Diagnostic Dilation and Curettage

https://emedicine.medscape.com/article/1848239-overview#a1

Updated: Oct 01, 2018

 Author: Janice L Bacon, MD

Overview
Background

Diagnostic dilation and curettage was originally intended to detect intrauterine endometrial
abnormalities and assist in the management of abnormal bleeding. Newer techniques are
available to assess the uterine cavity and endometrial findings. [1] However, dilation and
curettage still has a role in centers where advanced technology is not available or when other
diagnostic modalities are unsuccessful.

Traditionally, dilation and curettage has been performed in a blind fashion. The procedure
can be performed under ultrasound guidance or in conjunction with visualization of the
uterine cavity by a hysteroscope.

Indications

Diagnostic dilation and curettage is typically employed to assess endometrial histology.

Fractional dilation and curettage also includes assessment of the endocervix and biopsy of the
ectocervix and transformation zone.

Indications for a diagnostic dilation and curettage include the following:

 Abnormal uterine bleeding: irregular bleeding, menorrhagia, suspected malignant or

premalignant condition
 Retained material in the endometrial cavity
 Evaluation of intracavitary findings from imaging procedures (abnormal endometrial
appearance due to suspected polyps or fibroids)
 Evaluation and removal of retained fluid from the endometrial cavity (hematometra,
pyometra) in conjunction with evaluating the endometrial cavity and relieving
cervical stenosis
 Office endometrial biopsy insufficient for diagnosis or failed due to cervical stenosis
 Endometrial sampling in conjunction with other procedures (eg, hysteroscopy,
laparoscopy)

The evaluation of the uterine cavity by dilation and curettage may be helpful when an office
technique, such as ultrasound, is unable to fully elucidate the endometrium due to shadowing
from leiomyomata, a pelvic mass, or loops of bowel.

Several studies have evaluated the effectiveness of obtaining endometrial tissue by

endometrial sampling versus D&C. One study compared aspiration biopsy (Pipelle) with
D&C. The D&C procedure was performed without hysteroscopy. This sample of 673 women
underwent hysterectomy following the endometrial sampling or curettage. The concordance
of results was 67% between endometrial biopsy and hysterectomy versus 70% between D&C
without hysteroscopy and hysterectomy. The negative predictive value was 98% for detection
of malignancy. In their conclusions, the authors recommended a presampling evaluation of
the endometrium by a technique such as transvaginal ultrasound. [2]

Another study of 366 women evaluated histopathologic findings obtained by

hysteroscopically directed biopsies, versus pathology results of tissue obtained at D&C.
Concordance of results for the 2 procedures was 88.8%. In their conclusions, the authors
stated that although hysteroscopy with directed biopsy was adequate for obtaining diagnosis
from focal lesions, it may not be sufficient for diagnosis of all pathologic findings in the
endometrium, including hyperplasia. They recommended global endometrial sampling, such
as by D&C, be included for more thorough diagnosis. [3]

Dilation and curettage may also be a therapeutic procedure. Examples of this use include the
following:

 Removal of retained products of conception (eg, incomplete abortion, missed

abortion, septic abortion, induced pregnancy termination)
 Suction procedures for management of uterine hemorrhage
 Treatment and evaluation of gestational trophoblastic disease
 Hemorrhage unresponsive to hormone therapy [1]
 In conjunction with endometrial ablation for histologic evaluation of the endometrium

Contraindications

There are few contraindications to gentle office dilation and curettage, but a more vigorous
examination may require an operative suite with regional or general anesthesia. Paracervical
block or intravenous sedation with an anesthesia team standing by for assistance may also be
an option. Intolerance to office examinations or procedures may determine the setting for the
procedure.

Absolute contraindications to dilation and curettage include the following:

 Viable desired intrauterine pregnancy

 Inability to visualize the cervical os
 Obstructed vagina

Relative contraindications to dilation and curettage include the following:

 Severe cervical stenosis

 Cervical/uterine anomalies
 Prior endometrial ablation
 Bleeding disorder
 Acute pelvic infection (except to remove infected endometrial contents)
 Obstructing cervical lesion
These contraindications may be surmounted in some cases. For example, magnetic resonance
imaging may define the anatomy of the cervical or uterine anomaly, allowing safe exploration
of the endocervix and endometrium.

Complications

Complications can occur at the time of diagnostic dilation and curettage. Careful performance
of the procedure should minimize these events. Possible complications include the following:

 Bleeding or hemorrhage
 Cervical laceration
 Uterine perforation
 Postprocedural infection
 Postprocedural intrauterine synechiae (adhesions)
 Anesthetic complications

Complications, particularly uterine perforation, may be increased in a patient with a recent

pregnancy or gestational trophoblastic disease, prior endometrial ablation, distorted anatomy,
cervical stenosis, or current uterine infection.

Cervical Injury

Laceration of the cervix primarily occurs during traction, with a counterforce applied during
dilation. It seems to occur most frequently with use of a single-tooth tenaculum, especially
when it is placed vertically on the lip of the cervix. A Bierer multi-toothed tenaculum
penetrates less deeply into the cervical tissue and transfers force over a greater area,
potentially decreasing the risk of laceration.

Lacerations are generally managed with an interrupted or running interlocking dissolvable

suture. The same technique would be applied for a laceration of the posterior cervical lip.

Placement of a tenaculum is not recommended at the lateral aspect of the cervix because of
the location of the cervical branches of the uterine artery.

The risk of laceration is reduced by reducing force at dilation, using more tapered Pratt
dilators or osmotic preparation before the procedure with laminaria or prostaglandin.

Uterine Perforation

Uterine perforation is one of the more common complications of dilation and curettage. Risks
are increased when dealing with a pregnant or recently postpartum uterus (5.1%) and are less
frequent at the time of a dilation and curettage remote from pregnancy (0.3% for
premenopausal women and 2.6% for postmenopausal women). [4, 5, 6]

The instruments most commonly associated with uterine perforation are the uterine sound or
dilators. If perforation is known to have occurred with a blunt instrument, observation of vital
and peritoneal signs for several hours is all that is needed. If suspicion that a sharp
instrument, such as a curette, has perforated the uterus or if the fat has been retrieved by
curettage, then intraabdominal injury must be excluded by laparoscopy. Active bleeding may
necessitate a laparotomy.
Infection

Infection related to diagnostic dilation and curettage is rare and is most likely when cervicitis
is present at the time of the procedure. One study of infections related to dilation and
curettage documented a 5% incidence of bacteremia following dilation and curettage with a
very rare incidence of septicemia.

Prophylactic antibiotics are not recommended for any dilation and curettage, including for
those women who generally require subacute bacterial endocarditis prophylaxis.

Intrauterine Adhesions

Curettage after delivery or abortion may result in endometrial injury and subsequent
development of intrauterine adhesions, termed Asherman syndrome. The development of
uterine synechiae may also be associated with prior endometrial ablation procedures.
Intrauterine adhesions may make future diagnostic curettage more difficult and increase the
risk of uterine perforation. Previous procedures such as endometrial ablation may also
increase the risk of cervical stenosis.

A study by Hooker et al reported that intrauterine application of auto-crosslinked hyaluronic

acid gel after D&C for miscarriage in women with at least one previous D&C may reduce the
incidence and severity of intrauterine adhesions, however, it does not eliminate the process of
adhesion formation completely. Further studies are needed to evaluate these results. [7]

Trophoblastic Embolization

Embolization of trophoblastic tissue in the systemic circulation is a very rare complication of

dilation and curettage for removal of gestational trophoblastic disease. This event has been
associated with thyroid storm, cardiovascular collapse, and death. A diagnostic dilation and
curettage in patients for whom gestational trophoblastic neoplasia is suspected should be
performed in an operating room with anesthesia.