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Pulmonary Embolism: Feedback Manage
Pulmonary Embolism: Feedback Manage
Summary
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Definition
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Epidemiology
Incidence [2]
o ∼ 1–2 venous thromboembolism per 1,000 in the United States per year
o Rises with age
Sex:
overall ♂ > ♀ but women have a slight increase during the reproductive years [2]
Mortality: Venous thromboembolism accounts for ∼ 100,000 deaths in the US per
year. [2]
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Etiology
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Clinical features
Common features of PE [5]
o Acute onset of symptoms
o Dyspnea (> 75% of cases) [5]
o Tachycardia and tachypnea (up to 50% of cases) [5]
o Sudden pleuritic chest pain (∼ 20% of cases) [5]
o Cough and hemoptysis
o Associated features of DVT: e.g., unilaterally painful leg swelling [6]
Less common features of PE [5]
o Decreased breath sounds
o Dullness to percussion
o Split S2
o Low-grade fever
o Rarely, upper abdominal pain [7][8]
Features of massive PE: (e.g., due to a saddle thrombus)
o Presyncope or syncope
o Jugular venous distension and Kussmaul sign
o Hypotension and obstructive shock
o Circulatory collapse
Features of intraoperative PE: all features typically have an abrupt onset [9][10]
o Decrease in EtCO2 (early sign)
o Decrease in SpO2
o Hypotension
o Tachycardia
symptoms. [5]
etiology.
Pretest probability of pulmonary embolism
Overview [11][12]
High PTP of PE
o Modified Wells score > 4
o Original Wells score ≥ 7
o Revised Geneva score > 10
Intermediate PTP of PE
o Original Wells score 2–6
o Revised Geneva score 4–10
Low PTP of PE
o Modified Wells score ≤ 4
o Original Wells score < 2
o Revised Geneva score < 4
Very low PTP of PE: Low PTP of PE plus PERC = 0
Criteria Points
Previous PE/DVT 1.5
Wells criteria for PE [15][16]
Criteria Points
Hemoptysis 1
Malignancy 1
Original Wells score (clinical probability) [15]
Criteria Points
Age > 65 years 1
Criteria Points
Hemoptysis 2
Heart rate 75–94/min 3
Clinical pretest probability
Criteria Points
Age > 50 years 1
Criteria Points
Hemoptysis 1
Estrogen use 1
Clinical pretest probability
testing.
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Diagnostics
Approach [5][20][12]
Initial evaluation
The initial evaluation of patients with dyspnea and/or chest pain typically includes laboratory
studies, CXR, and ECG. Findings may suggest but do not confirm PE. [5]
D-dimer [21][12]
Indications
o Intermediate PTP of PE
o Low PTP of PE and PERC > 0
Findings
o Normal levels: < 500 ng/mL
o If ≥ 500 ng/mL: Further testing is required (see below).
o If the patient is > 50 years of age, adjust for age: age x 10 ng/mL = cutoff
value in ng/mL [12][24]
Interpretation
o High sensitivity and negative predictive value: A negative D-dimer test
most likely rules out PE.
o Low specificity: positive results in all forms of fibrinolysis
increased fibrinolysis.
Additional laboratory studies [12]
Chest x-ray [22]
Characteristic findings
o Hampton hump: a wedge-shaped opacity in the peripheral lung with its
base at the thoracic wall; caused by pulmonary infarction and not specific
for PE
o Westermark sign: an area of lung parenchyma lucency caused by
oligemia secondary to occlusion of blood flow
o Fleischner sign: a prominent pulmonary artery caused by vessel
distention due to a large pulmonary embolus (common in massive PE)
Nonspecific findings
o Atelectasis
o Pleural effusions
o Cardiomegaly
Electrocardiography (ECG)
Confirmatory imaging
CT pulmonary angiography (CTPA) [22][12][31]
Adjunctive imaging
The absence of a DVT does not rule out PE, but the presence of a DVT can justify
ECG and cardiac biomarkers
↑ BNP is nonspecific but can predict early adverse outcomes in patients with PE. [21]
Echocardiography
Goal: mostly used for prognosis; can be used as a diagnostic tool in patients too
unstable for confirmatory imaging
Indications
o Suspected right-heart strain or RV dysfunction
o Critically ill patients with suspected PE
Findings [21][22][41]
o Dilatation and hypokinesis of the right ventricle (RV)
o RV dysfunction
o McConnell sign: akinesia of the mid-free RV wall and hypercontractility
of the apical wall
o Venous reflux with IVC dilation
o Tricuspid regurgitation (tricuspid valve insufficiency)
o ↑ PASP
o Increased right atrial pressure
Evaluation for thrombophilia [47]
o Indicated in younger patients with any of the following
No or weak risk factors
Family history
Recurrence of venous thrombosis
o Timing: after the completion of therapy
o See “Hypercoagulable states.”
Evaluation for malignancies: age-appropriate screening studies; See “Preventive
Medicine.”
Classification
Classification by PE severity [48]
Nonmassive PE
o Stable blood pressure (SBP > 90 mm Hg)
o No RV dysfunction
o Normal cardiac biomarkers
Submassive PE
o Stable blood pressure (SBP > 90 mm Hg) PLUS ≥ 1 of the following:
RV dysfunction
Evidence of myocardial necrosis (elevated troponin)
Massive PE: hemodynamic instability (due to right heart failure)
o Systolic BP < 90 mm Hg for > 15 minutes
o Acute decrease in systolic BP ≥ 40 mm Hg
o Hemodynamic support is needed.
Classification by overall PE prognosis [49][50]
This system guides disposition using prognostic risk stratification scores (e.g., PESI or sPESI).
PESI and sPESI
Points
Criteria
PESI [49] sPESI [50]
History of cancer 30 1
Heart failure 10 1
PESI and sPESI
Points
Criteria
PESI [49] sPESI [50]
Chronic lung disease 10
Male: 10
Sex
Female: 0
sPESI interpretation (30-day mortality) [50]
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Management
General principles [21][51][46]
Start empiric anticoagulation for PE if clinical suspicion is high unless there is a high risk
Bleeding risk
Low High
Bleeding risk
Low High
ervative
management o
nly for
patients with
subsegmental
PE,
no proximal
DVT, and a
low risk of
recurrence
Outpatient
management
is often
appropriate.
Submass
Anticoagulati Consider a
ive PE
on temporary IV
Consider thro C filter.
mbolysis for Consider em
PE if high risk bolectomy
for for PE in
decompensati patients at
on (e.g., high risk of
severe RV decompensati
dysfunction) on.
or
deterioration
despite
anticoagulatio
Pulmonary embolism treatment by severity and bleeding risk [23]
[51][46]
Bleeding risk
Low High
n.
Thrombolysis
for
PE followed
by
anticoagulatio Embolectom
Massive
PE n. y for PE
Embolectomy
for
PE if thrombo
lysis fails.
Unstable patients
Start ACLS [53]
Consider POCUS to identify indirect signs of PE. [53][54][55]
o Subxiphoid view (consider only during pulse check): thin-walled (< 5
mm), dilated RV
o Lower extremity views: US findings of DVT
Consider intra-arrest thrombolytics (e.g., tPA DOSAGE ). [56][53]
Consider ECMO. [46][5]
Stable patients [21][23][51]
Disposition [21][23][51]
PESI and sPESI score can be used to help guide disposition.
Low-risk PE (PESI class I–II or sPESI score = 0)
o Consider outpatient management in consultation with specialists.
o Criteria for outpatient management include:
Hemodynamic stability and adequate room air oxygenation
Opiates are not required for pain relief.
Availability of family or social support, easy access to health
care
No other major comorbidities or reasons for hospitalization
Intermediate-risk PE or high-risk PE (PESI class ≥ III or sPESI score ≥ 1)
o Hospitalization is required; consult PERT if available.
o ICU admission: commonly necessary for massive PE or patients with
severe RV dysfunction [5]
Anticoagulation
The benefits of anticoagulation in PE outweigh the bleeding risks in most patients who do
Indications
o High PTP of PE: Initiate in all patients.
o Intermediate PTP of PE: Consider in all patients.
o Low PTP of PE: only if imaging is expected to be delayed for > 24 hours
Contraindication: risk of major bleeding on anticoagulant therapy in patients with
VTE
Choice of medication
o Stable patients: low molecular weight heparin (LMWH) DOSAGE [59]
o Unstable patients or patients with renal insufficiency: unfractionated
heparin (UFH) DOSAGE [57]
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Reperfusion therapy
Systemic thrombolysis [57][51]
Catheter-directed thrombolysis [70]
Procedure
o Direct infusion of thrombolytics into the obstructed pulmonary artery via
pulmonary arterial catheter
o May be combined with mechanical or ultrasound fragmentation of
the embolus
Indication: Alternative to systemic thrombolysis in patients with a high bleeding
risk.
Contraindications: See “Contraindications to thrombolysis for PE.”
Contraindications
Active bleeding
Prior intracranial hemorrhage
Ischemic stroke ≤ 3 months ago
Absolute Recent spinal or brain surgery
contraindications
Structural intracranial disease
Recent head trauma with brain injury or fracture
Bleeding diathesis
Uncontrolled hypertension
Current anticoagulation use
Recent nonintracranial bleeding
Recent surgery, invasive procedure, or trauma
Ischemic stroke > 3 months ago
Relative Traumatic CPR
contraindications
Pregnancy
Age > 75 years
Weight < 60 kg
Pericardial fluid or pericarditis
Diabetic retinopathy
Indications
o Contraindications to thrombolysis for PE in patients with massive PE or
high-risk submassive PE
o Failure of thrombolysis for PE
Options
o Surgical embolectomy: removal of the embolus through an incision in
the pulmonary artery
o Endovascular embolectomy: catheter-based thrombus removal [70]
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Initial management
Perform ABCDE assessment.
Provide analgesia and oxygen therapy as needed.
Unstable patients (i.e., massive PE): Stabilize, obtain ECG, and consider
bedside echocardiogram and empiric therapy based on bleeding risk.
Stable patients order initial diagnostic based on PTP of PE.
Assess bleeding risk on anticoagulation for VTE.
Consider empiric anticoagulation if the bleeding risk is low.
Evaluate RV function to determine the severity of PE.
Consult PERT.
Nonmassive PE
Submassive PE
Massive PE
Evaluate the need for mechanical ventilation.
Have a crash cart at the bedside.
Consider limited IV fluid therapy for hemodynamic support (e.g., 250–500
mL crystalloid fluid IV once).
Begin vasopressor infusion for hemodynamic support if needed.
Check for contraindications to thrombolysis for PE.
o No absolute contraindications: Initiate thrombolysis for PE.
o Absolute contraindications: Consult interventional radiology
and/or surgery to perform embolectomy for PE.
Continuous telemetry and pulse oximetry.
Transfer to ICU.
Start ACLS.
Consider administration of a reduced dose of tPA.
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Complications
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Pathology
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