Brenner: Pharmacology, 4th Edition

Chapter 03: Pharmacodynamics

Test Bank

Multiple Choice

1. In what way is the log-concentration effect (dose response) curve of an agonist drug

modified in the presence of a competitive receptor antagonist?

A. shifted to the right without a change in slope or maximum effect

B. shifted to the left without a change in slope or maximum effect

C. shifted to the right with a decreased slope and maximum effect

D. shifted to the left with a decreased slope and maximum effect

E. not shifted right or left but shows a decreased maximum effect

ANS: A. shifted to the right without a change in slope or maximum effect

2. A patient exhibits a rapid loss of responsiveness to a drug during the first several

hours of drug administration. Which event is most likely responsible for this effect?

A. up-regulation of drug metabolizing enzymes

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Test Bank 2

B. down-regulation of drug metabolizing enzymes

C. internalization of cell membrane receptors

D. formation of receptor antibodies

E. phosphorylation of G protein–coupled receptors

ANS: E. phosphorylation of G protein–coupled receptors

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