SymSitive®

1609
4-t-Butylcyclohexanol

INSTANT
SKIN RELIEF

SOOTHING

SKIN TOLERANCE ENHANCEMENT

& DISCOMFORT SENSATIONS REDUCTION
 INSPIRING MORE

WHAT IF YOU CAN INSTANTLY RELIVE

YOUR SENSITIVE SKIN?

More and more consumers tend to perceive their skin as overreactive or

intolerant to external aggressions or personal care products. Most of the
time, the irritation symptoms include redness, tingling, tightness, but
they may also include burning and stinging sensations. Research has
shown that the latter are distinct characteristics of sensitive to highly
sensitive skin.
In order to bring strong and instant relief to hypersensitive skin, Symrise
has designed a soothing active ingredient with a specific focus on
burning and stinging sensations.
SymSitive® 1609 helps in modulating the TRVP1 receptors which when
activated lead to an increase of calcium influx resulting in discomfort
sensations such as burning and stinging.

OF GLOBAL CONSUMERS THINK THAT THEIR SKIN IS

70% MORE SENSITIVE THAN FEMW YEARS AGO
CONSUMER INSIGHTS

OF GLOBAL CONSUMERS WITH FACE SKIN

56% SENSITIVITY ARE HIGHLY CONCERNED BY
ITCHING/TINGLING/SCRATCHING SENSASTIONS

OF GLOBAL CONSUMERS WITH FACE SKIN

49% SENSITIVITY ARE HIGHLY CONCERNED BY
STINGING/HEATING/BURNING SENSASTIONS

Symrise – Cosmetic Ingredients – Consumer & Market Insights – CICS 2021 – 5 countries
 SYMRISE INNOVATION

TARGETING SPECIFIC
DISCOMFORT
SENSATIONS
 SymSitive® 1609
ULTIMATE SKIN TOLERANCE SOLUTION

INCREASES
SKIN COMFORT
BENEFITS

CLINICALLY PROVEN TO
REDUCE BURNING &
STINGING SENSATIONS

DECREASES SKIN TOLERANCE

DISCOMFORT ENHANCER
INDUCED BY SOME IMMEDIATE
COSMETIC INGREDIENTS EFFECT
HELPS TO REDUCE RETINOL INDUCED
DISCOMFORT SENSATIONS

70%
ASSETS

NATURAL ORIGIN

CONTENT
(ISO 16128)
99.9% PATENTED
READILY BIODEGRADABLE

Suitable Vegan according to Symrise criteria

Halal status available upon request
Biodegradability tested according to OECD 301
 PRODUCT FEATURES

SymSitive® 1609
FOR AN INSTANT SKIN & SCALP RELIEF

APPLICATIONS
MAIN APPLICATIONS
with pH between 3 and 12

• SENSITIVE SKIN CARE

(LOTION, SERUMS,
CREAMS…)
• SCALP CARE (HAIR
COLORS, PERMS &
RELAXERS)
• ORAL CARE

BSB Innovation Award as « Most Innovative Raw

2010 Material – Naturals/Actives »
AWARDS

PCHi Award in the category « Most significant

2011 technology in China’s Personal Care and Cosmetic
Industry 2010-2011 »
 SymSitive® 1609
SENSITIVE SKIN & SCALP FOCUS

IMMEDIATE RELIEF OF VARIOUS DISCOMFORT SENSATIONS

MODULATION OF CAPSAICIN INDUCED MISPERCEPTIONS
IN VIVO STUDY

1.2% of SymSitive® 1609 significantly helps to down-modulate capsaicin-induced

burning, stinging & tightness sensations.
4
Average of discomfort sensations

PROTOCOL
3 30 VOLUNTEERS SENSITIVE TO
CAPSAICIN. NASOLABIAL FOLD
APPLICATION.
2 -70% DAY 1: ASSESSMENT SAMPLE WITH
**** SymSitive® 1609 VS CONTROL. DAY
-60% 2: ASSESSMENT SAMPLE WITHOUT
1 *** -67% SymSitive® 1609 VS CONTROL.
-50% *** EVALUATION OF STINGING,
* BURNING, TINGLING & TIGHTNESS
0 EFFECT 3MIN AFTER APPLICATION.
STINGING BURNING TINGLING TIGHTNESS

*p<0.05, ***p<0.001, ****p<0.0001 ■ Capsaicin ■1.2% SymSitive® 1609

Scale: 0 = no perception, 1 = doubtful, barely perception, 2 = slight perception, 3 = moderate perception, 4 = strong perception

REDUCTION OF RETINOL INDUCED DISCOMFORT SENSATIONS

IN VIVO STUDY

SymSitive® 1609 significantly reduces instant uncomfortable sensations induced

by Retinol: stinging, itching, warming sensations.
3
PROTOCOL
Average grade discomfort

22 VOLUNTEERS SENSITIVE TO
RETINOL. 1 NASOLABIAL FOLD
2 APPLICATION OF EMULSION
FORMULA WITH 1% RETINOL VS
PLACEBO AND 1% RETINOL + 3%
SymSitive® 1609 VS PLACEBO.
1 - 76% - 83%
- 72% ***
EVALUATION OF DISCOMFORT
** ** (STINGING, ITCHING, WARMING
- 72% SENSATIONS) AT 30S, 2.5MIN, 5MIN
AND 10MIN AFTER APPLICATION.
0
T30 sec T2.5 min T5 min T10 min

**p≤0.01, ***p ≤ 0.001 ■ with 1% Retinol ■ with 1% Retinol + 3% SymSitive® 1609

Scale: 0 = no sensation, 1 = mild sensation, 2 = moderate sensation, 3 = severe sensation
 EFFICACY DATA

COSMETIC INTOLERANCE SYNDROME (CIS)

IN VIVO STUDY
1.2% of SymSitive® 1609 significantly helps to down-modulate overall
misperceptions by 65% as fast as 1min and immediately reduces facial
misperceptions felt by persons with CIS.

D1+1mn Baseline+3m
Baseline+1m D1+3mn D5+1mn
Day 5+1m D5+3mn
Day 5+3m
0,2
Variation of discomfort sensations

PROTOCOL
20 VOLUNTEERS SUFFERING FROM
-0,3 CIS. 2x DAILY APPLICATION ON
HALF FACE VS PLACEB FOR 5
DAYS. TESTED PRODUCT: O/W
EMULSION WITH & WIHOUT 1.2%
-0,8 - 65% SymSitive® 1609.
* ASSESSMENT OF OVERALL
MISPERCEPTIONS (INCLUDING
-1,3 - 25% STINGING & BURNING) AFTER 1
- 20% AND 3 MINUTES AFTER NOXIOUS
SENSORY STIMULATION.
-1,8

*p≤0.05 ■ Placebo ■ 1.2% SymSitive® 1609

+10%
SCALP RELIEF
**

IN VIVO STUDY
SymSitive® 1609 eases discomfort sensations of scalp sensitive to hair coloration
without changing the expected shade of coloration.

Discomfort on PROTOCOL
15 VOLUNTEERS WITH SENSITIVE
both hemi-heads SCALP TO HAIR COLORATION,
13% WITH OILY OR DRY HAIR.
SINGLE & STANDARDIZED HEMI-
Reduced HEAD APPLICATION OF
discomfort on 13% PROFESSIONAL SOFT HAIR
treated hemi-head COLORATION FOR SENSITIVE
SCAKP (WITHOUT AMMONIAC
13% 61% WITH MEA) + 3% SymSitive® 1609
No functional No functional MIXED TO THE HAIR COLORATION
discomfort on discomfort on JUST BEFORE APPLICATION VS
both hemi-head treated hemi-head PLACEBO (COLORATION).
ASSESSMENT OF PRODUCT
TOLERANCE & INFLUENCE ON THE
SHADE OF COLORATION BY
% OF SUBJECTS VOLUNTEERS & HAIRDRESER.
 ACTIVES SOOTHING SKIN TOLERANCE

SymSitive® 1609
INCI: Pentylene Glycol, 4-t-Butylcyclohexanol

Product number
399944

Formulation details
Colorless to pale yellow clear & odorless liquid
Recommended dose: 1.0 - 3.0%
Soluble in glycols, common cosmetic oils and alcohol
Stable and effective over a wide pH (3-12) and up to 85°C
Compatible with widely used cosmetic ingredients

Main applications
Suitable for sensitive skin care, lotions & serums, hair colors, perms & relaxers, oral care

Visit SymSelect® to request samples and discover

new ingredients. Scan code or visit www.symselect.com

DISCLAIMER
“These suggestions and data are based on information we believe to be reliable. They are offered in good faith, but without guarantee, as conditions and
methods of use of our products are beyond our control. Symrise makes no warranties, either expressed or implied, as to the accuracy or appropriateness of
this data. Symrise expressly disclaims any implied warranty of fitness for a particular use. We recommend that prospective users determine for themselves
the suitability of Symrise materials and suggestions for any use prior to their adoption. We also recommend that prospective users, as required, obtain
approval from appropriate regulatory authorities. Suggestions for uses of our products or the inclusion of descriptive material from patents and the citation
of specific patents in this publication should not be understood as recommending the use of our products in violation of any patent or as a permission or
licence to use any patent of Symrise.”

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