Nanotechnology is the collection of techniques that allows for the manipulation of
nanoparticles on an atomic, molecular, and supramolecular scale. Nanoparticles are insoluble particles less than 100 nm in size.A lot of research is being focused on the application of nanotechnology in orthodontics. Though much of the research has taken place in the labs, gradually in vivo studies are making their way. Biosafety of nanoparticles and materials is a subject of concern, demanding focus on further studies of the toxic effects of nano-particles to ensure their ethical usage in the oral cavity.This offers a suggestion for identifying the physical and biological characteristics of the new substance. The use of nanotechnology in orthodontics is the subject of a lot of research. In vivo investigations are gradually becoming more common, despite the fact that the majority of the research has been conducted in labs.