Generic/ Classification Mechanism of Action
Brand
Pharmacologic Antibacterial action: Drug
classification: lincomyci
inhibits bacterial protein
Clindamycin n derivative synthesis by binding to
ribosome’s 50S subunit.
Dosage: 200
Therapeutic Clindamycin may produce
mg. / BID
classification: antibiotic bacteriostatic or
bactericidal effects on
Pregnancy risk category susceptible bacteria,
B including most aerobic
gram-positive cocci and
anaerobic gram-negative
and gram-positive
organisms. It’s
considered a first-line
drug in the treatment
of Bacteroides fragilis and
most other gram-positive
and gram-negative
anaerobes. It’s also
effective
against Mycoplasma
pneumoniae, Leptotrichia
buccalis, and some gram-
positive cocci and bacilli.
Consideration/ What to Adverse Effect
Observe/ Look
• Take culture and sensitivity GI: esophagitis, nausea, vomiting,
tests before treatment starts; abdominal pain, diarrhea,
repeat as needed. pseudomembranous colitis.
• Don’t refrigerate
reconstituted oral solution GU: cervicitis, vaginitis, Candida
because it will thicken. Drug albicans overgrowth, vulvar
remains stable for 2 weeks at irritation.
room temperature.
• I.M. preparation should be Hematologic: transient
given deep I.M. Rotate sites. leukopenia, eosinophilia,
Doses exceeding 600 mg  thrombocytopenia.
aren’t recommended.
• I.M. injection may increase Hepatic: jaundice.
creatine kinase levels
because of muscle irritation. Skin: maculopapular rash,
• For I.V. infusion, dilute each urticaria,
300 mg in 50 ml of D5W, dryness, redness, pruritus,
normal saline solution, or swelling, irritation, contact
lactated Ringer’s solution and dermatitis, burning.
give no more than 30
mg/minute. Don’t administer Other: anaphylaxis.
more than 1.2 g/hour.
• Topical form may produce
adverse systemic effects.
• Monitor renal, hepatic, and
hematopoietic functions
during prolonged therapy.