Name: Kelas A2 Kelompok 2

Exercise 4: Endocrine System Physiology: Activity 4: Measuring Cortisol and Adrenocorticotropic Hormone Lab Report

Pre-lab Quiz Results

You scored 100% by answering 5 out of 5 questions correctly.

1. Cortisol
You correctly answered: d. is a hormone important in the body's response to stress.

2. ACTH
You correctly answered: d. is a tropic hormone that stimulates cortisol release.

3. CRH
You correctly answered: b. has a tropic effect on the anterior pituitary gland.

4. Cushing's syndrome refers to

You correctly answered: c. a hypercortisolism, which could be iatrogenic.

5. A condition of hypocortisolism
You correctly answered: d. refers to low levels of cortisol in the blood.

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Experiment Results
Stop & Think Questions:
Normally high levels of cortisol would inhibit release of
You correctly answered: c. both ACTH and CRH

Which hormone(s) stimulate(s) the pituitary gland to release ACTH?

You correctly answered: a. CRH

Experiment Data:

Patient Cortisol High/Low ACTH High/Low

(mcg/dl) (pg/ml)
1 2.13 Low 19.09 Low
2 36.73 High 12.65 Low
3 40.88 High 85.86 High
4 2.60 Low 104.77 High
5 53.55 High 16.35 Low

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Post-lab Quiz Results
You scored 100% by answering 6 out of 6 questions correctly.

1. Under normal conditions, if the amount of secreted CRH increases, then

You correctly answered: c. the amount of secreted ACTH will increase.

2. Under normal conditions, if the amount of secreted ACTH increases, then

You correctly answered: d. the amount of secreted CRH will likely decrease.

3. Under normal conditions, if the amount of secreted cortisol increases, then

You correctly answered: b. the amount of secreted ACTH will likely decrease.

4. If a hypersecreting pituitary tumor develops, then an expected outcome is

You correctly answered: a. a diagnosis of Cushing's disease.

5. If a hypersecreting adrenal cortex tumor develops, then an expected outcome is

You correctly answered: b. abnormally low levels of CRH due to negative feedback.

6. A patient's chart lists the diagnosis of Addison's disease. Therefore, you expect
You correctly answered: b. abnormally high levels of ACTH.

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Review Sheet Results
1. Which patient would most likely be diagnosed with Cushing's disease (view Table 4.1 in Experiment Results)? Why?
Your answer:
Pasien yang kemungkinan besar mengalami Cushing's disease adalah pasien nomor 3. Hal ini dikarenakan pasien no 3
memiliki kadar kortisol yang tinggi dan ACTH yang tinggi, dan berdasarkan informasi pada tabel 4.1, Cushing's disease
ditandai dengan kadar kortisol dan ACTH yang tinggi. Oleh karena itu, dapat disimpulkan bahwa pasien nomor 3 mengalami
Cushing's disease

2. Which two patients have hormone levels characteristic of Cushing's syndrome (view Table 4.1 in Experiment Results)?
Your answer:
Pasien yang kadar hormonnya menunjukkan karakteristik dari Cushing's syndrome berdasarkan hasil eksperimen adalah
pasien nomor dua dan lima

3. Patient 2 is being treated for rheumatoid arthritis with prednisone. How does this information change the diagnosis (view
Table 4.1 in Experiment Results)?
Your answer:
Dengan adanya informasi ini, dapat disimpulkan bahwa kondisi pasien tersebut bersifat iatrogenik, yang berarti disebabkan
oleh tindakan medis atau pengobatan yang diberikan oleh dokter.

4. Which patient would most likely be diagnosed with Addison's disease (view Table 4.1 in Experiment Results)? Why?
Your answer:
Pasien yang kemungkinan besar mengalami Addison's Disease adalah pasien ke-4. Hal ini terjadi karena terdapat kadar
kortisol yang relatif rendah dari batas normal sedangkan kadar ACTH pasien relatif tinggi dari batas normal pada tubuh
pasien.

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