde 50-00-0 x x x x
Formaldehyde Methylene glycol 463-57-0 x
Formaldehyde Methanediol
Formaldehyde Formalin 30525-89-4 x
457 Formaldehyde (gas) 50-00-0 x x
458 Fuel oils, residual (heavy) --- x x
459 Fumonisin B1 116355-83-0 x x x x
460 Furan 110-00-9 x x x
461 Furazole (Mon 13900) 121776-33-8 x x
462 Furazolidone 67-45-8 x x x
463 Furfuryl alcohol 98-00-0 x x x
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Chemical Synonyms CAS No.
Heptachlor 76-44-8 x x x
494 Heptachlor epoxide 1024-57-3 x x x
Herbal remedies containing plant species of the
495 --- x x
genus Aristolochia
496 Hexachlorobenzene 118-74-1 x x x x
Hexachlorobenzene 118-74-1 x x
497 Hexachlorobutadiene 87-68-3 x x x
498 Hexachlorocyclohexane (alpha isomer) alpha-HCH 319-84-6 x x x
499 Hexachlorocyclohexane (beta isomer) --- x x x
500 Hexachlorocyclohexane (gamma isomer) --- x x x
501 Hexachlorocyclohexane (technical grade) t-HCH 608-73-1 x x x
502 Hexachlorodibenzodioxin 34465-46- 8 x x
Hexachlorodibenzo-p-dioxin (HxCDD), mixture of
503 57653-85-7 x x
1,2,3,6,7,8-HxCDD and 1,2,3,7,8,9-HxCDD
504 Hexachloroethane 67-72-1 x x x x
505 Hexafluoroacetone 684-16-2 x x x
506 Hexamethylphosphoramide 680-31-9 x x x
Hexamethylphosphoramide 680-31-9 x x
507 Histrelin acetate --- x x
508 Hydramethylnon 67485-29-4 x x x x
509 Hydrazine 302-01-2 x x x x
510 Hydrazine sulfate 10034-93-2 x x
511 Hydrazobenzene (1,2-Diphenylhydrazine) 122-66-7 x x x
512 Hydrochlorothiazide 58-93-5 x x
513 Hydrogen cyanide (HCN) & cyanide salts (CN salts) --- x x
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Chemical Synonyms CAS No.
MeIQx (2-Amino-3,8-dimethylimidazo[4,5-
569 77500-04-0 x x x
f]quinoxaline)
570 Melphalan 148-82-3 x x x
Melphalan 148-82-3 x x x
571 Menotropins 9002-68-0 x x
572 Mepanipyrim 110235-47-7 x x
Mepanipyrim 110235-47-7 x x
573 Meprobamate 57-53-4 x x
574 Mercaptopurine 6112-76-1 x x
575 Mercury and mercury compounds --- x x
576 Merphalan 531-76-0 x x x
577 Mestranol 72-33-3 x x
578 Metam potassium 137-41-7 x x
579 Methacycline hydrochloride 3963-95-9 x x
580 Metham sodium 137-42-8 x x x
Metham sodium 137-42-8 x x x
581 Methanol 67-56-1 x x x
582 Methazole 20354-26-1 x x
583 Methimazole 60-56-0 x x x
584 Methotrexate 59-05-2 x x
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Chemical Synonyms CAS No.
12054-48-7
648 Nickel hydroxide x x
12125-56-3
649 Nickel oxide 1313-99-1 x x
Nickel refinery dust from the pyrometallurgical
650 --- x x
process
651 Nickel subsulfide 12035-72-2 x x x
652 Nickel, metallic and alloys x x
653 Nickelocene 1271-28-9 x x
654 Nicotine 54-11-5 x x
655 Nifedipine 21829-25-4 x x x x
656 Nimodipine 66085-59-4 x x
657 Niridazole 61-57-4 x x x
658 Nitrapyrin 1929-82-4 x x x x
Nitrate or nitrite, ingested under conditions that
659 --- x x
result in endogenous nitrosation
660 Nitrilotriacetic acid and its salts 139-13-9 x x x
661 Nitrilotriacetic acid, trisodium salt monohydrate 18662-53-8 x x
662 Nitrobenzene 98-95-3 x x x x
Nitrobenzene 98-95-3 x x x
663 Nitrofen (technical grade) 1836-75-5 x x x
664 Nitrofurantoin 67-20-9 x x
665 Nitrofurazone 59-87-0 x x
666 Nitrogen mustard (Mechlorethamine) 51-75-2 x x x
Nitrogen mustard (Mechlorethamine) 51-75-2 x x
Nitrogen mustard hydrochloride (Mechlorethamine
667 55-86-7 x x
hydrochloride)
Nitrogen mustard hydrochloride (Mechlorethamine
55-86-7 x x
hydrochloride)
668 Nitrogen mustard N-oxide 126-85-2 x x x
669 Nitrogen mustard N-oxide hydrochloride 302-70-5 x x
670 Nitromethane 75-52-5 x x x x
671 Nitrous oxide 10024-97-2 x x x
672 N-Methyl-N'-nitro-N-nitrosoguanidine 70-25-7 x x x
673 N-Methylolacrylamide 924-42-5 x x
674 N-Methylpyrrolidone 872-50-4 x x x
675 N-Nitrosodiethanolamine 1116-54-7 x x x x
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Chemical Synonyms CAS No.
trans -2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-
910 55738-54-0 x x
2-furyl)vinyl]-1,3,4-oxadiazole
trans -2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-
25962-77-0 x x
2-furyl)-vinyl]-1,3,4-oxadiazole
911 Treosulfan 299-75-2 x x x
912 Triadimefon 43121-43-3 x x x x x
913 Triamterene 396-01-0 x x x
914 Triazolam 28911-01-5 x x
915 Tribufos 78-48-8 x x
916 Tributyltin methacrylate 2155-70-6 x x x
917 Trichlorfon 52-68-6 x x
918 Trichlormethine (Trimustine hydrochloride) 817-09-4 x x x
919 Trichloroacetic acid 76-03-9 x x x x
920 Trichloroethylene 79-01-6 x x x x x
Trichloroethylene 79-01-6 x x x
921 Trientine hydrochloride 38260-01-4 x x
922 Triforine 26644-46-2 x x x
923 Trilostane 13647-35-3 x x
924 TRIM® VX --- x x
925 Trimethadione 127-48-0 x x
926 Trimethyl phosphate 512-56-1 x x
927 Trimethylolpropane triacrylate, technical grade 15625-89-5 x x
928 Trimetrexate glucuronate 82952-64-5 x x
929 Triphenyltin hydroxide 76-87-9 x x x x
930 Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) 13674-87-8 x x
931 Tris(1-aziridinyl)phosphine sulfide (Thiotepa) 52-24-4 x x x
932 Tris(2,3-dibromopropyl)phosphate 126-72-7 x x x
933 Tris(2-chloroethyl) phosphate 115-96-8 x x
934 Trp-P-1 (Tryptophan-P-1) 62450-06-0 x x x
935 Trp-P-2 (Tryptophan-P-2) 62450-07-1 x x x
936 Trypan blue 72-57-1 x x x
937 Tungsten carbide 12070-12-1 x x
Ultraviolet radiation (wavelengths 100-400 nm,
938 --- x x
encompassing UVA, UVB, and UVC)
939 Ultraviolet-emitting tanning devices --- x x
940 Unleaded gasoline (wholly vaporized) --- x x
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Chemical Synonyms CAS No.