DISORDERS OF THE

NEUROMUSCULAR JUNCTION

 Disorder of the neuromuscular junction

Disorders of the neuromuscular junction decrease

conduction of nervous system impulse to the peripheral
muscle, resulting in muscle weakness. Different clinical
syndromes are caused by defects

in different molecules or
components of the neuromuscular junction.
 The common cause of the disorders of the
neuromuscular junction is myasthenia gravis, an
autoimmune disease where the immune system
produces antibodies that attach themselves to the
neuromuscular junction and prevent transmission
of the nerve impulse to the muscle
LAMBERT EATON SYNDROME

Another syndrome of neuromuscular weakness arising

from a disorder at the neuromuscular junction is LES.
more that 50% which accounts for 80% of malignancies
causing the syndrome.of cases of LES are associated
with cancer especially small cell carcinoma of the lung,