Prepared by (PRP Klinik Kesihatan Putrajaya Presint 18):

Hazirah Binti Zamri

Puteri Atdriann Binti Tilang
Tengku Putri Sharah Qistina Binti Tengku Nasiruddin
Date : 30/9/2020
 Item
Acetylsalicylic Acid 100mg +
Glycine 45mg Tab.
C; D (if full dose used
Acetylsalicylic Acid 300mg
Tab.
Acriflavine 0.1% Lotion
Acyclovir 200/800mg Tab.
Adrenaline Acid Tartrate
1mg/ml Inj
Albendazole 200mg Tab.
Allopurinol 300mg Tab.
Amiloride Hcl 5mg + Hctz
50mg Tab
Artificial Tears/Eye Lubricant
Ophthalmic Solution (With
Preservative)
Amlodipine 10mg +
Valsartan 160mg Tab
Amlodipine 5mg/10mg Tab.
Amoxycillin & Clavulanate
625mg Tab.
Pregnancy Category Use in pregnancy Use in lactation
Should not be used in pregnancy as
Mothers who are breast-
1 it may prolong labour and
Not assigned feeding their infants should not
contribute to maternal and neonatal
take aspirin4
bleeding4
Compatible (Low-Dose). Human
Limited Human Data—
in 3rd trimester)1 Data Suggest Risk in 1st and 3rd
Potential Toxicity3
C2 Trimesters (Full-Dose)3
- Use with caution4 Use with caution 4
B1
Compatible3 Compatible3
B32
C1 Human and Animal data suggest No Human Data- Potential
A2 risk3 Toxicity3
C1 Limited Human Data—
Compatible3
D1 Probably Compatible3
C1 Limited Human Data—No Relevant Limited Human Data—
B22 Animal Data3 Potential Toxicity3
Not recommended. Drugs cross the
placenta and appear in the cord
blood. Therefore, the use requires
Not recommended. Drug
that the potential benefit of the
appears in breast milk. If use of
B1 drug must be weight against
the drug is deemed essential,
C2 possible hazards to the fetus. These
the patient should stop
hazards include foetal and neonatal-
nursing4
jaundice, thrombocytopenia and
other side effects that have
occurred in the adults4
C1 Use with caution4 Use with caution4
Contraindicated. Drugs that act
directly on the renin-angiotensin The proportion of the maternal
system can cause fetal/neonatal dose received by the infant has
morbidity and mortality). If this drug been estimated with an
D1
is used during pregnancy, or if the interquartile range of 3 – 7%,
D2
patient becomes pregnant while with a maximum of 15%. Not
taking this drug, the patient should advisable for women who are
be apprised of the potential hazard breast-feeding4
to the fetus4
C1 Limited Human Data—Animal Data Limited Human Data—
C2 Suggest Moderate Risk3 Probably Compatible3
Animal Data—No Teratogenic Effect.
Use with caution as it may lead
Limited Human Data—Avoid
to sensitisation, diarrhea,
B1 especially during 1st and 3rd
candidiasis and skin rash in the
Trimesters, unless considered
infant4
essential by the physician4
 Item Pregnancy Category Use in pregnancy Use in lactation
B1 Human Data Suggest Risk in 1st and Compatible3
Amoxycillin 500mg Capsule
A2 3rd Trimesters3
The use of unasyn during
Animal Data- No evidence of
lactation is not recommended.
impaired fertility or harm to the
Low concentrations of unasyn
fetus due to unasyn. Sulbactam
are excreted in the milk. This
Ampicillin + Sulbactam crosses the placental barrier.
B1 should be considered as the
375mg Tab (Unasyn) Limited Human Data- Unasyn should
neonate may be exposed,
be used during pregnancy only if the
particularly since renal function
potential benefits outweigh the
is not fully developed in
potential risk6
neonate6

Ascorbic Acid 100mg Tab. A1 Compatible3 Compatible3

D1 Human Data Suggest Risk in 2nd and Limited Human Data—

Atenolol 100mg Tab.
C2 3rd Trimesters3 Potential Toxicity3
X1
Atorvastatin 40mg Tab Contraindicated in 1st Trimester3 Contraindicated3
D2
Atropine Sulphate 1mg/ml C1 Limited Human Data- Probably
Human Data Suggest Low Risk3
Inj. A2 Compatible3
B1
Azithromycin 250mg Tab Compatible3 Compatible3
B12
Benzathine Penicillin 2.4MU B1
Compatible3 Compatible3
(1.8gm) Inj. A2
Benzoic & Salicylic Acids Limited Human Data—Probably No Human Data—Probably
C1
Ointment ( Whitfield's) Compatible3 Compatible3

Benzoyl Peroxide 5% Gel C1 Use with caution6 Use with caution6

Benzyl Benzoate 25%

- Contraindicated6 Contraindicated6
Emulsion

Betamethasone 17- Valerate C1 No Human Data—Probably

Compatible3
0.01-0.05% Cream B32 Compatible3
C1 No Human Data—Probably Limited Human Data—
Bisacodyl 5mg Tab.
A2 Compatible3 Probably Compatible3
Bismuth Subgallate & Benzyl No Human Data—Potential
- Human Data Suggest Low Risk3
Benzoate Suppository Toxicity3

Bisoprolol Fumarate 2.5/5
mg Tab.
Bromhexine HCl 8mg Tab.
Budesonide 160mcg +
Formoterol 4.5mcg Inhaler
C1 Human Data Suggest Risk in 2nd and
C2 3rd Trimesters3
Available data find no ill effects
A1 following oral administration.
Precautions should be practised4
No clinical data on exposed
pregnancies are available. The
C1
lowest effective dose of budesonide
B32
needed to maintain adequate
asthma control should be used4
No Human Data—Potential
Toxicity3
Bromhexine is expected to
enter breast milk, and
therefore should be avoided
during lactation4
Administration of Symbicort
should only be considered if
the expected benefit to the
mother is greater than any
possible risk to the child4
 Item Pregnancy Category Use in pregnancy Use in lactation
Probably compatible3
The amounts of inhaled
budesonide excreted into
Compatible3
B1 breast milk are minute and
Budesonide 64mcg Nasal This drug should be used in
A2 infant exposure is negligible.
Spray pregnancy only if the benefit
Most experts consider oral and
outweighs the risk to the fetus3
inhaled corticosteroids
acceptable to use during
breastfeeding5
C1
Calcitriol 0.25mcg Cap. Compatible3 Compatible3
B32
Calcium Carbonate 500mg
C1 Compatible3 Compatible3
Tab.
Animal studies are not available.
There is no controlled data in
human pregnancy. The background
birth defect and miscarriage risk for
Calcium Gluconate 10% Inj. C1 Infant risk cannot be ruled out7
the indicated population is not
Exempt2
known. In the US general
population, the estimated major
birth defect risk is 2 to 4% and the
miscarriage risk is 15 to 20%4
D1 Human Data Suggest Risk in 2nd and
Captopril 25mg Tab. Compatible3
D2 3rd Trimesters3
D1 Compatible—Maternal Benefit >>
Carbamazepine 200mg Tab. Compatible3
D2 Embryo–Fetal Risk3
Carbimazole 5mg Tab. D1 Human Data Suggest Risk3 Compatible3
B1
Ceftriaxone 250mg Inj. ‘ Compatible3 Compatible3
B12
Cefuroxime Axetil 250mg B1
Compatible3 Compatible3
Tab. B12
Cephalexin Monohydrate B1
Compatible3 Compatible3
250mg Capsule A2
Cetirizine Dihydrochloride B1 Limited Human Data—Animal Data No Human Data—Probably
10mg Tab. B22 Suggest Low Risk3 Compatible3
Charcoal Activated 250mg C1
Not documented4 Not documented4
Tab. B22
There is no evidence on the
Chloramphenicol 0.5% w/v safety in infants exposed via
Eye Drops breastfeeding after maternal
Compatible3 use; risks of toxicity in the
No association between topical infant are theoretical and not
Chloramphenicol 1% Eye C1
chloramphenicol in the 1st trimester supported by direct clinical
Ointment A2
of pregnancy and major congenital evidence. Therefore, the use of
malformations8 chloramphenicol via the ear or
eye can proceed with caution.
Chloramphenicol 5% w/v Ear However, it should be avoided
Drops if there is a past or family
history of blood dyscrasias9
 Item Pregnancy Category
Chlorhexidine 1% Cream
Chlorhexidine Gluconate 5%
Solution
Chlorpheniramine Maleate
10mg/ml Inj.
Chlorpheniramine Maleate
4mg Tab.
Cinnarizine 25mg Tab.
Clobetasol Butylrate 0.05%
Cream
Clotrimazole 1% Cream
Clotrimazole 500mg Vaginal
Tablet (Pessary)
Cloxacillin Sodium 500mg
Capsule
Colchicine 0.5mg Tab.
Use in pregnancy Use in lactation
No Human Data—Probably
B1 Compatible3
Compatible3
No Human Data—Probably
B1 Compatible3
Compatible3
B1 Compatible3
No Human Data—Probably
A2
Compatible 3
Not known whether
Cinnarizine is excreted in
human milk; however, low
concentrations of other
Animal Data—No Teratogenic Effect.
antihistamine have been
Human Data—The safety of
C1 dictated in human milk.
Cinnarizine in pregnancy has not
Because of the risk
been established. Not advisable4
antihistamic side effects in
infants, particularly in
neonates, patient should not
nurse while taking this drug4
The safe use of topical
corticosteroids during lactation
has not been established. If
used during lactation, should
not be applied to the breasts
There is limited data. Topical
to avoid accidental ingestion
administration of corticosteroids to
by the infant.4 Since only
pregnant animals can cause
C1 extensive application of the
abnormalities of foetal
B32 most potent corticosteroids
development. Benefit should
may cause systemic effects in
outweigh risk4
the mother, it is unlikely that
short-term application of
topical corticosteroids would
pose a risk to the breastfed
infant by passage into
breastmilk5
B1 Compatible3 Compatible3
B1 Compatible3 Compatible3
Cloxacillin is excreted in breast
milk. Althaugh no significant
Problems in humans have not been problems have been reported,
B1 documented. However, the risk- the risk benefit must be
benefit must be considered4 considered since its use by
nursing mothers may lead to
sensitization of infants4
C1 Limited Human Data—
Compatible3
D1 Probably Compatible3
 Item Pregnancy Category Use in pregnancy Use in lactation
Crotamiton 10% cream C1 Use with caution6 Use with caution6

Diclofenac Sodium 50mg Prior to 30 week

Tab. gestation: C1
Starting 30 week Human data suggest risk in 1st and No human data- Probably
Diclofenac Sodium gestation: D1 3rd trimesters3 compatible3
75mg/3ml Inj. C2
Not assigned 1 Limited Human Data—
Diltiazem HCl 30mg Tab. Human Data Suggest Low Risk3
C2 Probably Compatible 3
Animal Data—No Teratogenic Effect.
Diosmin 450mg & Hesperidin 1
Not assigned Human Data—No harmful effects Not recommended4
50mg Tab.
have been reported to date4
Diphenhydramine HCl B1 Limited human data- Probably
Compatible3
12.5mg/5ml Syrup (Adult) A2 compatible3
Animal reproduction studies have
shown an adverse effect on the
Diphenoxylate 2.5mg + fetus and there are no adequate and
C1
Atropine Sulphate 25mcg well-controlled studies in humans, Use with caution6
C2
Tab. but potential benefits may warrant
use of the drug in pregnant women
despite potential risks6
-Most products: D
-Doryx(R) MPC,
Vibramycin(R), Vibra- Contraindicated in 2nd and 3rd
Doxycycline 100mg Cap. Compatible3
Tabs(R): Not Trimesters3
assigned.1
D2
Paradichlorobenzene,
Turpentine Oil & Chlorbutol - Use with caution4 Use with caution4
Ear Drops (Cerumol)

D1 Human Data Suggest Risk in 2nd and Limited Human Data—

Enalapril 5mg/10mg Tab.
D2 3rd Trimesters3 Probably Compatible3
Erythromycin Ethylsuccinate B1
Compatible3 Compatible3
400mg Tab. A2
C1 Limited Human Data—
Ethambutol HCL 400mg Tab. Compatible3
A2 Probably Compatible3
Not assigned1 Contraindicated: Remove implant if May be used after the 4th
Etonogestrel 68mg Implant
B32 pregnancy occurs4 postpartum week4
Etoricoxib is excreted in the
- milk of lactating rats. It is not
Etoricoxib 90mg Tab Contraindicated4
C2 known whether this drug is
excreted in human milk4
C1 Limited Human Data—Animal Data No Human Data—Probably
Felodipine 5mg/10mg Tab.
C2 Suggest Risk3 Compatible3

Not assigned1 Limited human data- Animal data No human data- Potential
Fenofibrate 145mg Tab
B2 suggest risk3 toxicity3
 Item Pregnancy Category Use in pregnancy Use in lactation
Problems in humans have not been
Ferrous Fumarate 200mg 1 Problem in humans have not
Not assigned documented with orally intake of
Tab. been documented6
daily recommended amounts4
Fluorescein Sodium C1 Limited human data- Animal data Limited human data- Probably
Ophthalmic Strips B22 suggest low risk3 compatible3
Fluticasone Propionate C1
Use with caution6 Use with caution6
125mcg Inhaler B32
C1 Human Data Suggest Risk in 3rd Limited Human Data—
Fluvoxamine 50mg Tab.
C2 Trimester3 Potential Toxicity3
A1
Folic Acid 5mg Tab. Compatible3 Compatible3
A2
Frusemide 20mg/2ml Inj.
C1 Limited human data- Probably
Human data suggest low risk3
C2 compatible3
Frusemide 40mg Tab.

Limited human data- Probably

Gabapentine 300mg Cap
B32
Gamma Benzene 0.1% Lotion
compatible3
An expert consensus guideline
C1 Limited human data- Animal data
indicates that gabapentin is an
suggest risk3
acceptable choice for
refractory restless leg
syndrome during lactation5
Limited Human Data—Animal Data Limited Human Data—Probably
C1
Suggest Low Risk3 Compatible3

C1 Limited Human Data—Animal Data No Human Data—Potential

Gemfibrozil 300mg Cap.
B22 Suggest Risk3 Toxicity3

Gliclazide MR 30/60mg Tab. C1 Contraindicated6 Contraindicated6

Glycerin & Sodium Chloride

C1 Use with caution6 Use with caution6
Enema
Glyceryl Trinitrate 500mcg C1 No Human Data—Probably
Human Data Suggest Low Risk3
Tab. B22 Compatible3
It is unknown whether
There is no available data. Animal
glycopyrronium bromide is
studies do not indicate direct or
Glycopyrronium 50mcg excreted in human milk.
C1 indirect harmful effects with respect
Inhalation Powder Hard Should only be considered if
B22 to reproductive toxicity. Benefit
Capsules the expected benefit to the
should outweigh risk4
woman is greater than any
possible risk to the infant4
Microsize
formulation: X.
Ultramicrosize Limited Human Data—Probably No Human Data—Potential
Griseofulvin 125mg Tab.
formulation: Not Compatible3 Toxicity3
assigned1
D2
C1 Limited human data- Animal data Limited human data- Potential
Haloperidol 5mg/ml Inj.
C2 suggest moderate risk3 toxicity3
 Item Pregnancy Category
Heparin Sodium 10IU/ml in
Sodium Chloride 0.9% Inj.
Hydrochlorothiazide 25mg
Tab.
Hydrocortisone 1% Cream
Hydrocortisone Suc. 100mg
Inj.
Hyoscine N-Butylbromide
10mg Tab.
Hyoscine N-Butylbromide
20mg/ml Inj.
(Scopolamine)
Iberet-Folic 500 Tab.
Ibuprofen 100mg Tab
B; D (if used for >48
h/after 34 wk/near
Indomethacin 25mg Tab.
delivery) 1
Use in pregnancy Use in lactation
C1
Compatible3 Compatible3
C2
B1
Compatible3 Compatible3
C2
C1 Limited Human Data—Probably
Human Data Suggest Risk3
A2 Compatible3
Limited human data- Probably
compatible3
Systemically administered
corticosteroids appear in
Human data suggest risk3
human milk and could
Have been shown to be teratogenic
suppress growth, interfere
in many species when given in doses
with endogenous
equivalent to the human dose.
corticosteroid production, or
C1 Animal studies have yielded an
cause other untoward effects.
C2 increased incidence of cleft palate in
Because of the potential for
the offspring of pregnant mice, rats,
serious adverse reactions in
and rabbits. There are no adequate
nursing infants, a decision
and well-controlled studies in
should be made whether to
pregnant women4
continue nursing, or
discontinue the drug, taking
into account the importance of
the drug to the mother4
Limited human data- Probably
C1 Human data suggest low risk3
compatible3
Limited human data- Probably
compatible3
No information is available
during breastfeeding. Use
Human data suggest low risk3 during labor appears to have a
C1 Crosses placenta. However, studies detrimental effect on newborn
B2 have not been done in animals or infants' nursing behavior. Long-
humans4 term use of scopolamine might
reduce milk production or milk
letdown, but a single systemic
is not likely to interfere with
breastfeeding5
Studies have failed to reveal
evidence that Folic acid (Iberet Folic-
A1 500) increases the risk of fetal Compatible5
abnormalities if administered during
pregnancy5
C1 Human Data Suggest Risk in 1st and
Compatible3
C2 3rd Trimesters3
Human Data Suggest Risk in 1st and Limited Human Data—
3rd Trimesters3 Probably Compatible3
C2
 Item
Insulin Aspart 30%/Aspart
Protamine 70%(NovoMix-30)
100 IU/ml FlexPen
Insulin Detemir (Levemir)
100 IU/ml FlexPen
Insulin Glargine (Basalog)
100 IU/ml Pre-filled Pen
Insulin Isophane (Insugen-N)
100 IU/mL Penfill
Insulin Regular (Insugen-R)
100 IU/mL Penfill
Insulin Regular/Isophane
(Insugen-30/70) 100 IU/mL
Penfill
Ipratropium Bromide 20mcg
+ Fenoterol 50mcg/dose
Inhalation
Ipratropium Bromide and
Salbutamol Respirator
Solution
Iron Dextran 50mg Fe/ml in
2ml Inj.
Isoniazid 100mg Tab.
Isosorbide Dinitrate 10mg
Tab.
Itraconazole 100mg Tab.
Ketoprofen 2.5% Gel
Pregnancy Category Use in pregnancy Use in lactation
B1 Limited human data- Probably
Compatible3
A2 compatible3
B1
Compatible3 Compatible3
A2
C1
Compatible3 Compatible3
B32
B1 Compatible3 Compatible3
B1 Compatible3 Compatible3
B1 Compatible3 Compatible3
C1 No Human Data—Probably
Human Data Suggest Low Risk3
B12 Compatible3
C1 No Human Data—Probably
Human Data Suggest Low Risk3
B12 Compatible3
Limited data indicate trace
Limited human data- Animal data amounts of iron dextran
C1
suggest reproductive toxicity. excreted into breastmilk5
-
Benefit should outweigh risk4 It is preferable to not use
during breast-feeding4
C1 Compatible—Maternal Benefit >> Limited Human Data—
A2 Embryo–Fetal Risk3 Probably Compatible3
C1 Limited Human Data—Animal Data No Human Data—Probably
B12 Suggest Moderate Risk3 Compatible3
C1 Limited human data- Potential
Human data suggest low risk3
B32 toxicity3
During 1st and 2nd trimester: In
mice and rats, there is no evidence
of teratogenic or embryotoxicity. In
the rabbit, slight embryotoxicity
No data are available on
likely related to maternal toxicity
excretion of ketoprofen in
has been reported.
human milk. Ketoprofen is not
C1 During 3rd trimester:
recommended in nursing
C2 Contraindicated4
mothers4
Fetal toxicity can occur in response
to not only systemic, but also
transdermal administration, and
accounts well for the sustained fetal
toxicity after discontinuing the
administration of ketoprofen10
 Item Pregnancy Category
Labetalol HCL 100mg Tab.
Lactulose Liquid
LevoThyroxine Sodium
50mcg/100mcg Tab.
Lignocaine 2% Jelly
Lignocaine HCl (Lidocaine)
100 mg/5 ml Inj. (2%) IV/IM
Not assigned1
Loratadine 10mg Tab.
Loratadine 5mg +
Not Assigned1
Pseudoephedrine 120mg
Tab.
Losartan 50/100mg Tab
Magnesium Sulfate
2.47gm/5ml Inj.
Magnesium Sulphate Paste
Use in pregnancy
C1
Human Data Suggest Low Risk3
C2
No human data- Probably
B1
compatible3
A1
Compatible3
A2
B1
Use with caution6
A2
Compatible. The majority of the
information on the drug in
pregnancy derives from its use as a
B1 local anesthetic during labor and
A2 delivery. Reproduction studies have
revealed no evidence of fetal harm
in pregnant rats a doses up to 6.6
times the human dose3
Limited Human Data—Animal Data
B12 Suggest Low Risk3
Safe use of loratadine +
pseudoephedrine during pregnancy
has not been established. Therefore,
B22 the drug should be used only if
potential benefit justifies the
potential risk to the foetus6
D1 Human Data Suggest Risk in the 2nd
D2 and 3rd Trimesters3
Compatible.
Does not usually pose a risk to the
fetus or newborn. Longterm
infusions of magnesium may be
D1 associated with sustained
D2 hypocalcemia in the fetus resulting
in congenital rickets. Neonatal
neurologic depression may occur
with respiratory depression, muscle
weakness, and loss of reflexes3
D1
Compatible3
D2
Use in lactation
Limited Human Data—
Probably Compatible3
No human data- Probably
compatible3
Compatible3
Use with caution6
Limited human data- Probably
compatible3
Lidocaine concentrations in
milk during continuous IV
infusion, epidural
administration and in high
doses as a local anesthetic are
low and the lidocaine is poorly
absorbed by the infant.
Lidocaine is not expected to
cause any adverse effects in
breastfed infants. No special
precautions are required5
Limited Human Data—
Probably Compatible3
Since loratadine and
pseudoephedrine sulphate are
excreted in breast milk, a
decision should be made
whether to discontinue nursing
or discontinue the use of this
product6
No Human Data—Probably
Compatible3
Compatible.
IV magnesium increases milk
magnesium concentrations
only slightly and oral
absorption of magnesium by
the infant is poor, so maternal
magnesium therapy is not
expected to affect the
breastfed infant's serum
magnesium3
Compatible3
 Item Pregnancy Category Use in pregnancy Use in lactation
Meclozine may be distributed
into breast milk. However,
problems in humans have not
been documented. Due to its
anticholinergic actions,
Meclozine may inhibit
lactation. Therefore, it is not
Meclozine is not expected to harm
recommended for lactating
an unborn baby.
women unless the expected
Meclozine HCL 25mg + Meclozine HCL: B1 Pyridoxine is considered to be safe
benefits outweigh any
Pyridoxine 50mg Tab. Pyridoxine: A1 for use during pregnancy. Pyridoxine
potential risk.
requirements increase during
Pyridoxine is excreted into
pregnancy.6
milk. While some have
expressed concern over the
inhibition of breast milk
secretion by Pyridoxine, others
have cautioned that Pyridoxine
deficiency may cause seizures
in neonate.6
Meclozine may be distributed
into breast milk. However,
problems in humans have not
been documented. Due to its
anticholinergic actions,
Meclozine may inhibit
lactation. Therefore, it is not
Meclozine is not expected to harm
recommended for lactating
an unborn baby.
women unless the expected
Meclozine HCL 25mg + Meclozine HCL: B1 Pyridoxine is considered to be safe
benefits outweigh any
Pyridoxine 50mg Tab. Pyridoxine: A1 for use during pregnancy. Pyridoxine
potential risk.
requirements increase during
Pyridoxine is excreted into
pregnancy.6
milk. While some have
expressed concern over the
inhibition of breast milk
secretion by Pyridoxine, others
have cautioned that Pyridoxine
deficiency may cause seizures
in neonate.6
Medroxyprogesterone 5mg X1
Contraindicated3 Compatible3
Tab. D2
C ;D(in 3rd trimester
Human Data Suggest Risk in 1st and Limited Human Data—
Mefenamic Acid 250mg Tab. or near delivery)1
3rd Trimesters3 Probably Compatible3
C2
Human data suggest risk in 1st and
C1
3rd trimesters3 No human data- Probably
Meloxicam 7.5mg Tab. 3rd trimester: D1
Avoid during 3rd trimester or near compatible3
C2
delivery
Metformin HCl +
B1
Glibenclamide 500/2.5mg Not recommended6 Not recommended6
C2
Tab.
 Item Pregnancy Category Use in pregnancy Use in lactation
B1
Metformin HCL 500mg Tab. Human Data Suggest Low Risk3 Compatible3
C2
B1
Metformin XR 500mg Tab. Human Data Suggest Low Risk3 Compatible3
C2
B1 Limited Human Data—
Methyldopa 250 mg Tab. Compatible3
A2 Probably Compatible3
Compatible3
Metoclopramide HCL 10mg B1 Metoclopramide is excreted in
Compatible. Metoclopramide has
Tab. A2 variable amounts in breastmilk.
been used during all stages of
Although most studies have
pregnancy. No evidence of embryo,
found no adverse effects in
fetal, or newborn harm has been
breastfed infants during
Metoclopramide Hcl B1 found in human and animal studies3
maternal metoclopramide use,
10mg/2ml Inj. A2 many did not adequately
observe for side effects5
Metoprolol Tartrate 100mg C1 Human Data Suggest Risk in 2nd and Limited Human Data—
Tab. C2 3rd Trimesters3 Potential Toxicity3
Hold Breastfeeding (Single
1
B Dose) Limited. Human Data—
Metronidazole 200mg Tab. Human Data Suggest Low Risk3
B22 Potential Toxicity (Divided
Dose)3
Miconazole Nitrate 2% C1
Compatible3 Compatible3
Cream A2
No human data- Probably
compatible3
Very low levels appear in
B1 Limited human data- Probably
Montelukast 10mg Tab breastmilk. Amounts ingested
B12 compatible3
by the infant would not be
expected to cause any adverse
effects5
C1 No human data- Probably
Naloxone HCl 0.4mg/ml Inj. Compatible3
B12 compatible3
D1 No Human Data—Probably
Neomycin 0.5% Cream Human Data Suggest Low Risk3
D2 Compatible3

C1 Limited Human Data—Probably

Nifedipine 10mg Tab Human Data Suggest Low Risk3
C2 Compatible3
B1
Human Data Suggest Risk in 3rd Limited Human Data—
Nitrofurantoin 100mg Tab A (short-term
Trimester3 Probably Compatible3
therapy)2
Nystatin 100,000 IU/ml C1
Compatible3 Compatible3
Suspension A2
C1 Limited Human Data—Potential
Omeprazole 20mg Cap Human Data Suggest Low Risk3
B32 Toxicity3

B1
Paracetamol 500mg Tab Human Data Suggest Low Risk3 Compatible3
A2
 Item Pregnancy Category Use in pregnancy Use in lactation

Perindopril 4mg/8mg/4mg + D1
Contraindicated6 Contraindicated6
indapamide 1.25mg D2

Phenoxymethylpenicillin B1
Compatible3 Compatible3
125mg Tab A2

Compatible—Not be used unless Compatible—Not be used

Phenytoin Sodium 100mg D1
maternal benefit outweighs risk to unless maternal benefit
Cap D2
fetus3 outweighs risk to fetus3

-
Pizotifen 0.5mg Tab. Use with caution Use with caution
B12

Potassium Chloride SR C1
Compatible3 Compatible3
600mg Tab Exempt2

Potassium Permanganate BP - Use with caution4 Use with caution4

C1 Limited Human Data—Animal Data Limited Human Data—Potential

Prazosin HCL 1mg/2mg Tab.
B22 Suggest Low Risk3 Toxicity3

C/D1
Prednisolone 5mg Tab. Human Data Suggest Risk3 Compatible3
A2

Prolase Tab. - Use with caution Use with caution

C1 Human Data Suggest Risk in 2nd and Limited Human Data—Potential

Propranolol 40mg Tab.
C2 3rd Trimesters3 Toxicity3

D1 Compatible—Maternal Benefit >>

Propylthiouracil 50mg Tab. Compatible3
C2 Embryo–Fetal Risk3

C1 Compatible—Maternal Benefit >> Limited Human Data—Probably

Pyrazinamide 500mg Tab.
Embryo–Fetal Risk3 Compatible3

A1
Pyridoxine 10mg Tab. Compatible3 Compatible3
Exempt2

Ranitidine 150mg Tab.

B1 Limited human data- Probably
Ranitidine 25mg/ml Compatible3
B12 compatible3
(2ml/amp) Inj.
Rifampicin 150mg/300mg C1
Compatible3 Compatible3
Tab. C2

Rifampicin 150mg + Isoniazid C1

Compatible3 Compatible3
75mg Tab. (Akurit-2) C2

Rifampicin 150mg, Isonizid

C1
75mg, Pyrazinamide 400mg, Limited Human Data—Probably
A2 Compatible3
Ethambutol HCL 275mg Tab. Compatible3
(Akurit-4)
 Item Pregnancy Category Use in pregnancy Use in lactation

C1 Compatible—Maternal Benefit >> Limited Human Data—Potential

Risperidone 1mg/2mg Tab.
D2 Embryo–Fetal Risk3 Toxicity3

C1 No Human Data—Probably
Salbutamol 2mg Tab. Compatible3
A2 Compatible3

Concentrations in plasma after

Salmeterol 50mcg +
Flutisone Propionate 250mcg
Saxagliptin 5mg Tab.
Selenium Sulphide Shampoo
25mg/ml
Sertraline 50mg Tab
There is insufficient experience of
the use in human pregnancy.
Reproductive toxicity studies in
animals revealed the foetal effects
C1
expected at excessive systemic
B32
exposure levels of a potent β2-
adrenoreceptor agonist and
glucocorticosteroid. Benefit should
outweigh risk4
B1 No human data- Animal data
B32 suggest low risk3
Animal reproductive studies have
not been conducted. There is no
C1 controlled data in human
- pregnancy. Most manufacturer
stated that their product should not
be used by pregnant women4
C1 Human Data Suggest Risk in 3rd
C2 Trimester3
inhaled therapeutic doses are
very low and therefore,
concentrations in human
breast milk are likely to be
correspondingly low. This is
supported by studies in
lactating animals, in which low
drug concentrations were
measured in milk. No data
available for human breast
milk4
No human data- Probably
compatible3
Monitoring of the breastfed
infant's blood glucose is
advisable during maternal
therapy with saxagliptin.
However, an alternate drug
may be preferred, especially
while nursing a newborn or
preterm infant5
There is no data on the
excretion of selenium topical
into human milk. Because
many drugs are secreted in
human milk, caution is
recommended4
Limited Human Data—Potential
Toxicity3

Silver Sulphadiazine 1% B1
Contraindicated6 Contraindicated6
Cream C2

X1
Simvastatin 10mg/40mg Contraindicated3 Contraindicated3
D2

Sodium Bicarbonate 8.4% Inj. C1 Limited human data- Animal data No human data- Potential
(10ml) - suggest low risk toxicity3

Sodium Bicarbonate, Citric - Limited Human Data—Probably Limited Human Data—Probably

Acid, Citrate & Tartaric Acid Compatible3 Compatible3
 Item Pregnancy Category
Sodium Cromoglycate 2%
Eye Drops
Sodium Valproate 200mg
Tab
Spironolactone 25mg Tab.
Sulphamethoxazole 400 mg
& Trimethoprim 80 mg
(Co-Trimoxazole) Tab.
Sulpiride 200mg Tab.
Telmisartan 40mg/ 80mg/
80+12.5mg HCTZ
Terazosin 2mg Tab.
Theophylline B.P. 250mg SR
Tab.
Ticlopidine 250mg Tab.
Tramadol HCL 50mg Tab.
Tranexamic Acid 250mg
Capsule
Triamcinolone 0.1% Dental
Paste
Trimetazidine 35mg MR Tab.
Triprolidine &
Pseudoephedrine Tab.
Use in pregnancy Use in lactation
It is not known whether
There are no adequate and well-
Sodium Cromoglicate is
controlled studies in pregnant
excreted in human milk.
B1 women. Therefore, use during
Therefore caution should be
A2 pregnancy is not recommended
exercised when the eye drops
unless the benefit outweighs the
are administered to nursing
potential risk4
mothers4
D1 Limited Human Data—Potential
Human Data Suggest Risk3
D2 Toxicity3
C1 Limited Human Data—Animal Data Limited Human Data—Probably
B32 Suggest Risk3 Compatible3
D1 Human Data Suggest Risk in 3rd Limited Human Data—Potential
D2 Trimester3 Toxicity3
- Use with caution6 Use with caution6
D1 Human Data Suggest Risk in 2nd and No Human Data—Probably
D2 3rd Trimesters3 Compatible3
C1 No human data- Animal data No human data- Probably
B22 suggest low risk3 compatible3
C1
Compatible3 Compatible3
A2
B1 Limited Human Data—Animal Data No Human Data—Potential
Suggest Low Risk3 Toxicity3
C1 Limited Human Data—Potential
Human Data Suggest Risk3
C2 Toxicity3
Limited Human Data—Animal Data Limited Human Data—Probably
B1
Suggest Low 3 Compatible3
C1
Use with caution6 Use with caution6
B32
Itt is unknown whether
There are no data from the use of trimetazidine/metabolites are
trimetazidine in pregnant women. excreted in human milk. A risk
- As a precautionary measure, it is to the newborns/infants
preferable to avoid the use during cannot be excluded. Should
pregnancy4 not be used during breast-
feeding4
Limited Human Data—Probably
C1 Compatible3
Compatible3
 Item Pregnancy Category Use in pregnancy Use in lactation

There are no or limited amount of
C1 data from the use of Tropicamide in
Tropicamide 1% Eye Drops
B22 pregnant women. It is not
recommended during pregnancy4
however, during long-term use,
Unknown whether
tropicamide/metabolites are
excreted in human milk. A
decision must be made
whether to discontinue
breastfeeding or to
discontinue/abstain from
tropicamide4
A single dose of is not likely to
interfere with breastfeeding;
observe the infant for signs of
decreased lactation (e.g.,
insatiety, poor weight gain)5

Valsartan 80mg & HCTZ D1 Human Data Suggest Risk in 2nd and No Human Data—Probably
12.5mg Tab. D2 3rd Trimesters3 Compatible3
D1 Human data suggest risk in 2nd and
Valsartan 80mg Tab Probably compatible 3
D2 3rd trimesters 3
C1 Limited Human Data—Probably
Verapamil HCL 40mg Tab. Compatible3
C2 Compatible3
There are no adequate data from It is unknown whether
the use of vildagliptin in pregnant vildagliptin is excreted in
women. Studies in animals have human milk. Animal studies
C1
Vildagliptin 50mg Tab shown reproductive toxicity at high have shown excretion of
B32
doses. Due to lack of human data, it vildagliptin in milk. It should
should not be used during not be used during breast-
pregnancy4 feeding4
C1
Vitamin K1 1mg/ml Inj. Compatible3 Compatible3
-

REFERENCES

1- US FDA
2. AU TGA
3. Drugs in pregnancy and lactation, 11th Edition (BRIGGS)
4. Product Information Leaflet
5. LACTMED
6.MIMS
7. Micromedex
8. Thomseth V, Cejvanovic V, Jimenez-Solem E, Petersen K, Poulsen H, Andersen J. Exposure to topical
chloramphenicol during pregnancy and the risk of congenital malformations: a Danish nationwide cohort study.
Acta Ophthalmologica. 2015;93(7):651-653.
9. United Kingdom National Health Service (NHS)
10. Tanaka S, Kanagawa T, Momma K, Hori S, Satoh H, Nagamatsu T et al. Prediction of sustained fetal toxicity
induced by ketoprofen based on PK/PD analysis using human placental perfusion and rat toxicity data. British
Journal of Clinical Pharmacology. 2017;83(11):2503-2516.
 APPENDIX A: Drug safety in Pregnancy classification (US FDA)

Category A Controlled studies in women fail to demonstrate a risk to the fetus in the first trimester (and there is no
evidence of a risk in later trimesters), and the possibility of fetal harm appears remote.

Category B Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies
in pregnant women or animal-reproduction studies have shown an adverse effect that was not confirmed
in controlled studies in women in the first trimester.

Category C Either studies in animals have revealed adverse effects on the fetus (teratogenic or embryocidal or other)
and there are no controlled studies in women or studies in women and animals are not available. Drugs
should be given only if the potential benefit justifies the potential risk to the fetus.

Category D There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be
acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease
for which safer drugs cannot be used or are ineffective).

Category X Studies in animals or human beings have demonstrated fetal abnormalities or there is evidence of fetal
risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly
outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.

APPENDIX B: Drug safety in Pregnancy classification (AU TGA)

Category A Drugs which have been taken by a large number of pregnant women and women of childbearing age without
any proven increase in the frequency of malformations or other direct or indirect harmful effects on the
fetus having been observed.

Category B1 Drugs which have been taken by only a limited number of pregnant women and women of childbearing age,
without an increase in the frequency of malformation or other direct or indirect harmful effects on the
human fetus having been observed.
Studies in animals have not shown evidence of an increased occurrence of fetal damage.

Category B2 Drugs which have been taken by only a limited number of pregnant women and women of childbearing age,
without an increase in the frequency of malformation or other direct or indirect harmful effects on the
human fetus having been observed.
Studies in animals are inadequate or may be lacking, but available data show no evidence of an increased
occurrence of fetal damage.

Category B3 Drugs which have been taken by only a limited number of pregnant women and women of childbearing age,
without an increase in the frequency of malformation or other direct or indirect harmful effects on the
human fetus having been observed.
Studies in animals have shown evidence of an increased occurrence of fetal damage, the significance of
which is considered uncertain in humans.

Category C Drugs which, owing to their pharmacological effects, have caused or may be suspected of causing, harmful
effects on the human fetus or neonate without causing malformations. These effects may be reversible.
Accompanying texts should be consulted for further details.

Category D Drugs which have caused, are suspected to have caused or may be expected to cause, an increased
incidence of human fetal malformations or irreversible damage. These drugs may also have adverse
pharmacological effects. Accompanying texts should be consulted for further details.

Category X Drugs which have such a high risk of causing permanent damage to the fetus that they should not be used in
pregnancy or when there is a possibility of pregnancy.